Structure of a Pancreatic ATP-Sensitive Potassium Channel
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Items 101–200 of 249
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- KATP channel mutations in congenital hyperinsulinism: Progress and challenges towards mechanism-based therapiesAssmaa ElSheikh, S. Shyng · 2023 · Frontiers in Endocrinology
- G protein–coupled receptors differentially regulate glycosylation and activity of the inwardly rectifying potassium channel Kir7.1Sheridan J. S. Carrington, Ciria C. Hernández, Daniel R. Swale, Oluwatosin A. Aluko, Jerod S. Denton, Roger D. Cone · 2018 · Journal of Biological Chemistry
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- The dynamic interplay of PIP2 and ATP in the regulation of the KATP channelTanadet Pipatpolkai, S. Usher, Natascia Vedovato, F. Ashcroft, P. Stansfeld · 2021 · bioRxiv
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- ATP binding without hydrolysis switches sulfonylurea receptor 1 (SUR1) to outward-facing conformations that activate KATP channelsJelena Sikimic, Timothy S. McMillen, Cita Bleile, Frank Dastvan, Ulrich Quast, Peter Krippeit‐Drews, Gisela Drews, Joseph Bryan · 2018 · Journal of Biological Chemistry
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- The pore-forming subunit Kir6.1 of the K-ATP channel negatively regulates the NLRP3 inflammasome to control insulin resistance by interacting with NLRP3Ren‐Hong Du, Ming Lu, Cong Wang, Jian-Hua Ding, Guangyu Wu, Gang Hu · 2019 · Experimental & Molecular Medicine
- The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin SecretionGregor Sachse, Elizabeth Haythorne, Thomas Hill, Peter Proks, Russell Joynson, Raúl Terrón-Expósito, Liz Bentley, Stephen J. Tucker, Roger Cox, Frances Mary Ashcroft · 2021 · Diabetes
- Role of upregulation of the KATP channel subunit SUR1 in dopaminergic neuron degeneration in Parkinson’s diseaseMin Liu, Cui Liu, Xue Xiao, Shuaishuai Han, Mingxia Bi, Qian Jiao, Xi Chen, Chunling Yan, Xixun Du, Hong Fu Jiang · 2022 · Aging Cell
- Envisioning the role of inwardly rectifying potassium (Kir) channel in epilepsyEnes Akyüz, Betül Köklü, Arda Kaan Üner, Efthalia Angelopoulou, Yam Nath Paudel · 2021 · Journal of Neuroscience Research
- Structural identification of vasodilator binding sites on the SUR2 subunitDian Ding, Jing-Xiang Wu, Xinli Duan, Songling Ma, Lipeng Lai, Lei Chen · 2022 · Nature Communications
- Chansporter complexes in cell signalingGeoffrey Winston Abbott · 2017 · FEBS Letters
- ABCG2: does resolving its structure elucidate the mechanism?Parth Kapoor, Aaron J. Horsey, Megan H. Cox, Ian Derek Kerr · 2018 · Biochemical Society Transactions
- From in silico to in vitro: a trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channelAlfonso Trezza, Vittoria Cicaloni, Piera Porciatti, Andrea Langella, Fabio Fusi, Simona Saponara, Ottavia Spiga · 2018 · PeerJ
- Transporters RevealedJyh‐Yeuan Lee, Daniel M. Rosenbaum · 2017 · Cell
- A novel high-affinity inhibitor against the human ATP-sensitive Kir6.2 channelYajamana Ramu, Yanping Xu, Zhe Lü · 2018 · The Journal of General Physiology
- The Pharmacology of ATP-Sensitive K+ Channels (KATP)Yiwen Li, Qadeer H. Aziz, Andrew Tinker · 2021 · Handbook of experimental pharmacology
- The short form of the SUR1 and its functional implications in the damaged brainPenélope Aguilera, Iván Alquisiras-Burgos, Javier Franco‐Pérez, Moisés Rubio‐Osornio · 2021 · Neural Regeneration Research
- Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome KATP Channel Mutations in Intact CellsJian Hua Gao, Conor McClenaghan, Kenneth A. Matreyek, Dorothy Katherine Grange, Colin G. Nichols · 2023 · Journal of Pharmacology and Experimental Therapeutics
- Pharmacological polysulfide suppresses glucose-stimulated insulin secretion in an ATP-sensitive potassium channel-dependent mannerTomohiro Shoji, Mikio Hayashi, Chisato Sumi, Munenori Kusunoki, Takeo Uba, Yoshiyuki Matsuo, Hideo Kimura, Kiichi Hirota · 2019 · Scientific Reports
