Hsp90-Tau complex reveals molecular basis for specificity in chaperone action

Karagöz, G. Elif, Duarte, Afonso M.S., Akoury, Elias, Ippel, Hans, Biernat, Jacek, Morán Luengo, Tania, Radli, Martina, Didenko, Tatiana +8 more·2014·Cell

DOI 10.1016/j.cell.2014.01.037

Cited by (321)

Items 101–200 of 321

The Bacterial Hsp90 Chaperone: Cellular Functions and Mechanism of Action
Sue Wickner, Thu-Lan Lily Nguyen, Olivier Genest · 2021 · Annual Review of Microbiology
A methylated lysine is a switch point for conformational communication in the chaperone Hsp90
Rehn, Alexandra, Lawatscheck, Jannis, Jokisch, Marie-Lena, Mader, Sophie L., Luo, Qi, Tippel, Franziska, Blank, Birgit, Richter, Klaus, Lang, Kathrin, Kaila, Ville R. I. et al. · 2020 · Nature Communications
The multiple roles of chronic stress and glucocorticoids in Alzheimer's disease pathogenesis
Mia R Burke, Ioannis Sotiropoulos, Clarissa L. Waites · 2024 · Trends in Neurosciences
Reciprocal Molecular Interactions between the Aβ Peptide Linked to Alzheimer’s Disease and Insulin Linked to Diabetes Mellitus Type II
Jinghui Luo, Sebastian K.T.S. Wärmländer, Astrid Gräslund, Jan Pieter Abrahams · 2016 · ACS Chemical Neuroscience
The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics
Sarah N. Fontaine, Mackenzie D. Martin, Elias Akoury, Victoria A. Assimon, Sergiy I. Borysov, Bryce A. Nordhues, Jonathan J. Sabbagh, Matt Cockman, Jason E. Gestwicki, Markus Zweckstetter et al. · 2015 · Human Molecular Genetics
Aging as a Precipitating Factor in Chronic Restraint Stress-Induced Tau Aggregation Pathology, and the Protective Effects of Rosmarinic Acid
Shan Ye, Dandan Wang, Yuxia Xu, Chu Wang, Lan Cao, Yunsheng Liu, Cuiqing Zhu · 2015 · Journal of Alzheimer s Disease
Isotope-labeling strategies for solution NMR studies of macromolecular assemblies
Heyi Zhang, Hugo van Ingen · 2016 · Current Opinion in Structural Biology
Solution NMR Spectroscopy Provides an Avenue for the Study of Functionally Dynamic Molecular Machines: The Example of Protein Disaggregation
Rina Rosenzweig, Lewis E. Kay · 2015 · Journal of the American Chemical Society
Modulation of Molecular Chaperones in Huntington’s Disease and Other Polyglutamine Disorders
Sara Reis, Brígida R. Pinho, Jorge M. A. Oliveira · 2016 · Molecular Neurobiology
The penalty of stress ‐ Epichaperomes negatively reshaping the brain in neurodegenerative disorders
Stephen D. Ginsberg, Suhasini Joshi, Sahil Sharma, Gianny Guzman, Tai Wang, Ottavio Arancio, Gabriela Chiosis · 2021 · Journal of Neurochemistry
Substrate specificity in the context of molecular chaperones
Dipayan Bose, Abhijit Chakrabarti · 2017 · IUBMB Life
Dihydropyridines Allosterically Modulate Hsp90 Providing a Novel Mechanism for Heat Shock Protein Co-induction and Neuroprotection
Stephen Mark Roe, Ben Wahab, Zsolt Török, Ibolya Horváth, László Vı́gh, Chrisostomos Prodromou · 2018 · Frontiers in Molecular Biosciences
NMR Meets Tau: Insights into Its Function and Pathology
Guy M. Lippens, Isabelle Landrieu, Caroline Smet‐Nocca, Isabelle Huvent, Neha S. Gandhi, Benoı̂t Gigant, Clément Despres, Haoling Qi, Juan M. Lopez · 2016 · Biomolecules
Isoform-Specific Phosphorylation in Human Hsp90β Affects Interaction with Clients and the Cochaperone Cdc37
