Host-microbe co-metabolism dictates cancer drug efficacy in C. elegans

Scott, Timothy A., Quintaneiro, Leonor M., Norvaisas, Povilas, Lui, Prudence P., Wilson, Matthew P., Leung, Kit-Yi, Herrera-Dominguez, Lucia, Sudiwala, Sonia +8 more·2017·Cell

Cited by (254)

Items 201–254 of 254

  1. Quorum Sensing: A New Target for Anti-infective Drug Therapy
    Meghana Konda, Radhika Tippani, Mahendar Porika, Lakpathi Banoth · 2023 · Royal Society of Chemistry eBooks
  2. Doxifluridine promotes host longevity through bacterial metabolism
    Rui Wei, Yuling Peng, Yamei Luo, Xinyuan Wang, Zhenzhong Pan, Ran Zhou, Huan Yang, Zongyao Huang, Yaojia Liu, Lunzhi Dai et al. · 2025 · PLoS Genetics
  3. Quantification of Duloxetine in the Bacterial Culture and Medium to Study Drug-gut Microbiome Interactions
    Prasad B. Phapale, Sonja Blasche, Kiran Raosaheb Patil, Theodore Alexandrov · 2021 · BIO-PROTOCOL
  4. Making Millennial Medicine More Meta
    Peter James Turnbaugh · 2018 · mSystems
  5. 2′, 3′, 5′-tri-O-acetyl-N6-(3-hydroxyphenyl) adenosine alleviates diet-induced hyperlipidemia by modulating intestinal gene expression profiles and metabolic pathway
    Qifeng Liu, Yue Xu, Xueqi Lv, Congcong Guo, Haibo Zhu, Yang Liu, Yinghong Wang · 2024 · Life Sciences
  6. A conserved enzyme found in diverse human gut bacteria interferes with anticancer drug efficacy
    Peter Spanogiannopoulos, Than S. Kyaw, Ben G. H. Guthrie, Patrick H. Bradley, Joyce V. Lee, Jonathan Melamed, Ysabella Noelle Amora Malig, Kathy N. Lam, Daryll Gempis, Moriah Sandy et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  7. Emerging Role of Gut Microbiome in Cancer Immunotherapy
    Meghali Bharti, Sonakshi Modeel, Sheetal Yadav, Pankaj Yadav, Sneha Siwach, Padma Dolkar, Shekhar Nagar, Tarana Negi, Ram Krishan Negi · 2023 · Springer eBooks
  8. A DNA Part Library for Reliable Engineering of the Emerging Model Nematode Symbiotic Bacterium Xenorhabdus griffiniae HGB2511
    Elin M. Larsson, Olivia Y. Wang, Richard M. Murray · 2025 · ACS Synthetic Biology
  9. Functional studies of human variants in C. elegans link iron metabolism to DPD deficiency and 5-FU sensitivity
    Xiao Li, Ivette M. Menéndez‐Perdomo, André B. P. Kuilenburg, Maja Tarailo‐Graovac · 2025 · Genetics
  10. Context-dependent serotonin signaling links dietary quality to foraging decisions
    Likui Feng, Javier Marquina-Solis, Lishu Yue, Audrey Harnagel, Yarden Greenfeld, Cornelia I. Bargmann · 2025 · Nature Communications
  11. Dynamic response by commensal E. coli two-component system Cpx contributes to C. elegans development
    Huiyang Xiong, Beilei Hua, Huanhu Zhu · 2026 · BMC Biology
  12. Longitudinal changes in the gut microbiota of Vietnamese patients with colorectal cancer undergoing surgery and chemotherapy
    Hang Thi Thu Le, Hung Xuan Le, Dao Thi Huyen, Tuan-Anh Tran, Đồng Văn Quyền, Le Huu Song, Thuan V. Tran, Olivier Thas, Pham Hong Nhung, Tam T. T. Tran · 2026 · World Journal of Gastroenterology
  13. Nematode gut microbiota confers cadmium tolerance through microbial-dependent activation of detoxification and innate immune pathways
    Fei Zheng, Jingwei Gao, Xun Han, S K Kang, Tao Zhou, Dong Zhu, Roy Neilson, Ziye Zhang, Bing Chen · 2026 · Journal of Advanced Research
  14. Vitamin B6 produced by gut microbiome regulates host behavioral phenotypes through dopaminergic metabolism
