SnapShot: Growing Organoids from Stem Cells
Open accessAbstract
Tissue stem cells require unique niche microenvironments. In the presence of specific combinations of niche factors, mouse and human epithelial tissues from stomach, small intestine, colon, pancreas duct, and liver bile duct efficiently form stereotypic organoids. The platform of epitheloid organoids can also be employed for in vitro generation of digestive tissue from human pluripotent stem cells. Organoids hold great promise for basic and translational research.
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Matrigel has been successfully utilized in several epithelial stem cell platforms.
“Next, we examined whether embedding cells in a basement membrane-like extracellular 3D environment such as Matrigel, which has been successfully utilized in several epithelial stem cell platforms, could enable establishment of SG organoids (Fig. 1d)12–14.”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [13]
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Cited by 168
- Authors
- Sato, T., & Clevers, H.
- Affiliations
- Keio University (JP)
- University Medical Center Utrecht (NL)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 161
- Issue
- 7
- Pages
- 1700-1700.e1
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1606493563
- Cited by
- 168
- References
- 0
- Citations by year
- 2026: 2 · 2025: 12 · 2024: 12 · 2023: 19 · 2022: 20 · 2021: 18 · 2020: 16 · 2019: 17 · 2018: 22 · 2017: 11 · 2016: 16 · 2015: 3
- FWCI
- 7.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- organoids, tissue stem cells, stem cell niche, epithelium, pluripotent stem cells, in vitro organogenesis, digestive tissue, mouse model, human models, stomach, small intestine, colon, bile ducts
- MeSH terms
- Animals, Digestive System, Epithelial Cells, Humans, Organoids, Stem Cells, Pluripotent Stem Cells, Tissue Culture Techniques, Translational Research, Biomedical
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