ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P
Kim, Ju Youn, Garcia-Carbonell, Ricard, Yamachika, Shinichiro, Zhao, Peng, Dhar, Debanjan, Loomba, Rohit, Kaufman, Randal J., Saltiel, Alan R. +1 more·2018·Cell
Cited by (332)
Items 101–200 of 332
- Surf4 regulates expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) but is not required for PCSK9 secretion in cultured human hepatocytesYishi Shen, Bingxiang Wang, Shijun Deng, Lei Zhai, Hong-mei Gu, Adekunle Alabi, Xiaodan Xia, Yongfang Zhao, Xiaole Chang, Shucun Qin et al. · 2019 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- From Liver Fat to Cancer: Perils of the Western DietJu Youn Kim, Feng He, M. Karin · 2021 · Cancers
- DHT causes liver steatosis via transcriptional regulation of SCAP in normal weight female miceTina A. Seidu, Patrick McWhorter, Jessie Myer, Rabita Alamgir, Nicole Eregha, Dilip Bogle, Taylor Lofton, CAROLYN A. ECELBARGER, Stanley Andrisse · 2021 · Journal of Endocrinology
- FMO2 ameliorates nonalcoholic fatty liver disease by suppressing ER-to-Golgi transport of SREBP1Changle Ke, Changchen Xiao, Jiamin Li, Xianpeng Wu, Yu Zhang, Yongjian Chen, Shuyuan Sheng, Zaiyang Fu, Lingjun Wang, Cheng Ni et al. · 2023 · Hepatology
- Dietary sodium acetate and sodium butyrate attenuate intestinal damage and improve lipid metabolism in juvenile largemouth bass (Micropterus salmoides) fed a high carbohydrate diet by reducing endoplasmic reticulum stressLiulan Zhao, Liangshun Cheng, Yifang Hu, Xiaohui Li, Yuhui Yang, Jin Mu, Lianfeng Shen, Guojun Hu, Kuo He, Haoxiao Yan et al. · 2023 · Animal nutrition
- The Role of Endoplasmic Reticulum Stress and NLRP3 Inflammasome in Liver DisordersXueqin Lü, Haitao Huang, Xiaodi Fu, Chaoran Chen, Huiyang Liu, Honggang Wang, Dongdong Wu · 2022 · International Journal of Molecular Sciences
- Loss of hepatic FTCD promotes lipid accumulation and hepatocarcinogenesis by upregulating PPARγ and SREBP2Siying Wang, Yangyang Zhou, Ruobing Yu, Ling Jing, Botai Li, Yang Chen, Zhuoan Cheng, Ruolan Qian, Zhang Lin, Chengtao Yu et al. · 2023 · JHEP Reports
- NPY stimulates cholesterol synthesis acutely by activating the SREBP2-HMGCR pathway through the Y1 and Y5 receptors in murine hepatocytesFu Chen, Yong Zhou, Keyu Yang, Mingyang Shen, Yong Wang · 2020 · Life Sciences
- Blockade of C5aR1 alleviates liver inflammation and fibrosis in a mouse model of NASH by regulating TLR4 signaling and macrophage polarizationKeqing Jiang, Shibang Lu, Dongxiao Li, Mingjiang Liu, Jin Hu, Biao Lei, Sifan Wang, Kang Long, Songqing He, Fudi Zhong · 2023 · Journal of Gastroenterology
- GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injuryKhrystyna Platko, Paul F. Lebeau, Jae Hyun Byun, Samantha V. Poon, Emily Anne Day, Melissa E. MacDonald, Nicholas Timothy Holzapfel, Aurora Mejía‐Benítez, Kenneth N. Maclean, Joan C. Krepinsky et al. · 2019 · Molecular Metabolism
- Establishment of a non‐alcoholic fatty liver disease model by high fat diet in adult zebrafishXiang Li, Lei Zhou, Yuying Zheng, Taiping He, Honghui Guo, Jiangbin Li, Jingjing Zhang · 2023 · Animal Models and Experimental Medicine
