Cand1 Promotes Assembly of New SCF Complexes through Dynamic Exchange of F Box Proteins
Pierce, Nathan W., Lee, J. Eugene, Liu, Xing, Sweredoski, Michael J., Graham, Robert L.J., Larimore, Elizabeth A., Rome, Michael, Zheng, Ning +4 more·2013·Cell
Cited by (261)
Items 201–261 of 261
- CAND1 is required for pollen viability in Arabidopsis thaliana—a test of the adaptive exchange hypothesisLihong Li, Melaku Garsamo, Jing Yuan, Xiaojin Wang, Susan H. Lam, Kranthi Varala, Leonor C. Boavida, Yun Zhou, Xing Liu · 2022 · Frontiers in Plant Science
- Cullin-associated NEDD8-dissociated protein 1, a novel interactor of rabphilin-3A, deubiquitylates rabphilin-3A and regulates arginine vasopressin secretion in PC12 cellsKohtaro Nakashima, Seiji Takeuchi, Shintaro Iwama, Atsushi Kiyota, Yoshinori Yasuda, Naoko Iwata, Atsushi Enomoto, Hiroshi Arima, Yoshihisa Sugimura · 2018 · Endocrine Journal
- Regulation of Cullin-RING E3 ligase dynamics by Inositol hexakisphosphateDaniel C. Scott, Gary Kleiger · 2020 · Proceedings of the National Academy of Sciences
- Fungal COP9 signalosome assembly requires connection of two trimeric intermediates for integration of intrinsic deneddylaseFruzsina Bakti, Helena Stupperich, Kerstin Schmitt, Oliver Valerius, Anna M. Köhler, Cindy Meister, Anja Strohdiek, Rebekka Harting, Christoph Sasse, Kai Heimel et al. · 2023 · Proceedings of the National Academy of Sciences
- Lunapark ubiquitinates atlastin-2 for the tubular network formation of the endoplasmic reticulumPutri Chynthia Anggrandariyanny, Hiroaki Kajiho, Yasunori Yamamoto, Toshiaki Sakisaka · 2022 · The Journal of Biochemistry
- New Insights Into the Mechanism of COP9 Signalosome–Cullin-RING Ubiquitin-Ligase Pathway Deregulation in Urological CancersLinda Gummlich, Thilo Kähne, Michael Naumann, Ergin Kilic, Klaus Jung, Wolfgang Dubiel · 2016 · International review of cytology
- CAND1 inhibits Cullin-2-RING ubiquitin ligases for enhanced substrate specificityKankan Wang, Stephanie Diaz, Lihong Li, Jeremy R. Lohman, Xing Liu · 2024 · Nature Structural & Molecular Biology
- Molecular mechanisms of CAND2 in regulating SCF ubiquitin ligasesKankan Wang, Lihong Li, Sebastian Kenny, Dailin Gan, Justin M. Reitsma, Yun Zhou, Chittaranjan Das, Xing Liu · 2025 · Nature Communications
- SUV39H1-dependent methyl-degron is a critical regulator of skeletal homeostasisQian Li, Hongguang An, Rushui Bai, Qiannan Sun, Ruili Yang, Tianyi Xin, Zimeng Zhuang, Yuntao Lu, Yunyi Tang, Gengyao Chen et al. · 2025 · Cell Reports
- Illuminating ubiquitination mechanisms: How cryo-EM has shed light on Cullin RING E3 ligase functionZeba Rizvi, Gabriel C. Lander · 2025 · Current Opinion in Structural Biology
- Targeting E3 ubiquitin ligases to sensitize cancer radiation therapyZan Chen, Wei Xu · 2019 · Precision Radiation Oncology
- The COP9 Signalosome Variant CSNCSN7A Stabilizes the Deubiquitylating Enzyme CYLD Impeding Hepatic SteatosisXiaohua Huang, Dawadschargal Dubiel, Wolfgang Dubiel · 2021 · Livers
- Using In Vitro Fluorescence Resonance Energy Transfer to Study the Dynamics Of Protein Complexes at a Millisecond Time ScaleMelaku Garsamo, Yun Zhou, Xing Liu · 2019 · Journal of Visualized Experiments
- Structure and dynamics of a pentameric KCTD5/Cullin3/Gβγ E3 ubiquitin ligase complexDuc Minh Nguyen, Deanna H. Rath, Dominic Devost, Darlaine Pétrin, Robert Rizk, Alan X. Ji, Naveen Narayanan, Darren Yong, Andrew Zhai, D.A. Kuntz et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- The COP9 signalosome variants CSNCSN7A and CSNCSN7B form complexes with specific CRLs which are targets of autophagyWolfgang Dubiel, Dawadschargal Dubiel · 2025 · Essays in Biochemistry
- Overview of Protein Degradation in Plant Hormone SignalingDomnita V. Rusnac, Ning Zheng · 2018 · Springer eBooks
- TRF4, the novel TBP‐related protein of Drosophila melanogaster , is concentrated at the endoplasmic reticulum and copurifies with proteins participating in the processes associated with endoplasmic reticulumМ. М. Куршакова, Elena N. Nabirochkina, Sofia G. Georgieva, Daria V. Kopytova · 2018 · Journal of Cellular Biochemistry
