Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex

Weick, Eva-Maria, Puno, M. Rhyan, Januszyk, Kurt, Zinder, John C., DiMattia, Michael A., Lima, Christopher D.·2018·Cell
DOI 10.1016/j.cell.2018.05.041

Cited by (153)

Items 101–153 of 153

  1. Analysis of RNA Exosome Subunit Transcript Abundance Across Tissues: Implications for Neurological Disease Pathogenesis
    Julia L. de Amorim, Don Asafu-Adjaye, Anita H. Corbett · 2023 · RNA & DISEASE
  2. The RNA helicase DDX1 associates with the nuclear RNA exosome and modulates R-loops
    Julia L. de Amorim, Sara W. Leung, Ramona Haji‐Seyed‐Javadi, Yingzi Hou, David S. Yu, Homa Ghalei, Sohail Khoshnevis, Bing Yao, Anita H. Corbett · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  3. Somatic DIS3 mutations in Multiple Myeloma arise early in clonal evolution, but are later counterselected due to toxicity
    Tomasz M. Kuliński, Olga Gewartowska, Seweryn Mroczek, Marcin Szpila, Katarzyna Sałas, Vladyslava Liudkovska, Andrzej Dziembowski · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  4. TRAMP assembly alters the conformation and RNA binding of Mtr4 and Trf4-Air2
    Joshua Denson, Naifu Zhang, Darby Ball, Kayla Thompson, Sean Johnson, Sheena D’Arcy · 2025 · Proceedings of the National Academy of Sciences
  5. The Hidden Layer of RNA Variants
    Kenzui Taniue, Nobuyoshi Akimitsu · 2023 · RNA technologies
  6. Conserved Residues at the Mtr4 C-Terminus Coordinate Helicase Activity and Exosome Interactions
    Matthew Yim, Catherine J Stuart, Markell I. Pond, Ambro van Hoof, Sean J. Johnson · 2023 · Biochemistry
  7. A Biallelic Variant of the RNA Exosome Gene EXOSC4 Causes Translational Defects Associated with a Neurodevelopmental Disorder
    Milo B. Fasken, Sara W. Leung, Lauryn A. Cureton, Maha Al-Awadi, Adila Al‐Kindy, Sohail Khoshnevis, Homa Ghalei, Almundher A. Al-Maawali, Anita H. Corbett · 2023 · medRxiv
  8. Primate-specific adaptation of Ku protects transcriptomic integrity by suppressing Alu-mediated alternative splicing
    Tianji Yu, Jimin Yoon, Yimeng Zhu, Angelina Li, Brian J. Lee, Daniel F. Moakley, Jing Duan, Qiannian Deng, Fei Hou, Mengfang Yan et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  9. EXOSC3 G191 Variants Trigger System-Wide Recalibration of RNA Processing Machinery
    Wijeratne, H.R. Sagara, Runnebohm, Avery M., Barron, Monica P., Hampton, Ariana J., Li, Rudong, Peck Justice, Sarah A., Lenceski, Sophia H., Rooney, James D., Smith-Kinnaman, Whitney R., Chang, Gina S. et al. · 2026
  10. Strategies for Generating RNA Exosome Complexes from Recombinant Expression Hosts
    Eva‐Maria Weick, John C. Zinder, Christopher D. Lima · 2019 · Methods in molecular biology
  11. Understanding the impact of DIS3 cancer-associated mutations by in silico structure modeling
    Esmat Fazel-Najafabadi, Shirin Fattahpour, Hossein Abdali, Jafar Nasiri, Maryam Sedghi · 2020 · Gene Reports
  12. RNA-regulatory exosome complex suppresses an apoptotic program to confer erythroid progenitor cell survival in vivo
    Isabela Fraga de Andrade, Kirby D. Johnson, Charu Mehta, Colin N. Dewey, Uttiya Basu, Emery H. Bresnick · 2022 · Blood Advances
  13. N-Terminus of Cid14 Activates RNA Unwinding by Mtr4 in the Schizosaccharomyces pombe TRAMP Complex
    Mark D. Gold, Matthew D. Staten, Kamryn E. Morgan, Edna Naa Adukwei Armah, Sean J. Johnson · 2025 · Biochemistry
  14. Role of RNA helicases in circRNA biogenesis and regulation
    Musaed Hamood Al-subari, Yugang Xiao, Qubo Zhu · 2026 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
  15. Ribonuclease DIS3 delays aging and senescence by generating tRNA halves
    Seokjun G. Ha, Hanseul Lee, Jisoo Park, Donghun Lee, Gee‐Yoon Lee, 함석진, Sujeong Kwon, Sangsoon Park, Sieun S. Kim, Yoonji Jung et al. · 2026 · Nature Communications
  16. Enhancer RNAs: similarities with both lncRNAs and mRNAs reveal novel functions
    Pavel A. Vlasov, James L. Manley · 2026 · RNA Biology
  17. Human Variation‐Informed Prioritization of MPHOSPH6 in Lung Adenocarcinoma: A Source‐Aware Multiomics Evidence Framework
    Chongwen Fang, Min Wu, Jing Lv, Yanping Zhang, Qinyun Zheng, Xiang Shen, Shangke Huang · 2026 · Human Mutation
  18. Reconstitution of S. cerevisiae RNA Exosome Complexes Using Recombinantly Expressed Proteins
    John C. Zinder, Christopher D. Lima · 2019 · Methods in molecular biology
  19. Closing in on ATPase Activity by an RNA Helicase
    Sean J. Johnson, Matthew Yim · 2020 · Structure
  20. Recent progress in label-free techniques for characterization of extracellular vesicle heterogeneity
    Yichuan Dai, Yajun Yu, Xianli Wang, Ziling Jiang, Kaiqin Chu, Smith Zachary J. · 2022 · Scientia Sinica Chimica
  21. DIS3 ribonuclease prevents the cytoplasmic accumulation of lncRNAs carrying non-canonical ORFs, which represent a source of cancer immunopeptides.
