Dynamic Human Environmental Exposome Revealed by Longitudinal Personal Monitoring
Open accessAbstract
Human health is dependent upon environmental exposures, yet the diversity and variation in exposures are poorly understood. We developed a sensitive method to monitor personal airborne biological and chemical exposures and followed the personal exposomes of 15 individuals for up to 890 days and over 66 distinct geographical locations. We found that individuals are potentially exposed to thousands of pan-domain species and chemical compounds, including insecticides and carcinogens. Personal biological and chemical exposomes are highly dynamic and vary spatiotemporally, even for individuals located in the same general geographical region. Integrated analysis of biological and chemical exposomes revealed strong location-dependent relationships. Finally, construction of an exposome interaction network demonstrated the presence of distinct yet interconnected human- and environment-centric clouds, comprised of interacting ecosystems such as human, flora, pets, and arthropods. Overall, we demonstrate that human exposomes are diverse, dynamic, spatiotemporally-driven interaction networks with the potential to impact human health.
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The rapid rise in urbanization over the past 200 years brought an unprecedented increase in human exposure to xenobiotics, such as air pollutants, hazardous waste and industrial chemicals that drive SCI.
“The rapid rise in urbanization over the past 200 years8 brought with it an unprecedented increase in humans’ exposure to various xenobiotics, including air pollutants, hazardous waste products and industrial chemicals that promote SCI8,161”
From Chronic inflammation in the etiology of disease across the life span (2019) · cites this paper as [161]
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References 38 · Cited by 218
- Authors
- Jiang, C., Wang, X., Li, X., Inlora, J., Wang, T., Liu, Q., & Snyder, M.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Jiang, Chao
- Wang, Xin
- Snyder, Michael
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 175
- Issue
- 1
- Pages
- 277-291.e31
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC6472932
- OpenAlex
- W2890462141
- Cited by
- 218
- References
- 38
- Citations by year
- 2026: 27 · 2025: 25 · 2024: 25 · 2023: 31 · 2022: 26 · 2021: 29 · 2020: 23 · 2019: 29 · 2018: 1
- FWCI
- 10.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (U54DK102556, P30DK116074)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- environmental exposure, insecticides, carcinogens, spatiotemporal variation, human-nature relationship, PET, arthropods, flora, human health
- MeSH terms
- Adult, Animals, Environmental Exposure, Environmental Monitoring, Humans, Ecosystem, Environmental Illness
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