Host-microbe co-metabolism dictates cancer drug efficacy in C. elegans
Scott, Timothy A., Quintaneiro, Leonor M., Norvaisas, Povilas, Lui, Prudence P., Wilson, Matthew P., Leung, Kit-Yi, Herrera-Dominguez, Lucia, Sudiwala, Sonia +8 more·2017·Cell
Cited by (254)
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- A conserved enzyme found in diverse human gut bacteria interferes with anticancer drug efficacyPeter Spanogiannopoulos, Than S. Kyaw, Ben G. H. Guthrie, Patrick H. Bradley, Joyce V. Lee, Jonathan Melamed, Ysabella Noelle Amora Malig, Kathy N. Lam, Daryll Gempis, Moriah Sandy et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Emerging Role of Gut Microbiome in Cancer ImmunotherapyMeghali Bharti, Sonakshi Modeel, Sheetal Yadav, Pankaj Yadav, Sneha Siwach, Padma Dolkar, Shekhar Nagar, Tarana Negi, Ram Krishan Negi · 2023 · Springer eBooks
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- Functional studies of human variants in C. elegans link iron metabolism to DPD deficiency and 5-FU sensitivityXiao Li, Ivette M. Menéndez‐Perdomo, André B. P. Kuilenburg, Maja Tarailo‐Graovac · 2025 · Genetics
- Context-dependent serotonin signaling links dietary quality to foraging decisionsLikui Feng, Javier Marquina-Solis, Lishu Yue, Audrey Harnagel, Yarden Greenfeld, Cornelia I. Bargmann · 2025 · Nature Communications
- Dynamic response by commensal E. coli two-component system Cpx contributes to C. elegans developmentHuiyang Xiong, Beilei Hua, Huanhu Zhu · 2026 · BMC Biology
- Longitudinal changes in the gut microbiota of Vietnamese patients with colorectal cancer undergoing surgery and chemotherapyHang Thi Thu Le, Hung Xuan Le, Dao Thi Huyen, Tuan-Anh Tran, Đồng Văn Quyền, Le Huu Song, Thuan V. Tran, Olivier Thas, Pham Hong Nhung, Tam T. T. Tran · 2026 · World Journal of Gastroenterology
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- Vitamin B6 produced by gut microbiome regulates host behavioral phenotypes through dopaminergic metabolismDoyeon Kim, Minshu Li, Thi Ha Nguyen, Yu‐Jeong Choi, Sojeong Jang, Minhyeong Kim, Yong Wook Kim, Min‐Kyoo Shin, Arvie Camille V. de Guzman, Sunghyouk Park · 2026 · Gut Microbes
- α-Mangostin Promotes DAF-16-Mediated Thermotolerance in Caenorhabditis elegansNattapong Thammawong, Haruka Takahashi, Takaya Sugawara, Kazuichi Sakamoto · 2018 · Food and Nutrition Sciences
- The role of model animals in the study of symbiotic microorganismsXiao Yaqian, Liu Chuan, Liang Xiao, BGI-Shenzhen, Shenzhen, Guangdong 518000 · 2019 · Biodiversity Science
- The Interaction of Gut Microbiota-brain Axis in Relation to Human Health with the Use of Animal ModelsGaythri Thergarajan, Subha Bhassu · 2022 · IntechOpen eBooks
- Intestinal Microbiomes In Gastrointestinal CancerJiahao Liu, Zitian Lin, Yiran Zhao · 2023 · Highlights in Science Engineering and Technology
- Association of embryonic inositol status with susceptibility to neural tube defects, metabolite profile, and maternal inositol intakeKit‐Yi Leung, Eleanor Weston, Sandra C. de Castro, Evanthia Nikolopoulou, Sonia Sudiwala, Dawn Savery, Simon D. Eaton, Andrew J. Copp, Nicholas D. E. Greene · 2024 · The FASEB Journal
- MicronutrientsPeter Theodore Clayton, Philippa B. Mills · 2018 · Journal of Inborn Errors of Metabolism and Screening
- Microbiome genetics underpins chemotherapyTimothy A. Scott, Leonor M. Quintaneiro, Filipe Cabreiro · 2017 · Oncotarget
- Dietary S. maltophilia promotes fat storage by enhancing lipogenesis and ER-LD contacts in C. elegansKang Xie, Yangli Liu, Xixia Li, Hong Zhang, Shuyan Zhang, Ho Yi Mak, Pingsheng Liu · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Unravelling Effects of Anti-aging Drugs on C. elegans using LiposomesAihan Zhang, Kuei Ching Hsiung, Carina C. Kern, Yuting Wang, Anna Girtle, Nuo Xu, David Gems · 2022 · Preprints.org
- Using molecular ecological network analysis to explore the effects of chemotherapy on intestinal microbial communities of colorectal cancer patientsJing Cong, Jingjuan Zhu, Chuantao Zhang, Tianjun Li, Kewei Liu, Dong Liu, Na Zhou, Man Jiang, Helei Hou, Xiaochun Zhang · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
- The Aging Gut MicrobiotaErin S. Keebaugh, Leslie D. Williams, William W. Ja · 2019 · Springer eBooks
- Biophysics applications in drug discovery: Working toward a new integrative modelJuan Bueno · 2020 · Elsevier eBooks
- Exploring novel strategies to rescue Coenzyme A deficiency-related diseases in Drosophila melanogaster modelsYi Yu · 2021
