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Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation
Open accessAbstract
Aberrant activation of innate immune receptors can cause a spectrum of immune disorders, such as Aicardi-Goutières syndrome (AGS). One such receptor is MDA5, a viral dsRNA sensor that induces antiviral immune response. Using a newly developed RNase-protection/RNA-seq approach, we demonstrate here that constitutive activation of MDA5 in AGS results from the loss of tolerance to cellular dsRNAs formed by Alu retroelements. While wild-type MDA5 cannot efficiently recognize Alu-dsRNAs because of its limited filament formation on imperfect duplexes, AGS variants of MDA5 display reduced sensitivity to duplex structural irregularities, assembling signaling-competent filaments on Alu-dsRNAs. Moreover, we identified an unexpected role of an RNA-rich cellular environment in suppressing aberrant MDA5 oligomerization, highlighting context dependence of self versus non-self discrimination. Overall, our work demonstrates that the increased efficiency of MDA5 in recognizing dsRNA comes at a cost of self-recognition and implicates a unique role of Alu-dsRNAs as virus-like elements that shape the primate immune system.
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“Major sources of dsRNA, inverted Alu repeats, are normally deaminated by ADAR to reduce their double-stranded character; decreased processing can be sensed by MDA5, resulting in IFN-I activation50, 51, 98.”
From The role of retrotransposable elements in ageing and age-associated diseases (2021) · cites this paper as [98]
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Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
Analysis of protein-coding genetic variation in 60,706 humans
Exome Aggregation Consortium, Lek, M., Karczewski, K. J., Minikel, E. V., Samocha, K. E., Banks, E., Fennell, T., O’Donnell-Luria, A. H., Ware, J. S., Hill, A. J., et al. (2016) · Nature · doi:10.1038/nature19057 · Cited by 9,587
Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration
Thorvaldsdottir, H., Robinson, J. T., & Mesirov, J. P. (2013) · Briefings in Bioinformatics · doi:10.1093/bib/bbs017 · Cited by 9,049
Automated generation of heuristics for biological sequence comparison
Slater, G., & Birney, E. (2005) · BMC Bioinformatics · doi:10.1186/1471-2105-6-31 · Cited by 2,959
RSeQC: quality control of RNA-seq experiments
Wang, L., Wang, S., & Li, W. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts356 · Cited by 2,753
Chiappinelli, K. B., Strissel, P. L., Desrichard, A., Li, H., Henke, C., Akman, B., Hein, A., Rote, N. S., Cope, L. M., Snyder, A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.011 · Cited by 2,022
Roulois, D., Loo Yau, H., Singhania, R., Wang, Y., Danesh, A., Shen, S. Y., Han, H., Liang, G., Jones, P. A., Pugh, T. J., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.056 · Cited by 1,527
Hou, F., Sun, L., Zheng, H., Skaug, B. A., Jiang, Q., & Chen, Z. J. (2011) · Cell · doi:10.1016/j.cell.2011.06.041 · Cited by 1,306
RNA Editing by Adenosine Deaminases That Act on RNA
Bass, B. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135501 · Cited by 1,272
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Vaidhya, A., Prakash, G. R., Deepthi, V., Rathore, L. S., Panigrahi, M., Aneesha, V. A., Madhu, C. L., Singh, T. U., & Parida, S. (2025) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2025.104637 · Cited by 3
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Li, S., Deng, X., Pathak, D., Basavaraj, R., Sun, L., Cheng, Y., Li, J., Burke, M., Britz, G. W., Cheng, C., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.29.601251 · Cited by 1
Quack, S., Maity, S., America, P. P. B., Klein, M., del Valle, A. H., Singh, R., Smitskamp, Q., Papini, F. S., Broedersz, C. P., Roos, W. H., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.27.609867 · Cited by 1
Herrmann, M., Krebs, Y., Acosta, F. M., Parusel, S., Siering, O., Andres, F. G. M., Taye, B., Miskey, C., & Pfaller, C. K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.13.621086 · Cited by 1
Heraud-Farlow, J. E., Taylor, S., Goradia, A., Chalk, A. M., Harrison, P. F., Liang, Z., Smeets, M. F. M. A., Izon, D. J., Hu, S.-B., Li, J. B., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.14.682456 · Cited by 1
RIG-I-like receptors sense replication stress through ribosomal DNA integrity to drive inflammationPreprint
Wu, I.-H., Wang, X., Clark, R., Farahnak, S., Ahmad, S., & Hur, S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.27.728122 · Cited by 1
Self-citationFrachette, C., Cimaz, R., & Bélot, A. (2019) · Rare diseases of the immune system · doi:10.1007/978-3-030-19055-2_14
Choi, H., Kwon, J., Sun, J., Cho, M. S., Sun, Y., Casey, J. L., Toretsky, J. A., & Han, C. (2020) · doi:10.21203/rs.3.rs-60342/v1
The Mechanisms of Cytokine Dependent IFN-Production and Grown Inhibition in ADAR1 Loss
Panda, A. (2018) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
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Yu, Q., Qu, K., & Modis, Y. (2018) · SSRN Electronic Journal · doi:10.2139/ssrn.3232170
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Grant, M. J., Politi, K. A., & Gettinger, S. N. (2021) · Current cancer research · doi:10.1007/978-3-030-74028-3_5
Faculty Opinions recommendation of N6-Methyladenosine Modification Controls Circular RNA Immunity.
