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Cited by 294

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone

Open access
Park, Daniel J., Dudas, Gytis, Wohl, Shirlee, Goba, Augustine, Whitmer, Shannon L.M., Andersen, Kristian G., Sealfon, Rachel S., Ladner, Jason T., Kugelman, Jeffrey R., Matranga, Christian B., Winnicki, Sarah M., Qu, James, Gire, Stephen K., Gladden-Young, Adrianne, Jalloh, Simbirie, Nosamiefan, Dolo, Yozwiak, Nathan L., Moses, Lina M., Jiang, Pan-Pan, Lin, Aaron E., Schaffner, Stephen F., Bird, Brian, Towner, Jonathan, Mamoh, Mambu, Gbakie, Michael, Kanneh, Lansana, Kargbo, David, Massally, James L.B., Kamara, Fatima K., Konuwa, Edwin, Sellu, Josephine, Jalloh, Abdul A., Mustapha, Ibrahim, Foday, Momoh, Yillah, Mohamed, Erickson, Bobbie R., Sealy, Tara, Blau, Dianna, Paddock, Christopher, Brault, Aaron, Amman, Brian, Basile, Jane, Bearden, Scott, Belser, Jessica, Bergeron, Eric, Campbell, Shelley, Chakrabarti, Ayan, Dodd, Kimberly, Flint, Mike, Gibbons, Aridth, Goodman, Christin, Klena, John, McMullan, Laura, Morgan, Laura, Russell, Brandy, Salzer, Johanna, Sanchez, Angela, Wang, David, Jungreis, Irwin, Tomkins-Tinch, Christopher, Kislyuk, Andrey, Lin, Michael F., Chapman, Sinead, MacInnis, Bronwyn, Matthews, Ashley, Bochicchio, James, Hensley, Lisa E., Kuhn, Jens H., Nusbaum, Chad, Schieffelin, John S., Birren, Bruce W., Forget, Marc, Nichol, Stuart T., Palacios, Gustavo F., Ndiaye, Daouda, Happi, Christian, Gevao, Sahr M., Vandi, Mohamed A., Kargbo, Brima, Holmes, Edward C., Bedford, Trevor, Gnirke, Andreas, Ströher, Ute, Rambaut, Andrew, Garry, Robert F., Sabeti, Pardis C.·2015·Cell
DOI 10.1016/j.cell.2015.06.007
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Abstract

The 2013-2015 Ebola virus disease (EVD) epidemic is caused by the Makona variant of Ebola virus (EBOV). Early in the epidemic, genome sequencing provided insights into virus evolution and transmission and offered important information for outbreak response. Here, we analyze sequences from 232 patients sampled over 7 months in Sierra Leone, along with 86 previously released genomes from earlier in the epidemic. We confirm sustained human-to-human transmission within Sierra Leone and find no evidence for import or export of EBOV across national borders after its initial introduction. Using high-depth replicate sequencing, we observe both host-to-host transmission and recurrent emergence of intrahost genetic variants. We trace the increasing impact of purifying selection in suppressing the accumulation of nonsynonymous mutations over time. Finally, we note changes in the mucin-like domain of EBOV glycoprotein that merit further investigation. These findings clarify the movement of EBOV within the region and describe viral evolution during prolonged human-to-human transmission.

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Authors
Park, D. J., Dudas, G., Wohl, S., Goba, A., Whitmer, S. L. M., Andersen, K. G., Sealfon, R. S., Ladner, J. T., Kugelman, J. R., Matranga, C. B., Winnicki, S. M., Qu, J., Gire, S. K., Gladden-Young, A., Jalloh, S., Nosamiefan, D., Yozwiak, N. L., Moses, L. M., Jiang, P.-P., Lin, A. E., Schaffner, S. F., Bird, B., Towner, J., Mamoh, M., Gbakie, M., Kanneh, L., Kargbo, D., Massally, J. L. B., Kamara, F. K., Konuwa, E., Sellu, J., Jalloh, A. A., Mustapha, I., Foday, M., Yillah, M., Erickson, B. R., Sealy, T., Blau, D., Paddock, C., Brault, A., Amman, B., Basile, J., Bearden, S., Belser, J., Bergeron, E., Campbell, S., Chakrabarti, A., Dodd, K., Flint, M., Gibbons, A., Goodman, C., Klena, J., McMullan, L., Morgan, L., Russell, B., Salzer, J., Sanchez, A., Wang, D., Jungreis, I., Tomkins-Tinch, C., Kislyuk, A., Lin, M. F., Chapman, S., MacInnis, B., Matthews, A., Bochicchio, J., Hensley, L. E., Kuhn, J. H., Nusbaum, C., Schieffelin, J. S., Birren, B. W., Forget, M., Nichol, S. T., Palacios, G. F., Ndiaye, D., Happi, C., Gevao, S. M., Vandi, M. A., Kargbo, B., Holmes, E. C., Bedford, T., Gnirke, A., Ströher, U., Rambaut, A., Garry, R. F., & Sabeti, P. C.
Venue
Cell
Publisher
Elsevier BV
Published
2015-06
Volume
161
Issue
7
Pages
1516-1526
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2015.06.007
OpenAlex
W1919517754
Cited by
294
References
1
FWCI
32.76
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone. https://app.cochat.ai/papers/10.1016/j.cell.2015.06.007
The paper
Park, D. J., Dudas, G., Wohl, S., Goba, A., Whitmer, S. L. M., Andersen, K. G., Sealfon, R. S., Ladner, J. T., Kugelman, J. R., Matranga, C. B., Winnicki, S. M., Qu, J., Gire, S. K., Gladden-Young, A., Jalloh, S., Nosamiefan, D., Yozwiak, N. L., Moses, L. M., Jiang, P.-P., . . . Sabeti, P. C. (2015). Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone. Cell. https://doi.org/10.1016/j.cell.2015.06.007

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.