Coordination of Two Genomes by Mitochondrial Translational Plasticity
Open accessAbstract
The dual genetic origin of mitochondrial respiratory chain complexes leads to the synthesis of subunits by mitochondrial and cytosolic ribosomes. Now, Richter-Dennerlein et al. report that membrane-integrated assembly factors associate with ribosome nascent chain complexes in human mitochondria to coordinate translational plasticity with the import of subunits from the cytosol.
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The vast majority of mitochondrial proteins require import, proteolytic maturation, and delivery to the correct submitochondrial compartment.
“the vast majority of mitochondrial proteins require import, proteolytic maturation, and delivery to the correct submitochondrial compartment [38]”
From Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function (2019) · cites this paper as [38]
Cites
Mitochondrial protein synthesis adapts to influx of nuclear-encoded protein
Richter-Dennerlein, R., Oeljeklaus, S., Lorenzi, I., Ronsör, C., Bareth, B., Schendzielorz, A. B., Wang, C., Warscheid, B., Rehling, P., & Dennerlein, S. (2016) · Cell · doi:10.1016/j.cell.2016.09.003 · Cited by 232 · see citing works
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Orr, A. L., Kim, C., Jimenez-Morales, D., Newton, B. W., Johnson, J. R., Krogan, N. J., Swaney, D. L., & Mahley, R. W. (2019) · Journal of Alzheimer's Disease · doi:10.3233/jad-181184 · Cited by 103 · see citing works
- Authors
- Rampelt, H., & Pfanner, N.
- Affiliations
- University of Freiburg (DE)
- Corresponding author
- Rampelt, Heike
- Pfanner, Nikolaus
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 167
- Issue
- 2
- Pages
- 308-310
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2528698686
- Cited by
- 9
- References
- 1
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 2 · 2019: 1 · 2018: 2 · 2017: 1
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- respiratory chain complexes, ribosome-nascent chain complex, mitochondrial ribosome, subunit assembly
- MeSH terms
- Cytosol, Humans, Mitochondria, Ribosomes, Protein Biosynthesis
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