- Faculty Opinions recommendation of Prostaglandin signals from adult germ stem cells delay somatic aging of Caenorhabditis elegans.Siegfried Hekimi, Noah Lilienfeldt · 2021 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.Jason M. Crawford, Tyler N. Goddard · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.Nelson Jen An Chao · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.Jing‐Dong J. Han · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Vitamin B6Philippa B. Mills, Emma J. Footitt, Peter Theodore Clayton · 2022 · Elsevier eBooks
- Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradationWeihong Jiang · 2022 · Research Square
- Effect of Anticancer Treatment Approaches on Gut MicrobiotaRuchika Sharma, Anoop Kumar · 2023 · Springer eBooks
- Additional file 1 of Automated recognition and analysis of body bending behavior in C. elegansHui Zhang, Weiyang Chen · 2023 · Figshare
- Intestinal Microbiota as a Determinant of Effectiveness and Safety of Anticancer TherapyKatarzyna Karłowicz-Bodalska, Dorota Bęben, Natalia Janicka, Łukasz Gądek, Grażyna Bodalska · 2024 · Farmacja Polska
- Microbiome-Based Therapeutics for the Management of CancerMuhammad Usman Munir, Ibrahim Javed, Muhammad Hammad Butt, Yusra Habib Khan, Muhammad Salman, Zia Ur Rehman, Faiz Ullah Khan, Shamsi Saad Shamsi, Tauqeer Hussain Mallhi · 2024 · Springer eBooks
- Fecal Microbiota Transplantation and Cancer Immunotherapy: Current Evidence and Future DirectionsKasra Mokhtarpour, Milad Akbarzadehmoallemkolaei, Nima Rezaei · 2024 · Interdisciplinary cancer research
- Hidden allies: the role of gut microbes in carcinogen-driven cancerYe Tian, Hui Zhu Wang, Hao Wu, Jingyan Zhang · 2024 · Science China Life Sciences
- Effects of feces storage conditions for host-microbiota screenings in C. elegansLaury Caron, Claudia Miriam Alonzo De la Rosa, Khoudia Diop, Stéphanie Miard, Stefan Taubert, André Marette, Frédéric Picard · 2024 · Frontiers in Microbiomes
- Metabolic immunity to infection is driven by mitochondrial one-carbon metabolismTania Medeiros, Silvia Reato, Xianhe Li, Bruna Martins Garcia, Irina Rais, Kira Allmeroth, Matías Daniel Hartman, Martin Sebastian Denzel, Martin Purrio, Andrea Mesaros et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Additional file 2 of Automated recognition and analysis of body bending behavior in C. elegansZhang, Hui, Chen, Weiyang · 2023 · Figshare
- A protein language model links the E. coli pangenome functional landscape geometry to host proteostasisDaniel Martínez‐Martínez, Cassandra Backes, Aleksandra Zečić, Andreea Aprodu, Hannah M. Doherty, Jonas Widder, Ivan Andrew, Laurence Game, Iliyana Kaneva, Georgia Roumelioti et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- A C. elegans model of copper deficiency: Dietary interventions rescue CTR1/CHCA-1 copper transporter mutant phenotypeYang Fu, Xu Bai, Lei Chun, X. Z. Shawn Xu, Jianfeng Liu · 2026 · PLoS Genetics
- Circulating tumor DNA methylation and gut microbiota in colorectal cancer: diagnostic, prognostic, and therapeutic implicationsKazuhito Sasaki, Shigenobu Emoto, Yuichiro Yokoyama, Soichiro Ishihara · 2026 · International Journal of Clinical Oncology
- Genomic Signatures and Functional Pathways Underlying 5-Fluorouracil Resistance in Head and Neck Cancer associated StreptococciLinh Mai, George Bouras, Kenny K. L. Yeo, Emma F. Barry, Bhavya Kulathunga, John-Charles Hodge, Peter‐John Wormald, Rowan J. Valentine, Alkis James Psaltis, Sarah Vreugde et al. · 2026 · Research Square
- Role of the gut microbiome in the development of colorectal cancerAnirudh P. Shanbhag · 2026 · Elsevier eBooks
- Bacteria producing the bioplastic polyhydroxybutyrate kill the nematode Caenorhabditis elegansGabrielle E. Giese, Daniel M. Richards, Jeremy Florman, Alyxandra N. Starbard, Ann A. Xu, Daniel J. Durning, Mark J. Alkema, Albertha J.M. Walhout · 2026 · PLoS Biology
- The Microbiome and Cancer: Exploring the Gut ConnectionHari Om, Shamlan M. S. Reshamwala, Padma V. Devarajan · 2026 · BENTHAM SCIENCE PUBLISHERS eBooks
- Immunomodulatory effects of nematode-microbiota interactions in cancer therapyValentyn Oksenych, Marjan Rashidan, Meisam Khazaei, Hamed Tahmasebi · 2026 · Frontiers in Immunology
- Caenorhabditis elegans as an experimental model for resilience-boosting microbiota interventions in nonmodel ectothermsCharlotte Sprason, Philip Donkersley, Jason P. Chin, Alexandre Benedetto · 2026 · FEMS Microbiology Reviews
- Aging regulation by gut microbiota: molecular insights from Caenorhabditis elegansQin Liu, Haiqing Tang · 2026 · Biogerontology
- Pharmacological Effects on Gut Pathogens and MicrobesDayong Wang · 2026 · Springer eBooks
- The microbiome: Its impact on cancer development and therapeutic responsesSanjeev Kumar Sahu, Picheswara Rao Polu, Iqubal Singh, Sambit Kumar Parida · 2026 · Elsevier eBooks