Direct GR Binding Sites Potentiate Clusters of TF Binding across the Human Genome
Vockley, Christopher M., D’Ippolito, Anthony M., McDowell, Ian C., Majoros, William H., Safi, Alexias, Song, Lingyun, Crawford, Gregory E., Reddy, Timothy E.·2016·Cell
Cited by (182)
Items 101–182 of 182
- Novel formononetin-7-sal ester ameliorates pulmonary fibrosis via MEF2c signaling pathwayXueying Zhao, Guiwu Qu, Chenguang Song, Rongrong Li, Weili Liu, Changjun Lv, Xiaodong Song, Jinjin Zhang, Minge Li · 2018 · Toxicology and Applied Pharmacology
- Klf9 plays a critical role in GR –dependent metabolic adaptations in cardiomyocytesChandni S. Thakkar, Saleena Alikunju, Nandita Niranjan, Wajiha Rizvi, Ali K. Abbas, Maha Abdellatif, Danish H Sayed · 2023 · Cellular Signalling
- Interaction network of coexpressed mRNA, miRNA, and lncRNA activated by TGF-β1 regulates EMT in human pulmonary epithelial cellHuizhu Liu, Xueying Zhao, Jing Xiang, Jie Zhang, Chao Meng, Jinjin Zhang, Minge Li, Xiaodong Song, Changjun Lv · 2017 · Molecular Medicine Reports
- Expanding the repertoire of glucocorticoid receptor target genes by engineering genomic response elementsVerena Thormann, Laura V. Glaser, Maika Rothkegel, Marina Borschiwer, Melissa Bothe, Alisa Fuchs, Sebastiaan H. Meijsing · 2019 · Life Science Alliance
- Advances in Fungal Promoter Engineering for Enhancing Secondary Metabolite BiosynthesisNan Pu, Huawei Zhang · 2025 · Biotechnology Journal
- Cushing syndrome and glucocorticoids: T-cell lymphopenia, apoptosis, and rescue by IL-21SuJin Hwang, Christina Tatsi, Hye Sun Kuehn, Julie E. Niemela, Jennifer L. Stoddard, Yan Su, Maya Beth Lodish, Gülbû Uzel, Rosanne J. Spolski, Warren J. Leonard et al. · 2021 · Journal of Allergy and Clinical Immunology
- The glucocorticoid receptor is affected by its target ZBTB16 in a dissociated mannerSekar Galuh, Erin L. Faught, Ingeborg Klaassen, Lisa L. Koorneef, Joost Brinks, Elon H. C. van Dijk, Dirk Sw Elewaut, Reinier O. Schlingemann, Marcel J. M. Schaaf, Camiel J. F. Boon et al. · 2025 · Journal of Endocrinology
- The Dm-Myb Oncoprotein Contributes to Insulator Function and Stabilizes Repressive H3K27me3 PcG DomainsJuan F. Santana, Mrutyunjaya Parida, Abby Long, Joshua Wankum, Anthony J. Lilienthal, Krishna Madhav Nukala, John Robert Manak · 2020 · Cell Reports
- Glucocorticoid receptor wields chromatin interactions to tune transcription for cytoskeleton stabilization in podocytesHongfei Wang, Aiping Duan, Jing Zhang, Qi Wang, Yuexian Xing, Zhaohui Steve Qin, Zhihong Liu, Jingping Yang · 2021 · Communications Biology
- Single molecule microscopy to profile the effect of zinc status on transcription factor dynamicsLeah J. Damon, Jesse Aaron, Amy E. Palmer · 2022 · Scientific Reports
- Bronchial epithelial cell transcriptional responses to inhaled corticosteroids dictate severe asthmatic outcomesScott P. Ginebaugh, Matthias Hagner, Anuradha Ray, SERPIL CEM ERZURUM, SUZY A. A. COMHAIR, Loren C. Denlinger, Nizar N. Jarjour, Mario Castro, Prescott G. Woodruff, Stephanie A. Christenson et al. · 2023 · Journal of Allergy and Clinical Immunology
- Chromatin organization as an indicator of glucocorticoid induced natural killer cell dysfunctionM.S. Misale, Linda Witek Janusek, Dina Tell, Herbert L. Mathews · 2017 · Brain Behavior and Immunity
