Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing

Zhang, Yanjia J., Reddy, Manchi C., Ioerger, Thomas R., Rothchild, Alissa C., Dartois, Veronique, Schuster, Brian M., Trauner, Andrej, Wallis, Deeann +5 more·2013·Cell

Cited by (356)

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  2. A tRNA modification in Mycobacterium tuberculosis facilitates optimal intracellular growth
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  3. Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis
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  4. Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis
    Mehak Zahoor Khan, Deborah M. Hunt, Biplab Singha, Yogita Kapoor, Nitesh Kumar Singh, D. V. Sai Prasad, Dharmarajan Sriram, Divya Tej Sowpati, Luiz Pedro S. de Carvalho, Vinay Kumar Nandicoori · 2024 · eLife
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    Neharika Jain, Emmanuel C. Ogbonna, Zoltan Maliga, Connor A. Jacobson, Liang Zhang, Angela R. Shih, Jacob M. Rosenberg, Haroon Kalam, Andréanne Gagné, Isaac H. Solomon et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  6. Transcriptomic responses of Vibrio campbellii to quorum sensing inhibition and antibiotic stress
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  7. A Conserved Mycobacterial Nucleomodulin Hijacks the Host COMPASS Complex to Reprogram Pro-Inflammatory Transcription and Promote Intracellular Survival
    Liu Chen, Baojie Duan, Pingping Chen, Qiang Jiang, Yifan Wang, Lu Lu, Yingyu Chen, Changmin Hu, Lei Zhang, Aizhen Guo · 2026 · eLife
  8. Mtb takes a Trp
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  9. The effect of glutamate homeostasis on the survival of M. bovis BCG
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  10. Role of Kynurenine Pathway in the Respiratory System
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  11. The role of N157 of A-ATP synthase subunit B in nucleotide binding and expression, production and structural and mechanistic features of subunits α and ε of Mycobacterium tuberculosis F-ATP synthase
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    Marte Singsås Dragset, Thomas R. Ioerger, Maja Loevenich, Markus Haug, Niruja Sivakumar, Anne Marstad, Père-Joan Cardona, Geir Klinkenberg, Eric J. Rubin, Magnus Steigedal et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  14. Development of a Novel Method for Genome-wide Identification of Proteins Exported during Infection and Functional Studies of One in vivo Exported Protein in Mycobacterium tuberculosis
    Ellen F. Perkowski · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
  15. Intervening along the spectrum of tuberculosis: meeting report from the World TB Day nanosymposium in the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town
    Sabelo Hadebe, Melissa Dalcina Chengalroyen, Reto Guler, Kehilwe C. Nakedi, Anastasia Sideris Koch, Mohau S. Makatsa, Muki Shehu Shey, Suraj P. Parihar, Bryan D. Bryson, Mohlopheni Jackson Marakalala et al. · 2020 · Gates Open Research
  16. A Stealthy Fungal Attack Requires an Equally Clandestine Approach to Onychomycosis Treatment
    Aditya Gupta, Jessie Carviel, Neil H. Shear · 2019 · Journal of the American Podiatric Medical Association
  17. Inhibition and reaction mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase: A potential target for novel drug design
    Preeti Kundu · 2020
  18. Intervening along the spectrum of tuberculosis: meeting report from the World TB Day nanosymposium in the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town
    Sabelo Hadebe, Melissa Dalcina Chengalroyen, Reto Guler, Kehilwe C. Nakedi, Anastasia Sideris Koch, Mohau S. Makatsa, Muki Shehu Shey, Suraj P. Parihar, Bryan D. Bryson, Mohlopheni Jackson Marakalala et al. · 2019 · Gates Open Research
  19. Faculty Opinions recommendation of Diagnostic host gene signature for distinguishing enteric fever from other febrile diseases.
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  20. Intervening along the spectrum of tuberculosis: meeting report from the World TB Day nanosymposium in the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town
    Sabelo Hadebe, Melissa Dalcina Chengalroyen, Reto Guler, Kehilwe C. Nakedi, Anastasia Sideris Koch, Mohau S. Makatsa, Muki Shehu Shey, Suraj P. Parihar, Bryan D. Bryson, Mohlopheni Jackson Marakalala et al. · 2019 · Gates Open Research
  21. Intervening along the spectrum of tuberculosis: meeting report from the World TB Day nanosymposium in the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town
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  22. Multifaceted roles of mycobacterium cell envelope glycolipids during host cell membrane interactions
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  23. Lysophospholipids - underestimated molecules of the unique phospholipidome of Campylobacter jejuni
    Xuefeng Cao · 2022
  24. A tRNA modification in Mycobacterium tuberculosis facilitates optimal intracellular growth
    Francesca G. Tomasi, 木村聡, Eric J. Rubin, Matthew K. Waldor · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  25. A tRNA modification in Mycobacterium tuberculosis facilitates optimal intracellular growth
