A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

Adamson, Britt, Norman, Thomas M., Jost, Marco, Cho, Min Y., Nuñez, James K., Chen, Yuwen, Villalta, Jacqueline E., Gilbert, Luke A. +9 more·2016·Cell

Cited by (1,009)

Items 901–1,000 of 1,009

  1. Discrete Diffusion for Single-Cell Gene Expression Modeling
    Sanjukta Bhattacharya, Christian Gensbigler, Shaamil Karim, Jonathan Gill Lees · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  2. Optimized parameters for Cas9 CRISPR interference library design
    Smriti Srikanth, Fengyi Zheng, Laura M. Drepanos, Spencer T. Shah, E L Kaplan, Daytan Gibson, Grace O Lynch, Allison Uebele, Ganna Reint, Sarra Merzouk et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  3. IRE1 drives a homeostatic response to reduced protein influx into the endoplasmic reticulum
    Francesca Zappa, Advait Subramanian, Benjamin Yang, Julia E. Conrad, Tsan‐Wen Lu, Jing Wang, Nicolas A. DeBeaubien, Rose Yan, Renato Minopoli, Tristan Ian Croll et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  4. Systematic identification of seed-driven off-target effects in Perturb-seq experiments
    Austin Hartman, John D. Blair, Thao P. Nguyen, Kyle A. Dyson, Alexandra Bradu, Oliver Takacsi-Nagy, Katherine E. Santostefano, Theresa Boade, Matthew Bolaños, Ronghui Zhu et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  5. Spurious correlation inflates performance in single-cell perturbation prediction
    Phillip B. Nicol, Shriya Shivakumar, Rafael A. Irizarry · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  6. Global cell-state and gene-program representations reveal conserved and context-specific perturbation responses of cells
    Xingjie Pan, Reuben A. Saunders, Joseph M. Replogle, Jonathan S. Weissman, Xiaowei Zhuang · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  7. Scalable multimodal mapping of macrophage regulatory architecture by integrating optical and transcriptomic pooled screens
    Takamasa Kudo, Romain Lopez, Ana M. Meireles, Antonio Rios, Paula Pinto Coelho, Vineethkrishna Chandrasekar, Dylan C. Lam, Jan-Christian Huetter, Mineto Ota, Orit Rozenblatt–Rosen et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  8. A multimodal perturbation atlas defines the phenotypic resolution of cellular morphology
    Chad Liu, Alexander V. Hillsley, Madhurya Sekhar, Cassidy Jones, Gabriel Sturm, Taihei Fujimori, Diane M. Wiener, Karen W. Cheng, Talon Chandler, Alexander Lin et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  9. Lineage specifying transcription factors determine cell function by direct control of metabolism
    Alex J. Bott, Joshua C. Youngs, Corey Nathaniel Cunningham, Jonathan G. Van Vranken, Peng Wei, Ahmad A. Cluntun, Steven P. Gygi, Donald E. Ayer, Jared P. Rutter · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  10. Evaluating the learnability of single-cell large language models on multiple tasks
    Yan, Yu, Wang, Xutao, Song, Dongyuan · 2026
  11. Evaluating the learnability of single-cell large language models on multiple tasks
    Yan, Yu, Wang, Xutao, Song, Dongyuan · 2026 · BMC Genomics
  12. Detection of gene cis-regulatory element perturbations in single-cell transcriptomes
    Grace Hui Ting Yeo, Oscar Juez, Qing Chen, Budhaditya Banerjee, Lendy Chu, Max W. Shen, May Sabry, Ive Logister, Richard I. Sherwood, David K. Gifford · 2021 · PLoS Computational Biology
  13. A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α
    Joanne Tung, Lei Huang, Ginto George, Heather P. Harding, David Ron, Adriana Ordóñez · 2024 · eLife
  14. Single-cell CRISPR screening in mouse brain
    Eugenia V. Pankevich, Christoph Bock · 2025 · Nature Protocols
  15. Advancing Cardiovascular Medicine: Innovative Therapeutic Pathways with Single-Cell Technologies