    Doyeon Kim, Minshu Li, Thi Ha Nguyen, Yu‐Jeong Choi, Sojeong Jang, Minhyeong Kim, Yong Wook Kim, Min‐Kyoo Shin, Arvie Camille V. de Guzman, Sunghyouk Park · 2026 · Gut Microbes
  15. α-Mangostin Promotes DAF-16-Mediated Thermotolerance in Caenorhabditis elegans
    Nattapong Thammawong, Haruka Takahashi, Takaya Sugawara, Kazuichi Sakamoto · 2018 · Food and Nutrition Sciences
  16. The role of model animals in the study of symbiotic microorganisms
    Xiao Yaqian, Liu Chuan, Liang Xiao, BGI-Shenzhen, Shenzhen, Guangdong 518000 · 2019 · Biodiversity Science
  17. The Interaction of Gut Microbiota-brain Axis in Relation to Human Health with the Use of Animal Models
    Gaythri Thergarajan, Subha Bhassu · 2022 · IntechOpen eBooks
  18. Intestinal Microbiomes In Gastrointestinal Cancer
    Jiahao Liu, Zitian Lin, Yiran Zhao · 2023 · Highlights in Science Engineering and Technology
  19. Association of embryonic inositol status with susceptibility to neural tube defects, metabolite profile, and maternal inositol intake
    Kit‐Yi Leung, Eleanor Weston, Sandra C. de Castro, Evanthia Nikolopoulou, Sonia Sudiwala, Dawn Savery, Simon D. Eaton, Andrew J. Copp, Nicholas D. E. Greene · 2024 · The FASEB Journal
  20. Micronutrients
    Peter Theodore Clayton, Philippa B. Mills · 2018 · Journal of Inborn Errors of Metabolism and Screening
  21. Microbiome genetics underpins chemotherapy
    Timothy A. Scott, Leonor M. Quintaneiro, Filipe Cabreiro · 2017 · Oncotarget
  22. Dietary S. maltophilia promotes fat storage by enhancing lipogenesis and ER-LD contacts in C. elegans
    Kang Xie, Yangli Liu, Xixia Li, Hong Zhang, Shuyan Zhang, Ho Yi Mak, Pingsheng Liu · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  23. Unravelling Effects of Anti-aging Drugs on C. elegans using Liposomes
    Aihan Zhang, Kuei Ching Hsiung, Carina C. Kern, Yuting Wang, Anna Girtle, Nuo Xu, David Gems · 2022 · Preprints.org
  24. Using molecular ecological network analysis to explore the effects of chemotherapy on intestinal microbial communities of colorectal cancer patients
    Jing Cong, Jingjuan Zhu, Chuantao Zhang, Tianjun Li, Kewei Liu, Dong Liu, Na Zhou, Man Jiang, Helei Hou, Xiaochun Zhang · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  25. The Aging Gut Microbiota
    Erin S. Keebaugh, Leslie D. Williams, William W. Ja · 2019 · Springer eBooks
  26. Biophysics applications in drug discovery: Working toward a new integrative model
    Juan Bueno · 2020 · Elsevier eBooks
  27. Exploring novel strategies to rescue Coenzyme A deficiency-related diseases in Drosophila melanogaster models
    Yi Yu · 2021
  28. Faculty Opinions recommendation of Prostaglandin signals from adult germ stem cells delay somatic aging of Caenorhabditis elegans.
    Siegfried Hekimi, Noah Lilienfeldt · 2021 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  29. Faculty Opinions recommendation of Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.
    Jason M. Crawford, Tyler N. Goddard · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  30. Faculty Opinions recommendation of Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.
    Nelson Jen An Chao · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  31. Faculty Opinions recommendation of Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.