- Structural Insights Into the High Selectivity of the Anti-Diabetic Drug MitiglinideMengmeng Wang, Jing-Xiang Wu, Lei Chen · 2022 · Frontiers in Pharmacology
- The inhibition mechanism of the SUR2A-containing KATP channel by a regulatory helixDian Ding, Tianyi Hou, Miao Wei, Jing-Xiang Wu, Lei Chen · 2023 · Nature Communications
- To Be or Not to Be an Ion Channel: Cryo-EM Structures Have a SayGuilan Chen, Jian Li, Jin Zhang, Bo Zeng · 2023 · Cells
- Production and purification of ATP-sensitive potassium channel particles for cryo-electron microscopyCamden Driggers, Show‐Ling Shyng · 2021 · Methods in enzymology on CD-ROM/Methods in enzymology
- Functional protection against cardiac diseases depends on ATP‐sensitive potassium channelsPeng Ye, Yan-Rong Zhu, Yue Gu, Dai-Min Zhang, Shao-Liang Chen · 2018 · Journal of Cellular and Molecular Medicine
- Photo-Switchable Sulfonylureas Binding to ATP-Sensitive Potassium Channel Reveal the Mechanism of Light-Controlled Insulin ReleaseKatarzyna Walczewska-Szewc, Wiesław Nowak · 2021 · The Journal of Physical Chemistry B
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- Sodium butyrate activates the KATP channels to regulate the mechanism of Parkinson's disease microglia model inflammationYe Xu, Laofu Wen, Yunyi Tang, Zhenqiang Zhao, Miaojing Xu, Tan Wang, Zhibin Chen · 2024 · Immunity Inflammation and Disease
- Tuning SBDs as Endoplasmic Reticulum Self-Targeting Fluorophores and Its Application for Zn2+ Tracking in ER StressMingfeng Li, Hao Yuan, Yuncong Chen, Shankun Yao, Zijian Guo, Weijiang He · 2024 · Chemical & Biomedical Imaging
- Structural Determinants of Insulin Release: Disordered N-Terminal Tail of Kir6.2 Affects Potassium Channel Dynamics through Interactions with Sulfonylurea Binding Region in a SUR1 PartnerKatarzyna Walczewska-Szewc, Wiesław Nowak · 2020 · The Journal of Physical Chemistry B
- Strategies for cystic fibrosis transmembrane conductance regulator inhibition: from molecular mechanisms to treatment for secretory diarrhoeasHugo R. de Jonge, Maria C. Ardelean, Marcel J. C. Bijvelds, Paola Vergani · 2020 · FEBS Letters
- Zoledronic Acid as a Novel Dual Blocker of KIR6.1/2-SUR2 Subunits of ATP-Sensitive K+ Channels: Role in the Adverse Drug ReactionsFatima Maqoud, Rosa Scala, Vincenzo Tragni, Ciro Leonardo Pierri, Maria Grazia Perrone, Antonio Scilimati, Domenico Tricarico · 2021 · Pharmaceutics
- Control of Biophysical and Pharmacological Properties of Potassium Channels by Ancillary SubunitsGeoffrey Winston Abbott · 2021 · Handbook of experimental pharmacology
- A family of orthologous proteins from centipede venoms inhibit the hKir6.2 channelYajamana Ramu, Zhe Lü · 2019 · Scientific Reports
- Kir6.1 improves cardiac dysfunction in diabetic cardiomyopathy via the AKT‐FoxO1 signalling pathwayJinxin Wang, Jing Bai, Peng Duan, Hao Wang, Yang Li, Qinglei Zhu · 2021 · Journal of Cellular and Molecular Medicine
- Insights into channel dysfunction from modelling and molecular dynamics simulationsMaria Musgaard, Teresa Páramo, Laura Domicevica, Ole Juul Andersen, Philip Charles Biggin · 2017 · Neuropharmacology
- Phosphorylation Alters the Residual Structure and Interactions of the Regulatory L1 Linker Connecting NBD1 to the Membrane-Bound Domain in SUR2BClarissa R. Sooklal, Jorge Pedro López-Alonso, Natalia Papp, Voula Kanelis · 2018 · Biochemistry
- Plastic structures for diverse substrates: A revisit of human ABC transportersWen‐Tao Hou, Da Xu, Liang Wang, Yu Chen, Zhipeng Chen, Cong‐Zhao Zhou, Yuxing Chen · 2022 · Proteins Structure Function and Bioinformatics
- Exploring the Role of Surface and Mitochondrial ATP-Sensitive Potassium Channels in Cancer: From Cellular Functions to Therapeutic PotentialsDong‐Oh Moon · 2024 · International Journal of Molecular Sciences