    Jiahui Ji, Eric L. Lindberg, Daniel Reichart · 2025 · Current Treatment Options in Cardiovascular Medicine
  16. The Expanding Landscape of Neural Architectures and Their Impact in Biomedicine
    Zijun Frank Zhang, Huixin Zhan, Tinghui Wu, Robert Burns, Jasreet Hundal, Helio A. Costa · 2025 · Annual Review of Biomedical Data Science
  17. Prediction of Single-Cell perturbation response based on Direction-Constrained diffusion Schrödinger Bridge
    Yiqing Luo, Lin Liu, Yaxin Fu, Yi Xuan Deng, Lin Tang · 2025 · Journal of Biomedical Informatics
  18. Genome-wide CRISPR interference screen identifies Clip2 as a novel regulator of osteocyte maturation and morphology
    Courtney M. Mazur, Parthena E. Kotsalidis, M. A. George, Tom Whalley, Tadatoshi Sato, John G. Doench, Lauren E. Surface, Marc Nathan Wein · 2026 · Journal of Biological Chemistry
  19. CRISPR-Based Functional Genomics in Pluripotent Stem Cells
    Setareh Zahedi · 2025 · Stem Cell Reviews and Reports
  20. RAPID-DASH: fast and efficient assembly of guide RNA arrays for multiplexed CRISPR-Cas9 applications
    Asfar Lathif Salaudeen, Nicholas Mateyko, Carl G. de Boer · 2025 · Synthetic Biology
  21. VIST: variational inference for single cell time series
    Bingxian Xu, Rosemary Braun · 2026 · Genome biology
  22. Single-cell exon deletion profiling reveals splicing events that shape gene expression and cell state dynamics
    Bandana Kumari, Arun Prasath Damodaran, Wilfried M. Guiblet, Mei‐Sheng Xiao, Amit K. Behera, Tyler A. On, CARL E. MCINTOSH, Maxwell Teszler, Chelsee Holloway, Sandra M. Le et al. · 2026 · Nature Communications
  23. Insights from pooled CRISPRi single-cell screens in K562 cells reveal gene functions, regulatory networks, and highlight opportunities and limitations
    Hong Zhang, Peifen Zhang, Eric Bindels, Eskeatnaf Mulugeta · 2026 · BMC Genomics
  24. Decoding neurodegeneration one cell at a time
    Olivia Gautier, Thao P. Nguyen, Aaron D. Gitler · 2026 · Journal of Clinical Investigation
  25. A single-cell CRISPR screen defines a gene regulatory network governing human pluripotency in primed and naive cells
    Gal Keshet, Nissim Benvenisty · 2026 · Cell Reports
  26. From CRISPR functional genomics to synthetic interventions: engineering antiviral strategies
    Wenjie Qiao · 2026 · Journal of Virology
  27. Mitophagy and Immune Infiltration in Primary Sjögren’s Disease: Insights from Bioinformatics Analysis
    Liqiong Hou, Gaxue Jiang, Yanfei Chen · 2026 · International Journal of Molecular Sciences
  28. Pool-packaged AAV libraries exhibit extensive length-dependent and homology-dependent chimerism
    Jean‐Benoît Lalanne, Chau Huynh, John K. Mich, Avery C. Hunker, Troy A. McDiarmid, Haedong Kim, Boaz P. Levi, Jonathan T. Ting, Jay Shendure · 2026 · Nature Biotechnology
  29. IRE1–XBP1driven induction of TMED9 stabilizes ATF6 during ER stress to promote cell survival
    Chen Lenchisky, Areen Muhammad Majadly, Irena Bronshtein Berger, Danielle Biton, Alaa Daoud Sarsour, Narkis Arbeli, Tamar Cohen, Naama Amos, Sara Kinstlinger, Ortal Cohen et al. · 2026 · Cellular & Molecular Biology Letters
  30. A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response
    Fiona Shilliday, Miguel Gancedo-Rodrigo, Ginto George, Shintaro Aibara, Santosh Adhikari, Syedah Neha Ashraf, Evelyne J. Barrey, Damian C. Crowther, Paige Dickson, Diana Gikunju et al. · 2026 · Nature Communications
  31. Causal circuit tracing reveals distinct computational architectures in single-cell foundation models: inhibitory dominance, biological coherence, and cross-model convergence
    Ihor Kendiukhov · 2026 · Bioinformatics
  32. Dissecting the host determinants of orthoflavivirus infection using QIC-seq
    Allison Dupzyk, Benjamin S. Waldman, James R. Zengel, Fabio Zanini, Jan E. Carette · 2026 · PLoS Pathogens
