Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation
Lui, Hansen, Zhang, Jiasheng, Makinson, Stefanie R., Cahill, Michelle K., Kelley, Kevin W., Huang, Hsin-Yi, Shang, Yulei, Oldham, Michael C. +20 more·2016·Cell
Cited by (733)
Items 701–733 of 733
- Sustained inhibitory dysfunction in complement component C1qa-deficient mice underlies epilepsy and comorbiditiesJoseane Righes Marafiga, Thy Vu, Jessica Bowlus, Scott C. Baraban · 2026 · Progress in Neurobiology
- The role of microglia in mediating the beneficial effects of environmental enrichment in neurodegenerative diseases and dementiaSharon Tsang, Huan Liao, Anthony John Hannan · 2026 · Brain and Environment
- Integrated protocol for concurrent generation of microglial and neuronal cells in human cerebral organoidsYukyeong Lee, Joshua L. Roffman, Rakesh Karmacharya · 2026 · BMC Methods
- Modeling C9ORF72 loss-of-function : a knockdown mouse modelMaria-Belen Lopez-Herdoiza · 2016 · theses.fr (ABES)
- Rôle de la neuroinflammation et du récepteur microglial TREM2 dans la progression de deux modèles de tauopathieAudrey Vautheny · 2019 · theses.fr (ABES)
- Rôle de la protéine C3 du système du complément dans les déficits mnésiques précoces sur un modèle expérimental de sclérose en plaquesJulien Bourel · 2019 · theses.fr (ABES)
- Étude de la composante neuroinflammatoire dans les DFT/SLAJulie Smeyers · 2020 · theses.fr (ABES)
- Altérations de la connectivité corticale au cours de périodes critiques du développementMélanie Druart · 2020 · theses.fr (ABES)
- Role of astrocytic calcium signaling in synaptic transmission, plasticity and memory : implications for neurodegenerative diseasesElsie Moukarzel · 2021 · theses.fr (ABES)
- MafB and c-Maf transcriptional control of macrophage self-renewal and activationHao Huang · 2021 · theses.fr (ABES)
- La vulnérabilité des internautes suite au partage de données personnelles en ligneSalma Khrifech · 2024
- Differential lysosomal burden in the excitatory and inhibitory neurons of the FTD-GRN brain.John Joyce · 2023
- Interleukin 27-induced photoreceptor survival is associated with suppression of a novel Muller glia subpopulationLaura D. McGee, Brandon M. Bessen, James Jarad Dollar, Marco Galizia, Saili Khorjekar, Ashley N. Zuniga, Stefan Kurtenbach, Abigail S. Hackam · 2026 · Cell Communication and Signaling
- Single-cell multiomics reveals microglia–neuron granulin signaling associated with brain agingSe-eun Han, Hyunjeong Kim, Jieun Song, Dabin Song, Soyeon Cho, Changsoo Kim, Eosu Kim, Byungjin Hwang · 2026 · Research Square
- Biased multi-view contrastive learning with attentive masking for spatial transcriptomic analysisLaiyi Fu, Wenkai Cui, Yuehua Chen, Danyang Wu, Han Sun · 2026 · Briefings in Bioinformatics
- A GPCR atlas across human microglial states in Alzheimer's disease: Insights from snRNA-seq and hiPSC modelsBing Zhang, Ran Zhao, Xiao-Yan Li, Zi-Han Wei, Dong-Mei Wang, Mei-Hong Lu · 2026 · Experimental Neurology
- Mechanisms of autophagy–lysosome pathway impairment in Alzheimer's diseaseKun Lü, Yirui Lu, Runyu Tang, Xiaofeng Dong, Pingping Zhuang, Yu Gao, Min Cheng, Yi Wang, Yubing Wang · 2026 · Journal of Alzheimer s Disease
- Plaque-associated microglial polarization in visual brain regions of the 5xFAD mouse modelShaylah McCool, Arnav Jain, Jennie C. Smith, Matthew J. Van Hook · 2026 · Frontiers in Aging Neuroscience
