An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. Elegans and Cancer

Wu, Lianfeng, Zhou, Ben, Oshiro-Rapley, Noriko, Li, Man, Paulo, Joao A., Webster, Christopher M., Mou, Fan, Kacergis, Michael C. +5 more·2016·Cell

Cited by (227)

Items 201–227 of 227

  1. Total quality management (tqm) and systems thinking in translational science
    R. E. F. Smith · 2018 · Journal of Translational Science
  2. Probing apoptosis signaling proteins in single living cells for precision efficacy evaluation of anti-cancer drugs
    Yanrong Wen, Jia Liu, Hui He, Zhen Liu · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  3. Gender Specificity of the Effect of Neonatal Melatonin Administration on Lifespan and Age-Associated Pathology in 129/Sv Mice
    M. N. Yurova, Маргарита Леонидовна Тындык, Irina G. Popovich, Alexey G. Golubev, Vladimir Nikolaevich Anisimov · 2019 · Advances in Gerontology
  4. Metformin chlorination byproducts in drinking water exhibit marked toxicity to nematode worms, human cells, and mice
    Runshuai Zhang, Yuanzhen He, Luxia Yao, Jie Chen, Shihao Zhu, Xinxin Rao, Peiyuan Tang, Jia Emil You, Guoqiang Hua, Lu Zhang et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  5. Identification of fitness genes and genotype-specific vulnerabilities using functional genetic screens in human cancer cells
    Megha Chandrashekhar · 2018 · TSpace (University of Toronto)
  6. Alleviation of Liver Fibrosis Via Hepatic Stellate Cells Mitochondrial Apoptosis Induced by Metformin
    Ying Su, Shan Lu, Kehan Ren, Meili Wang, Chenjian Hou, Xiaoli Liu, Shanyu Zhao, Xiuping Liu · 2021 · SSRN Electronic Journal
  7. Author’s Reply: The Subcellular Localization of RRAGD
    Karl P. Schlingmann, François Jouret, Nine V.A.M. Knoers, Jeroen H. F. de Baaij · 2022 · Journal of the American Society of Nephrology
  8. Faculty Opinions recommendation of Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.
    Jason M. Crawford, Tyler N. Goddard · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  9. Faculty Opinions recommendation of Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.
    Nelson Jen An Chao · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  10. Faculty Opinions recommendation of Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.
    Jing‐Dong J. Han · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  11. Can gene expression delay aging and increase longevity?
    Xanya Sofra · 2023 · Journal of Diabetes Metabolic Disorders & Control
  12. Synergistic Effects of Metformin and Captopril on C. elegans
    Ulu Kadolu, Belgin Ouzalp · 2018 · Journal of Emerging Investigators
  13. Examining the Effect of Metformin on Cell Death Mechanisms in Relation to Hippo Signaling in MDA-MB-231 Breast Cancer Cells
    Özge Rencüzoğulları, Zeynep Gülşah Sonalp · 2024 · Cumhuriyet Science Journal
  14. Metformin-induced mitochondrial reactive oxygen species and host defense mechanisms
    Heiichiro Udono · 2024 · Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
  15. Why do we age? questions and answers in regenerative medicine
    Xanya Sofra · 2024 · Journal of Diabetes Metabolic Disorders & Control
  16. Hormetic nutrient stress promotes longevity by orchestrating histone acetylation on key lipid catabolism and antioxidant defense genes
    Yifei Zhou, Fasih M. Ahsan, Sainan Li, Alexander A. Soukas · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  17. ACAD10 encodes two orphan enzymes in the ether lipid biosynthetic and salvage pathways
    James S. Ye, Elena Purlyte, Víctor A. López, Jericha Mill, Lexus Tatge, Thomas Kizzar, Dominique A. Baldwin, Edrees H. Rashan, Juhee Kim, David J. Pagliarini et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  18. Repurposing Metformin: A New Frontier in Cancer Therapy
    Shrenika Patil, Samiksha Sawant, Ms Chandani Kamble · 2025 · International Journal of Advanced Research in Science Communication and Technology
  19. Reductive death is averted by an ancient metabolic switch
    Fasih M. Ahsan, Jen F. Rotti, Armen I. Yerevanian, Sinclair W. Emans, Nicole L. Stuhr, Jose A. Aceves-Salvador, Wei Wang, Daniel J. Baker, Dimitra Pouli, Owen S. Skinner et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  20. AMPK targets PDZD8 to trigger carbon source shift to glutamine
    Mengqi Li, Yu Wang, 魏晓妍, Wei-Feng Cai, Mingxia Zhu, Luming Yao, Yongliang Wang, Yan-Hui Liu, Jianfeng Wu, Jinye Xiong et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  21. Immune regulators PALS-25 and PALS-22 localize to mitochondria and regulate mitochondrial fragmentation in C. elegans
    Spencer S. Gang, Max W Strul, Desmond Richmond-Buccola, Emily R. Troemel · 2026 · iScience
  22. Hormetic fasting extends Caenorhabditis elegans lifespan via H3K27 acetylation of lipid catabolism and antioxidant genes
    Yifei Zhou, Fasih M. Ahsan, S Li, Mengjiao Song, Jen F. Rotti, Armen I. Yerevanian, Shen Yidong, Alexander A. Soukas · 2026 · Cell Reports
  23. Paternal preconceptional metformin exposure induces metabolic dysregulation in offspring
    Tao Pan, Guangyuan Fan, Xingyu Ji, Yuqing Zhou, Yuan Li, Feifei Wang, Changyou Jiang, Xing Liu, Lan Ma, Qiumin Le · 2026 · Cell Discovery
  24. Mutations in nucleoporins and their roles in human diseases: Integrating evidence on specific NUP functions
    Siying Cai, Xinlei Ma, Huaibiao Li, Houze Zhu, Wenpei Xiang · 2026 · European Journal of Cell Biology
  25. A lipid‐sensitive food choice behavior influences aging outcomes from a longevity‐promoting diet
    Nicole L. Stuhr, Carmen M. Ramos, Chris Turner, Alexander A. Soukas, Sean P. Curran · 2026 · FEBS Journal
  26. Developmental priming of adult proteostasis and longevity by NuA4 complex activity in early life
    Yihan Wang, Xiong Xiong, Runshuai Zhang, Long Xiao, Xinyu Ruan, Tianyi Ni, Zicheng Liu, J Chen, Shenlu Qin, Zhuo Du et al. · 2026 · The EMBO Journal
  27. O-GlcNAcylation is a mitochondrial-nuclear signal that regulates passive transport through the nuclear pore complex
    Talia Hart, Ashley Duke, Yifei Zhou, Alexander A. Soukas, Armen I. Yerevanian · 2026 · Journal of Biological Chemistry