- NF-κB-dependent GR cistrome redistribution recruits GR to inflammatory genes but correlates with lesser glucocorticoid-mediated repressionMahmoud Mostafa, Amandah Necker‐Brown, Alex Gao, Andrew J. Thorne, Akanksha Bansal, Lucy H. Swift, Annika M. Maj, Sarah K. Sasse, Pina Colarusso, Anthony N. Gerber et al. · 2025 · iScience
- Enhancer RNA Expression in Response to Glucocorticoid Treatment in Murine MacrophagesFranziska Greulich, Kirsten A. Bielefeld, Ronny Scheundel, Aikaterini Mechtidou, Benjamin A. Strickland, N. Henriette Uhlenhaut · 2021 · Cells
- PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemiaBeck, Dominik, Cao, Honghui, Tian, Feng, Huang, Yizhou, Jiang, Miao, Zhao, Han, Tai, Xiaolu, Xu, Wenqian, Kosasih, Hansen J., Kealy, David J. et al. · 2024 · Nature Communications
- Identification, Design, and Application of Noncoding Cis-Regulatory ElementsLingna Xu, Yuwen Liu · 2024 · Biomolecules
- Unraveling the Genetics of Shared Clinical and Serological Manifestations in Patients With Systemic Inflammatory Autoimmune DiseasesMatteo Bianchi, Sergey V. Kozyrev, Antonella Notarnicola, Johanna K. Sandling, Mats E. Pettersson, Dag Leonard, Christopher Sjöwall, Iva Gunnarsson, Solbritt Rantapää‐Dahlqvist, Anders A Bengtsson et al. · 2024 · Arthritis & Rheumatology
- Dissecting the genomic activity of a transcriptional regulator by the integrative analysis of omics dataGiulio Ferrero, Valentina Miano, Marco Beccuti, Gianfranco Balbo, Michele De Bortoli, Francesca Cordero · 2017 · Scientific Reports
- Evaluation of chromatin accessibility in prefrontal cortex of schizophrenia cases and controlsBryois, Julien, Garrett, Melanie E, Song, Lingyun, Safi, Alexias, Giusti-Rodriguez, Paola, Johnson, Graham D, Demur, Alfonso Buil, Fullard, John F, Roussos, Panos, Sklar, Pamela et al. · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
- DNA-binding factor footprints and enhancer RNAs identify functional non-coding genetic variantsSimon Cameron Biddie, Giovanna Weykopf, Elizabeth F Hird, Elias T. Friman, Wendy A. Bickmore · 2024 · Genome biology
- Variant-to-function approaches for adipose tissue: Insights into cardiometabolic disordersSophia Metz, Jonathan Robert Belanich, Melina Claussnitzer, Tuomas O. Kilpeläinen · 2025 · Cell Genomics
- Decoding the dual recognition mechanism of the glucocorticoid receptor for DNA and RNA: sequence versus shapeJohanna Hörberg, Anna Reymer · 2023 · Scientific Reports
- funMotifs: Tissue-specific transcription factor motifsHusen Muhammad Umer, Karolina Smolinska Garbulowska, Nour‐Al‐Dain Marzouka, Zeeshan Khaliq, Claes Wadelius, Jan Komorowski · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Functional annotation of noncoding mutations in cancerHusen Muhammad Umer, Karolina Smolińska, Jan Komorowski, Claes Wadelius · 2021 · Life Science Alliance
- Early transcriptomic response of mouse adrenal gland and Y-1 cells to dexamethasoneHuifei Sophia Zheng, Jeffrey G. Daniel, Julia M. Salamat, Laci Mackay, Chad D. Foradori, Robert James Kemppainen, Satyanarayana R. Pondugula, Ya‐Xiong Tao, Chen‐Che Jeff Huang · 2022 · Endocrine Connections
- Glucocorticoid receptor collaborates with pioneer factors and AP-1 to execute genome-wide regulationErin M. Wissink, Delsy M. Martinez, Kirk Tevebaugh Ehmsen, Keith R. Yamamoto, John T. Lis · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Molecular Mechanisms of Transcription Factors with Dual Activator and Repressor FunctionsJinhong Dong, Michael J. Guertin · 2026 · Molecular and Cellular Biology
