Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

Lui, Hansen, Zhang, Jiasheng, Makinson, Stefanie R., Cahill, Michelle K., Kelley, Kevin W., Huang, Hsin-Yi, Shang, Yulei, Oldham, Michael C. +20 more·2016·Cell

Cited by (733)

Items 701–733 of 733

  1. Sustained inhibitory dysfunction in complement component C1qa-deficient mice underlies epilepsy and comorbidities
    Joseane Righes Marafiga, Thy Vu, Jessica Bowlus, Scott C. Baraban · 2026 · Progress in Neurobiology
  2. The role of microglia in mediating the beneficial effects of environmental enrichment in neurodegenerative diseases and dementia
    Sharon Tsang, Huan Liao, Anthony John Hannan · 2026 · Brain and Environment
  3. Integrated protocol for concurrent generation of microglial and neuronal cells in human cerebral organoids
    Yukyeong Lee, Joshua L. Roffman, Rakesh Karmacharya · 2026 · BMC Methods
  4. Modeling C9ORF72 loss-of-function : a knockdown mouse model
    Maria-Belen Lopez-Herdoiza · 2016 · theses.fr (ABES)
  5. Rôle de la neuroinflammation et du récepteur microglial TREM2 dans la progression de deux modèles de tauopathie
    Audrey Vautheny · 2019 · theses.fr (ABES)
  6. Rôle de la protéine C3 du système du complément dans les déficits mnésiques précoces sur un modèle expérimental de sclérose en plaques
    Julien Bourel · 2019 · theses.fr (ABES)
  7. Étude de la composante neuroinflammatoire dans les DFT/SLA
    Julie Smeyers · 2020 · theses.fr (ABES)
  8. Altérations de la connectivité corticale au cours de périodes critiques du développement
    Mélanie Druart · 2020 · theses.fr (ABES)
  9. Role of astrocytic calcium signaling in synaptic transmission, plasticity and memory : implications for neurodegenerative diseases
    Elsie Moukarzel · 2021 · theses.fr (ABES)
  10. MafB and c-Maf transcriptional control of macrophage self-renewal and activation
    Hao Huang · 2021 · theses.fr (ABES)
  11. La vulnérabilité des internautes suite au partage de données personnelles en ligne
    Salma Khrifech · 2024
  12. Differential lysosomal burden in the excitatory and inhibitory neurons of the FTD-GRN brain.
    John Joyce · 2023
  13. Interleukin 27-induced photoreceptor survival is associated with suppression of a novel Muller glia subpopulation
    Laura D. McGee, Brandon M. Bessen, James Jarad Dollar, Marco Galizia, Saili Khorjekar, Ashley N. Zuniga, Stefan Kurtenbach, Abigail S. Hackam · 2026 · Cell Communication and Signaling
  14. Single-cell multiomics reveals microglia–neuron granulin signaling associated with brain aging
    Se-eun Han, Hyunjeong Kim, Jieun Song, Dabin Song, Soyeon Cho, Changsoo Kim, Eosu Kim, Byungjin Hwang · 2026 · Research Square
  15. Biased multi-view contrastive learning with attentive masking for spatial transcriptomic analysis
    Laiyi Fu, Wenkai Cui, Yuehua Chen, Danyang Wu, Han Sun · 2026 · Briefings in Bioinformatics
  16. A GPCR atlas across human microglial states in Alzheimer's disease: Insights from snRNA-seq and hiPSC models
    Bing Zhang, Ran Zhao, Xiao-Yan Li, Zi-Han Wei, Dong-Mei Wang, Mei-Hong Lu · 2026 · Experimental Neurology
  17. Mechanisms of autophagy–lysosome pathway impairment in Alzheimer's disease
    Kun Lü, Yirui Lu, Runyu Tang, Xiaofeng Dong, Pingping Zhuang, Yu Gao, Min Cheng, Yi Wang, Yubing Wang · 2026 · Journal of Alzheimer s Disease
  18. Plaque-associated microglial polarization in visual brain regions of the 5xFAD mouse model
    Shaylah McCool, Arnav Jain, Jennie C. Smith, Matthew J. Van Hook · 2026 · Frontiers in Aging Neuroscience
