ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

Kim, Ju Youn, Garcia-Carbonell, Ricard, Yamachika, Shinichiro, Zhao, Peng, Dhar, Debanjan, Loomba, Rohit, Kaufman, Randal J., Saltiel, Alan R. +1 more·2018·Cell

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  2. From Liver Fat to Cancer: Perils of the Western Diet
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  3. DHT causes liver steatosis via transcriptional regulation of SCAP in normal weight female mice
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  6. The Role of Endoplasmic Reticulum Stress and NLRP3 Inflammasome in Liver Disorders
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  7. Loss of hepatic FTCD promotes lipid accumulation and hepatocarcinogenesis by upregulating PPARγ and SREBP2
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  8. NPY stimulates cholesterol synthesis acutely by activating the SREBP2-HMGCR pathway through the Y1 and Y5 receptors in murine hepatocytes
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  9. Blockade of C5aR1 alleviates liver inflammation and fibrosis in a mouse model of NASH by regulating TLR4 signaling and macrophage polarization
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  10. GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury
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  11. Establishment of a non‐alcoholic fatty liver disease model by high fat diet in adult zebrafish
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  12. Glycine‐β‐muricholic acid antagonizes the intestinal farnesoid X receptor–ceramide axis and ameliorates NASH in mice
    Jie Jiang, Yuandi Ma, Yameng Liu, Dasheng Lu, Xiaoxia Gao, Kristopher W. Krausz, Dhimant H. Desai, Shantu Amin, Andrew D. Patterson, Frank J. Gonzalez et al. · 2022 · Hepatology Communications
  13. Relieving ER stress to target NASH-driven hepatocellular carcinoma
    Saskia Reibe, Mark Anthony Febbraio · 2018 · Nature Reviews Endocrinology
  14. Caspase-2 and p75 neurotrophin receptor (p75NTR) are involved in the regulation of SREBP and lipid genes in hepatocyte cells
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  15. Inflammation in Primary and Metastatic Liver Tumorigenesis–Under the Influence of Alcohol and High-Fat Diets
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  17. New insights into the pathogenesis and treatment of non-viral hepatocellular carcinoma: a balancing act between immunosuppression and immunosurveillance
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  23. Involvement of the Autophagy-ER Stress Axis in High Fat/Carbohydrate Diet-Induced Nonalcoholic Fatty Liver Disease
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  24. Mitochondrial general control of amino acid synthesis 5 like 1 promotes nonalcoholic steatohepatitis development through ferroptosis‐induced formation of neutrophil extracellular traps
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  32. The hepatic integrated stress response suppresses the somatotroph axis to control liver damage in nonalcoholic fatty liver disease
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  33. Autophagy, Ferroptosis, Apoptosis and Pyroptosis in Metabolic Dysfunction-Associated Steatotic Liver Disease.
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  36. DNA damage promotes ER stress resistance through elevation of unsaturated phosphatidylcholine in Caenorhabditis elegans
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  40. NAFLD-Related HCC: Focus on the Latest Relevant Preclinical Models
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  41. Deletion of Tfap2a in hepatocytes and macrophages promotes the progression of hepatocellular carcinoma by regulating SREBP1/FASN/ACC pathway and anti-inflammatory effect of IL10
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  42. Comprehensive analysis of endoplasmic reticulum-related and secretome gene expression profiles in the progression of non-alcoholic fatty liver disease
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  43. Asperosaponin VI protects alcohol-induced hepatic steatosis and injury via regulating lipid metabolism and ER stress
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  44. Processes exacerbating apoptosis in non-alcoholic steatohepatitis
    Marta B. Afonso, Rui Eduardo Castro, Cecília M. P. Rodrigues · 2019 · Clinical Science
  45. Riboflavin Deficiency and Apoptosis: A Review
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  51. The molecular basis for current targets of NASH therapies
    Kamran Qureshi, Brent A. Neuschwander‐Tetri · 2019 · Expert Opinion on Investigational Drugs
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  57. SLPI suppresses hepatocellular carcinoma progression via endoplasmic reticulum stress induced apoptosis
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