- Glycine‐β‐muricholic acid antagonizes the intestinal farnesoid X receptor–ceramide axis and ameliorates NASH in miceJie Jiang, Yuandi Ma, Yameng Liu, Dasheng Lu, Xiaoxia Gao, Kristopher W. Krausz, Dhimant H. Desai, Shantu Amin, Andrew D. Patterson, Frank J. Gonzalez et al. · 2022 · Hepatology Communications
- Relieving ER stress to target NASH-driven hepatocellular carcinomaSaskia Reibe, Mark Anthony Febbraio · 2018 · Nature Reviews Endocrinology
- Caspase-2 and p75 neurotrophin receptor (p75NTR) are involved in the regulation of SREBP and lipid genes in hepatocyte cellsDan Duc Pham, Céline Bruelle, Hai Thi, Ceren Pajanoja, Congyu Jin, Vignesh Srinivasan, Vesa M. Olkkonen, Ove Eriksson, Matti Jauhiainen, Maciej M. Lalowski et al. · 2019 · Cell Death and Disease
- Inflammation in Primary and Metastatic Liver Tumorigenesis–Under the Influence of Alcohol and High-Fat DietsLauren S. Strathearn, Afanasii I. Stepanov, Joan Font-Burgada · 2020 · Nutrients
- Sphingosine 1-Phosphate Regulates Obesity and Glucose HomeostasisKazuo Kajita, Isao Ishii, Ichiro Mori, Motochika Asano, Masayuki Fuwa, Hiroyuki Morita · 2024 · International Journal of Molecular Sciences
- New insights into the pathogenesis and treatment of non-viral hepatocellular carcinoma: a balancing act between immunosuppression and immunosurveillanceMichael Karin · 2018 · Precision Clinical Medicine
- CRELD2, endoplasmic reticulum stress, and human diseasesQin Tang, Qinhui Liu, Yanping Li, Li Mo, Jinhan He · 2023 · Frontiers in Endocrinology
- Ufmylation on UFBP1 alleviates non-alcoholic fatty liver disease by modulating hepatic endoplasmic reticulum stressZiming Mao, Xiaowen Ma, Yu Jing, Minyan Shen, Xirui Ma, Jing Zhu, Huifang Liu, Guangya Zhang, Fengling Chen · 2023 · Cell Death and Disease
- Unveiling the role of ferroptosis in the progression from NAFLD to NASH: recent advances in mechanistic understandingQian Yu, Lixing Song · 2024 · Frontiers in Endocrinology
- Mitochondrial ROS, a trigger for mitochondrial dysfunction and inflammasome activation and a therapeutic target in liver diseasesH. Jaara, S. Torres · 2024 · Exploration of Digestive Diseases
- Orai calcium release-activated calcium modulator 1 (ORAI1) plays a role in endoplasmic reticulum stress in bovine mammary epithelial cells challenged with physiological levels of ketone bodiesBingbing Zhang, Ming Li, Wei Yang, Juan J. Loor, Shuang Wang, Yingying Zhao, Han Guo, Xinru Ma, Cheng Xia, Chuang Xu · 2020 · Journal of Dairy Science
- Involvement of the Autophagy-ER Stress Axis in High Fat/Carbohydrate Diet-Induced Nonalcoholic Fatty Liver DiseaseXiu Zhou, Sherouk Fouda, Dongli Li, Kun Zhang, Ji‐Ming Ye · 2020 · Nutrients
- Mitochondrial general control of amino acid synthesis 5 like 1 promotes nonalcoholic steatohepatitis development through ferroptosis‐induced formation of neutrophil extracellular trapsTingting Lv, Xiaofeng Xiong, Wei Yan, Mei Liu, Hongwei Xu, Qin He · 2023 · Clinical and Translational Medicine
- Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp. c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1α/XBP-1s axis and JNK signalingYong Rao, Rui Jun Su, Chenyan Wu, Xingxing Chai, Jinjian Li, Guanyu Yang, Junjie Wu, Tingting Fu, Zhongping Jiang, Zhi‐Kai Guo et al. · 2023 · Acta Pharmaceutica Sinica B
- Centriole signaling restricts hepatocyte ploidy to maintain liver integrityValentina C. Sladky, Hanan Akbari, Daniel Tapias-Gomez, Lauren T. Evans, Chelsea G Drown, Margaret A. Strong, Gina M. LoMastro, Tatianna C. Larman, A. Holland · 2022 · Genes & Development
- At the Crossroads of Health and Disease: Consequences of Fat in the LiverMatthew Dukewich, Liyun Yuan, Norah A. Terrault · 2025 · Annual Review of Physiology
- Mulberry Leaf (Morus alba L.) Extracts and Its Chlorogenic Acid Isomer Component Improve Glucolipotoxicity-Induced Hepatic Lipid Accumulation via Downregulating miR-34a and Decreased InflammationTsung‐Yuan Yang, Meng-Hsun Yu, Yi-Liang Wu, Ching-Chun Hong, Chin‐Shuh Chen, Kuei‐Chuan Chan, Chau‐Jong Wang · 2022 · Nutrients
- Exogenous H 2 S promotes ubiquitin‐mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S‐sulfhydrationShiwu Zhang, Mengyi Wang, Hongxia Li, Qianzhu Li, Ning Liu, Shiyun Dong, Yajun Zhao, Kemiao Pang, Jiayi Huang, Cheng Ren et al. · 2023 · Journal of Cachexia Sarcopenia and Muscle
- Polysaccharide-Enriched Fraction from Amillariella Mellea Fruiting Body Improves Insulin ResistanceSiwen Yang, Yuhan Meng, Jingmin Yan, Na Wang, Zhujun Xue, Hang Zhang, Yuying Fan · 2018 · Molecules
- Metabolic injury of hepatocytes promotes progression of NAFLD and AALDCarvalho-Gontijo, Raquel, Han, Cuijuan, Zhang, Lei, Zhang, Vivian, Hosseini, Mojgan, Mekeel, Kristin, Schnabl, Bernd, Loomba, Rohit, Karin, Michael, Brenner, David A. et al. · 2022 · Seminars in Liver Disease
- The hepatic integrated stress response suppresses the somatotroph axis to control liver damage in nonalcoholic fatty liver diseaseRika Ohkubo, Wei‐Chieh Mu, Chih-Ling Wang, Zehan Song, Marine Barthez, Yifei Wang, Nathaniel Mitchener, Rasul Abdullayev, Yeong Rim Lee, Yuze Ma et al. · 2022 · Cell Reports
- Autophagy, Ferroptosis, Apoptosis and Pyroptosis in Metabolic Dysfunction-Associated Steatotic Liver Disease.Shuang-Shuang Zhao, Yan Guo, Xunzhe Yin · 2024 · Frontiers in Bioscience
- ERAD deficiency promotes mitochondrial dysfunction and transcriptional rewiring in human hepatic cellsQingqing Liu, Xiaoqin Yang, Guangyu Long, Yabing Hu, Zhenglong Gu, Yves R. Boisclair, Qiaoming Long · 2020 · Journal of Biological Chemistry
- Transcription factor old astrocyte specifically induced substance is a novel regulator of kidney fibrosisAyaha Yamamoto, Hitomi Morioki, Takafumi Nakae, Yoshiaki Miyake, Takeo Harada, Shunsuke Noda, Sayuri Mitsuoka, Kotaro Matsumoto, Masashi Tomimatsu, Soshi Kanemoto et al. · 2020 · The FASEB Journal
- DNA damage promotes ER stress resistance through elevation of unsaturated phosphatidylcholine in Caenorhabditis elegansJianhui Deng, Xue Bai, Haiqing Tang, Shanshan Pang · 2020 · Journal of Biological Chemistry