Minh Tú Nguyễn, Robert A. Knieß, Soumya Daturpalli, Laura Le Breton, Xiangyu Ke, Xuemei Chen, Matthias P. Mayer · 2017 · Journal of Molecular Biology
Alzheimer Cells on Their Way to Derailment Show Selective Changes in Protein Quality Control Network
Koopman, Margreet B., Rüdiger, Stefan G. D. · 2020 · Frontiers in Molecular Biosciences
Carboxy Terminus Heat Shock Protein 70 Interacting Protein Reduces Tau-Associated Degenerative Changes
Laiq-Jan Saidi, Manuela Polydoro, Kevin R. Kay, Laura Sanchez, Eva‐Maria Mandelkow, Bradley T. Hyman, Tara L. Spires‐Jones · 2015 · Journal of Alzheimer s Disease
Atomistic simulations and network-based modeling of the Hsp90-Cdc37 chaperone binding with Cdk4 client protein: A mechanism of chaperoning kinase clients by exploiting weak spots of intrinsically dynamic kinase domains
Josh Czemeres, Kurt Buse, Gennady M. Verkhivker · 2017 · PLoS ONE
Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone
Jay K. Singh, Darren M. Hutt, Bradley D. Tait, Naihsuan C. Guy, Jeffrey C. Sivils, Nina R. Ortiz, Ashley N. Payan, Shravan Kumar Komaragiri, Jazzmin Jovonna Owens, David S. Culbertson et al. · 2020 · Cell chemical biology
The metamorphic nature of the Tau protein: dynamic flexibility comes at a cost
Sabbagh, Jonathan J., Dickey, Chad A. · 2016 · Frontiers in Neuroscience
The Charged Linker Modulates the Conformations and Molecular Interactions of Hsp90
López, Abraham, Elimelech, Annika R., Klimm, Karolin, Sattler, Michael · 2021 · ChemBioChem
Heat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase
Anindya Sarkar, Yue Dai, Mohammad Mahfuzul Haque, Franziska Seeger, Arnab Ghosh, Elsa D. Garcin, W.R. Montfort, Stanley L. Hazen, Saurav Misra, Dennis J. Stuehr · 2015 · Journal of Biological Chemistry
Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease
Michael C. Pace, Guilian M. Xu, Susan Fromholt, John Clair Howard, Keith W. Crosby, Benoit I. Giasson, Jada M. Lewis, David Borchelt · 2018 · Acta Neuropathologica
A Two-Component Adhesive: Tau Fibrils Arise from a Combination of a Well-Defined Motif and Conformationally Flexible Interactions
ShengQi Xiang, Natalia Kulminskaya, Birgit Habenstein, Jacek Biernat, Katharina Tepper, Maria Paulat, Christian Griesinger, Stefan Becker, Adam Lange, Eckhard Mandelkow� et al. · 2017 · Journal of the American Chemical Society
Colostrum oxytocin modulates cellular stress response, inflammation, and autophagy markers in newborn rat gut villi
Klein, Benjamin Y., Tamir, Hadassah, Ludwig, Robert J., Glickstein, Sara B., Welch, Martha G. · 2017 · Biochemical and Biophysical Research Communications
Therapeutic Strategies for Restoring Tau Homeostasis
Zapporah T. Young, Sue‐Ann Mok, Jason E. Gestwicki · 2017 · Cold Spring Harbor Perspectives in Medicine
Capturing a Dynamic Chaperone–Substrate Interaction Using NMR-Informed Molecular Modeling
Loïc Salmon, Logan S. Ahlstrom, Scott A. Horowitz, Alex Dickson, Charles L. Brooks, James C.A. Bardwell · 2016 · Journal of the American Chemical Society
The known unknowns of the Hsp90 chaperone
Laura‐Marie Silbermann, Benjamin Vermeer, Sonja Schmid, Katarzyna M. Tych · 2024 · eLife
Hsp90 directly interacts, in vitro, with amyloid structures and modulates their assembly and disassembly