  33. Protocol for one-step design of a triple sgRNA-based CRISPR/Cas9 construct for neuronal gene knockout in the mouse brain
    Gibson Dowd, Yuki Ogawa · 2026 · STAR Protocols
  34. Hacking hematopoiesis – emerging tools for examining variant effects
    Michael C. Gundry, Vijay G. Sankaran · 2023 · Disease Models & Mechanisms
  35. Using Synthetic DNA Libraries to Investigate Chromatin and Gene Regulation
    Holly Kleinschmidt, Cheng Xu, Lu Bai · 2023 · Chromosoma
  36. Factoring single-cell perturbations
    Bicna Song, Wei Li · 2023 · Nature Methods
  37. Unbiased genome-wide approaches to identify vulnerability factors in Huntington's disease
    Suphinya Sathitloetsakun, Myriam Heiman · 2024 · Elsevier eBooks
  38. dFLASH; dual FLuorescent transcription factor activity sensor for histone integrated live-cell reporting and high-content screening
    Timothy P. Allen, Alison E. Roennfeldt, Moganalaxmi Reckdharajkumar, Adrienne E. Sullivan, Miaomiao Liu, Ronald J. Quinn, Darryl Lyndon Russell, Daniel J. Peet, Murray L. Whitelaw, David C. Bersten · 2025 · Nature Communications
  39. Barcodes based on nucleic acid sequences: Applications and challenges (Review)
    Ying Wei, Faquan Lin · 2025 · Molecular Medicine Reports
  40. Single-Cell RNA Sequencing (sc-RNAseq) in the Development of Biomedical Therapeutics
    Phei Er Saw, Erwei Song · 2025 · Springer eBooks
  41. The new technologies of high-throughput single-cell RNA sequencing
    Ekaterina A. Vodiasova, Elina S. Chelebieva, О. Н. Кулешова · 2019 · Vavilov Journal of Genetics and Breeding
  42. Validation of a Miniaturized Permeability Assay Compatible with CRISPR-Mediated Genome-Wide Screen
    Claire Simonneau, Junning Yang, Xianguo Kong, Robert Kilker, Leonard C. Edelstein, Paolo M. Fortina, Eric R. Londin, Arie Horowitz · 2019 · Scientific Reports
  43. Inferring perturbation profiles of cancer samples
    Martin Pirkl, Niko Beerenwinkel · 2021 · Bioinformatics
  44. Development and Application of CRISPR-Mediated Genetic Screening in Oncology
    Wanji Li · 2020 · International Conference on Biomedical and Bioinformatics Engineering (ICBBE)
  45. Gene network modeling via TopNet reveals functional dependencies between diverse tumor-critical mediator genes
    Helene R. McMurray, Aslihan Ambeskovic, Laurel A. Newman, Jordan Aldersley, Vijaya Balakrishnan, Bradley Smith, Harry A. Stern, Hartmut Land, Matthew N. McCall · 2021 · Cell Reports
  46. CRISPR for Rewriting Genetic Code
    Zulqurnain Khan, Asim Razzaq, Ayesha Muneer, Maria Siddique, Umar Iqbal, Muhammad Asif Raza, Tahmina Sattar · 2022 · Springer eBooks
  47. Parallel genome-wide CRISPR analysis identifies a role for heterotypic ubiquitin chains in ER-associated degradation
    Dara E. Leto, David W. Morgens, Lichao Zhang, Christopher Paul Walczak, Joshua Eric Elias, Michael Cory Bassik, Ron R. Kopito · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  48. Mapping Transcription Factor Networks By Comparing Tf Binding Locations To Tf Perturbation Responses
    Yiming Kang, Nikhil Patel, Christian A. Shively, Pamela Samantha Recio, Xuhua Chen, Bernd J. Wranik, Griffin Kim, Robi David Mitra, R. Scott McIsaac, Michael R. Brent · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  49. Single-Cell Convert-Seq Decodes Regulatory Factors Driving Neuronal Diversity
    Joachim Luginbühl, Tsukasa Kouno, Rei Nakano, Thomas Edward Chater, Divya Mundackal Sivaraman, Mami Kishima, Filip Roudnicky, Piero Carninci, Charles Plessy, Jay W. Shin · 2019 · SSRN Electronic Journal
  50. P53 is a direct regulator of the immune co-stimulatory molecule CD80
    Eziwoma Alibo, Gürkan Mollaoglu, Maxime Dhainaut, Royce Zhao, Samuel A. Rose, Alessia Baccarini, Ramon E. Parsons, Brian D. Brown · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  51. Modeling of Alpha-1 Antitrypsin Deficiency with Syngeneic Human iPSC-Hepatocytes Reveals Metabolic Dysregulation and Cellular Heterogeneity in PiMZ and PiZZ Hepatocytes
