Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

Kapoor, Avnish, Yao, Wantong, Ying, Haoqiang, Hua, Sujun, Liewen, Alison, Wang, Qiuyun, Zhong, Yi, Wu, Chang-Jiun +22 more·2014·Cell

Cited by (717)

Items 601–700 of 717

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  9. Targeting KRAS and SHP2 signaling pathways for immunomodulation and improving treatment outcomes in solid tumors
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  10. Rac1 GTPase Regulates the βTrCP-Mediated Proteolysis of YAP Independently of the LATS1/2 Kinases
    Chitra Palanivel, Tabbatha N. Somers, Bailey M. Gabler, Yuanhong Chen, Yongji Zeng, Jesse L. Cox, Parthasarathy Seshacharyulu, Jixin Dong, Ying Yan, Surinder K. Batra et al. · 2024 · Cancers
  11. Road Map to Defeat Pancreatic Cancer
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  14. Blockage of glioma cell survival by truncated TEAD-binding domain of YAP
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  15. Emerging Therapeutic Targets in Pancreatic Adenocarcinoma
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  16. Current Model Systems for Investigating Epithelioid Haemangioendothelioma
    Emily Neil, Valérie Kouskoff · 2023 · Cancers
  17. Selective targeting of KRAS-driven lung tumorigenesis via unresolved ER stress
    Iwao Shimomura, Naoaki Watanabe, Tomofumi Yamamoto, Minami Kumazaki, Yuji Tada, Koichiro Tatsumi, Takahiro Ochiya, Yusuke Yamamoto · 2021 · JCI Insight
  18. Viral manipulation of mechanoresponsive signaling disassembles processing bodies
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  19. Multiplexed Quantitative Screens of Single Cell Shape and YAP/TAZ Localisation Identify DOCK5 as a Coincident Detector of Polarity and Adhesion During Migration
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  20. Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation
    Trang H. Pham, Kanika Bajaj Pahuja, Thijs J. Hagenbeek, Jason Zbieg, Cameron L. Noland, Victoria C. Pham, Xiaosai Yao, Christopher M. Rose, Kristen C. Browder, Ho-June Lee et al. · 2024 · eLife
  21. Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling
    Rachel M. Nakagawa, Andrew R. Beardsley, Sophia Durney, Mary-Kate Hayward, Vishvak Subramanyam, Nathaniel P. Meyer, Harrison Wismer, Hani Goodarzi, Valerie Marie Weaver, Daniel Van de Mark et al. · 2025 · eLife
  22. Transposon mediated functional genomic screening for BRAF inhibitor resistance reveals convergent Hippo and MAPK pathway activation events
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  23. PR55α subunit of protein phosphatase 2A supports KRASG12D-driven tumorigenesis that requires YAP activation
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  24. Roles of TEAD Transcription Factors and their Coactivators in the Progression and Metastasis of Cancers
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  25. TIMP-1 Modulation Correlates with KRAS Dependency and EMT Induction in NSCLC
    Ilamathi M-Thirusenthilarasan, Pankaj Kumar Ahluwalia, Nithyananda Thorenoor, Sampa Ghoshal-Gupta, Byung Rho Lee, Bilal Karim Siddiqui, Ravindra B Kolhe, Amyn M. Rojiani, Mumtaz V. Rojiani · 2025 · Cells
  26. Pancreatic cancer: emerging small molecule pharmacotherapies
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  30. Developmental and MAPK-responsive transcription factors regulate distinct malignant cell states and associated genetic dependencies in pancreatic cancer
    Pasquale Laise, Mikko Turunen, Álvaro Curiel‐García, Lorenzo Tomassoni, H. Carlo Maurer, Ela Elyada, Bernhard Schmierer, Jeremy Worley, Jordan S. Kesner, Xiangtian Tan et al. · 2026 · Nature Genetics
  31. KRAS is required for plexiform neurofibroma formation and represents a targetable vulnerability in established tumors
    Liang Hu, Niousha Ahmari, Abby Schaeper, Jay Pundavela, Mi‐Ok Kim, Eva Dombi, Jianqiang Wu, Julia Brunmair, Özlem Yüce Petronczki, Nancy Ratner · 2026 · Science Advances
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  36. YAP/TAZ-mediated resistance to EGFR inhibitors
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  37. Molecular Genetic Profiling of Adolescent Glassy Cell Carcinoma of the Cervix Reveals Targetable EGFR Amplification with Potential Therapeutic Implications
    Troy A. McEachron, Leonard S. Sender, Keri B. Zabokrtsky, Brian Kaltenecker, W. Nathan Holmes, Irene Cherni, Zarko Manojlovic, Shu‐Yuan Liao, David Wesley Craig, John David Carpten et al. · 2016 · Journal of Adolescent and Young Adult Oncology
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    Imani Bijou, Jin Wang · 2019 · Annals of Pancreatic Cancer
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  40. Investigation of KRAS Dependency Bypass and Functional Characterization of All Possible KRAS Missense Variants
    Seav Huong Ly · 2018 · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
  41. YAP/TAZ enhance P-body formation to promote tumorigenesis
    Xia Shen, Xiang Peng, Yuegui Guo, Zhujiang Dai, Long Cui, Wei Yu, Yun Liu, Chen‐Ying Liu · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  42. Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation
    Trang H. Pham, Kanika Bajaj Pahuja, Thijs J. Hagenbeek, Jason Zbieg, Cameron L. Noland, Victoria C. Pham, Xiaosai Yao, Christopher M. Rose, Kristen C. Browder, Ho-June Lee et al. · 2024 · eLife