    Jing‐Dong J. Han · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  32. Vitamin B6
    Philippa B. Mills, Emma J. Footitt, Peter Theodore Clayton · 2022 · Elsevier eBooks
  33. Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation
    Weihong Jiang · 2022 · Research Square
  34. Effect of Anticancer Treatment Approaches on Gut Microbiota
    Ruchika Sharma, Anoop Kumar · 2023 · Springer eBooks
  35. Additional file 1 of Automated recognition and analysis of body bending behavior in C. elegans
    Hui Zhang, Weiyang Chen · 2023 · Figshare
  36. Intestinal Microbiota as a Determinant of Effectiveness and Safety of Anticancer Therapy
    Katarzyna Karłowicz-Bodalska, Dorota Bęben, Natalia Janicka, Łukasz Gądek, Grażyna Bodalska · 2024 · Farmacja Polska
  37. Microbiome-Based Therapeutics for the Management of Cancer
    Muhammad Usman Munir, Ibrahim Javed, Muhammad Hammad Butt, Yusra Habib Khan, Muhammad Salman, Zia Ur Rehman, Faiz Ullah Khan, Shamsi Saad Shamsi, Tauqeer Hussain Mallhi · 2024 · Springer eBooks
  38. Fecal Microbiota Transplantation and Cancer Immunotherapy: Current Evidence and Future Directions
    Kasra Mokhtarpour, Milad Akbarzadehmoallemkolaei, Nima Rezaei · 2024 · Interdisciplinary cancer research
  39. Hidden allies: the role of gut microbes in carcinogen-driven cancer
    Ye Tian, Hui Zhu Wang, Hao Wu, Jingyan Zhang · 2024 · Science China Life Sciences
  40. Effects of feces storage conditions for host-microbiota screenings in C. elegans
    Laury Caron, Claudia Miriam Alonzo De la Rosa, Khoudia Diop, Stéphanie Miard, Stefan Taubert, André Marette, Frédéric Picard · 2024 · Frontiers in Microbiomes
  41. Metabolic immunity to infection is driven by mitochondrial one-carbon metabolism
    Tania Medeiros, Silvia Reato, Xianhe Li, Bruna Martins Garcia, Irina Rais, Kira Allmeroth, Matías Daniel Hartman, Martin Sebastian Denzel, Martin Purrio, Andrea Mesaros et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  42. Additional file 2 of Automated recognition and analysis of body bending behavior in C. elegans
    Zhang, Hui, Chen, Weiyang · 2023 · Figshare
  43. A protein language model links the E. coli pangenome functional landscape geometry to host proteostasis
    Daniel Martínez‐Martínez, Cassandra Backes, Aleksandra Zečić, Andreea Aprodu, Hannah M. Doherty, Jonas Widder, Ivan Andrew, Laurence Game, Iliyana Kaneva, Georgia Roumelioti et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  44. A C. elegans model of copper deficiency: Dietary interventions rescue CTR1/CHCA-1 copper transporter mutant phenotype
    Yang Fu, Xu Bai, Lei Chun, X. Z. Shawn Xu, Jianfeng Liu · 2026 · PLoS Genetics
  45. Circulating tumor DNA methylation and gut microbiota in colorectal cancer: diagnostic, prognostic, and therapeutic implications
    Kazuhito Sasaki, Shigenobu Emoto, Yuichiro Yokoyama, Soichiro Ishihara · 2026 · International Journal of Clinical Oncology
  46. Genomic Signatures and Functional Pathways Underlying 5-Fluorouracil Resistance in Head and Neck Cancer associated Streptococci
    Linh Mai, George Bouras, Kenny K. L. Yeo, Emma F. Barry, Bhavya Kulathunga, John-Charles Hodge, Peter‐John Wormald, Rowan J. Valentine, Alkis James Psaltis, Sarah Vreugde et al. · 2026 · Research Square
  47. Role of the gut microbiome in the development of colorectal cancer
    Anirudh P. Shanbhag · 2026 · Elsevier eBooks
  48. Bacteria producing the bioplastic polyhydroxybutyrate kill the nematode Caenorhabditis elegans
    Gabrielle E. Giese, Daniel M. Richards, Jeremy Florman, Alyxandra N. Starbard, Ann A. Xu, Daniel J. Durning, Mark J. Alkema, Albertha J.M. Walhout · 2026 · PLoS Biology
  49. The Microbiome and Cancer: Exploring the Gut Connection
    Hari Om, Shamlan M. S. Reshamwala, Padma V. Devarajan · 2026 · BENTHAM SCIENCE PUBLISHERS eBooks
  50. Immunomodulatory effects of nematode-microbiota interactions in cancer therapy
    Valentyn Oksenych, Marjan Rashidan, Meisam Khazaei, Hamed Tahmasebi · 2026 · Frontiers in Immunology
  51. Caenorhabditis elegans as an experimental model for resilience-boosting microbiota interventions in nonmodel ectotherms
    Charlotte Sprason, Philip Donkersley, Jason P. Chin, Alexandre Benedetto · 2026 · FEMS Microbiology Reviews
  52. Aging regulation by gut microbiota: molecular insights from Caenorhabditis elegans
    Qin Liu, Haiqing Tang · 2026 · Biogerontology
  53. Pharmacological Effects on Gut Pathogens and Microbes
    Dayong Wang · 2026 · Springer eBooks
  54. The microbiome: Its impact on cancer development and therapeutic responses
    Sanjeev Kumar Sahu, Picheswara Rao Polu, Iqubal Singh, Sambit Kumar Parida · 2026 · Elsevier eBooks