KRAS and YAP1 Converge to Regulate EMT and Tumor Survival

Shao, Diane D., Xue, Wen, Krall, Elsa B., Bhutkar, Arjun, Piccioni, Federica, Wang, Xiaoxing, Schinzel, Anna C., Sood, Sabina +7 more·2014·Cell

DOI 10.1016/j.cell.2014.06.004

Cited by (754)

Items 601–700 of 754

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Is cell migration a selectable trait in the natural evolution of cancer development?
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Ankur Chakravarthy, Ian G. Reddin, Stephen R Henderson, Cindy Dong, Nerissa K. Kirkwood, Maxmilan Jeyakumar, Daniela Rothschild-Rodriguez, Natalia Gonzalez-Martinez, Jacqueline R. McDermott, Xiaoping Su et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
SPDEF promotes the classical subtype of pancreatic ductal adenocarcinoma
Claudia Tonelli, Georgi N. Yordanov, Hao Yuan, Astrid Deschênes, Olaf Klingbeil, Hsiu-Chi Ting, Erin Brosnan, Abishek Doshi, Youngkyu Park, Christopher R. Vakoc et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
YAP1-2α heterodimerization with TAZ promotes cancer aggressiveness through BRD4-dependent liquid-liquid phase separation at super-enhancers
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Discovery of Pan-TEAD Inhibitors That Disrupt YAP-TEAD Interaction as a Potential Therapy for Gastric Cancers and Mutant KRAS and EGFR Lung Cancers
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ACSS2 enables melanoma cell survival and tumor metastasis by negatively regulating the Hippo pathway
Baolu Zhang, Qing Zhu, Di Qu, Mao Zhao, Juan Du, Hengxiang Zhang, Hao Wang, Linhan Jiang, Xiuli Yi, Sen Guo et al. · 2024 · Frontiers in Molecular Biosciences
A review and perspective paper: Ras oncogene gets modest, from kingpin to mere henchman
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Ras and the Hippo Pathway in Cancer
Eric E. O’Neill · 2016 · Elsevier eBooks
An RGDKGE-Containing Cryptic Collagen Fragment Regulates Phosphorylation of Large Tumor Suppressor Kinase-1 and Controls Ovarian Tumor Growth by a Yes-Associated Protein–Dependent Mechanism
Xianghua Han, Jennifer M. Caron, Christine W. Lary, Pradeep Sathyanarayana, Calvin Vary, Peter C. Brooks · 2020 · American Journal Of Pathology
LATS kinases and SLUG regulate the transition to advanced stage in aggressive oral cancer cells
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Ganesh C. Ingavle, Dr. Madhurima Das · 2022 · ACS Biomaterials Science & Engineering
NKp44-Derived Peptide Used in Combination Stimulates Antineoplastic Efficacy of Targeted Therapeutic Drugs
Muhammed Iraqi, Priyanka Bolel, Rhitajit Sarkar, Baisali Bhattacharya, Muhammad Abu Ahmad, Avishay Edri, Laila C. Roisman, Moshe Elkabets, Walid Shalata, Nir Peled et al. · 2022 · International Journal of Molecular Sciences
Transcription factor glucocorticoid modulatory element-binding protein 1 promotes hepatocellular carcinoma progression by activating Yes-associate protein 1
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Runx3 Restoration Regresses K-Ras-Activated Mouse Lung Cancers and Inhibits Recurrence
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Drugging the undruggable: Advances in targeting KRAS signaling in solid tumors
Prajna Tripathi, Rajni Kumari, Rajiv Pathak · 2024 · International review of cytology
Whole genome profiling of rare pediatric thoracic tumors elucidates a YAP1::LEUTX fusion in an unclassified biphasic embryonal neoplasm
Georgi Lukose, Majd Al Assaad, Jordan H. Driskill, Max Fine Levine, Gunes Gundem, Alissa Semaan, David C. Wilkes, Nitsana Spigland, Juan Santiago Medina-Martinez, Andrea Sboner et al. · 2024 · Pathology - Research and Practice
Advances towards potential cancer therapeutics targeting Hippo signaling
Rui Zhu, Zhihan Jiao, Fa‐Xing Yu · 2024 · Biochemical Society Transactions
Interplay between Skeletal Muscle Catabolism and Remodeling of Arteriovenous Fistula by Yes-Associated Protein 1 (YAP1) Signaling
Yongdong Wu, Tae Hoon Lee, Owen H. Cheng, Eric Kevin Peden, Qingtian Li, Jun Wang, Fengzhang Huang, Marites Pasuelo Melancon, David Sheikh‐Hamad, Tao Wang et al. · 2025 · Journal of the American Society of Nephrology
Role of RUNX3 in Restriction Point Regulation
Jung-Won Lee, You‐Soub Lee, Minkyu Kim, Xin‐Zi Chi, Dohun Kim, Suk‐Chul Bae · 2023 · Cells
Retraction Note: Long noncoding RNA MLK7-AS1 promotes ovarian cancer cells progression by modulating miR-375/YAP1 axis
Huan Yan, Hong Li, Pengyun Li, Xia Li, Jianjian Lin, Linlin Zhu, Maria A. Silva, Xiaofang Wang, Ping Wang, Zhan Zhang · 2020 · Journal of Experimental & Clinical Cancer Research · Retracted
Epigenomic Heterogeneity of Non-Functional Pancreatic Neuroendocrine Tumors Uncovered by Single nucleus and Spatial ATAC Profiling
Dejiang Wang, Xiangjun Di, Fu Gao, Guangqiang Li, Liyun Lin, Shaohui He, Di Zhang, Junyi Yu Jin, Yuanxin Liang, Michael Cecchini et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Post-translational modifications in hepatocellular carcinoma: mechanisms and therapeutic potential