Claire Schirmer, Eléonore Lepvrier, Laurence Duchesne, Olivier Decaux, Daniel Thomas, Christian Delamarche, Cyrille Garnier · 2016 · Biochimica et Biophysica Acta (BBA) - General Subjects
Molecular chaperones biochemistry and role in neurodegenerative diseases
Ali Châari · 2019 · International Journal of Biological Macromolecules
HSP90 Interacts with the Fibronectin N-terminal Domains and Increases Matrix Formation
Abir Chakraborty, Natasha Marie-Eraine Boel, Adrienne Lesley Edkins · 2020 · Cells
Structural Basis for Chaperone‐Independent Ubiquitination of Tau Protein by Its E3 Ligase CHIP
Francesca Munari, Luca Mollica, Carlo Valente, Francesca Parolini, Elham Ataie Kachoie, Giorgio Arrigoni, Mariapina D’Onofrio, Stefano Capaldi, Michael Assfalg · 2022 · Angewandte Chemie International Edition
Mechanistic Asymmetry in Hsp90 Dimers
Julia M. Flynn, Parul Mishra, Daniel N. A. Bolon · 2015 · Journal of Molecular Biology
Hsp90 inhibitor HSP990 in very low dose upregulates EAAT2 and exerts potent antiepileptic activity
Longze Sha, Ting Chen, Yu Deng, Tingfu Du, Kaili Ma, Wanwan Zhu, Yan Shen, Qi Xu · 2020 · Theranostics
How do Chaperones Bind (Partly) Unfolded Client Proteins?
Iva Sučec, Beate Bersch, Paul Schanda · 2021 · Frontiers in Molecular Biosciences
Assembly mechanism of early Hsp90-Cdc37-kinase complexes
Dimitra Keramisanou, M.V. Vasantha Kumar, Nicole Boose, Rinat R. Abzalimov, Ioannis Gelis · 2022 · Science Advances
Increased Aggregation Tendency of Alpha-Synuclein in a Fully Disordered Protein Complex
David Adrian Merle, Anja Witternigg, Carmen Tam‐Amersdorfer, Christoph Hartlmüller, Emil Spreitzer, Evelyne Schrank, Sabine Wagner-Lichtenegger, Oliver Werzer, Klaus Zangger, Andreas J. Kungl et al. · 2019 · Journal of Molecular Biology
The dynamic triage interplay of Hsp90 with its chaperone cycle and client binding
Xiaozhan Qu, Simin Wang, Shuo Zhao, Chanjuan Wan, Weiya Xu, Chengdong Huang · 2024 · Nature Communications
Molecular basis of the interaction of Hsp90 with its co‐chaperone Hop
Antonia Lott, Javier Oroz, Markus Zweckstetter · 2020 · Protein Science
The Mitochondrial Hsp90 TRAP1 and Alzheimer’s Disease
Françoise A. Dekker, Stefan Rüdiger · 2021 · Frontiers in Molecular Biosciences
The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells
Magdalena Oroń, Marcin Grochowski, Akanksha Jaiswar, Justyna Legierska, Kamil Jastrzębski, Magdalena Nowak-Niezgoda, Małgorzata Kołos, Wojciech Kaźmierczak, Tomasz Olesiński, Małgorzata Lenarcik et al. · 2022 · Cell Reports
Structures of Hsp90α and Hsp90β bound to a purine‐scaffold inhibitor reveal an exploitable residue for drug selectivity
John D. Huck, Nanette L. S. Que, Sahil Sharma, Tony Taldone, Gabriela Chiosis, Daniel T. Gewirth · 2019 · Proteins Structure Function and Bioinformatics
Proteomic interrogation of HSP90 and insights for medical research
Lorenz Weidenauer, Tai Wang, Suhasini Joshi, Gabriela Chiosis, Manfredo Quadroni · 2017 · Expert Review of Proteomics
Upregulated levels and pathological aggregation of abnormally phosphorylated Tau-protein in children with neurodevelopmental disorders
Marija Rankovic, Markus Zweckstetter · 2018 · Neuroscience & Biobehavioral Reviews
Large Rotation of the N-terminal Domain of Hsp90 Is Important for Interaction with Some but Not All Client Proteins