    Dominika Foretek, Marc Gabriel, Isabelle Hatin, Julien Jarroux, Marina Pinskaya, Elise Pepermans, Kurt Boonen, Rachel Topno, Věra Slaninová, Marina Serna et al. · 2023 · Research Square
  22. Accumulation of lncRNAs in cytoplasm upon DIS3 depletion leads to production of cryptic peptides detected in Multiple Myeloma.
    Dominika Foretek, Marc Gabriel, Isabelle Hatin, Julien Jarroux, Marina Pinskaya, Elise Pepermans, Kurt Boonen, Rachel Topno, Věra Slaninová, Marina Serna et al. · 2024 · Research Square
  23. Quantifying the Structural and Energetic Consequences of EXOSC3 S1 Domain Variants from a Comparative Assessment of λ-Dynamics with Two Charge-Changing Perturbation Strategies
    Barron, Monica P., Wijeratne, H.R. Sagara, Runnebohm, Avery M., Caric, Katelyn M., Mosley, Amber L., Vilseck, Jonah Z. · 2025
  24. Insights into the regulation of RNA helicases by protein cofactors
    Indira Memet · 2019 · eDiss (Georg-August-Universität Göttingen)
  25. Recent Progresses of Computational Analysis of RNA-Protein Interactions
    Chunqiu Xia, Xiaoyong Pan, Yang Yang, Yan Huang, Hong‐Bin Shen · 2019 · Elsevier eBooks
  26. Purification of Endogenous Tagged TRAMP4/5 and Exosome Complexes from Yeast and In Vitro Polyadenylation-Exosome Activation Assays
    Dagmar Zigáčková, Veronika Rájecká, Štěpánka Vaňáčová · 2019 · Methods in molecular biology
  27. Reconstitution of the Schizosaccharomyces pombe RNA Exosome
    Kurt Januszyk, Christopher D. Lima · 2019 · Methods in molecular biology
  28. Genome-scale conserved molecular principles of mRNA half-life regulation
    Sudipto Basu, Saurav Mallik, Suman Hait, Sudip Kundu · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  29. High-throughput siRNA screening reveals functional interactions and redundancies of human processive exoribonucleases
    Anna Hojka-Osińska, Aleksander Chlebowski, Ewelina P. Owczarek, Kamila Affek, Kamila Kłosowska-Kosicka, Roman J. Szczęsny, Andrzej Dziembowski · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  30. Methods to assess helicase and translocation activities of human nuclear RNA exosome and RNA adaptor complexes
    M Rhyan Puno, Christopher D. Lima · 2022 · Methods in enzymology on CD-ROM/Methods in enzymology
  31. In vivo Characterization of the Critical Interaction between the RNA Exosome and the Essential RNA Helicase Mtr4 in Saccharomyces cerevisiae
    Maria C. Sterrett, Daniela Farchi, Sarah E. Strassler, Lawrence Boise, Milo B. Fasken, Anita H. Corbett · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  32. DIS3 ribonuclease prevents the cytoplasmic accumulation of lncRNAs carrying non-canonical ORFs.