    Joseph E. Kaserman, Rhiannon B. Werder, Feiya Wang, Taylor M. Matte, Michelle I. Higgins, Mark Dodge, Jonathan Lindstrom-Vautrin, Anne Hinds, Esther Bullitt, Ignacio S. Caballero et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  52. SLC15A4 favors inflammasome function via mTORC1 signaling and autophagy restraint in dendritic cells
    Cynthia López‐Haber, Zachary Hutchins, Xianghui Ma, Kathryn E. Hamilton, Adriana R. Mantegazza · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  53. TCGADEPMAP – Mapping Translational Dependencies and Synthetic Lethalities within The Cancer Genome Atlas
    Xu Shi, Christos Gekas, Daniel Verduzco, Sakina M. Petiwala, Cynthia Jeffries, Charles Lu, Erin R. Murphy, Tifani Anton, Andy H. Vo, Zoe Xiao et al. · 2022 · bioRxiv
  54. Minimized combinatorial CRISPR screens identify genetic interactions in autophagy
    Valentina Diehl · 2022
  55. Faculty Opinions recommendation of CRISPR Activation Screens Systematically Identify Factors that Drive Neuronal Fate and Reprogramming.
    Kazutoshi Takahashi · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  56. Single cell RNA-seq by mostly-natural sequencing by synthesis
    Sean Simmons, Gila Lithwick‐Yanai, Xian Adiconis, Florian C. Oberstrass, Nika Iremadze, Kathryn Geiger-Schuller, Pratiksha I. Thakore, Chris J. Frangieh, Omer Barad, Gilad Almogy et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  57. In vivo single-cell CRISPR uncovers distinct TNF-α programs in clonal expansion and tumorigenesis
    Peter F. Renz, Umesh Ghoshdastider, Simona Baghai Sain, Fabiola Valdivia-Francia, Ameya Khandekar, Mark Ormiston, Martino Bernasconi, Jonas A. Kretz, Minkyoung Lee, Katie Hyams et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  58. Prevalence of and gene regulatory constraints on transcriptional adaptation in single cells
    Ian A. Mellis, Nicholas Bodkin, Madeline E. Melzer, Yogesh Goyal · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  59. Genome-wide CRISPRi Screen in Human iNeurons to Identify Novel Focal Cortical Dysplasia Genes
    Andrew M. Tidball, Jing-Hui Luo, J. Walker, T. Takla, G. Carvill, Jack M. Parent · 2023 · bioRxiv
  60. Targeted Perturb-seq Reveals EGR1 and FOS as Key Regulators of the Transcriptional RAF-MAPK Response
    Ghanem El Kassem, Anja Sieber, Bertram Klinger, Florian Uhlitz, David Steinbrecht, Mirjam van Bentum, Jasmine Hillmer, Jennifer von Schlichting, Reinhold Schäfer, Nils Blüthgen et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  61. Scalable single-cell pooled CRISPR screens with conventional knockout vector libraries
    Mirazul Islam, Yilin Yang, Alan J. Simmons, Yanwen Xu, Emilie L. Fisher, Wentao Deng, Brian C. Grieb, Paola Molina, Christian R. de Caestecker, Marisol A Ramirez-Solano et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  62. Multifaceted Representation of Genes via Deep Learning of Gene Expression Networks
    Zheng Su, Mingyan Fang, Andrei Smolnikov, Marcel E. Dinger, Emily C. Oates, Fatemeh Vafaee · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  63. A scalable, high-throughput neural development platform identifies shared impact of ASD genes on cell fate and differentiation
    Xuran Wang, Matthew A. Lalli, Urvashi Thopte, Joseph D. Buxbaum · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  64. Discovering root causal genes with high-throughput perturbations
    Eric V Strobl, Eric R. Gamazon · 2024 · eLife
  65. Scouter: Predicting Transcriptional Responses to Genetic Perturbations with LLM embeddings
    Ouyang Zhu, Jun Li · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  66. Joint single-cell capture of Cas9 edits and transcriptomes reveals on- and off-target effects on gene expression