  43. Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling
    Rachel M. Nakagawa, Andrew R. Beardsley, Sophia Durney, Mary-Kate Hayward, Vishvak Subramanyam, Nathaniel P. Meyer, Harrison Wismer, Hani Goodarzi, Valerie Marie Weaver, Daniel Van de Mark et al. · 2025 · eLife
  44. The role of PAK4 in pancreatic cancer
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  45. Strategies to Target Pancreatic Cancer
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  46. Cross Talk Between Snail and Mutant K-Ras Contributes to Pancreatic Cancer Progression
    Christina R. Chow, Kazumi Ebine, Holly Z. Hattaway, Krishan Kumar, Hidayatullah G. Munshi · 2016 · Elsevier eBooks
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  49. Specificity protein 1 induces the expression of angiomotin in response to IL-6/STAT3 activation to mediate YAP-dependent growth of breast cancer cells
    Lauren R. Bringman · 2016 · IUScholarWorks (Indiana University)
  50. Understanding and Targeting Tumor Microenvironment in Prostate Cancer to Inhibit Tumor Progression and Castration Resistance
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  76. Data from Machine-Learning and Chemicogenomics Approach Defines and Predicts Cross-Talk of Hippo and MAPK Pathways
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  77. Supplementary Methods, Figure Legends, Figures S1 - S7 from Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression
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  78. Supplementary Figure S10 from Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC
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  79. Supplementary Figure S10 from Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC
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  80. Supplementary Figure S10 from Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC
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  81. Supplementary Figure S10 from Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC
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  82. YAP/TAZ enhance P-body formation to promote tumorigenesis
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  83. Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation
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  84. Data from CRISPR Screening Identifies Mechanisms of Resistance to KRASG12C and SHP2 Inhibitor Combinations in Non–Small Cell Lung Cancer
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  85. Data from CRISPR Screening Identifies Mechanisms of Resistance to KRASG12C and SHP2 Inhibitor Combinations in Non–Small Cell Lung Cancer
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  86. YAP/TAZ enhance P-body formation to promote tumorigenesis
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  87. Additional file 5 of Promoter hypermethylation and comprehensive regulation of ncRNA lead to the down-regulation of ZNF880, providing a new insight for the therapeutics and research of colorectal cancer
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  90. Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling
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  92. YAP signaling promotes resistance to MEK and AKT inhibition in NF1 -related MPNSTs
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  93. MED12 mutation induces RTK inhibitor resistance in NSCLC via MEK/ERK pathway activation by inflammatory cytokines
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  94. Caenorhabditis elegans Uses Canonical and Non-canonical Hippo signaling
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  95. A YAP / TAZ – CDC6 Axis Initiates and Maintains Malignant Transformation
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  96. p53 and YAP/TAZ-TEAD activities determine metaplastic heterogeneity in pancreatic cancer
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  97. Additional file 1 of Overexpressed WDR3 induces the activation of Hippo pathway by interacting with GATA4 in pancreatic cancer
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  98. Additional file 4 of Promoter hypermethylation and comprehensive regulation of ncRNA lead to the down-regulation of ZNF880, providing a new insight for the therapeutics and research of colorectal cancer
    Xiangqian Dong, Zhang, Yinghui, Sun, Yang, Nan, Qiong, Li, Maojuan, Ma, Lanqing, Zhang, Lei, Luo, Juan, Yating Qi, Miao, Yinglei · 2023 · Figshare
  99. Additional file 3 of Promoter hypermethylation and comprehensive regulation of ncRNA lead to the down-regulation of ZNF880, providing a new insight for the therapeutics and research of colorectal cancer
    Xiangqian Dong, Zhang, Yinghui, Sun, Yang, Nan, Qiong, Li, Maojuan, Ma, Lanqing, Zhang, Lei, Luo, Juan, Yating Qi, Miao, Yinglei · 2023 · Figshare
  100. Additional file 1 of Promoter hypermethylation and comprehensive regulation of ncRNA lead to the down-regulation of ZNF880, providing a new insight for the therapeutics and research of colorectal cancer
    Xiangqian Dong, Zhang, Yinghui, Sun, Yang, Qiong Nan, Li, Maojuan, Ma, Lanqing, Zhang, Lei, Luo, Juan, Yating Qi, Miao, Yinglei · 2023 · Figshare