Daturpalli, Soumya, Knieß, Robert A., Lee, Chung-Tien, Mayer, Matthias P. · 2017 · Journal of Molecular Biology
Hsp90, a team player in protein quality control and the stress response in bacteria
Anushka C. Wickramaratne, Sue Wickner, Andrea N. Kravats · 2024 · Microbiology and Molecular Biology Reviews
Modulation of hippocampal neuronal resilience during aging by the Hsp70/Hsp90 co‐chaperone STI1
Rachel E. Lackie, Abdul R. Razzaq, Sali M.K. Farhan, Lily R. Qiu, Gilli Moshitzky, Flávio H. Beraldo, Marilene Hohmuth Lopes, Andrzej Maciejewski, Robert Gros, Jue Fan et al. · 2019 · Journal of Neurochemistry
Sequence features governing aggregation or degradation of prion-like proteins
Sean M. Cascarina, Kacy R. Paul, Satoshi Machihara, Eric D. Ross · 2018 · PLoS Genetics
Structural transitions modulate the chaperone activities of Grp94
Amankwah, Yaa S., Fleifil, Yasmeen, Unruh, Erin, Collins, Preston, Wang, Yi, Vitou, Katherine, Bates, Alison, Obaseki, Ikponwmosa, Sugoor, Meghana, Alao, John Paul et al. · 2024 · Proceedings of the National Academy of Sciences
Heat shock protein 104 (HSP104) chaperones soluble Tau via a mechanism distinct from its disaggregase activity
Xiang Zhang, Shengnan Zhang, Li Zhang, Jinxia Lu, Chunyu Zhao, Feng Luo, Dan Li, Xueming Li, Cong Liu · 2019 · Journal of Biological Chemistry
Revisiting silibinin as a novobiocin-like Hsp90 C-terminal inhibitor: Computational modeling and experimental validation
Elisabet Cuyàs, Sara Verdura, Vicente Micol, Jorge Joven, Joaquim Bosch‐Barrera, José Antonio Encinar, Javier Abel Menéndez · 2019 · Food and Chemical Toxicology
Chaperone-mediated heterotypic phase separation regulates liquid-to-solid phase transitions of tau into amyloid fibrils
Sandeep K. Rai, Roopali Khanna, Anusha Sarbahi, Ashish Joshi, Samrat Mukhopadhyay · 2025 · Science Advances
Molecular insights into the interaction of Hsp90 with allosteric inhibitors targeting the C-terminal domain
Vasantha Kumar MV, Radwan Ebna Noor, Rachel E. Davis, Zheng Zhang, Edvinas Sipavicius, Dimitra Keramisanou, Brian S. J. Blagg, Ioannis Gelis · 2018 · MedChemComm
The molecular basis of chaperone-mediated interleukin 23 assembly control
Susanne Meier, Sina Bohnacker, Carolin J. Klose, Abraham López, Christian A. Choe, Philipp W. N. Schmid, Nicolas Bloemeke, Florian Rührnößl, Martin Haslbeck, Julia Esser‐von Bieren et al. · 2019 · Nature Communications
Non-equilibrium conformational dynamics in the function of molecular chaperones
Alessandro Barducci, Paolo De Los Rios · 2015 · Current Opinion in Structural Biology
Chaperone–client complexes: A dynamic liaison
Sebastian Hiller, Björn M. Burmann · 2018 · Journal of Magnetic Resonance
The role of the FKBP51–Hsp90 complex in Alzheimer’s disease: An emerging new drug target
Xavier Jeanne, Zsolt Török, László Vı́gh, Chrisostomos Prodromou · 2024 · Cell Stress and Chaperones
Dynamics-based community analysis and perturbation response scanning of allosteric interaction networks in the TRAP1 chaperone structures dissect molecular linkage between conformational asymmetry and sequential ATP hydrolysis
Gennady M. Verkhivker · 2018 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
The Potential of Targeting P53 and HSP90 Overcoming Acquired MAPKi-Resistant Melanoma
Chi–Che Hsieh, Che‐Hung Shen · 2019 · Current Treatment Options in Oncology