    Michael H. Lorenzini, Brad Balderson, Shanna N. Lavalle, Karthyayani Sajeev, Aaron J. Ho, Madelyn Light, Olalekan H. Usman, Gavin Kurgan, Graham McVicker · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  67. Simultaneous single-cell CRISPR, RNA, and ATAC-seq enables multiomic CRISPR screens to identify gene regulatory relationships
    Kaivalya Shevade, Yeqing Angela Yang, Kevin Feng, Karl Mader, Volkan Sevi̇m, Jacob Parsons, Gunisha Arora, Hasnaa A. Elfawy, Rachel Mace, Scot Federman et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  68. Incorporating Large Language Model-Derived Information into Hypothesis Testing for Genomics
    Jordan Bryan, Hongqian Niu, Didong Li · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  69. Study on Liver Sinusoidal Endothelial Cell Fenestrations Based on Cellular Omics-Structure Integration Technology and Its Application in Metabolic Diseases
    Zhuang Wei, Jiji Chen, Maria A. Aronova, Richard D. Leapman · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  70. High-throughput single-cell CRISPRi screens stratify neurodevelopmental functions of schizophrenia-associated genes
    Umut Yildiz, Annique Claringbould, Mikael Marttinen, Víctor Campos-Fornés, Mantha Lamprousi, Manu Saraswat, Mathias Saver, Daria Bunina, Michael W. Dorrity, Judith B. Zaugg et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  71. Cell barcoding with tandem fluorescent proteins enables high-throughput signaling dynamics analysis
    Jhen-Wei Wu, Jr-Ming Yang, Suyang Wang, Yun Chen, Chuan‐Hsiang Huang · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  72. Dissecting the host determinants of flavivirus infection using QIC-seq
    Allison Dupzyk, Benjamin S. Waldman, James R. Zengel, Jan E. Carette · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  73. Systematic identification and characterization of regulators of aryl hydrocarbon receptor signaling
    Manasvi Verma, Kushaal Desai, Yufang Ding, Xingren Wang, Minwoo Bae, Seth Rakoff-Nahoum, Emily P. Balskus, Michael Andrew Fischbach, Marco Jost · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  74. GeneJepa: A Predictive World Model of the Transcriptome
    Elon Litman, Tyler D. Myers, Vinayak Agarwal, Ekansh Mittal, Orion Li, Ashwin Gopinath, Timothy Kassis · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  75. Causality-oriented regulatory inference and rational transcriptomic reprogramming design with CASCADE
    Zhi‐Jie Cao, Tianzi Guo, Li Cheng, Fan Zhang, Ping Lü, Chan Gu, Fan Guo, Ge Gao · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  76. Causal gene regulatory network inference from Perturb-seq via adaptive instrumental variable modeling
    Zhongxuan Sun, Hyunseung Kang, Sündüz Keleş · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  77. MAP: A Knowledge-driven Framework for Predicting Single-cell Responses for Unprofiled Drugs
    Jinghao Feng, Ziheng Zhao, Xiaoman Zhang, Mingfei Liu, Jingyi Chen, Xingran Quan, Jian Zhang, Yanfeng Wang, Ya Ping Zhang, Weidi Xie · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  78. pertTF: context-aware AI modeling for genome-scale and cross-system perturbation prediction
    Yangqi Su, Dingyu Liu, Vipin K. Menon, Bicna Song, Samuel Boccara, Nan Zhang, Huan Zhao, Jiahui Hazel Zhao, Lei Wang, Nan Hu et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  79. Predicting Unseen Gene Perturbation Response Using Graph Neural Networks with Biological Priors
    Sajib Acharjee Dip, Liqing Zhang · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  80. Stitch-seq: Scalable CRISPR gene expression response profiling
    Frances R Keer, Aziz M. Al’Khafaji, Paul C. Blainey · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  81. PerturbPlan: An analytical framework for designing Perturb-seq experiments
