The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity
Open accessAbstract
SUMMARY Memory T cells are critical for long-term immunity against reinfection and require interleukin-7 (IL-7), but the mechanisms by which IL-7 controls memory T cell survival, particularly metabolic fitness, remain elusive. We discover that IL-7 induces expression of the glycerol channel aquaporin 9 (AQP9) in virus-specific memory CD8+ T cells, but not naive cells, and that AQP9 is vitally required for their long-term survival. AQP9 deficiency impairs glycerol import into memory CD8+ T cells for fatty acid esterification and triglyceride (TAG) synthesis and storage. These defects can be rescued by ectopic expression of TAG synthases, which restores lipid stores and memory T cell survival. Finally, we find that TAG synthesis is a central component of IL-7-mediated survival of human and mouse memory CD8+T cells. This study uncovers the metabolic mechanisms by which IL-7 tailors the metabolism of memory T cells to promote their longevity and fast response to rechallenge.
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“Further fractionation of the effector CD8 T cells into KLRG1 IL-7Ra terminal effector and KLRG1 IL-7Ra memory precursor effector cell subsets at 14 dpi revealed that AQP9 was selectively expressed in the IL-7Ra effector cells that preferentially seed the memory T cell pool (Figure 1C) (Kaech et al., 2003; Schluns et a…”
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Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
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Homeostatic Immunity and the Microbiota
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Metadata
- Authors
- Cui, G., Staron, M. M., Gray, S. M., Ho, P.-C., Amezquita, R. A., Wu, J., & Kaech, S. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 161
- Issue
- 4
- Pages
- 750-761
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1563775926
- Cited by
- 324
- References
- 52
- FWCI
- 14.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cui, G., Staron, M. M., Gray, S. M., Ho, P.-C., Amezquita, R. A., Wu, J., & Kaech, S. M. (2015). IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity. Cell. https://doi.org/10.1016/j.cell.2015.03.021
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