Molecular Chaperones as Therapeutic Target: Hallmark of Neurodegenerative Disorders
Aditi Sharma, Om Prakash Shah, Lalit Kumar Sharma, Monica Gulati, Tapan Behl, Asaad Khalid, Syam Mohan, Asim Najmi, Khalid A. Zoghebi · 2023 · Molecular Neurobiology
Stressing Out Hsp90 in Neurotoxic Proteinopathies
Carmen Inda, Alexander Bolaender, Tai Wang, Srinivasa R. Gandu, John Koren · 2016 · Current Topics in Medicinal Chemistry
Key Physicochemical and Biological Factors of the Phase Behavior of Tau
Geewoo Nam, Yuxi Lin, Mi Hee Lim, Young‐Ho Lee · 2020 · Chem
Large Chaperone Complexes Through the Lens of Nuclear Magnetic Resonance Spectroscopy
Theodoros K. Karamanos, G. Marius Clore · 2022 · Annual Review of Biophysics
Evidence for Hsp90 Co-chaperones in Regulating Hsp90 Function and Promoting Client Protein Folding
Marc B. Cox, Jill L. Johnson · 2017 · Methods in molecular biology
Human chaperones untangle fibrils of the Alzheimer protein Tau
Luca Ferrari, Willie J. C. Geerts, Marloes D. van Wezel, Renate Kos, Aikaterini Konstantoulea, Laura S. van Bezouwen, Friedrich G. Förster, Stefan Rüdiger · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
Recombinant production and purification of the human protein Tau
Luca Ferrari, Stefan Rüdiger · 2018 · Protein Engineering Design and Selection
Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress
Lulu Jiang, Pijush Chakraborty, Lushuang Zhang, Melissa Wong, Shannon E. Hill, Chelsea Joy Webber, Jenna Libera, Laura J. Blair, Benjamin L. Wolozin, Markus Zweckstetter · 2023 · Science Advances
Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies
Yuwei Jiang, Lesley T. MacNeil · 2023 · Molecular Neurodegeneration
Structural basis for the dynamic chaperoning of disordered clients by Hsp90
Xiaozhan Qu, Shuo Zhao, Chanjuan Wan, Lei Zhu, Tuo Ji, Paolo Rossi, Junfeng Wang, Charalampos G. Kalodimos, Chao Wang, Weiya Xu et al. · 2024 · Nature Structural & Molecular Biology
NMR characterization of HtpG, the E. coli Hsp90, using sparse labeling with 13C-methyl alanine
Kari Pederson, Gordon R. Chalmers, Qi Gao, Daniel Elnatan, Theresa A. Ramelot, Li-Chung Ma, Gaetano Thomas Montelione, Michael A. Kennedy, David A. Agard, James H. Prestegard · 2017 · Journal of Biomolecular NMR
Flexible Stoichiometry and Asymmetry of the PIDDosome Core Complex by Heteronuclear NMR Spectroscopy and Mass Spectrometry
Lily A. Nematollahi, Acely Garza-Garcı́a, Chérine Bechara, Diego Esposito, Nina Morgner, Carol V. Robinson, Paul C. Driscoll · 2014 · Journal of Molecular Biology
ATP Impedes the Inhibitory Effect of Hsp90 on Aβ40 Fibrillation
Hongzhi Wang, Max Lallemang, Bianca A. Hermann, Cecilia Wallin, Rolf Antonie Loch, Alain Blanc, Bizan N. Balzer, Thorsten Hugel, Jinghui Luo · 2020 · Journal of Molecular Biology
Structural and functional insights on the roles of molecular chaperones in the mistargeting and aggregation phenotypes associated with primary hyperoxaluria type I
José Ángel Fernández-Higuero, Isabel Betancor-Fernández, Noel Mesa‐Torres, Arturo Muga, EDUARDO C. SALIDO, Angel Luis Pey · 2018 · Advances in protein chemistry and structural biology
FKBP52 in Neuronal Signaling and Neurodegenerative Diseases: A Microtubule Story
Béatrice Chambraud, Cillian Byrne, Geri Méduri, E.E. Baulieu, Julien Giustiniani · 2022 · International Journal of Molecular Sciences