    Dominika Foretek, Marc Gabriel, Isabelle Hatin, Julien Jarroux, Marina Pinskaya, Elise Pepermans, Kurt Boonen, Rachel Topno, Věra Slaninová, Marina Serna et al. · 2023 · Research Square
  33. Unveiling the mystery of nuclear RNA homeostasis
    Shan Lin, Ling‐Ling Chen · 2024 · Cell stem cell
  34. Exosomal non-coding rnas as potential biomarkers in the diagnosis and prognosis of lung cancer. Review
    Киреев Андрей Андреевич, M.A. Semushina, Anna B. Semenova · 2024 · Laboratory Service
  35. Hierarchical assembly and functional resilience of the mammalian RNA exosome
    Tsimafei Navalayeu, Nikolaus Beer, Monika Bebjaková, Robert Kalis, Karel Stejskal, Gabriela Krššáková, Nina Fasching, Veronika A. Herzog, Niko P. Popitsch, Elisabeth Roitinger et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  36. Aging-dependent dysregulation of EXOSC2 is maintained in cancer as a dependency
    Maria Skamagki, Cheng Zhang, Ezgi Hacisuleyman, Giuseppe Galleti, Chao Wu, Vinagolu K. Rajasekhar, HyoKyeong Cha, Deniz Ata, Jongjin Kim, Taylor Weisskittel et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  37. RNA Classes and Their Maturation and Degradation Enzymes
    Manon Batista, Béatrice Clouet-d’Orval, Marie Bouvier · 2025
  38. Compound heterozygosity of EXOSC2 ‘missense’ variants causes a bi-allelic decrease in protein expression through novel unexpected pathomechanisms
    Shin Hayashi, Kenichiro Yamada, Takuma Mori, Y. Suzuki, Yosuke Nishio, Tomoo Ogi, Mie Inaba · 2026 · Research Square
  39. Coordination of sequential RNase activities in an ancient molecular machine
    Mathias Girbig, Francesca D. Naughton-Allen, Simone Prinz, Laura Andreas, Jan M. Schuller, Justin L. P. Benesch, Georg K. A. Hochberg · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  40. Métabolisme de l'ARN chez les archées : dialogue entre l'hélicase à ARN ASH-Ski2, l'exoribonucléase 5'- 3' aRNase J et l'exosome 3'- 5' à ARN, à proximité du ribosome
    Manon Batista · 2020 · theses.fr (ABES)
  41. ADAR1 and ADAR2 associate with the RNA exosome and modulate RNA stability
    Dragana Vukić, Qiupei Du, Anna Cherian, Damiano Amoruso, Květoslava Brožinová, Ludivine Wacheul, Valentina Lacovich, Christiane Zorbas, Leena Yadav, Jiří Sedmík et al. · 2026 · Nucleic Acids Research
  42. Precision in RNA degradation: helicases, ribosome and RNA polymerase stalling, and RNA modifications
    Daniel Whisenant, Justine Soltys, Jerson D. Estrella, Uttiya Basu · 2026 · Trends in Cell Biology
  43. ORF57/MTA in KSHV biology and pathogenesis: update from 2015
    Zhi-Ming Zheng, V. Majerciak · 2026 · Journal of Medical Virology
  44. The RNA exosome: mechanisms of RNA surveillance, regulation, and disease
    Priyanka Upadhyai, Neha Quadri, Divya Chandran · 2026 · RNA Biology
  45. Cellular assembly and functional resilience of the mammalian RNA exosome
    Tsimafei Navalayeu, Nikolaus Beer, Monika Bebjaková, Robert Kalis, Ulrich Hohmann, Karel Stejskal, Gabriela Krššáková, Nina Fasching, Veronika A. Herzog, Niko P. Popitsch et al. · 2026 · The EMBO Journal
  46. HUSH, NEXT PROMPT: Epigenetics and the Nuclear RNA Exosome in Human Aging and Disease
    Andrew G. Newman, Prim B. Singh · 2026 · Cells
  47. Biallelic protein truncating EXOSC6 variants cause a neurodevelopmental disorder with cerebellar atrophy, ataxia, and global developmental delay
    Khondakar Sayef Ahammed, Renzo Guerrini, Milo B. Fasken, Anita H. Corbett, Ambro van Hoof, Davide Mei · 2026 · medRxiv
  48. Systematic comparison of pathogenic variants of the RNA exosome gene EXOSC3/RRP40 in Saccharomyces cerevisiae reveals variant-specific functional consequences
    Milo B. Fasken, Sara W. Leung, Leonardo Farias Serafim, Chunli Yan, Madison L. Intemann, Dustin L. Gable, Kristin W. Baranano, Ivaylo N. Ivanov, Homa Ghalei, Anita H. Corbett · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  49. Mechanisms of transcription termination across the coding and noncoding loci of the genome
    Aixia Song, Minhui Hu, Fei Chen · 2026 · Nature Reviews Molecular Cell Biology
  50. MTR4 deficiency attenuates abdominal aortic aneurysm progression through suppressing VSMC senescence via the MTR4-RAP1a axis
    Yajing Li, Keying Tian, Ying Wang, Shuokang Wu, Cao Qi, Sihan Wang, Xinhua Zhang, Xugang Wang, Hongguang Lian, Xin Liu et al. · 2026 · iScience
  51. Structure of the human mitochondrial RNA degradosome reveals a distinct mode of helicase–nuclease coupling
    Paula Favoretti Vital do Prado, Saruby Sharma, Arjun Bhatta, Ana N. Vučković, Maral Parvizian Marani, Andrei Philipp Llarena David, Bernhard Kuhle, Hauke S. Hillen · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  52. Functional dynamics of the eukaryotic RNA exosome upon complex formation
    Jobst Liebau, Svetlana Kucher, Gloria Candy Danielle Sedoh, Enrica Bordignon, Remco Sprangers · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  53. Chemically stabilized long antisense oligonucleotides perturb RNA exosome function
    Daniel Tobias Hofacker, Stefanie Gackstatter, Vanessa Deisling, Thorsten Stafforst · 2026 · Nucleic Acids Research