- Vitamin C Deficiency Inhibits Nonalcoholic Fatty Liver Disease Progression through Impaired de Novo LipogenesisSeoung-Woo Lee, Su-Min Baek, Kyung‐Ku Kang, A-Rang Lee, Tae–Un Kim, Seong‐Kyoon Choi, Yoon‐Seok Roh, Il‐Hwa Hong, Sang‐Joon Park, Tae‐Hwan Kim et al. · 2021 · American Journal Of Pathology
- Dietary and Genetic Cholesterol Loading Rather Than Steatosis Promotes Liver Tumorigenesis and NASH-Driven HCCVicent Ribas, Laura Conde de la Rosa, David Robles, Susana Núñez, Paula Segalés, Naroa Insausti-Urkia, Estel Solsona‐Vilarrasa, José Carlos Fernández-Checa, Carmen García‐Ruiz · 2021 · Cancers
- Effects of XIAP on high fat diet-induced hepatic steatosis: a mechanism involving NLRP3 inflammasome and oxidative stressZilu Shi, Qian Huang, WU Hai-bin, Chenxu Ge, Lou Deshuai, Li Qiang, Linfeng Hu, Tan Jun, Minxuan Xu · 2019 · Aging
- NAFLD-Related HCC: Focus on the Latest Relevant Preclinical ModelsJing‐Yuan Fang, Séverine Celton‐Morizur, Chantal Desdouets · 2023 · Cancers
- Deletion of Tfap2a in hepatocytes and macrophages promotes the progression of hepatocellular carcinoma by regulating SREBP1/FASN/ACC pathway and anti-inflammatory effect of IL10Zhiwei Li, Chun Zhang, Gui‐Xiang Huang, Zixin Zhang, Qinghao Wang, Xiran Liu, Yanling Qin, Hao Zhou, Anyi Hou, Jun He et al. · 2025 · Cell Death and Disease
- Comprehensive analysis of endoplasmic reticulum-related and secretome gene expression profiles in the progression of non-alcoholic fatty liver diseaseRong Gao, Jin Wang, Xuemin He, Tongtong Wang, Li Zhou, Zhitao Ren, Jifeng Yang, Xiaoxin Xiang, Shiyi Wen, Zhuojun Yu et al. · 2022 · Frontiers in Endocrinology
- Asperosaponin VI protects alcohol-induced hepatic steatosis and injury via regulating lipid metabolism and ER stressLinlin Wei, Hui Luo, Yan Jin, Yue Long Shu, Cailing Wen, Tian Qin, Xinru Yang, Liqing Ma, Ying Liu, Yan You et al. · 2023 · Phytomedicine
- Processes exacerbating apoptosis in non-alcoholic steatohepatitisMarta B. Afonso, Rui Eduardo Castro, Cecília M. P. Rodrigues · 2019 · Clinical Science
- Riboflavin Deficiency and Apoptosis: A ReviewBo Zhang, Shuisheng Hou, Jing Tang · 2024 · Journal of Nutrition
- Adipokines regulate the development and progression of MASLD through organellar oxidative stressKe Zhao, Heng Zhang, Wenyu Ding, Xinfeng Yu, Yanli Hou, Xihong Liu, Xinhua Li, Xiaolei Wang · 2025 · Hepatology Communications
- Interventional hepatic apoC-III knockdown improves atherosclerotic plaque stability and remodeling by triglyceride loweringBastian Ramms, Sohan Patel, Xiaoli Sun, Ariane R. Pessentheiner, Gloria Michelle Ducasa, Adam E. Mullick, Richard G. Lee, Rosanne M. Crooke, Sotirios Tsimikas, Joseph Lee Witztum et al. · 2022 · JCI Insight
- Stearoyl‐CoA desaturase 1 inhibition impairs triacylglycerol accumulation and lipid droplet formation in colorectal cancer cellsZuzanna Tracz‐Gaszewska, Adrian Sówka, Paweł Dobrzyń · 2023 · Journal of Cellular Physiology
- Core liver homeostatic co-expression networks are preserved but respond to perturbations in an organism- and disease-specific mannerSaeed Esmaili, Peter Langfelder, T. Grant Belgard, Daniele Vitale, Mahmoud Karimi Azardaryany, Ghazal Alipour Talesh, Mehdi Ramezani–Moghadam, Vikki Ho, Daniel Dvorkin, Suat Dervish et al. · 2021 · Cell Systems