- Structural Insights into ATP-Sensitive Potassium Channel Mechanics: A Role of Intrinsically Disordered RegionsKatarzyna Walczewska-Szewc, Wiesław Nowak · 2023 · Journal of Chemical Information and Modeling
- Identification and Expression of Inward-Rectifying Potassium Channel Subunits in Plutella xylostellaXiaoyi Lai, Jie Xu, Haihao Ma, Zheming Liu, Wei Hao Zheng, Jia Liu, Hang Zhu, Yong Zhou, Xiaomao Zhou · 2020 · Insects
- Functional characterization of ABCC8 variants of unknown significance based on bioinformatics predictions, splicing assays and protein analyses: benefits for the accurate diagnosis of congenital hyperinsulinismC. Saint-Martin, Marine Cauchois-Le Mière, Emily A. Rex, O. Soukarieh, J. Arnoux, J. Buratti, D. Bouvet, T. Frebourg, Pascaline Gaildrat, S. Shyng et al. · 2021 · Human Mutation
- Simulating PIP2-Induced Gating Transitions in Kir6.2 ChannelsMichael Bründl, Sarala Pellikan, Anna Stary‐Weinzinger · 2021 · Frontiers in Molecular Biosciences
- The mechano-sensitivity of cardiac ATP-sensitive potassium channels is mediated by intrinsic MgATPase activityMohammad Fatehi, Christian C. Carter, Nermeen Youssef, Peter E. Light · 2017 · Journal of Molecular and Cellular Cardiology
- Blocking Kir6.2 channels with SpTx1 potentiates glucose-stimulated insulin secretion from murine pancreatic β cells and lowers blood glucose in diabetic miceYajamana Ramu, Jayden Yamakaze, Yufeng Zhou, Toshinori Hoshi, Zhe Lü · 2022 · eLife
- Hyperinsulinism-Causing Mutations Cause Multiple Molecular Defects in SUR1 NBD1Claudia Alvarez, Marijana Stagljar, D.R. Muhandiram, Voula Kanelis · 2017 · Biochemistry
- A new familial form of a late-onset, persistent hyperinsulinemic hypoglycemia of infancy caused by a novel mutation in KCNJ11Yen-Yu Yang, Roger K. Long, Christine T. Ferrara, Stephen Eric Gitelman, Michael S. German, Shi‐Bing Yang · 2017 · Channels
- Structural polymorphism of the antigenic loop in HBV surface antigen dictates binding of diverse neutralizing antibodiesXiao Dong He, Weiyu Tao, Yunlu Kang, Jiaxuan Xu, Xiaoyu Liu, Lei Chen · 2025 · Cell Discovery
- The Selective Rat Toxicant Norbormide Blocks KATP Channels in Smooth Muscle Cells But Not in Insulin-Secreting CellsSimona Saponara, Fabio Fusi, Ottavia Spiga, Alfonso Trezza, Brian Hopkins, Margaret Anne Brimble, David Rennison, Sergio Bova · 2019 · Frontiers in Pharmacology
- Structural and functional insights into the interaction and targeting hub TMD0 of the polypeptide transporter TAPLChristoph Bock, Frank Löhr, Franz Tumulka, Katrin Reichel, Julia Maren Würz, Gerhard Hummer, Lars V. Schäfer, Robert Tampé, Benesh Joseph, Frank Bernhard et al. · 2018 · Scientific Reports
- From glucose sensing to exocytosis: takes from maturity onset diabetes of the youngSama Samadli, Qiaoli Zhou, Bixia Zheng, Wei Gu, Aihua Zhang · 2023 · Frontiers in Endocrinology
- Preclinical Insights into the Role of Kir4.1 in Chronic Pain and Depression: Mechanisms and Therapeutic PotentialTingfeng Zha, Xinyi Fang, Jiamin Wan, Xiaoyan Chen, Jiu Lin, Qianming Chen · 2025 · Biomolecules
- Hyperbranched Polymer‐Based Multipath Proton Transmembrane Transport System with Redox‐Switchable Characteristics for Cancer Cell ApoptosisCong Li, Yaqi Wu, Sheng Bao, Zhengwei Xu, Jing Yan, Hui Li, Xiaoxuan Yu, Zihui Weng, Jiayun Xu, Tingting Wang et al. · 2025 · Angewandte Chemie International Edition
- Computational Identification of Novel Kir6 Channel InhibitorsXingyu Chen, Arthur Garon, Marcus Wieder, Marien J. C. Houtman, Eva‐Maria Zangerl‐Plessl, Thierry Langer, Marcel A. G. van der Heyden, Anna Stary‐Weinzinger · 2019 · Frontiers in Pharmacology
- Structural insights into toxicant export mediated by ABCC2 in Arabidopsis thalianaXG Qiu, Zhisen Yang, Yongxiang Gao, Linfeng Sun, Xin Liu · 2025 · Nature Communications