- STK19 drives Transcription-Coupled Repair by stimulating repair complex stability, Pol II ubiquitylation and TFIIH recruitmentAnisha R. Ramadhin, Shun-Hsiao Lee, Di Zhou, Anita P. T. Salmazo, Camila Gonzalo-Hansen, Marjolein van Sluis, Cindy M.A. Blom, Roel C. Janssens, Anja Raams, Dick H. W. Dekkers et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Functional characterisation of components in two Plasmodium falciparum Cullin-RING-Ligase complexesDanushka S. Marapana, Simon A. Cobbold, Michał Pasternak, Gerald John Shami, Stuart A. Ralph, Sash Lopaticki, Jumana M. Yousef, Vineet Vaibhav, Laura F. Dagley, David Komander et al. · 2025 · Scientific Reports
- Structural basis of CSN-mediated SCF deneddylationShan Ding, Julie A. Clapperton, Märt-Erik Mäeots, Simone Kunzelmann, Mohammed Shaaban, Radoslav Ivanov Enchev · 2026 · Nature Communications
- Differential dynamics of cullin deneddylation via COP9 signalosome subunit 5 interactionYeong-Mu Kim, Hye‐Ji Kim, Dong-Kyu Kim, Dong-Hyun Jung, Hyo Je Cho, Sangjune Kim, Jihoon Nah, Sang‐Min Jang · 2022 · Biochemical and Biophysical Research Communications
- SCF E3 Ligase Substrates Switch from CAN-D to Can-ubiquitylateDaniel C. Scott, Brenda Arlene Schulman · 2018 · Molecular Cell
- Cryo-EM reveals important regulatory mechanism of the workhorses of targeted protein degradationRoland Hjerpe, Thimo Kurz · 2023 · Molecular Cell
- Genome-wide identification of RUB activating enzyme and conjugating enzyme gene families and their expression analysis under abiotic stresses in Capsicum annuumMin Wei, Panpan Duan, Shufang Zhao, Bingdiao Gou, Yongfu Wang, Nan Yang, Yan Ma, Zhengbao Ma, Gaoyuan Zhang, Bingqiang Wei · 2022 · PROTOPLASMA
- Identification and Characterization of Copper-Responsive miRNAs and Their Target Genes in Jerusalem ArtichokeXi Xian Chen, Tianyun Shao, Wenhan Dong, Jiayan Lin, Lixiang Dai, Yilong Ma, Zhaosheng Zhou, Xiaohua Long · 2025 · Plants
- MDM2-amplified esophageal adenocarcinomas exhibit an activated metabolic and immunosuppressive phenotype with multiple potential therapeutic targetsKarl Knipper, Christiane J. Bruns, Felix Popp, Thomas Schmidt, Bastian Grothey, Alexander Quaas, Su Ir Lyu · 2025 · BMC Cancer
- CAND1 mediates CUL7-dependent HER2 protein stability to drive breast cancer progressionXiaohong Xia, Xiaoyue He, Mengfan Tang, Yuanlin Chen, Yuning Liao, Jiangyu Zhang, Hongbiao Huang · 2025 · Breast Cancer Research
- Oxidation‐Induced C‐Terminal Amidation Marks Proteins for DegradationIan A. McLauchlan, Jack S. White, Mohamed A. Eldeeb · 2026 · BioEssays
- COP9 Signalosome NetworkAnna Franciosini, Giovanna Serino, Xing‐Wang Deng · 2014 · Springer eBooks
- How “rock-and-roll” solved the cullin supply chain problemSheena Faye Garcia, Michele Pagano · 2023 · Cell Research
- Inhibition of miR-29a-3p Alleviates Apoptosis of Lens Epithelial Cells via Upregulation of CAND1Rui Fang, Hailong Li, Ning-Xin Lv, Pei-Lin Yue, Yu-Xuan Jia, Zhao-Chuan Liu, Honggang Zhou, Xudong Song · 2023 · Current Eye Research
- Phosphorylation dependent stability control of the deneddylase DenA and its impact on Aspergillus nidulans developmentJosua Schinke · 2016
- Signals | AuxinDamilola Olatunji, Dior R. Kelley · 2021 · Elsevier eBooks
- Signaling: COP9 SignalosomeAnna Franciosini, Giovanna Serino, Xing‐Wang Deng · 2014 · Springer eBooks
- Em busca da etiologia das displasias frontonasaisMelina Guerreiro Rodrigues · 2013 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
- Identification of new regulators for PML nuclear bodiesThibaut Snollaerts · 2016 · theses.fr (ABES)
- Interaction Between Two E3 ligases, NEDD8ylated Cullin and HHARIKheewoong Baek · 2016
- Coordination of Replication-Coupled Protein Destruction and Origin Licensing Control During Cell Cycle TransitionsKate E. Coleman · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
- A Role for The CRL4-WDTC1 E3 Ligase in the Suppression of AdipogenesisBeezly S. Groh · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
