Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease
Finan, Brian, Clemmensen, Christoffer, Zhu, Zhimeng, Stemmer, Kerstin, Gauthier, Karine, Müller, Luisa, De Angelis, Meri, Moreth, Kristin +34 more·2016·Cell
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- Using Single-Cell RNA-Seq Data to Trace Tissue Cells Responsive to Thyroid HormonesLiang Hu, Chao Wu · 2021 · Frontiers in Endocrinology
- Hormetic effect of triiodothyronine in metabolically healthy obese personsJi Eun Jun, Tae Hyuk Kim, Seung‐Eun Lee, You‐Bin Lee, Jae Hwan Jee, Ji Cheol Bae, Sang‐Man Jin, Kyu Yeon Hur, Jae Hyeon Kim, Sun Wook Kim et al. · 2017 · Endocrine
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- Scaling it down: new in vitro tools to get the balance rightEmma K. Biggs, Fiona Mary Gribble, Frank M. Reimann · 2016 · Biochemical Journal
- Hybrid peptides in the landscape of drug discoveryDaniel Fourmy · 2017 · Peptides
- Pas de Deux: Glucagon and Thyroid Hormone Moving in Perfect Synchrony.Alexandra L. Ghaben, Philipp E. Scherer · 2017 · PubMed
- De la découverte des incrétines aux blockbusters coupe-faim. 100 ans de recherches pour arriver sous les feux de l’actualité thérapeutiqueBernard Portha, Junjun Liu, Jamileh Movassat, Cécile Tourrel‐Cuzin · 2024 · Cahiers de Nutrition et de Diététique
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- Cross-Talk Between Thyroid Disorders and Nonalcoholic Fatty Liver Disease: From Pathophysiology to TherapeuticsYan Yang, Jiyuan Xiao, Wen Qiu, Luxia Jiang · 2024 · Hormone and Metabolic Research
- Role of serum fasting glucagon in hypothyroidism-related nonalcoholic fatty liver diseaseMervat M. El-Eshmawy, Amira F. Barakat, Azza A. El-Baiomy, Mohamed Mosad Abo Elnaga, Mohamed Adel Elbasiony · 2025 · Nutrition & Metabolism
- Hypothyroidism, diabetes, and cardiovascular diseaseMargaret L. England, Jon M. Gerrard · 2024 · Elsevier eBooks
- Doubles-agonistes, tri-agonistes et multi-agonistes incrétines/glucagonFranck Phan, Fabrizio Andréelli · 2021 · Médecine des Maladies Métaboliques
- Targeted delivery of thyroid hormone improves metabolic outcomesClaire Greenhill · 2016 · Nature Reviews Endocrinology
- From incretin discovery to anti-obesity blockbuster drugs. One hundred years of research to move from shadow to spotlightBernard Portha, Junjun Liu, Jamileh Movassat, Cécile Tourrel‐Cuzin · 2025 · Cahiers de Nutrition et de Diététique
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- The Role of Iron in Adipose Tissue Function, Crosstalk, and TransdifferentiationJiamin Guo, Panpan Yu, 李陈康, 聂桂英, Wenchen Xu, Meiyi Chen, Liang Li, Tianhong Peng, Wei Xie · 2026 · Cell Biochemistry and Function
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- Master role of glucose-6-phosphate in cell signaling and consequences of its deregulation in the liver and kidneysFabienne Rajas, Gilles Mithieux · 2019 · Elsevier eBooks
- Polypharmakologie als ein neuer Ansatz zur Präzisionsmedizin in der Adipositas- und DiabetestherapieSigrid Jall, A. Götz, M. Tschöp, Timo D. Müller · 2018 · Adipositas - Ursachen Folgeerkrankungen Therapie
- New advances and novel approaches in obesity pharmacotherapyJavier Gargallo Vaamonde, Gema Frühbeck, Javier Salvador · 2018 · Current Opinion in Endocrine and Metabolic Research
- Association of Visceral Fat with Pulmonary Function in Hypothyroidism PatientsDr. Harminder Singh · 2021 · Scholars Journal of Applied Medical Sciences