  19. Progranulin haploinsufficiency remodels the cerebral microvasculature and neurovascular unit
    Supriya Chakraborty, Madeleine Weick, Sofia Andrea Franciosa, Zeynab Tabrizi, Charlotte Swinehart, Gabriela Rodriguez Moore, Dylan Lee, Nairuti Nikhil Bhatt, Alejandra Cano, Poorva Poorva et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  20. Integration of multi-omics and artificial intelligence for therapeutic insights in Alzheimer's disease: A comprehensive review
    Tamilarasi Sambu Periyasamy, Nishu Sekar, Hariprasath Lakshmanan · 2026 · Journal of Alzheimer s Disease
  21. Rapid Hematological Profiling of the GPNMB/GRN Ratio via Bioelectronic Platform for Early Diagnosis of Parkinson's Disease
    Xiaohong Jiang, Jintao Zheng, Jiacheng Yu, Rui Chen, Minchao Lai, Zheng Liang, Runzhi Zhou, Weilai Fu, Haoyang Yan, Hong Du et al. · 2026 · Advanced Materials
  22. Brain macrophages in neurodegeneration
    Rachel J. Johnston, Nicole A. Pagán Torres, Yangchen Li, Claudia Z. Han · 2026 · Advances in immunology
  23. The microbiota–gut–brain axis in neuropsychiatric disorders: Mechanisms, advances, and clinical applications
    Tongyun Li, Yiheng Chang, Shiqi Tang, Yuehua Chen, Xiaobai Li, Yan Wang · 2026 · Brain Research Bulletin
  24. From biology to therapy: advances in progranulin-related neurodegenerative diseases
    Sixian Hu, Kairui Qiu, Fangyuan Zhen, Xiaolai Zhou · 2026 · Molecular Neurodegeneration Advances
  25. The delta-opioid receptor: a therapeutic target for Alzheimer's disease
    Yuan Xu, Wei Guan, Yilin Yang, Yujiao Yang, Ying Xia, Ya Peng · 2026 · Frontiers in Aging Neuroscience
  26. α-Asarone attenuates synaptic loss in APP/PS1 mice by restoring microglial phagocytic-lysosomal balance via the SPP1-mTOR-TFEB axis
    Haitao Jiang, Longmin Fan, Jiancong He, Zheyu Zhang · 2026 · Phytomedicine
  27. Glial-neuronal crosstalk via GABA signaling: mechanistic insights into neuropsychiatric and neurological pathophysiology
    Panlin Liao, Liang Zhang, Lina Zhang, Zhonghua Hu · 2026 · Molecular Psychiatry
  28. Overlapping pathologies in different dementia-causing diseases
    Tara L. Spires‐Jones · 2026 · Oxford University Press eBooks
  29. A single-nucleus transcriptome atlas of cell diversity in human prefrontal cortex across the postnatal lifespan
    Rui-Ze Niu, Meng‐Yuan Zhang, Zhi-Lan Yang, Cai-Hua Yang, Yingying Zhang, Weiwei Wang, Xiao-Feng Zeng, Jia Liu, Tianhao Bao · 2026 · npj Aging
  30. Microglia as candidate links between hormonal signals and neuronal circuits in polycystic ovary syndrome: evidence gaps and a research agenda
    李红涛, Tong Yin, Yichen Wang, Yi Wang, Xiaoyuan Lin, Xinyan Jia, Wei Yi, Han Yang · 2026 · Frontiers in Endocrinology
  31. Plasma Angiotensin‐Converting Enzyme as a Prioritized Candidate Target for Alzheimer's Disease: Evidence From Proteome‐Wide Mendelian Randomization and a Large Prospective Cohort Study
    Peiyuan Huang, Haibo Tang, Zeying Feng, Evie Stergiakouli, Tom R. Gaunt, Jie Zheng, Yao Lu · 2026 · Journal of the American Heart Association
  32. CSF1R haploinsufficiency reveals subtle and selective age- and sex-dependent vulnerabilities in cognition and white matter without overt neurodegeneration
    Scheila Daiane Schmidt, Daniel Menezes Guimarães, Aja E. Hogan-Cann, Alycia M Crooks, Vladislav Novikov, Liliana German‐Castelan, Jue Fan, Matthew F. Cowan, Chris Fodor, Nikita Ollen‐Bittle et al. · 2026 · Neurobiology of Disease
  33. From Lesion to Dysmaturation: The Evolving Neuropathological Landscape of Encephalopathy of Prematurity
    Shuying Lin, Lir-Wan Fan, Yi Pang · 2026 · Brain Sciences