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Bending Gradients: How the Intestinal Stem Cell Gets Its Home
Open accessAbstract
SUMMARY We address the mechanism by which adult intestinal stem cells (ISCs) become localized to base of each villus during embryonic development. We find that, early in gut development, proliferating progenitors expressing ISC markers are evenly distributed throughout the epithelium, in both the chick and mouse. However as the villi form, the putative stem cells become restricted to the base of the villi. This shift in the localization is driven by mechanically influenced reciprocal signaling between the epithelium and underlying mesenchyme. Buckling forces physically distort the shape of the morphogenic field causing local maxima of epithelial signals, in particular Shh, at the tip of each villus. This induces a suite of high threshold response genes in the underlying mesenchyme to form a signaling center called the “villus cluster.” Villus cluster signals, notably Bmp4, feed back on the overlying epithelium, to ultimately restrict the stem cells to the base of each villus.
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Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
Imaging individual mRNA molecules using multiple singly labeled probes
Raj, A., van den Bogaard, P., Rifkin, S. A., van Oudenaarden, A., & Tyagi, S. (2008) · Nature Methods · doi:10.1038/nmeth.1253 · Cited by 2,028
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Gjorevski, N., Nikolaev, M., Brown, T. E., Mitrofanova, O., Brandenberg, N., DelRio, F. W., Yavitt, F. M., Liberali, P., Anseth, K. S., & Lutolf, M. P. (2022) · Science · doi:10.1126/science.aaw9021 · Cited by 505
Hayakawa, Y., Ariyama, H., Stancikova, J., Sakitani, K., Asfaha, S., Renz, B. W., Dubeykovskaya, Z. A., Shibata, W., Wang, H., Westphalen, C. B., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.10.003 · Cited by 328
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Metadata
- Authors
- Shyer, A. E., Huycke, T. R., Lee, C., Mahadevan, L., & Tabin, C. J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 161
- Issue
- 3
- Pages
- 569-580
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2025167083
- Cited by
- 292
- References
- 2
- FWCI
- 11.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shyer, A. E., Huycke, T. R., Lee, C., Mahadevan, L., & Tabin, C. J. (2015). Bending Gradients: How the Intestinal Stem Cell Gets Its Home. Cell. https://doi.org/10.1016/j.cell.2015.03.041
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