An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. Elegans and Cancer
Wu, Lianfeng, Zhou, Ben, Oshiro-Rapley, Noriko, Li, Man, Paulo, Joao A., Webster, Christopher M., Mou, Fan, Kacergis, Michael C. +5 more·2016·Cell
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- Gender Specificity of the Effect of Neonatal Melatonin Administration on Lifespan and Age-Associated Pathology in 129/Sv MiceM. N. Yurova, Маргарита Леонидовна Тындык, Irina G. Popovich, Alexey G. Golubev, Vladimir Nikolaevich Anisimov · 2019 · Advances in Gerontology
- Metformin chlorination byproducts in drinking water exhibit marked toxicity to nematode worms, human cells, and miceRunshuai Zhang, Yuanzhen He, Luxia Yao, Jie Chen, Shihao Zhu, Xinxin Rao, Peiyuan Tang, Jia Emil You, Guoqiang Hua, Lu Zhang et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Identification of fitness genes and genotype-specific vulnerabilities using functional genetic screens in human cancer cellsMegha Chandrashekhar · 2018 · TSpace (University of Toronto)
- Alleviation of Liver Fibrosis Via Hepatic Stellate Cells Mitochondrial Apoptosis Induced by MetforminYing Su, Shan Lu, Kehan Ren, Meili Wang, Chenjian Hou, Xiaoli Liu, Shanyu Zhao, Xiuping Liu · 2021 · SSRN Electronic Journal
- Author’s Reply: The Subcellular Localization of RRAGDKarl P. Schlingmann, François Jouret, Nine V.A.M. Knoers, Jeroen H. F. de Baaij · 2022 · Journal of the American Society of Nephrology
- Faculty Opinions recommendation of Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.Jason M. Crawford, Tyler N. Goddard · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.Nelson Jen An Chao · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.Jing‐Dong J. Han · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Can gene expression delay aging and increase longevity?Xanya Sofra · 2023 · Journal of Diabetes Metabolic Disorders & Control
- Synergistic Effects of Metformin and Captopril on C. elegansUlu Kadolu, Belgin Ouzalp · 2018 · Journal of Emerging Investigators
- Examining the Effect of Metformin on Cell Death Mechanisms in Relation to Hippo Signaling in MDA-MB-231 Breast Cancer CellsÖzge Rencüzoğulları, Zeynep Gülşah Sonalp · 2024 · Cumhuriyet Science Journal
- Metformin-induced mitochondrial reactive oxygen species and host defense mechanismsHeiichiro Udono · 2024 · Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
- Why do we age? questions and answers in regenerative medicineXanya Sofra · 2024 · Journal of Diabetes Metabolic Disorders & Control
- Hormetic nutrient stress promotes longevity by orchestrating histone acetylation on key lipid catabolism and antioxidant defense genesYifei Zhou, Fasih M. Ahsan, Sainan Li, Alexander A. Soukas · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- ACAD10 encodes two orphan enzymes in the ether lipid biosynthetic and salvage pathwaysJames S. Ye, Elena Purlyte, Víctor A. López, Jericha Mill, Lexus Tatge, Thomas Kizzar, Dominique A. Baldwin, Edrees H. Rashan, Juhee Kim, David J. Pagliarini et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Repurposing Metformin: A New Frontier in Cancer TherapyShrenika Patil, Samiksha Sawant, Ms Chandani Kamble · 2025 · International Journal of Advanced Research in Science Communication and Technology
- Reductive death is averted by an ancient metabolic switchFasih M. Ahsan, Jen F. Rotti, Armen I. Yerevanian, Sinclair W. Emans, Nicole L. Stuhr, Jose A. Aceves-Salvador, Wei Wang, Daniel J. Baker, Dimitra Pouli, Owen S. Skinner et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- AMPK targets PDZD8 to trigger carbon source shift to glutamineMengqi Li, Yu Wang, 魏晓妍, Wei-Feng Cai, Mingxia Zhu, Luming Yao, Yongliang Wang, Yan-Hui Liu, Jianfeng Wu, Jinye Xiong et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Immune regulators PALS-25 and PALS-22 localize to mitochondria and regulate mitochondrial fragmentation in C. elegansSpencer S. Gang, Max W Strul, Desmond Richmond-Buccola, Emily R. Troemel · 2026 · iScience
- Hormetic fasting extends Caenorhabditis elegans lifespan via H3K27 acetylation of lipid catabolism and antioxidant genesYifei Zhou, Fasih M. Ahsan, S Li, Mengjiao Song, Jen F. Rotti, Armen I. Yerevanian, Shen Yidong, Alexander A. Soukas · 2026 · Cell Reports
- Paternal preconceptional metformin exposure induces metabolic dysregulation in offspringTao Pan, Guangyuan Fan, Xingyu Ji, Yuqing Zhou, Yuan Li, Feifei Wang, Changyou Jiang, Xing Liu, Lan Ma, Qiumin Le · 2026 · Cell Discovery
- Mutations in nucleoporins and their roles in human diseases: Integrating evidence on specific NUP functionsSiying Cai, Xinlei Ma, Huaibiao Li, Houze Zhu, Wenpei Xiang · 2026 · European Journal of Cell Biology
- A lipid‐sensitive food choice behavior influences aging outcomes from a longevity‐promoting dietNicole L. Stuhr, Carmen M. Ramos, Chris Turner, Alexander A. Soukas, Sean P. Curran · 2026 · FEBS Journal
- Developmental priming of adult proteostasis and longevity by NuA4 complex activity in early lifeYihan Wang, Xiong Xiong, Runshuai Zhang, Long Xiao, Xinyu Ruan, Tianyi Ni, Zicheng Liu, J Chen, Shenlu Qin, Zhuo Du et al. · 2026 · The EMBO Journal
- O-GlcNAcylation is a mitochondrial-nuclear signal that regulates passive transport through the nuclear pore complexTalia Hart, Ashley Duke, Yifei Zhou, Alexander A. Soukas, Armen I. Yerevanian · 2026 · Journal of Biological Chemistry