PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells

Israelsen, William J., Dayton, Talya L., Davidson, Shawn M., Fiske, Brian P., Hosios, Aaron M., Bellinger, Gary, Li, Jie, Yu, Yimin +14 more·2013·Cell

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  15. Additional file 2 of DNMT1-targeting remodeling global DNA hypomethylation for enhanced tumor suppression and circumvented toxicity in oral squamous cell carcinoma
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  16. Additional file 1 of Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells
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  17. Additional file 2 of TBX15/miR-152/KIF2C pathway regulates breast cancer doxorubicin resistance via promoting PKM2 ubiquitination
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  18. Additional file 3 of Expression and activation of nuclear hormone receptors result in neuronal differentiation and favorable prognosis in neuroblastoma
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  19. Additional file 3 of Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells
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  20. Additional file 2 of Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells
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  23. Additional file 4 of An extensive bioinformatics study on the role of mitochondrial solute carrier family 25 in PC and its mechanism behind affecting immune infiltration and tumor energy metabolism
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  24. Additional file 1 of TBX15/miR-152/KIF2C pathway regulates breast cancer doxorubicin resistance via promoting PKM2 ubiquitination
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  25. Additional file 3 of An extensive bioinformatics study on the role of mitochondrial solute carrier family 25 in PC and its mechanism behind affecting immune infiltration and tumor energy metabolism
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  26. Additional file 1 of Pyruvate kinase isoform M2 impairs cognition in systemic lupus erythematosus by promoting microglial synaptic pruning via the β-catenin signaling pathway
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  27. Additional file 4 of Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells
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  47. BindingDB Entry 50019671: Discovery of Novel Sesquiterpene Lactone Derivatives as Potent PKM2 Activators for the Treatment of Ulcerative Colitis.
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  49. BindingDB Entry 50002232: Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia.
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  50. BindingDB Entry 50022260: Development of isoselenazolium chlorides as selective pyruvate kinase isoform M2 inhibitors.
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  51. Role of stromal fibroblasts in prostate carcinoma progression and metabolic reprogramming of cancer cells
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