Jianqi Qin, Weixiong Zhu, Zengxi Yang, Shuze Zhang, Wence Zhou · 2025 · Medical Oncology
Discovery and In Vivo Evaluation of Aryl Ether YAP1/TEAD Inhibitors for the Treatment of Hippo-Driven Malignancies
Brandon Vara, Jongwon Lim, Casey J. Moure, Sebastian E. Schneider, Charles See Yeung, Cayetana Zárate, Abdelghani Achab, Mangeng M. Cheng, Ronald M. Kim, R. Foti et al. · 2026 · Journal of Medicinal Chemistry
YAP1 signaling and cancer: molecular pathways reveal novel targeting opportunities
Jialin Wu, Bonan Chen, Fuda Xie, Jiahui Hu, Mingyu Liang, Yang Lyu, Peiyao Yu, Tiejun Feng, Ruoxi Tian, Wei Kang · 2026 · Expert Opinion on Therapeutic Targets
Macrophage-derived SPP1 promotes subretinal fibrosis by YAP1 phase separation in retinal pigment epithelium
Ruoyi Lin, Zixin Cai, Tianyu Zheng, Yan Wu, Zihang Xu, Yunhong Luo, Feng Liang, Manhui Zhu, Jing Yu, Wenting Cai · 2026 · Metabolism
A special subtype: Revealing the potential intervention and great value of KRAS wildtype pancreatic cancer
Zhihang Xu, Wenquan Wang, Liang Liu, Wenhui Lou · 2022 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Fibroblasts Promote Resistance to KRAS Silencing in Colorectal Cancer Cells
Susana Mendonça, Patrícia Dias Carvalho, André Serra‐Roma, Patrícia Oliveira, Andreia Ribeiro, Joana Carvalho, Flávia Martins, Ana Luísa Machado, María José Oliveira, Sérgia Velho · 2024 · Cancers
Oncogene Downregulation by Mahanine Suppresses Drug-Sensitive and Drug-Resistant Lung Cancer and Inhibits Orthotopic Tumor Progression
Raghuram Kandimalla, Disha Nagesh Moholkar, Suman Kumar Samanta, Neha Tyagi, Farrukh Aqil, Ramesh C. Gupta · 2024 · Cancers
Rac1 GTPase Regulates the βTrCP-Mediated Proteolysis of YAP Independently of the LATS1/2 Kinases
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Integration of focal adhesion morphogenesis and polarity by DOCK5 promotes YAP/TAZ-driven drug resistance in TNBC
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In vivo CRISPR screening reveals cooperation of KMT2D and TP53 deficiencies in B-cell lymphomagenesis
Kentaro Yamaguchi, Junji Koya, Kota Mizuno, Yosuke Mizukami, Kota Yoshifuji, Yuki Saito, Mariko Tabata, Sumito Shingaki, Mitsuhiro Yuasa, Yuta Ito et al. · 2025 · Blood Advances
Emerging Therapeutic Targets in Pancreatic Adenocarcinoma
Jennifer Hsing Choe, James L. Abbruzzese · 2016 · Springer eBooks
Identification of Mutations, Expression Alterations and Fusion Transcripts by Next Generation RNAseq in Castration-Resistant Prostate Cancer Cell lines with Possible Clinical Relevance
Yuanjun Ma, Yali Miao, Zhuochun Peng, Johanna Sandgren, Teresita Díaz de Ståhl, Lena Lennartsson, Sten F. Nilsson, Chunde Li · 2017 · Journal of Next Generation Sequencing & Applications
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Wei Zhao, Qiu‐Feng Dong, Liwen Li, Zhifeng Yan, Junli Huo, Xiao-yan Chen, Xin Yang, Peng-Qi Li, Zhou Fei, Hai-ning Zhen · 2021 · Journal of Cancer Research and Clinical Oncology
Emerging Therapeutic Targets in Pancreatic Adenocarcinoma
Jennifer Hsing Choe, James L. Abbruzzese · 2018 · Springer eBooks
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Shin‐Yi Chung, Wen‐Chen Huang, Zong‐Siang Chen, Ta‐Chung Chao, Yeu Su · 2019 · Journal of Cellular Physiology
Identification of key genes and microRNA regulatory network in development and progression of urothelial bladder carcinoma
Miao Mo, Xiheng Hu, Wei He, Xiongbing Zu, Long Wang, Yangle Li · 2021 · Translational Andrology and Urology
Selective targeting of KRAS-driven lung tumorigenesis via unresolved ER stress
Iwao Shimomura, Naoaki Watanabe, Tomofumi Yamamoto, Minami Kumazaki, Yuji Tada, Koichiro Tatsumi, Takahiro Ochiya, Yusuke Yamamoto · 2021 · JCI Insight
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William A. Nyberg, Tianlin He, Maria Sjöstrand, Diego A Velasquez Pulgarin, Lucia Pellé, Ruxandra Covacu, Alexander Espinosa · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
Multiplexed Quantitative Screens of Single Cell Shape and YAP/TAZ Localisation Identify DOCK5 as a Coincident Detector of Polarity and Adhesion During Migration
Patricia Pascual Vargas, Mar Arias-García, Theodoros I. Roumeliotis, Jyoti Sharma Choudhary, Chris Bakal · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
KRAS silencing impacts chromatin organization and transcriptional activity in colorectal cancer cells
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Yecheng Li, Xiaolong Wang, Hong-Pei Yu, Jinming Cao, Jiaming Xie, Jinhong Zhou, Zhenyu Feng, Wei Chen · 2024 · Molecular Carcinogenesis
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PR55α subunit of protein phosphatase 2A supports KRASG12D-driven tumorigenesis that requires YAP activation
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