Selective nitration of Hsp90 acts as a metabolic switch promoting tumor cell proliferation
Isabelle E. Logan, Kyle T. Nguyen, Tilottama Chatterjee, Bhagyashree Manivannan, Ngozi P. Paul, Sharon Kim, Evelyn Sixta, Lydia P. Bastian, Carrie L. Marean‐Reardon, Matthias A. Karajannis et al. · 2024 · Redox Biology
HSP70-HSP90 Chaperone Networking in Protein-Misfolding Disease
Chrisostomos Prodromou, Xavier Aran-Guiu, Jasmeen Oberoi, Laura Perna, J. Paul Chapple, Jacqueline van der Spuy · 2022 · Sub-cellular biochemistry/Subcellular biochemistry
HEAT SHOCK PROTEIN 90.6 interacts with carbon and nitrogen metabolism components during seed development
Jianghai Xu, Zhijia Yang, Xiaohong Fei, Meiling Zhang, Yang Cui, Xiangbo Zhang, Kaiwen Tan, E Lizhu, Haiming Zhao, Jinsheng Lai et al. · 2023 · PLANT PHYSIOLOGY
The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by Which LA1011 May Improve the Prognosis of Alzheimer’s Disease
Stephen Mark Roe, Zsolt Török, Andrew McGown, Ibolya Horváth, John Spencer, Tamás Pázmány, László Vı́gh, Chrisostomos Prodromou · 2023 · Biomolecules
Prion-Like Propagation Mechanisms in Tauopathies and Traumatic Brain Injury: Challenges and Prospects
Hadeel Alyenbaawi, W. Ted Allison, Sue‐Ann Mok · 2020 · Biomolecules
The ER Chaperones BiP and Grp94 Regulate the Formation of Insulin-Like Growth Factor 2 (IGF2) Oligomers
Yi Jin, Judy L.M. Kotler, Shiyu Wang, Bin Huang, Jackson C. Halpin, Timothy O. Street · 2021 · Journal of Molecular Biology
Establishing Order Through Disorder by the Hsp90 Molecular Chaperone
Neethu L. Babu, Brian Freeman · 2024 · Journal of Molecular Biology
Heat shock proteins regulates Tau protein aggregation in Alzheimer’s disease
Subashchandrabose Chinnathambi · 2024 · Advances in protein chemistry and structural biology
Characterization of the Grp94/OS-9 Chaperone–Lectin Complex
Paul M. Seidler, Stephen A. Shinsky, Feng Hong, Zihai Li, Michael S. Cosgrove, Daniel T. Gewirth · 2014 · Journal of Molecular Biology
Increased surface charge in the protein chaperone Spy enhances its anti-aggregation activity
Wei He, Jiayin Zhang, Veronika Sachsenhauser, Lili Wang, James C.A. Bardwell, Shu Quan · 2020 · Journal of Biological Chemistry
The Yeast Hsp70 Cochaperone Ydj1 Regulates Functional Distinction of Ssa Hsp70s in the Hsp90 Chaperoning Pathway
Deepika Gaur, Prashant R. Singh, Jyoti Guleria, Arpit Gupta, Satinderdeep Kaur, Deepak Sharma · 2020 · Genetics
Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer’s disease
Isabel Castanho, Pourya Naderi Yeganeh, Carles A. Boix, Sarah L. Morgan, Hansruedi Mathys, Dmitry Prokopenko, Bartholomew White, Larisa M. Soto, Giulia Pegoraro, Saloni A. Shah et al. · 2025 · Molecular Neurodegeneration
DJ-1 Molecular Chaperone Activity Depresses Tau Aggregation Propensity through Interaction with Monomers
Daniela Jimenez-Harrison, Carol J. Huseby, Claire N. Hoffman, Steven Sher, Dalton T. Snyder, Brayden Seal, Chunhua Yuan, Hongjun Fu, Vicki Hopper Wysocki, Flaviano Giorgini et al. · 2023 · Biochemistry
Exploring Mechanisms of Allosteric Regulation and Communication Switching in the Multiprotein Regulatory Complexes of the Hsp90 Chaperone with Cochaperones and Client Proteins: Atomistic Insights from Integrative Biophysical Modeling and Network Analysis of Conformational Landscapes