- Inhibiting EZH2 complements steroid effects in Duchenne muscular dystrophyEun Young Jeon, Yejin Kwak, Hyeji Kang, Hanbyeol Kim, Se Young Jin, Soojin Park, Ryeo Gyeong Kim, Dayoung Ko, Jae‐Kyung Won, Anna Cho et al. · 2025 · Science Advances
- Exploring the impact of dexamethasone on gene regulation in myeloma cellsVictor Gaborit, Jonathan Cruard, Catherine Guérin‐Charbonnel, Jennifer Derrien, Jean-Baptiste Alberge, Elise Douillard, Magali Devic, Sophie Deshayes, L. Campion, Frank Westermann et al. · 2023 · Life Science Alliance
- An Expanded Interplay Network between NF-κB p65 (RelA) and E2F1 Transcription Factors: Roles in Physiology and PathologySpyros Foutadakis, Eugenia Roupakia, Panagiotis Liakopoulos, Petros Kolovos, Evangelos Kolettas · 2022 · Cancers
- Decoding the non-coding genome: Opportunities and challenges of genomic and epigenomic consortium dataHenry Pratt, Zhiping Weng · 2018 · Current Opinion in Systems Biology
- The Oft-Overlooked Massively Parallel Reporter Assay: Where, When, and Which Psychiatric Genetic Variants are Functional?Bernard Mulvey, Tomas Lagunas, Joseph D. Dougherty · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Estrogen receptor 1 chromatin profiling in human breast tumors reveals high inter-patient heterogeneity with enrichment of risk SNPs and enhancer activity at most-conserved regionsStacey E. P. Joosten, Sebastian Gregoricchio, Suzan Stelloo, Elif Yapıcı, Chia-Chi Flora Huang, Kerim Yavuz, Maria Donaldson Collier, Tunç Morova, Umut Berkay Altıntaş, Yongsoo Kim et al. · 2024 · Genome Research
- Genome-wide dynamic nascent transcript profiles reveal that most paused RNA polymerases terminateRudradeep Mukherjee, Michael J. Guertin · 2026 · Nucleic Acids Research
- Applications of high-throughput reporter assays to gene regulation studiesBenedetta D’Elia, Juan I. Fuxman Bass · 2025 · Current Opinion in Structural Biology
- An evolutionarily conserved constellation of functional cis-elements programs the virus-responsive fate of the human (epi)genomeMarianna A. Koutsi, Marialena Pouliou, Dimitris Chatzopoulos, Lydia Champezou, Konstantinos Zagkas, Marili Vasilogianni, Alexandra G. Kouroukli, Marios Agelopoulos · 2025 · Nucleic Acids Research
- Predictable Engineering of Signal-Dependent Cis-Regulatory ElementsJake Cornwall-Scoones, Dirk Benzinger, Tianji Yu, Alberto Pezzotta, Andreas Sagner, Lina Gerontogianni, Shaun Bernadet, Elizabeth Finnie, Giulia L. M. Boezio, Hannah T. Stuart et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Serum- and glucocorticoid-induced kinase 3 orchestrates glucocorticoid signaling to facilitate chromatin remodeling during murine adipogenesisQilong Chen, Jialu Guo, Yuyi Liu, Tai Du, Jiapei Liu, Yuyao Zhang, Yuming Dai, Mengdi Zhang, Ziqian Zhou, Qiyang Zhang et al. · 2025 · Journal of Clinical Investigation
- Glucocorticoid stimulation induces regionalized gene responses within topologically associating domainsChristophe Tav, Éric Fournier, Michèle Fournier, Fatemeh Khadangi, Audrey Baguette, Maxime C. Côté, Maruhen Amir Datsch Silveira, Félix‐Antoine Bérubé‐Simard, Guillaume Bourque, Arnaud Droit et al. · 2023 · Frontiers in Genetics
