Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors

Rothwell, Patrick E., Fuccillo, Marc V., Maxeiner, Stephan, Hayton, Scott J., Gokce, Ozgun, Lim, Byung Kook, Fowler, Stephen C., Malenka, Robert C. +1 more·2014·Cell

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  15. Autism Mutations Preferentially Target Distributed Brain Circuits and Cell Types Associated with Sensory Integration and Decision Making
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  20. Role of adhesion proteins Neuroligin 2 and IgSF9b in the amygdala anxiety circuitry
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  24. Maternal Ube3a is Required for Neurotypical Motivational Drive and GABA co-release
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  40. Reviewer #2 (Public Review): Cntnap2 loss drives striatal neuron hyperexcitability and behavioral inflexibility
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  41. eLife Assessment: Cntnap2 loss drives striatal neuron hyperexcitability and behavioral inflexibility
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  42. Reviewer #1 (Public Review): Cntnap2 loss drives striatal neuron hyperexcitability and behavioral inflexibility
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  43. Reviewer #3 (Public Review): Cntnap2 loss drives striatal neuron hyperexcitability and behavioral inflexibility
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  45. Sleepless nights and social plights: medial septum GABAergic hyperactivity in a neuroligin 3–deficient autism model
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  55. Additional file 1 of Imbalance of flight–freeze responses and their cellular correlates in the Nlgn3−/y rat model of autism
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  62. Caractérisation du long ARN non codant COSMOC dérégulé dans les troubles du spectre autistique : une approche transcriptomique sur cellules souches olfactives humaines
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  67. Autism spectrum disorder: the interaction between dopaminergic and cholinergic systems in animal models
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