Müller, S. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736509064.793575749
RLR-mediated IFN signaling and aberrant activation
Yang, H., Feng, Y., Feng, C., & Mu, X. N. (2022) · Journal of Clinical Images and Medical Case Reports · doi:10.52768/2766-7820/1682
Self-citationGong, Y., Hu, H., Zhao, X., Wei, W., Zhang, M., Tuan, T. N., Ma, H., Zhang, Y., Chan, K., & Li, S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.08.515566
Choi, H., Kwon, J., Cho, M. S., Sun, Y., Zheng, X., Wang, J., Bouker, K. B., Casey, J. L., Atkins, M. B., Toretsky, J. A., et al. (2023) · doi:10.1158/0008-5472.c.6513106.v1
IFIH1 loss-of-function predisposes to inflammatory and SARS-CoV-2-related infectious diseasesPreprint
Najm, R., Yavuz, L., Jain, R., Naofal, M. E., Ramaswamy, S., Abuhammour, W., Loney, T., Nowotny, N. R., Alsheikh-Ali, A. A. A., Tayoun, A. N. A., et al. (2023) · medRxiv · doi:10.1101/2023.10.13.23297034
Stress-induced endogenous-dsRNAs drive beta-cells to IFN-I statePreprint
Chi, K. K., Senapati, P., Leung, A., & Schones, D. E. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.10.566600
Cellular dsRNA interactome reveals the regulatory map of exogenous RNA sensingPreprint
Lim, J., Lee, N., Ju, S., Kim, J., Mun, S., Jeon, M., Lee, Y.-K., Lee, S., Ku, J., Kim, S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.14.599134
Bi-directional Transcription, Double-Stranded RNA and the Implications on Genome Evolution
Al-Hashimi, S., Sadeq, S., & Werner, A. (2024) · Springer eBooks · doi:10.1007/978-3-031-59286-7_4
Alu overexpression leads to increased double-stranded RNA in dermatomyositisPreprint
Najjar, R., Mammen, A. L., & Mustelin, T. (2024) · medRxiv · doi:10.1101/2024.11.02.24316621
Miller, C. M., Morrison, J. H., Bankers, L., Dran, R. J., Kendrick, J., Briggs, E., Ferguson, V. L., & Poeschla, E. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.21.634124
Nuclear Retention and Rna Editing Suppress the Recognition of Undegraded Intron Lariats as Non-SelfPreprint
Lee, K., Ku, J., Park, S. Y., Kim, N., Widowati, T. A., Chung, H. W., Kim, M. J., Kim, D. S., Kim, H. Y., Jang, W. D., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5126151
Pradeepa, M. M., Patel, M., Ali, A., Dąbrowska, A., Boulet, F., Kulkarni, R., Ince, C., & Sinha, A. (2025) · Research Square · doi:10.21203/rs.3.rs-6121510/v1
NOD2 modulates MDA5 signaling to promote coxsackievirus B3 replicationPreprint
Kuss-Duerkop, S. K., Atencio, L. C., Nail, E. A., Sparks, I. L., Huynh, T. N. T., Russo, B. C., & Keestra, A. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.06.652463
Distinguishing self from non-self RNA by editing-specific inosine patterns
Varada, R., Leuchtenberger, A. F., Vesely, C., Kaczmarek, B., Mansouri, H. R., Mandl, T. C., Milanovic, K., Tamizkar, K. H., Rajendra, V., Senoner, H., et al. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag845
The Flipons, Infections, and Amyloids that Foreshadow the Fading Memories of Alzheimer’s Disease
Herbert, A. G. (2025) · Neuroscience Insights · doi:10.1177/26331055251338815
Monkey business: Primate Ku moonlights for the innate immune response
Ramsden, D. A., & Luthman, A. J. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.06.022
Metadata
- Authors
- Ahmad, S., Mu, X., Yang, F., Greenwald, E., Park, J. W., Jacob, E., Zhang, C.-Z., & Hur, S.
- Affiliations
- Boston Children's Hospital (US)
- Boston College (US)
- Broad Institute (US)
- Corresponding author
- Hur, Sun
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 172
- Issue
- 4
- Pages
- 797-810.e13
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC5807104
- OpenAlex
- W2784999778
- Cited by
- 449
- References
- 46
- Citations by year
- 2026: 58 · 2025: 54 · 2024: 45 · 2023: 44 · 2022: 43 · 2021: 85 · 2020: 49 · 2019: 38 · 2018: 33
- FWCI
- 22.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Cancer Research Institute
- Burroughs Wellcome Fund
- National Institutes of Health (R01AI106912, R21AI130791, R01AI111784)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- MDA5, Aicardi-Goutières syndrome, double-stranded RNA, self-tolerance, RNA duplex structure
- MeSH terms
- A549 Cells, Interferon-Induced Helicase, IFIH1, THP-1 Cells, Humans, Inflammation, Muramidase, Nervous System Malformations, Peptide Fragments, RNA, Double-Stranded, Self Tolerance, Alu Elements, Autoimmune Diseases of the Nervous System, Protein Multimerization
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