- Catching the glucocorticoid receptor in the act: Lessons from fluorescence fluctuation methodsMartín Stortz, Camila Oses, Agustina L. Lafuente, Diego M. Presman, Valeria Levi · 2025 · Biochemical and Biophysical Research Communications
- Decoding the Inversion Symmetry Underlying Transcription Factor DNA-Binding Specificity and Functionality in the GenomeLaurel A. Coons, Adam Burkholder, Sylvia C. Hewitt, Donald Patrick McDonnell, Kenneth Steven Korach · 2019 · iScience
- Optimizing the chances of success in the search for epigenetic biomarkers: Embracing genetic variationRobert A. Philibert, Stephen J. Glatt · 2017 · American Journal of Medical Genetics Part B Neuropsychiatric Genetics
- Profiling the quantitative occupancy of myriad transcription factors across conditions by modeling chromatin accessibility dataKaixuan Luo, Jianling Zhong, Alexias Safi, Linda K. Hong, Alok K. Tewari, Lingyun Song, Timothy E. Reddy, Li Ma, Gregory E. Crawford, Alexander J. Hartemink · 2022 · Genome Research
- Adrenal–adipose tissue crosstalk in health and diseaseMingyan Jiang, Ulrich Stifel, Matthias Blüher, Hervé Lefèbvre, Stefan Richard Bornstein, Nicole Bechmann · 2025 · European Journal of Endocrinology
- Epigenetic Landscape in Leukemia and Its Impact on Antileukemia TherapeuticsBingzhi He, Julia Hlavka-Zhang, Richard B. Lock, Duohui Jing · 2019 · IntechOpen eBooks
- Computational resources to define alleles and altered regulatory motifs at genomically edited candidate response elementsKirk Tevebaugh Ehmsen, Matthew T. Knuesel, Delsy M. Martinez, Masako Asahina, Haruna Aridomi, Keith R. Yamamoto · 2021 · Nucleic Acids Research
- Definition of alleles and altered regulatory motifs across Cas9-edited cell populationsKirk Tevebaugh Ehmsen, Matthew T. Knuesel, Delsy M. Martinez, Masako Asahina, Haruna Aridomi, Keith R. Yamamoto · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Assessment of glucocorticoid-induced enhancer activity of eSNP regions using STARR-seq reveals novel molecular mechanisms in psychiatric disordersSigne Penner-Goeke, Melissa Bothe, Nils Kappelmann, Peter Kreitmaier, Ezgi Kaya, Dorothee Pöhlchen, Anne Kühnel, Darina Czamara, BeCOME working group, Laura V. Glaser et al. · 2022 · medRxiv
- Comprehensive functional annotation of ESR1-driven enhancers in breast cancer reveals hierarchical activity independent of genomic and epigenomic contextsYanis Zekri, Sebastian Gregoricchio, Elif Yapıcı, Chia-Chi Flora Huang, Tunç Morova, Umut Berkay Altıntaş, Gözde Korkmaz, Nathan A. Lack, Wilbert T. Zwart · 2025 · Genome Research
- The gene regulatory effects of selective glucocorticoid receptor ligandsNicholas S. Giroux, Graham D. Johnson, Alejandro Barrera, Timothy E. Reddy · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Defining Native Enhancer FunctionMiles A. Pufall · 2017 · Cell Systems
- Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylationKenan Zhang, Lin He, Yizhou Wang, Sen Qin, Chunyu Yu, Enrun Zheng, Zedan Zhang, Yawei Xu, Xiaolin Chen, Yanhua Liu et al. · 2026 · Signal Transduction and Targeted Therapy
- Glucocorticoid receptor biology through the omics lens: context mattersPriya Singh, F. Greulich · 2026 · Biological chemistry
- Auricular malformations are driven by copy number variations in a hierarchical enhancer cluster and a dominant enhancer recapitulates human pathogenesisXiaopeng Xu, Qi Chen, Qingpei Huang, Timothy C. Cox, Hao‐Jie Zhu, Jintian Hu, Xi Han, Ziqiu Meng, Bingqing Wang, Zhiying Liao et al. · 2025 · Nature Communications
