The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Phosphatidylserine Vesicles Enable Efficient En Bloc Transmission of Enteroviruses
Open accessAbstract
A central paradigm within virology is that each viral particle largely behaves as an independent infectious unit. Here we demonstrate that clusters of enteroviral particles are packaged within phosphatidylserine (PS) lipid-enriched vesicles that are non-lytically released from cells and provide greater infection efficiency than free single viral particles. We show that vesicular PS lipids are co-factors to the relevant enterovirus receptors in mediating subsequent infectivity and transmission, in particular to primary human macrophages. We demonstrate that clustered packaging of viral particles within vesicles enables multiple viral RNA genomes to be collectively transferred into single cells. This study reveals a novel mode of viral transmission, where enteroviral genomes are transmitted from cell-to-cell en bloc in membrane-bound PS vesicles instead of single independent genomes. This has implications for facilitating genetic cooperativity among viral quasispecies as well as enhancing viral replication.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Imaging individual mRNA molecules using multiple singly labeled probes
Raj, A., van den Bogaard, P., Rifkin, S. A., van Oudenaarden, A., & Tyagi, S. (2008) · Nature Methods · doi:10.1038/nmeth.1253 · Cited by 2,028
Vignuzzi, M., Stone, J. K., Arnold, J. J., Cameron, C. E., & Andino, R. (2006) · Nature · doi:10.1038/nature04388 · Cited by 1,116
Rogov, V., Dötsch, V., Johansen, T., & Kirkin, V. (2014) · Molecular Cell · doi:10.1016/j.molcel.2013.12.014 · Cited by 992
Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion
Hochreiter-Hufford, A., & Ravichandran, K. S. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008748 · Cited by 503
Coxsackievirus B Exits the Host Cell in Shed Microvesicles Displaying Autophagosomal Markers
Robinson, S. M., Tsueng, G., Sin, J., Mangale, V., Rahawi, S., McIntyre, L. L., Williams, W., Kha, N., Cruz, C., Hancock, B. M., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004045 · Cited by 322
Veatch, S. L., Machta, B. B., Shelby, S. A., Chiang, E. N., Holowka, D. A., & Baird, B. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031457 · Cited by 290
Liu, Y., Wang, C., Mueller, S., Paul, A. V., Wimmer, E., & Jiang, P. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001066 · Cited by 142
Self-citation
Cited by
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
Self-citationPhagocytosis of apoptotic cells in homeostasis
Arandjelovic, S., & Ravichandran, K. S. (2015) · Nature Immunology · doi:10.1038/ni.3253 · Cited by 959
Autophagy during viral infection — a double-edged sword
Choi, Y., Bowman, J. W., & Jung, J. U. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0003-6 · Cited by 838
Autophagy in inflammation, infection, and immunometabolism
Deretic, V. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.018 · Cited by 862
Extracellular Vesicles and Nanoparticles: Emerging Complexities
Jeppesen, D. K., Zhang, Q., Franklin, J. L., & Coffey, R. J. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.01.002 · Cited by 705
Metadata
- Authors
- Chen, Y.-H., Du, W., Hagemeijer, M. C., Takvorian, P. M., Pau, C., Cali, A., Brantner, C. A., Stempinski, E. S., Connelly, P. S., Ma, H.-C., Jiang, P., Wimmer, E., Altan-Bonnet, G., & Altan-Bonnet, N.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 160
- Issue
- 4
- Pages
- 619-630
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2170585188
- Cited by
- 465
- References
- 7
- FWCI
- 27.21
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Phosphatidylserine Vesicles Enable Efficient En Bloc Transmission of Enteroviruses. https://app.cochat.ai/papers/10.1016/j.cell.2015.01.032
- The paper
- Chen, Y.-H., Du, W., Hagemeijer, M. C., Takvorian, P. M., Pau, C., Cali, A., Brantner, C. A., Stempinski, E. S., Connelly, P. S., Ma, H.-C., Jiang, P., Wimmer, E., Altan-Bonnet, G., & Altan-Bonnet, N. (2015). Phosphatidylserine Vesicles Enable Efficient En Bloc Transmission of Enteroviruses. Cell. https://doi.org/10.1016/j.cell.2015.01.032
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