- Elucidating the regulation of SPAK and OSR1 kinases by ubiquitylationBinar Asrining Dhiani · 2019 · ORCA Online Research @Cardiff (Cardiff University)
- E3-mediated Ubiquitin and Ubiquitin-like Protein Ligation: Mechanisms and Chemical ProbesDavid T. Krist, Brenda Arlene Schulman · 2020 · Royal Society of Chemistry eBooks
- Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradationZhenwei Pan, Xingda Li, Yang Zhang, Yue Zhao, Yang Zhou, Qilong Han, Ying Yang, Lingmin Zhang, Ling Shi, Xuexin Jin et al. · 2021 · Research Square
- Faculty Opinions recommendation of Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes.Arthur L. Horwich · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- CAND1 drives lipid metabolism and hepatocellular carcinoma progression by regulating FBXO11-mediated hnRNPA2B1 ubiquitinationHao Zhang, Peng Xia, Zhangshuo Yang, Jie Liu, Yimin Zhu, Caixia Dai, Zan Huang, Zhonglin Zhang, Yufeng Yuan · 2022 · Research Square
- A tissue-specific ubiquitin switch coordinates brain, craniofacial, and skin developmentAnthony J. Asmar, Rita M. Yazejian, Youmei Wu, Jason C. Collins, Jenny Hsin, Jean Cho, Andrew D. Doyle, Samhitha Cinthala, Marleen Simon, Richard H. van Jaarsveld et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- The way forward in multi-omics data analysesNhan Nguyen · 2022
- The CRL4B E3 ligase regulates mitosis by recruiting phospho-specific DCAFsAnna Stier, Samuel Gilberto, Weaam I Mohamed, Jonne H. Helenius, Ivan Mikičić, Tatjana Sajic, Petra Beli, Daniel J. Müller, Matthias Peter · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Mechanistic Insights Into the Assembly of Functional CRL3 Dimeric ComplexesWeize Wang, Zonglin Dai, Ling Liang, Youdong Mao, Yuxin Yin · 2025 · BioEssays
- Protist oxygen-sensing and the role of prolyl hydroxylase-regulation of E3(SCF) ubiquitin ligasesDonovan A. Cantrell, Ira J. Blader, Christopher M. West · 2026 · Biochimica et Biophysica Acta (BBA) - General Subjects
- CAND1 and CAND2 drive CUL4 substrate receptor exchange with largely comparable biochemical efficiency, unlike their relative effects on CUL1Kankan Wang, Sebastian Kenny, Zhana Chagan, Lihong Li, Chittaranjan Das, Xing Liu · 2026 · Structure
- Study of the role of neddylation in the regulation of meiotic recombinationMarina Tagliaro-Jahns · 2014 · theses.fr (ABES)
- Etude fonctionnelle et évolutive de LEAFY, un facteur de transcription clé dans la formation des fleursHicham Chahtane · 2014
- Regulation of proteotoxicity through atypical NEDDylationChantal M. Maghames · 2016 · theses.fr (ABES)
- An interactome-based framework for DDB1- and CUL4-associated factor prioritization in targeted protein degradationSatoshi Yamanaka, Koya Nagaoka, Yuki Shoya, Kohei Nishino, Yumi Mikura, Kenshi Tanaka, Keisuke Konishi, Yoshinori Hasegawa, Atsushi Hijikata, Hidetaka Kosako et al. · 2026 · Molecular Cell
- Identification and characterization of new Greatwall kinase substratesLena Sundermann · 2018
- Mapping the genetic landscape of HNF1B-dependent cell growthDeborah Gaglioti · 2024
- The multidimensional biology of SKP2: mechanisms, pathologies, and emerging therapeutic frontiersTao Hou, Xiangmei Hua, Peiqiang Yan, Wei Ni, Jingchao Wang, Hiroyuki Inuzuka, David K. Simon, Wenyi Wei · 2026 · Acta Materia Medica
- CAND1 drives intestinal ischemia/reperfusion injury via SCFFBXO6-PKM2-mediated mitochondrial fission and apoptosisMiaomiao Qiang, Y Zhao, Guorong Wang, Zhao Chen, Feng Zhang, Zhanyu Wang, Guangzhi Wang, Chengjun Zhuang, Shili Ning, Jihong Yao et al. · 2026 · Free Radical Biology and Medicine
- Proximal Proteomics Reveals Potential Regulators of Programmed Death-Ligand 1 in Human CancerFujin Shi, Danya Liu, Yaxiong Liu, Fan Li, Chris Zhiyi Zhang, Qiuli Li, Qiu‐Hong Tian · 2026 · ACS Omega
- KNOX-HDAC2 complex suppresses the CAND1 expression is involved in sporophytic development of Pyropia yezoensisXiuwen Yang, Ling Xu, Hongyan He, Aurang Zeb, Songdong Shen · 2026 · Plant Physiology and Biochemistry
- Covalent Targeting of the SKP1-βTrCP Interface Activates NRF1/2 SignalingWoojin Choi, Yu Cao, Jake Glicksman, Michael J. Bollong · 2026 · ACS Central Science