- Quantitative occupancy of myriad transcription factors from one DNase experiment enables efficient comparisons across conditionsKaixuan Luo, Jianling Zhong, Alexias Safi, Linda K. Hong, Alok K. Tewari, Lingyun Song, Timothy E. Reddy, Li Ma, Gregory E. Crawford, Alexander J. Hartemink · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Chromatin accessibility combined with enhancer clusters activation mediates heterogeneous response to dexamethasone in myeloma cellsVictor Gaborit, Jonathan Cruard, Catherine Guérin‐Charbonnel, Jennifer Derrien, Jean-Baptiste Alberge, Elise Douillard, Nathalie Roi, Magali Devic, L. Campion, Frank Westermann et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- DNA-binding factor footprints and enhancer RNAs identify functional non-coding genetic variantsSimon Cameron Biddie, Giovanna Weykopf, Elizabeth F Hird, Elias T. Friman, Wendy A. Bickmore · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Dysregulation in Spatiotemporal Expression of HMX1 Coordinated by Multifaceted Enhancers Drives an Auricular DisorderXiaopeng Xu, Qi Chen, Qingpei Huang, Timothy C. Cox, Hao Zhu, Jintian Hu, Xi Han, Ziqiu Meng, Bingqing Wang, Zhiying Liao et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- SMARCA2 is an essential and potent cofactor for a specific subset of the glucocorticoid response in A549 cellsSchuyler M. Melore, D. Dewran Koçak, Keith Siklenka, Graham D. Johnson, Courtney A. Williams, Luke C. Bartelt, Angela G. Jones, Alejandro Barrera, Revathy Venukuttan, Charles A. Gersbach et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Organizational Properties of a Functional Mammalian Cis-RegulomeVirendra K. Chaudhri, Krista Dienger-Stambaugh, Zhiguo Wu, Mahesh Shreshtha, Harinder Singh · 2018 · SSRN Electronic Journal
- Adaptation of STARR-seq method to be used with 3 rd generation integrase-deficient promoterless lentiviral vectorsMantas Matjusaitis, Donato Tedesco, Azuolas Ciukas · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Correction to: Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation2020 · Circulation Research
- Faculty Opinions recommendation of Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding.Stafford Louis Lightman, Felicity E. Stubbs · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Immune regulation by glucocorticoids can be linked to cell type-dependent transcriptional responses.Karen E. Chapman · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Joint profiling of chromatin accessibility and gene expression in thousands of single cells.Matthew Weirauch · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Decoding the Dual Recognition Mechanism of Glucocorticoid Receptor for DNA and RNA: Sequence vs. ShapeJohanna Hörberg, Anna Reymer · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Identification and Exploration of Novel Predictive Markers, Tumor-Related Biomarkers, in PreeclampsiaMei Yang, Menghui Wang, Qing Zhu, Xin Zhang, Nanfang Li · 2023 · Research Square
- Tumor-Related mRNA POU5F1: A Novel Predictive Marker in PreeclampsiaMei Yang, Menghui Wang, Nanfang Li · 2023 · Research Square