- Th17 cells in the liver: balancing autoimmunity and pathogen defenseNobuhito Taniki, Nobuhiro Nakamoto, Po–Sung Chu, Masataka Ichikawa, Toshiaki Teratani, Takanori Kanai∥ · 2022 · Seminars in Immunopathology
- The molecular basis for current targets of NASH therapiesKamran Qureshi, Brent A. Neuschwander‐Tetri · 2019 · Expert Opinion on Investigational Drugs
- Atorvastatin promotes AMPK signaling to protect against high fat diet‑induced non‑alcoholic fatty liver in golden hamstersBin Zhang, Chenyang Zhang, Xuelian Zhang, Nannan Li, Zhengqi Dong, Guibo Sun, Xiaobo Sun · 2020 · Experimental and Therapeutic Medicine
- Proteolytic activation of fatty acid synthase signals pan-stress resolutionHai Wei, Yi M. Weaver, Chendong Yang, Yuan Zhang, Guoli Hu, Courtney M. Karner, Matthew Sieber, Ralph J. DeBerardinis, Benjamin P. Weaver · 2024 · Nature Metabolism
- Early Diagnosis of Liver Injury and Real‐Time Evaluation of Photothermal Therapy Efficacy with a Viscosity‐Responsive NIR‐II Smart MoleculeQi Zan, Li Fan, Wenjing Lu, Yuewei Zhang, Yunong Huang, Xue Qing Yu, Yahong Han, Ruiping Zhang, Chuan Dong, Shaomin Shuang · 2024 · Advanced Healthcare Materials
- The multifunctionality of the caspase family of proteases: A new perspective beyond cell deathJiaqi Li, Qingqing Zhai, Wangzheqi Zhang, Yisheng Chen, Changli Wang, Xiaoming Deng, Haoling Zhang, Zhiheng Lin, Yalin Zhu · 2025 · Molecular Aspects of Medicine
- Selective targeting of endothelial and perivascular angiocrine ROCK2 treats liver fibrosisYan Hu, Biao Yang, Chengju Xiao, Xinchun Yang, Hua Zhang, Pengbo Yang, Xiao Du, Guixiang Zhang, Beibei Liang, Nan Bai et al. · 2026 · Cell
- SLPI suppresses hepatocellular carcinoma progression via endoplasmic reticulum stress induced apoptosisJie Lena Sun, Jinfan Li, Zhen Wu, Yuwan Liang, Rong Duan, Mengsha Zheng, Jing Wang, Derun Kong · 2021 · International Journal of Biological Sciences
- Chemoproteomics Identifies State-Dependent and Proteoform-Selective Caspase-2 InhibitorsJosé O. Castellón, Samuel Ofori, Nikolas R. Burton, Ashley R. Julio, Alexandra C. Turmon, Ernest Armenta, Carina Sandoval, Lisa M. Boatner, Evan E. Takayoshi, Marina Faragalla et al. · 2024 · Journal of the American Chemical Society
- Plant Sterol Ester of α-Linolenic Acid Attenuates Nonalcoholic Fatty Liver Disease by Rescuing the Adaption to Endoplasmic Reticulum Stress and Enhancing Mitochondrial BiogenesisHao Han, Yan Guo, Xiaoyu Li, Dongxing Shi, Tingli Xue, Linqi Wang, Yanyan Li, Mingming Zheng · 2019 · Oxidative Medicine and Cellular Longevity
- Aripiprazole Cytotoxicity Coincides with Activation of the Unfolded Protein Response in Human Hepatic CellsFrancesca Forno, Yossi Maatuf, Shatha Boukeileh, Priya Dipta, Mohamed Mahameed, Odai Darawshi, Vítor Ferreira, Patricia Rada, Irma García‐Martinez, Einav Gross et al. · 2020 · Journal of Pharmacology and Experimental Therapeutics
- Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to MalignancyDobrochna Dolicka, Cyril Sobolewski, Monika Gjorgjieva, Marta Correia de Sousa, Flavien Berthou, Claudio De Vito, Didier Colin, Olivia Bejuy, Margot Fournier, Christine Maeder et al. · 2020 · Cellular and Molecular Gastroenterology and Hepatology
- Redox regulation of metabolic syndrome: recent developments in skeletal muscle insulin resistance and non-alcoholic fatty liver disease (NAFLD)Yee Hui Yeo, Yen‐Chun Lai · 2019 · Current Opinion in Physiology
- Endoplasmic reticulum stress at the forefront of fatty liver diseases and cancerMichael Karin, Ju Youn Kim · 2025 · Pharmacological Reviews
- Mesenchymal stem cell-derived exosomes as cell-free therapeutics: mechanistic insights and engineering strategies for liver disease treatmentShihang Yu, Defu Kong, Beike Lu, Yixiao Pan, Zhaokai Zeng, Yuan Fu, Zhicong Zhao, Kang He, Ruqi Tang, Qiang Xia · 2025 · Stem Cell Research & Therapy
- Circulatory Endothelin 1-Regulating RNAs Panel: Promising Biomarkers for Non-Invasive NAFLD/NASH Diagnosis and Stratification: Clinical and Molecular Pilot StudyReda M. Albadawy, Sara H. A. Agwa, Eman Khairy, Maha Saad, Naglaa El Touchy, Mohamed O. Othman, Mohamed El‐Kassas, Marwa Matboli · 2021 · Genes
- Site 1 protease aggravates acute kidney injury by promoting tubular epithelial cell ferroptosis through SIRT3‐SOD2‐mtROS signalingShiying Xie, Wei Zou, Sirui Liu, Qinglan Yang, Tiantian Hu, Wei‐ping Zhu, Hua Tang, Cheng Wang · 2024 · FEBS Journal
- Microglia aggravate white matter injury via C3/C3aR pathway after experimental subarachnoid hemorrhageLei Yang, Jinpeng Wu, Fan Zhang, Lifang Zhang, Xianhui Zhang, Jian Zhou, Jinwei Pang, Bingqing Xie, Huangfan Xie, Yong Qing Jiang et al. · 2024 · Experimental Neurology
- Exploring the mechanism of PingTang No.5 capsule on nonalcoholic fatty liver disease through network pharmacology and experimental validationTzu-Chieh Hung, Nengjiang Zhao, Caoxin Huang, Suhuan Liu, Tao Liu, Wenfang Huang, Xiangbin Xu, Zhi‐Liang Ji, Shuyu Yang · 2021 · Biomedicine & Pharmacotherapy
- The Role and Interactive Mechanism of Endoplasmic Reticulum Stress and Ferroptosis in Musculoskeletal DisordersZhou Guo, Ruimin Chi, Yawen Peng, Kai Sun, Haigang Liu, Fengjing Guo, Jiachao Guo · 2024 · Biomolecules
- Lipogenesis and MASLD: re-thinking the role of SREBPsHayato Nakagawa · 2025 · Archives of Toxicology
- Tumor necrosis factor alpha receptor 1 deficiency in hepatocytes does not protect from non-alcoholic steatohepatitis, but attenuates insulin resistance in miceSena Bluemel, Yanhan Wang, Suhan Lee, Bernd Schnabl · 2020 · World Journal of Gastroenterology
- Tyrosine Kinase Inhibitors in the Treatment of Hepatocellular CarcinomaTiffany Sandra Wai Ling Khoo, Arif Rehman, John Kevin Olynyk · 2019 · Codon Publications eBooks
- Sweroside: unveiling broad therapeutic potential—from mechanistic insights to clinical potentialLiu Peng, Man Zuo, Tian Autumn Qiu, Wenying Lan, Yue Wen, Xiaoqin Ye · 2025 · Frontiers in Pharmacology
- Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stressTongxi Li, Yifan Chen, Peng Tan, Hao Shi, Zhiwei Huang, Tianying Cai, Yonglang Cheng, Yichao Du, Wenguang Fu · 2022 · Bioorganic Chemistry
- Genuine selective caspase-2 inhibition with new irreversible small peptidomimeticsElodie Bosc, Julie Anastasie, Feryel Soualmia, Pascale Coric, Ju Youn Kim, Lily Q. Wang, Gullen Lacin, Kaitao Zhao, Ronak Patel, Eric Duplus et al. · 2022 · Cell Death and Disease
- Longitudinal spatial mapping of lipid metabolites reveals pre-symptomatic changes in the hippocampi of Huntington's disease transgenic miceFarheen Farzana, Malcolm John McConville, Thibault Renoir, Shanshan Li, Shuai Nie, Harvey Tran, Anthony John Hannan, Danny M. Hatters, Berin A. Boughton · 2022 · Neurobiology of Disease
- Targeting endoplasmic reticulum stress—the responder to lipotoxicity and modulator of non-alcoholic fatty liver diseasesYu Luo, Qiangqiang Jiao, Yuping Chen · 2022 · Expert Opinion on Therapeutic Targets
- A mutation in Site‐1 Protease is associated with a complex phenotype that includes episodic hyperCKemia and focal myoedemaGeorge G. Schweitzer, Connie Y. Gan, Robert C. Bucelli, Daniel Wegner, Robert E. Schmidt, Marwan S. Shinawi, Brian N. Finck, Rita T. Brookheart · 2019 · Molecular Genetics & Genomic Medicine
- Mouse Models of Hepatocellular CarcinomaRodrigo Carlessi, Julia Köhn‐Gaone, John Kevin Olynyk, Janina E. E. Tirnitz‐Parker · 2019 · Codon Publications eBooks
- Dysregulation of the AMPK-SREBP1-FASN axis in MASLD: driving a vicious cycle of lipotoxicity and metabolic-immune crosstalkQi-Qi Zhao, Sheng-wen Lu, Yu Guan, Zhi-Wen Sun, Shi Qiu, Ai-Hua Zhang · 2026 · Lipids in Health and Disease
- Effects of the Gut Microbiota and Barrier Function on Melatonin Efficacy in Alleviating Liver InjuryHao Zhang, Xiaoyun Liu, Mabrouk Elsabagh, Ying Zhang, Yi Ma, Yaqian Jin, Mengzhi Wang, Hongrong Wang, Honghua Jiang · 2022 · Antioxidants
- Targeting caspase-2 interactions with tau in Alzheimer's disease and related dementiasSteffen Pockes, Michael A. Walters, Karen H. Ashe · 2022 · Translational research
- Activation of the PERK-CHOP signaling pathway during endoplasmic reticulum stress contributes to olanzapine-induced dyslipidemiaLu Liu, Lei Tang, Jiaming Luo, Siyu Chen, Chun-yan Yi, Xuemei Liu, Changhua Hu · 2023 · Acta Pharmacologica Sinica
- Apoptosis Inhibitor 5: A Multifaceted Regulator of Cell FateHafsia Abbas, Dalia Kheira Derkaoui, Louise Jeammet, Emilie Adicéam, Jérôme Tiollier, Hélène Sicard, Thorsten Braun, Jean‐Luc Poyet · 2024 · Biomolecules
- Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturationWei-Ze Zhu, Ying Hong, Zhao-Wei Tong, Xiaofang He, Yan Li, Hao Wang, Xinxin Gao, Pengtao Song, Xian-Shan Zhang, Xiao-Chang Wu et al. · 2024 · Cell Reports Medicine
- Examining the Pathogenesis of MAFLD and the Medicinal Properties of Natural Products from a Metabolic PerspectiveYansong Fu, Zhipeng Wang, Hong Qin · 2024 · Metabolites
- Pharmacological SERCA activation limits diet-induced steatohepatitis and restores liver metabolic function in miceTomasz K. Bednarski, Mohsin Rahim, Clinton M. Hasenour, Deveena R. Banerjee, Irina A. Trenary, David H. Wasserman, Jamey D. Young · 2024 · Journal of Lipid Research
- Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314Merlin Bresinsky, Jessica M. Strasser, Bernadette Vallaster, Peng Liu, William M. McCue, Jessica L. Fuller, Alexander Hubmann, Gurpreet Singh, Kathryn M. Nelson, Matthew E. Cuellar et al. · 2022 · ACS Pharmacology & Translational Science
- Icaritin, a metabolite of Icarrin, Alleviates non-alcoholic fatty liver disease via inhibition of lipogenesis and ER stressPeng Yu, Zhen Qian, Hongmei Yang, Tianyang Xu, Yulin Dai, Laihui Song, Jinling Liang, Yuying Shi, Zhiguo Zhang, Lijing Li · 2022 · European Journal of Pharmacology
- Non-Alcoholic Fatty Liver Disease: Translating Disease Mechanisms into Therapeutics Using Animal ModelsAmina Basha, Sarah C. May, Ryan M. Anderson, Niharika R. Samala, Raghavendra G. Mirmira · 2023 · International Journal of Molecular Sciences
- The Effect of Cholesterol Efflux on Endothelial Dysfunction Caused by Oxidative StressHua Ye, Qian Liu, Yuanyuan Wang, Ximian Zhen, Nianlong Yan · 2023 · International Journal of Molecular Sciences
- Emerging mechanisms of non-alcoholic steatohepatitis and novel drug therapiesHao CHEN, Yang Zhou, Haiping Hao, Jing XIONG · 2024 · Chinese Journal of Natural Medicines
- Combating oxidative stress in non-alcoholic fatty liver disease: From mechanisms to therapeutic strategiesAmr Ali Mohamed Abdelgawwad El‐Sehrawy, Abdulsalam Najm Mohammed, Jitendra Gupta, Jaafaru Sani Mohammed, R. Roopashree, Aditya Kashyap, J Bethanney Janney, Samir Sahoo, Shaker Al-Hasnaawei, Yassir Mohammed Nasr · 2025 · Pathology - Research and Practice
- Targeting endoplasmic reticulum proteostasis in liver fibrosis: From signaling mechanisms to therapeutic opportunities.Ya-Wei Kong, Zheng-Yang Chen, Zhen-Tian Nie, Wei Chen · 2025 · Pharmacological Research
- The PTP1B selective inhibitor MSI-1436 mitigates Tunicamycin-induced ER stress in human hepatocarcinoma cell line through XBP1 splicing modulationLynda Bourebaba, Sai Santosh Babu Komakula, Christine Weiß, Nabil Adrar, Krzysztof Marycz · 2023 · PLoS ONE
- Caspase-11 contributes to site-1 protease cleavage and SREBP1 activation in the inflammatory response of macrophagesYinglan Cheng, Ichiro Manabe, Sumio Hayakawa, Yusuke Endo, Yumiko Oishi · 2023 · Frontiers in Immunology
- Proteomic profiling in liver cancer: another new pageLo‐Kong Chan, Irene Oi‐Lin Ng · 2019 · Translational Gastroenterology and Hepatology
- Tale of two systems: the intertwining duality of fibrinolysis and lipoprotein metabolismWen Dai, Mark Castleberry, Ze Zheng · 2023 · Journal of Thrombosis and Haemostasis
- Nonalcoholic Fatty Liver Disease and the Intestinal Microbiome: An Inseparable LinkMaria Effenberger, Christoph Grander, Felix Grabherr, Herbert Tilg · 2023 · Journal of Clinical and Translational Hepatology
- The role of extracellular vesicles in non-alcoholic steatohepatitis: Emerging mechanisms, potential therapeutics and biomarkersQianrong Wang, Xiangning Tang, Yu Wang, Dan-Yi Zhang, Xia Li, Shanshan Liu · 2024 · Journal of Advanced Research