- Ischemic postconditioning reduces spinal cord ischemia-reperfusion injury through ATP-sensitive potassium channelJia Fu, Guo Mu, Xiangbo Liu, Cehua Ou, Jiaomei Zhao · 2021 · Spinal Cord
- The Emerging Structural Pharmacology of ATP-Sensitive Potassium ChannelsJing-Xiang Wu, Dian Ding, Lei Chen · 2022 · Molecular Pharmacology
- Lipophilicity predicts the ability of nonsulphonylurea drugs to block pancreatic beta‐cell KATP channels and stimulate insulin secretion; statins as a test caseJoana I. Real, CAROLINE A. MIRANDA, Charlotta S. Olofsson, Paul A. Smith · 2018 · Endocrinology Diabetes & Metabolism
- High-Resolution Structures of K+ ChannelsQiu‐Xing Jiang · 2021 · Handbook of experimental pharmacology
- Identification and characterisation of functional K ir 6.1‐containing ATP‐sensitive potassium channels in the cardiac ventricular sarcolemmal membraneSean Brennan, Shen Chen, Samir Makwana, Simona Esposito, Lauren R. McGuinness, Abrar I. M. Alnaimi, Mark W. Sims, Mansi Patel, Qadeer H. Aziz, Leona Ojake et al. · 2024 · British Journal of Pharmacology
- Caveolin-3 negatively regulates endocytic recycling of cardiac KATP channelsJianyi Huo, Yu-Long Feng, Yue-Tong Chen, Bo Yang, Ya-Ting Zhi, Hao-Jie Wang, Hua-Qian Yang · 2023 · American Journal of Physiology-Cell Physiology
- Structure based analysis of KATP channel with a DEND syndrome mutation in murine skeletal muscleShoichiro Horita, Tomoyuki Ono, Saul González-Resines, Yuko Ono, Megumi Yamachi, Songji Zhao, Cármen Domene, Yuko Maejima, Kenju Shimomura · 2021 · Scientific Reports
- The expression of KATP channel subunits in alpha-synuclein-transfected MES23.5 cellsShuaishuai Han, Qian Jiao, Mingxia Bi, Xixun Du, Hong Fu Jiang · 2018 · Annals of Translational Medicine
- Noncanonical Regulation of cAMP‐Dependent Insulin Secretion and Its Implications in Type 2 DiabetesSasanka Ramanadham, JOHN W. TURK, Sushant Bhatnagar · 2023 · Comprehensive physiology
- Mechanism of substrate recognition and release of human SGLT2Wenhao Cui, Zejian Sun, Jiaxuan Xu, Xiaoyu Liu, Yunlu Kang, Lei Chen · 2025 · Nature Communications
- Expression, purification, and electrophysiological characterization of a recombinant, fluorescent Kir6.2 in mammalian cellsMark T. Agasid, Xuemin Wang, Yiding Huang, Colleen M. Janczak, Robert Bränström, S. Scott Saavedra, Craig A. Aspinwall · 2018 · Protein Expression and Purification
- Relationship between conformation shift and disease related variation sites in ATP-binding cassette transporter proteinsMika Sakamoto, Hirofumi Suzuki, Kei Yura · 2019 · Biophysics and Physicobiology
- Structure of an open K ATP channel reveals tandem PIP 2 binding sites mediating the Kir6.2 and SUR1 regulatory interfaceCamden Driggers, Yi‐Ying Kuo, Phillip Zhu, Assmaa ElSheikh, Show‐Ling Shyng · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
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- A novel mutation in the KCNJ11 gene (p.Val36Glu), predisposes to congenital hyperinsulinemiaIdrees Ayoub Shah, Rabiya Rashid, Abid Bhat, Haroon Rashid, Rohina Bashir, Mir Mahmood Asrar, Imtiyaz Ahmad Wani, Bashir Ahmad Charoo, Venkatesan Radha, Viswanathan Mohan et al. · 2023 · Gene
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- Effects of hydrogen sulfide on relaxation responses in the lower esophageal sphincter in rabbits: the potential role of potassium channelsAyşegül Koç, Derya Koç, Celil Ilker Askin, Halil Kara, Gökçe Sevim Öztürk Fincan, Sevil Özger İlhan, Yusuf Sarıoğlu · 2023 · Naunyn-Schmiedeberg s Archives of Pharmacology
- A novel ABCC9 variant in a Greek family with Cantu syndrome affecting multiple generations highlights the functional role of the SUR2B NBD1Jian Hua Gao, Athina Ververi, Ellen Thompson, Rob Tryon, Alexandros Sotiriadis, Fotios Rouvalis, Dorothy Katherine Grange, Christos Giannios, Colin G. Nichols · 2024 · American Journal of Medical Genetics Part A
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