- Progranulin haploinsufficiency remodels the cerebral microvasculature and neurovascular unitSupriya Chakraborty, Madeleine Weick, Sofia Andrea Franciosa, Zeynab Tabrizi, Charlotte Swinehart, Gabriela Rodriguez Moore, Dylan Lee, Nairuti Nikhil Bhatt, Alejandra Cano, Poorva Poorva et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Integration of multi-omics and artificial intelligence for therapeutic insights in Alzheimer's disease: A comprehensive reviewTamilarasi Sambu Periyasamy, Nishu Sekar, Hariprasath Lakshmanan · 2026 · Journal of Alzheimer s Disease
- Rapid Hematological Profiling of the GPNMB/GRN Ratio via Bioelectronic Platform for Early Diagnosis of Parkinson's DiseaseXiaohong Jiang, Jintao Zheng, Jiacheng Yu, Rui Chen, Minchao Lai, Zheng Liang, Runzhi Zhou, Weilai Fu, Haoyang Yan, Hong Du et al. · 2026 · Advanced Materials
- Brain macrophages in neurodegenerationRachel J. Johnston, Nicole A. Pagán Torres, Yangchen Li, Claudia Z. Han · 2026 · Advances in immunology
- The microbiota–gut–brain axis in neuropsychiatric disorders: Mechanisms, advances, and clinical applicationsTongyun Li, Yiheng Chang, Shiqi Tang, Yuehua Chen, Xiaobai Li, Yan Wang · 2026 · Brain Research Bulletin
- From biology to therapy: advances in progranulin-related neurodegenerative diseasesSixian Hu, Kairui Qiu, Fangyuan Zhen, Xiaolai Zhou · 2026 · Molecular Neurodegeneration Advances
- The delta-opioid receptor: a therapeutic target for Alzheimer's diseaseYuan Xu, Wei Guan, Yilin Yang, Yujiao Yang, Ying Xia, Ya Peng · 2026 · Frontiers in Aging Neuroscience
- α-Asarone attenuates synaptic loss in APP/PS1 mice by restoring microglial phagocytic-lysosomal balance via the SPP1-mTOR-TFEB axisHaitao Jiang, Longmin Fan, Jiancong He, Zheyu Zhang · 2026 · Phytomedicine
- Glial-neuronal crosstalk via GABA signaling: mechanistic insights into neuropsychiatric and neurological pathophysiologyPanlin Liao, Liang Zhang, Lina Zhang, Zhonghua Hu · 2026 · Molecular Psychiatry
- Overlapping pathologies in different dementia-causing diseasesTara L. Spires‐Jones · 2026 · Oxford University Press eBooks
- A single-nucleus transcriptome atlas of cell diversity in human prefrontal cortex across the postnatal lifespanRui-Ze Niu, Meng‐Yuan Zhang, Zhi-Lan Yang, Cai-Hua Yang, Yingying Zhang, Weiwei Wang, Xiao-Feng Zeng, Jia Liu, Tianhao Bao · 2026 · npj Aging
- Microglia as candidate links between hormonal signals and neuronal circuits in polycystic ovary syndrome: evidence gaps and a research agenda李红涛, Tong Yin, Yichen Wang, Yi Wang, Xiaoyuan Lin, Xinyan Jia, Wei Yi, Han Yang · 2026 · Frontiers in Endocrinology
- Plasma Angiotensin‐Converting Enzyme as a Prioritized Candidate Target for Alzheimer's Disease: Evidence From Proteome‐Wide Mendelian Randomization and a Large Prospective Cohort StudyPeiyuan Huang, Haibo Tang, Zeying Feng, Evie Stergiakouli, Tom R. Gaunt, Jie Zheng, Yao Lu · 2026 · Journal of the American Heart Association
- CSF1R haploinsufficiency reveals subtle and selective age- and sex-dependent vulnerabilities in cognition and white matter without overt neurodegenerationScheila Daiane Schmidt, Daniel Menezes Guimarães, Aja E. Hogan-Cann, Alycia M Crooks, Vladislav Novikov, Liliana German‐Castelan, Jue Fan, Matthew F. Cowan, Chris Fodor, Nikita Ollen‐Bittle et al. · 2026 · Neurobiology of Disease
- From Lesion to Dysmaturation: The Evolving Neuropathological Landscape of Encephalopathy of PrematurityShuying Lin, Lir-Wan Fan, Yi Pang · 2026 · Brain Sciences