    Francesca G. Tomasi, 木村聡, Eric J. Rubin, Matthew K. Waldor · 2023 · eLife
  26. The Role of Gut Microbiota-derived Tryptophan Metabolites in Mycobacterium tuberculosis Infection: A Mini-Review
    Novi Maulina, Zinatul Hayati, Kartini Hasballah, Zulkarnain Zulkarnain, Baidillah Zulkifli · 2023 · The International Journal of Tropical Veterinary and Biomedical Research
  27. Chemical inhibition of histidine biosynthesis curtails M. tuberculosis infection
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  28. Biosensor-integrated transposon mutagenesis reveals rv0158 as a coordinator of redox homeostasis in Mycobacterium tuberculosis
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  29. Towards a New Class of Anti-Tuberculosis Drugs: Design and Synthesis of AnPRT TS Analogues
    Mason, Emily · 2023
  30. Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis
    Mehak Zahoor Khan, Deborah M. Hunt, Biplab Singha, Yogita Kapoor, Nitesh Kumar Singh, D. V. Sai Prasad, Dharmarajan Sriram, Divya Tej Sowpati, Luiz Pedro S. de Carvalho, Vinay Kumar Nandicoori · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  31. KatG inactivation generates vulnerabilities in isoniazid resistant strains of Mycobacterium tuberculosis
    Xinyue Wang, William J Jowsey, Chen‐Yi Cheung, Noon E. J. Seeto, Natalie J.E. Waller, Michael T Chrisp, Amanda L. Peterson, Brunda Nijagal, Peter C. Fineran, Gregory Murray Cook et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  32. Targeted Disruption of the Aspartate Pathway: A Promising Approach for Combating Persistent Tuberculosis Infections
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  33. Additional file 4 of Untargeted metabolomics analysis reveals Mycobacterium tuberculosis strain H37Rv specifically induces tryptophan metabolism in human macrophages
    Xiao, Guohui, Su Zhang, Like Zhang, Shuyan Liu, Guobao Li, Min Ou, Xuan Zeng, Zhaoqin Wang, Guoliang Zhang, Shuihua Lu · 2022 · Figshare
  34. Additional file 5 of Untargeted metabolomics analysis reveals Mycobacterium tuberculosis strain H37Rv specifically induces tryptophan metabolism in human macrophages
    Guohui Xiao, Su Zhang, Like Zhang, Shuyan Liu, Guobao Li, Min Ou, Xuan Zeng, Zhaoqin Wang, Guoliang Zhang, Shuihua Lu · 2022 · Figshare
  35. Additional file 3 of Untargeted metabolomics analysis reveals Mycobacterium tuberculosis strain H37Rv specifically induces tryptophan metabolism in human macrophages
    Guohui Xiao, Su Zhang, Like Zhang, Shuyan Liu, Guobao Li, Min Ou, Xuan Zeng, Zhaoqin Wang, Guoliang Zhang, Shuihua Lu · 2022 · Figshare
  36. Additional file 2 of Untargeted metabolomics analysis reveals Mycobacterium tuberculosis strain H37Rv specifically induces tryptophan metabolism in human macrophages
    Xiao, Guohui, Su Zhang, Like Zhang, Shuyan Liu, Guobao Li, Min Ou, Xuan Zeng, Zhaoqin Wang, Guoliang Zhang, Shuihua Lu · 2022 · Figshare
  37. Author Response: A tRNA modification in Mycobacterium tuberculosis facilitates optimal intracellular growth
    Francesca G. Tomasi, 木村聡, Eric J. Rubin, Matthew K. Waldor · 2023 · eLife
  38. Reviewer #1 (Public Review): Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis
    2024 · eLife
  39. Author response: Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis
    Mehak Zahoor Khan, Deborah M. Hunt, Biplab Singha, Yogita Kapoor, Nitesh Kumar Singh, D. V. Sai Prasad, Dharmarajan Sriram, Divya Tej Sowpati, Luiz Pedro S. de Carvalho, Vinay Kumar Nandicoori · 2024 · eLife
  40. Uncovering asparagine utilization pathway, a critical requirement for mycobacterial pH-driven adaptation at the host pathogen crossroads
    Bhanwar Bamniya, Kajal Kajal, Khushboo Mehta, Dibyendu Sarkar · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  41. Random barcode transposon-site sequencing in Mycobacterium tuberculosis reveals the functions of uncharacterized genes
    Kayla M. Dinshaw, Katie A. Lien, Matthew Knight, Sorel V. Yigma Ouonkap, Hualan Liu, David F. Savage, Hans K. Carlson, Adam M. Deutschbauer, Sarah A. Stanley · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  42. Additional file 1 of Untargeted metabolomics analysis reveals Mycobacterium tuberculosis strain H37Rv specifically induces tryptophan metabolism in human macrophages
    Xiao, Guohui, Zhang, Su, Zhang, Like, Liu, Shuyan, Li, Guobao, Ou, Min, Zeng, Xuan, Wang Zhaoqin, Zhang, Guoliang, Lu, Shuihua · 2022 · Figshare
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  53. Transcriptional control of asparagine utilization regulates mycobacterial pH-driven adaptation at the host–pathogen crossroads
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  54. Toxin-mediated tRNATrp depletion drives Trp-codon-dependent reprogramming in Mycobacterium tuberculosis while selectively enriching the PDIM biosynthetic machinery
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  55. Elevated Kynurenine to Tryptophan Ratio in Peripheral Blood Distinguishes Infectious from Non-Infectious Causes of Respiratory Disease and is Highest in Active Tuberculosis—A Diagnostic Accuracy Study
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