Lessons from a failed γ-secretase Alzheimer trial

De Strooper, Bart·2014·Cell
DOI 10.1016/j.cell.2014.10.016

Cited by (287)

Items 201–287 of 287

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  77. BindingDB Entry 50000473: Discovery of an Orally Bioavailable Benzofuran Analogue That Serves as aβ-Amyloid Aggregation Inhibitor for the Potential Treatment of Alzheimer's Disease.
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  79. BindingDB Entry 50046155: Design of Pyridopyrazine-1,6-dione¿-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability.
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  80. BindingDB Entry 50008815: Design and synthesis of a novel series of cyanoindole derivatives as potent γ-secretase modulators.
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  81. BindingDB Entry 50002402: Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead.
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  82. BindingDB Entry 50021223: Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease.
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  83. BindingDB Entry 50047387: Structure-Based Design of an Iminoheterocyclicß-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aß in Nonhuman Primates.
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  84. BindingDB Entry 50046747: Discovery of a Novel, Potent Spirocyclic Series of¿-Secretase Inhibitors.
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  85. BindingDB Entry 50046480: Potent benzoazepinone¿-secretase modulators with improved bioavailability.
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  86. BindingDB Entry 50012304: A dual-acting 5-HT
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  87. BindingDB Entry 50010006: Gamma Secretase Modulators: New Alzheimer's Drugs on the Horizon?
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