Multiple Autism-Linked Genes Mediate Synapse Elimination via Proteasomal Degradation of a Synaptic Scaffold PSD-95

Tsai, Nien-Pei; Wilkerson, Julia R.; Guo, Weirui; Maksimova, Marina A.; DeMartino, George N.; Cowan, Christopher W.; Huber, Kimberly M.

doi:10.1016/j.cell.2012.11.040

Multiple Autism-Linked Genes Mediate Synapse Elimination via Proteasomal Degradation of a Synaptic Scaffold PSD-95

Summary The activity-dependent transcription factor, Myocyte Enhancer Factor-2 (MEF2), induces excitatory synapse elimination in mouse neurons which requires Fragile X Mental Retardation Protein (FMRP), an RNA binding protein implicated in human cognitive dysfunction and autism. We report here th…