- Diabetes: Insights into Thyroid HormonesShahid Shehzad, Muhammad Naeem, Rasif Khan, Rashed Ali Khan, Saqibah Rehman, Rida Naz · 2022 · Pakistan Journal of Medical and Health Sciences
- Peptide‐small Molecule Drug Conjugates for Cancer, Metabolic Diseases, and BeyondRongjun He, Sumeet Singh, Adam R. Mezo · 2025 · Peptide Science
- Metabolic Syndrome: One Speckled Stone Kills a Flock of Birds?Ylva Bonde, Bo Angelin · 2017 · Trends in Molecular Medicine
- Einfluss der Fettleber auf den Glukosestoffwechsel nicht unterschätzenNorbert Stefan, F Pfeiffer Andreas, Andreas L. Birkenfeld, Stephan Herzig, Annette Schürmann, Matthias H. Tschöp, Hans-Ulrich Häring, Michael Roden · 2017 · Diabetes aktuell
- Inkretinbasierte Medikamente zur Diabetes- und AdipositastherapieA. Götz, Sigrid Jall, M. Tschöp, Timo D. Müller · 2017 · Der Diabetologe
- Le glucagon : le retour du vilain petit canardÉtienne Larger, Marc Diedisheim, Xavier Donath, C. Tiercelin · 2018 · Médecine des Maladies Métaboliques
- Folgeerkrankungen des Diabetes mellitusStephan Herzig, Barbara Thorand, Annette Peters, Dan Ziegler · 2021 · Diabetes aktuell
- Design and Characterization of a Fluorescent Reporter Enabling Live-cell Monitoring of MCT8 ExpressionAdina Sophie Graffunder, Sarah Paisdzior, Robert Opitz, Kostja Renko, Peter Kühnen, Heike Biebermann · 2021 · Experimental and Clinical Endocrinology & Diabetes
- Faculty Opinions recommendation of Regulation of hepatic glucose metabolism in health and disease.Carlos Alberto Aguilar-Salinas · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic diseaseStephan Sachs, Anna Götz, Brian Finan, Annette Feuchtinger, Richard D. DiMarchi, Yvonne Döring, Christian Weber, Matthias H. Tschöp, Timo D. Müller, Susanna M. Hofmann · 2023 · Research Square
- Knockdown of VAMP8 attenuates atherosclerosis and enhances the effect of simvastatin in APOE-deficient miceLei Zhan, Hua Zhao · 2023 · Tropical Journal of Pharmaceutical Research
- Progressive Study on Thyroid Hormones and Adipose Tissue蓉 朱 · 2023 · Advances in Clinical Medicine
- Evaluation of thyroid hormones in type 1 diabetes mellitusAmna Abdullah, Sardar Ahmed · 2024 · Zanco Journal of Medical Sciences
- Overnutrition directly impairs thyroid hormone biosynthesis and utilization, causing hypothyroidism, despite remarkable thyroidal adaptationsJessica Rampy, Alejandra Paola Torres-Manzo, Kendra Hoffsmith, Matthew A. Loberg, Quanhu Sheng, Federico Salas-Lucia, Antonio Carlos Bianco, Rafael Arrojo e Drigo, Huiying Wang, Vivian Lee Weiss et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Additional file 1 of Glucagon signaling via supraphysiologic GCGR can reduce cell viability without stimulating gluconeogenic gene expression in liver cancer cellsGodfrey, Jason, Romain Riscal, Nicolas Skuli, Marie Celeste Simon · 2022 · Figshare
- The application of metabolomics by high field nuclear magnetic resonance to study thyroid signalisation pathologies in miceHouda Boumaza · 2019 · theses.fr (ABES)
- Gènes cibles des hormones thyroïdiennes, un regard nouveau par le prisme des analyses pangénomiquesYanis Zekri · 2022 · theses.fr (ABES)
- Harnessing PPAR pharmacology through dual incretin-directed deliveryJonas Petersen, Christoffer Clemmensen · 2026 · Cell Metabolism
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- Histoire des incrétines GLP-1/GIP – De l’hormone au médicament couteau-suisseBernard Portha · 2026 · Biologie Aujourd hui
- BindingDB Entry 50002557: Optimization of peptide-based polyagonists for treatment of diabetes and obesity.BindingDB · 2020 · UC San Diego