A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

Jerby-Arnon, Livnat, Shah, Parin, Cuoco, Michael S., Rodman, Christopher, Su, Mei-Ju, Melms, Johannes C., Leeson, Rachel, Kanodia, Abhay +44 more·2018·Cell

Cited by (999)

Items 601–700 of 999

  1. Functional analysis of RPS27 mutations and expression in melanoma
    Alfredo Floristán, Leah J. Morales, Douglas Hanniford, Carlos N. Martinez, Elena Castellano‐Sanz, Igor Dolgalev, Alejandro J. Ulloa-Morales, Eleazar Vega‐Saenz de Miera, Una Moran, Farbod Darvishian et al. · 2019 · Pigment Cell & Melanoma Research
  2. Clinical Implications of Inter- and Intratumor Heterogeneity of Immune Cell Markers in Lung Cancer
    Zhao Wei, Bin Zhu, Amy A Hutchinson, Angela Cecilia Pesatori, Dario Consonni, Neil E. Caporaso, Tongwu Zhang, Difei Wang, Jianxin Shi, Maria Teresa Landi · 2021 · JNCI Journal of the National Cancer Institute
  3. Single-Cell Epigenomics Reveals Mechanisms of Cancer Progression
    Lindsay M. LaFave, Rachel E. Savage, Jason D. Buenrostro · 2022 · Annual Review of Cancer Biology
  4. Inactivation of Hippo pathway characterizes a poor-prognosis subtype of esophageal cancer
    Zihang Mai, Jianye Yuan, Hong Yang, Shuogui Fang, Xiuying Xie, Xinye Wang, Jiaxin Xie, Jing Wen, Jianhua Fu · 2022 · JCI Insight
  5. Insights and Strategies of Melanoma Immunotherapy: Predictive Biomarkers of Response and Resistance and Strategies to Improve Response Rates
    Attila A. Seyhan, Claudio Carini · 2022 · International Journal of Molecular Sciences
  6. Use of 3D Spheroid Models for the Assessment of RT Response in Head and Neck Cancer
    Marilyn Wegge, Rüveyda Dok, Ludwig Jerome Dubois, Sandra Nuyts · 2023 · International Journal of Molecular Sciences
  7. Identification and validation of Birc5 as a novel activated cell cycle program biomarker associated with infiltration of immunosuppressive myeloid‐derived suppressor cells in hepatocellular carcinoma
    Yun Liu, Xi Chen, Wenwu Luo, Yufei Zhao, Björn Nashan, Lei Huang, Xiaodong Yuan · 2023 · Cancer Medicine
  8. A Population of Tumor-Infiltrating CD4+ T Cells Co-Expressing CD38 and CD39 Is Associated with Checkpoint Inhibitor Resistance
    Ankita Mitra, Brian Thompson, Ann Strange, Carol M. Amato, Melinda Vassallo, Igor Dolgalev, Jonathan Hester-McCullough, Tomoaki Muramatsu, Diana A. Kimono, Amrutesh S. Puranik et al. · 2023 · Clinical Cancer Research
  9. FGL2 promotes tumour growth and attenuates infiltration of activated immune cells in melanoma and ovarian cancer models
    Kristianne J. C. Galpin, Galaxia M. Rodriguez, Vincent Maranda, David P. Cook, Elizabeth A Macdonald, Humaira Murshed, Shan Zhao, Curtis W. McCloskey, A. Chruscinski, Gary A Levy et al. · 2024 · Scientific Reports
  10. Single-cell transcriptome sequencing reveals aberrantly activated inter-tumor cell signaling pathways in the development of clear cell renal cell carcinoma
    Junfeng Zhang, Fuzhong Liu, Wenjia Guo, Xing Bi, Shuai Yuan, Fuerhaiti Shayiti, Ting Shuang Pan, Kailing Li, Peng Chen · 2024 · Journal of Translational Medicine
  11. Modulator of TMB-associated immune infiltration (MOTIF) predicts immunotherapy response and guides combination therapy
    Zheng-Yu Qian, Yi‐Qian Pan, Xuexin Li, Yan‐Xing Chen, Hao‐Xiang Wu, Zexian Liu, Martin Košař, Jiří Bártek, Zixian Wang, Rui‐Hua Xu · 2024 · 中国科学通报:英文版
  12. Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
    Shuang Wu, Xiangyu Dai, Yang Xia, Qingsong Zhao, Zhao Heng, Zhimin Shi, Xin Yin, Xue Liu, Aijie Zhang, Zhihui Yao et al. · 2024 · Cell Reports
  13. Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II Activity
    Luiza Martins Nascentes Melo, Marie Sabatier, Vijayashree Ramesh, Krystina J. Szylo, Cameron S. Fraser, Alex Pon, Evann C. Mitchell, Kelly A. Servage, Gabriele Allies, Isa V. Westedt et al. · 2024 · Cancer Research
  14. TBK1 Targeting Is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids
    Yi Sun, Luke Maggs, Apekshya Panda, Samuel J. Wright, Angelina M. Cicerchia, Anne Jenney, Matthew D. Perricone, Caitlin E. Mills, Giulia Cattaneo, Marco Ventin et al. · 2025 · Cancer Immunology Research
