CTCF and Cohesin: Linking Gene Regulatory Elements with Their Targets
Open accessAbstract
Current epigenomics approaches have facilitated the genome-wide identification of regulatory elements based on chromatin features and transcriptional regulator binding and have begun to map long-range interactions between regulatory elements and their targets. Here, we focus on the emerging roles of CTCF and the cohesin in coordinating long-range interactions between regulatory elements. We discuss how species-specific transposable elements may influence such interactions by remodeling the CTCF binding repertoire and suggest that cohesin's association with enhancers, promoters, and sites defined by CTCF binding has the potential to form developmentally regulated networks of long-range interactions that reflect and promote cell-type-specific transcriptional programs.
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CTCF is involved in regulating genome organization and gene regulation.
“CTCF is involved in regulating genome organization and gene regulation30.”
From Integrated analysis of behavioral, epigenetic, and gut microbiome analyses in AppNL-G-F, AppNL-F, and wild type mice (2021) · cites this paper as [30]
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References 151 · Cited by 345
Research works printed but not linked: 1
- [1]1. Baniahmad, A. ∙ Steiner, C. ∙ Köhne, A.C. ... Modular structure of a chicken lysozyme silencer: involvement of an unusual thyroid hormone receptor binding site Cell. 1990; 61:505-514
- Authors
- Merkenschlager, M., & Odom, D. T.
- Affiliations
- Imperial College London (GB)
- University of Cambridge (GB)
- Corresponding author
- Merkenschlager, Matthias
- Odom, Duncan T.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 152
- Issue
- 6
- Pages
- 1285-1297
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2078336790
- Cited by
- 345
- References
- 151
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 7 · 2023: 3 · 2022: 9 · 2021: 14 · 2020: 22 · 2019: 24 · 2018: 27 · 2017: 34 · 2016: 43 · 2015: 56 · 2014: 66 · 2013: 21 · 2012: 1
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (099276/Z/12/Z, 99276)
- Cancer Research UK (15603, A15603)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- CTCF, cohesin, long-range chromatin interactions, gene regulatory elements, enhancers, transposable elements, chromatin looping, cell-type-specific transcription, developmental gene regulation
- MeSH terms
- CCCTC-Binding Factor, Cohesins, Animals, Chromatin, Chromosomal Proteins, Non-Histone, Gene Expression Regulation, Humans, Repressor Proteins, Cell Cycle Proteins, Regulatory Elements, Transcriptional
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