Gennady M. Verkhivker · 2022 · Journal of Molecular Biology
Structural ensemble-based docking simulation and biophysical studies discovered new inhibitors of Hsp90 N-terminal domain
Hyun-Hwi Kim, Ja-Shil Hyun, Joonhyeok Choi, Kwang-Eun Choi, Jun‐Goo Jee, Sung Jean Park · 2018 · Scientific Reports
The Disease Associated Tau35 Fragment has an Increased Propensity to Aggregate Compared to Full-Length Tau
Chen Lyu, Stefano Da Vela, Youssra K. Al‐Hilaly, Karen E. Marshall, Richard Thorogate, Dmitri I. Svergun, Louise C. Serpell, Annalisa Pastore, Diane P. Hanger · 2021 · Frontiers in Molecular Biosciences
Chaperone-Mediated Regulation of Tau Phase Separation, Fibrillation, and Toxicity
Cecilia Mörman, Axel Leppert, Giusy Pizzirusso, Zihan Zheng, Xun Sun, Rakesh Kumar, Henrik Biverstål, Michael Landreh, Jan Johansson, Luis Enrique Arroyo‐García et al. · 2025 · Journal of the American Chemical Society
Microtubule‐affinity regulating kinase family members distinctively affect tau phosphorylation and promote its toxicity in a Drosophila model
Grigorii Sultanakhmetov, Iori Kato, Akiko Asada, Taro Saito, Kanae Ando · 2024 · Genes to Cells
Microtubule Organization and Microtubule-Associated Proteins (MAPs)
Elena Tortosa, Lukas C. Kapitein, Casper C. Hoogenraad · 2016 · Springer eBooks
Keeping α-Synuclein at Bay: A More Active Role of Molecular Chaperones in Preventing Mitochondrial Interactions and Transition to Pathological States?
Emelie E. Aspholm, Irena Matečko‐Burmann, Björn M. Burmann · 2020 · Life
Synthetic chaperone based on Hsp90-Tau interaction inhibits Tau aggregation and rescues physiological Tau-Microtubule interaction
Davide Di Lorenzo, Nicolò Bisi, J. Kaffy, L. Ramirez, M. Zweckstetter, Olivier Lequin, Irene Garfagnini, Jinghui Luo, Yvonne Hannappel, Inga Ennen et al. · 2024 · bioRxiv
Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin
Ricarda Törner, Tatsiana Kupreichyk, Lothar Gremer, Elisa Colas Debled, Daphna Fenel, Sarah Schemmert, Pierre Gans, Dieter Willbold, Guy Schoehn, Wolfgang Hoyer et al. · 2022 · Nature Communications
The role of heat shock proteins in preventing amyloid toxicity
Ricarda Törner, Tatsiana Kupreichyk, Wolfgang Hoyer, Jérôme Boisbouvier · 2022 · Frontiers in Molecular Biosciences
Molecular determinants of Hsp90 dependence of Src kinase revealed by deep mutational scanning
Vanessa Nguyen, Ethan Ahler, Katherine A. Sitko, Jason J. Stephany, Dustin J. Maly, Douglas M. Fowler · 2023 · Protein Science
Small molecules targeting molecular chaperones for tau regulation: Achievements and challenges
Chenxi He, Jinying Gu, Danni Wang, Keran Wang, Yuxuan Wang, Qidong You, Lei Wang · 2023 · European Journal of Medicinal Chemistry
Conformational Dynamics and Mechanisms of Client Protein Integration into the Hsp90 Chaperone Controlled by Allosteric Interactions of Regulatory Switches: Perturbation-Based Network Approach for Mutational Profiling of the Hsp90 Binding and Allostery
Gennady M. Verkhivker · 2022 · The Journal of Physical Chemistry B
Direct observation of Hsp90-induced compaction in a protein chain
Alireza Mashaghi, Fatemeh Moayed, Eline J. Koers, Yang Zheng, Katharina Till, Günter Kramer, Matthias P. Mayer, Sander J. Tans · 2022 · Cell Reports