- Hypothetical involvement of stress hormones-induced reprograming of adult stem/progenitor cells in tumorigenesisWaldemar Kanczkowski, Mariko Sue, Agnès Wlodarczyk, George Panagiotis Chrousos · 2024 · Exploration of Endocrine and Metabolic Diseases
- Comparative atlas of genome-wide chromatin-associated protein co-occupancyShannon M. White, Belle A. Moyers, Tao Wang, Mark Mackiewicz, Annika K K Weimer, Fabian Grubert, Vivekanandan Ramalingam, Jay X. J. Luo, Lixia Jiang, Minyi Shi et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- High-resolution dissection of human cell type-specific enhancers in cis and trans activitiesMeng Wang, Xiaoxu Yang, Qixi Wu · 2025 · Genomics
- LDLR H3K27ac in PBMCs: An Early Warning Biomarker for Hypercholesterolemia Susceptibility in Male Newborns Treated with Prenatal DexamethasoneKexin Liu, Can Ai, Dan Xu, Wen Hu, Guanghui Chen, Jin‐Zhi Zhang, Ning Zhang, Dongfang Wu, Hui Wang · 2025 · Toxics
- Additional file 1 of Functional mapping of androgen receptor enhancer activityHuang, Chia-Chi Flora, Shreyas Lingadahalli, Tunç Morova, Doğancan Özturan, Eugene Hu, Ivan Pak Lok Yu, Linder, Simon, Marlous Hoogstraat, Suzan Stelloo, Funda Sar et al. · 2021 · Figshare
- Additional file 2 of Functional mapping of androgen receptor enhancer activityHuang, Chia-Chi Flora, Shreyas Lingadahalli, Tunç Morova, Doğancan Özturan, Eugene Hu, Ivan Pak Lok Yu, Linder, Simon, Marlous Hoogstraat, Suzan Stelloo, Funda Sar et al. · 2021 · Figshare
- Additional file 4 of Functional mapping of androgen receptor enhancer activityHuang, Chia-Chi Flora, Shreyas Lingadahalli, Tunç Morova, Doğancan Özturan, Eugene Hu, Ivan Pak Lok Yu, Linder, Simon, Marlous Hoogstraat, Suzan Stelloo, Funda Sar et al. · 2021 · Figshare
- Additional file 2 of DNA-binding factor footprints and enhancer RNAs identify functional non-coding genetic variantsSimon Cameron Biddie, Giovanna Weykopf, Elizabeth F Hird, Elias T. Friman, Wendy A. Bickmore · 2024 · Figshare
- Additional file 1 of DNA-binding factor footprints and enhancer RNAs identify functional non-coding genetic variantsSimon Cameron Biddie, Giovanna Weykopf, Elizabeth F Hird, Elias T. Friman, Wendy A. Bickmore · 2024 · Figshare
- ChIP happens: from biochemical origins to the modern omics toolbox for understanding steroid hormone receptorsThomas F. Grimes, Jacob Pope, Jack Stenning, Taylor E. Smith, David G. Kent, Simon C. Baker, William J. Brackenbury, Lianne I. Willems, Andrew N. Holding · 2026 · Biochemical Journal
- Alpha-1 antitrypsin–glucocorticoid receptor axis: a new pathway in immune modulationKevin Möhlis, Julia Held, Elena Korenbaum, Sabine Wrenger, Sabina M Janciauskiene, John T. Heiker · 2026 · Molecular Medicine
- ROS, identified as a driver for fibroblast activation, can be counteracted by glucocorticoid in LINC00605-dependent GMD machineryHuayu Zhu, Liang Zhu, Jiarui Zhang, Yuming Luo, Jiang Zhang, Xin Shao, Xuelian Feng, Lei Yan, Lisen Zhang, Haihong Ning et al. · 2026 · Free Radical Biology and Medicine
- Glucocorticoid signalling exerts distinct lineage-permissive and dose-dependent disruptive actions during human osteoblast differentiationM. R. Madsen, Dalia Ali, Mathilde Palmier, Atenisa Caci, V. Akimov, A. Haakonsson, Blagoy Spasov Blagoev, M. Kassem, S. Mandrup, A. Rauch · 2026 · bioRxiv
- Integration by parts: The multi-layered mechanisms of cis-regulatory controlJake Cornwall-Scoones, James Briscoe, M. Joaquina Delàs · 2026 · Molecular Cell