    Ziang Niu, Yihui He, James Galante, Andreas R. Gschwind, Judhajeet Ray, Lars Michael Steinmetz, J Engreitz, Eugene Katsevich · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  82. Unbalanced Perturbation Dynamics For Cell Fate Design
    Qiangwei Peng, Yuchuan Wang, Jianzhe Li, Xinyu Wang, Yao Xiao, Peijie Zhou · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  83. CHOP promotes the transition to chronic integrated stress response signaling with suppression of hepatocyte identity
    Theo F Velarde, Kaihua Liu, Zewei Zhang, Reed C. Adajar, Chaoxian Zhao, Huojun Cao, D. Thomas Rutkowski · 2026 · eLife
  84. A systematic comparison of single-cell perturbation response prediction models
    Li, Lanxiang, You, Yue, Fu, Yunlin, Liao, Wenyu, Fan, Xueying, Lu, Shihong, Cao, Ye, Li, Bo, Ren, Wenle, Kong, Jiaming et al. · 2026 · Science Advances
  85. Dynamic changes in oligomeric complexes of UPR sensors induced by misfolded proteins in the ER
    Arunkumar Sundaram, Suhila Appathurai, Malaiyalam Mariappan · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
  86. Progenitor and Stem Cell Heterogeneity
    Mélanie Rodrigues, Paul A. Mittermiller, Jagannath Padmanabhan, Geoffrey C. Gurtner · 2018 · Elsevier eBooks
  87. Validation of a Miniaturized Permeability Assay Compatible with CRISPR-Mediated Genome-Wide Screen
    Claire Simonneau, Junning Yang, Xianguo Kong, Robert Kilker, Leonard C. Edelstein, Paolo M. Fortina, Eric R. Londin, Arie Horowitz · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  88. Investigation of transcription factor binding at distal regulatory elements
    Joanna Mitchelmore · 2017 · Apollo (University of Cambridge)
  89. Paring down to the essentials
    Tim Wang · 2018 · Science
  90. CRISPR Screens: The Right Tool for the Job
    Alasdair Russell · 2019 · The CRISPR Journal
  91. CRISPR Screens: The Right Tool for the Job
    Alasdair Russell · 2019 · Genetic Engineering & Biotechnology News
  92. Combinatorial Genetic Screening in Cancer
    Fadi J. Najm · 2019 · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
  93. Leveraging DNA Damage Response Pathways to Enhance the Precision of CRISPR-Mediated Genome Editing
    Tarun S. Nambiar · 2020
  94. Interrogating genome function using CRISPR tools: a narrative review
    Xingjie Ren, Maya Asami Takagi, Yin Shen · 2020 · Journal of Bio-X Research
  95. Multimodal Screening—The Future of Drug Discovery and Development
    Benedict C. S. Cross · 2020 · Genetic Engineering & Biotechnology News
  96. Gene network modeling via TopNet reveals robust epistatic interactions between functionally diverse tumor critical mediator genes
    Helene R. McMurray, Aslihan Ambeskovic, Laurel A. Newman, Jordan Aldersley, Vijaya Balakrishnan, Bradley Smith, Harry A. Stern, Hartmut Land, Matthew N. McCall · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  97. CRISPR/Cas-based Functional Genomic Approaches to Phenotypic Screening
    Beverley J. Isherwood, Samantha E. Peel, Shanade Dunn, Ultan McDermott · 2020 · Royal Society of Chemistry eBooks
  98. Mapping the Dynamic Transfer Functions of Epigenome Editing
    Jessica B. Lee, Leandra M. Caywood, Jennifer Y. Lo, Nicholas Levering, Albert J. Keung · 2021 · SSRN Electronic Journal
  99. Methods to interrogate cells and their interactions with single-cell resolution
    Alexander S. Genshaft · 2020 · DSpace@MIT (Massachusetts Institute of Technology)
  100. FoxA1 and FoxA2 regulate growth and cellular identity in NKX2-1-positive lung adenocarcinoma
    Grace Orstad, Gabriela Fort, Timothy J. Parnell, Alex D. Jones, Chris Stubben, Brian K. Lohman, Katherine L. Gillis, Walter A. Orellana, Rushmeen Tariq, Olaf Klingbeil et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)