Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma

Hugo, Willy, Zaretsky, Jesse M., Sun, Lu, Song, Chunying, Moreno, Blanca Homet, Hu-Lieskovan, Siwen, Berent-Maoz, Beata, Pang, Jia +10 more·2016·Cell

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  23. DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune cell activation
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  25. Toward Biomaterials for Enhancing Immune Checkpoint Blockade Therapy
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  26. Tumour Hypoxia-Mediated Immunosuppression: Mechanisms and Therapeutic Approaches to Improve Cancer Immunotherapy
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  28. A clonal expression biomarker associates with lung cancer mortality
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