  15. DNA Vaccines Targeting Novel Cancer-Associated Antigens Frequently Expressed in Head and Neck Cancer Enhance the Efficacy of Checkpoint Inhibitor
    Chuan Wang, Nur Syafinaz Zainal, San Jiun Chai, James Dickie, Chai Phei Gan, Natasha Zulaziz, Bryan Kit Weng Lye, Ruhcha V. Sutavani, Christian H. H. Ottensmeier, Emma Victoria King et al. · 2021 · Frontiers in Immunology
  16. A TCF4/BRD4-dependent regulatory network confers cross-resistance to targeted and immune checkpoint therapy in melanoma
    Joanna Poźniak, Dennis Pedri, Ewout Landeloos, Yannick Van Herck, Asier Antoranz, Panagiotis Karras, Ada Nowosad, Samira Makhzami, Greet Bervoets, Michael Dewaele et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  17. MCSP+ metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization
    Severin Guetter, Courtney König, Huiqin Koerkel-Qu, Aleksandra Markiewicz, Sebastian Scheitler, Marie Katzer, Mark Berneburg, Philipp Renner, Beatrix Cucuruz, Leonhard Guttenberger et al. · 2025 · Nature Cancer
  18. Lessons from neoadjuvant immunotherapy in melanoma: understanding antitumour immunity and tumour escape
    Francesca Fallarino, Christian U. Blank · 2025 · Nature reviews. Immunology
  19. Single-Cell Sequencing in Cancer: Recent Applications to Immunogenomics and Multi-omics Tools
    Michael C. Sierant, Jungmin Choi · 2018 · Genomics & Informatics
  20. Cell Communication Network factor 4 promotes tumor‐induced immunosuppression in melanoma
    Audry Fernández, Wentao Deng, Sarah L. McLaughlin, Anika Pirkey, Stephanie L. Rellick, Atefeh P. Razazan, David J. Klinke · 2022 · EMBO Reports
  21. Integrating pathway knowledge with deep neural networks to reduce the dimensionality in single-cell RNA-seq data
    Pelin Gundogdu, Carlos Loucera, Inmaculada Álamo-Álvarez, Joaquı́n Dopazo, Isabel Nepomuceno · 2022 · BioData Mining
  22. Tackling tumor complexity with single-cell proteomics
    Tamar Geiger · 2023 · Nature Methods
  23. Tackling of Immunorefractory Tumors by Targeting Alternative Immune Checkpoints
    Dharmindra Dulal, Andrew R. Boring, David Terrero, Tiffany L. Johnson, Amit Kumar Tiwari, Dayanidhi Raman · 2023 · Cancers
  24. Immune Checkpoint Inhibitor Rechallenge in Renal Cell Carcinoma: Current Evidence and Future Directions
    Enrico Sammarco, Fiorella Manfredi, Amedeo Nuzzo, Marco Ferrari, Adele Bonato, Alessia Salfi, Debora Serafin, Luca Zatteri, Andrea Antonuzzo, Luca Galli · 2023 · Cancers
  25. Stromal score is a promising index in tumor patients’ outcome determination
    Xiaoxian Xu, Yu Xu, Wangxiong Hu, Wenjie Hong, Yichen Wang, Xiaojing Zhang, Xiaoji Fan, Tingzhang Wang, Hanmei Lou, Yanmei Yang et al. · 2023 · Heliyon
  26. A Large-Scale Meta-Analysis Reveals Positive Feedback between Macrophages and T Cells That Sensitizes Tumors to Immunotherapy
    Jing Yang, Qi Liu, Yu Shyr · 2023 · Cancer Research
  27. ATF3 characterizes aggressive drug-tolerant persister cells in HGSOC
    Kathrin Böpple, Yaara Oren, Whitney S. Henry, Meng Dong, Sandra Weller, Julia Thiel, Markus Kleih, Andrea Gaißler, Damaris Zipperer, Hans‐Georg Kopp et al. · 2024 · Cell Death and Disease
  28. Efficacy of PARP inhibitor therapy after targeted BRAF/MEK failure in advanced melanoma
    Jordan Phillipps, George Nassief, Renée Morecroft, Tolulope Tosin Adeyelu, Andrew Elliott, Farah Rukhsana Abdulla, Ari M. Vanderwalde, Soohyung Park, Omar Hameed Butt, Alice Yao Zhou et al. · 2024 · npj Precision Oncology
  29. Targeted transcriptional profiling of the tumor microenvironment reveals lymphocyte exclusion and vascular dysfunction in metastatic osteosarcoma
    Laurie Sorenson, Yanfen Fu, Tressa Hood, Sarah E. Warren, Troy A. McEachron · 2019 · OncoImmunology
  30. Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling
    Joseph D. Butner, Geoffrey V. Martin, Zhihui Wang, Bruna Corradetti, Mauro Ferrari B, Nestor Esnaola, Caroline Chung, David S. Hong, James Welsh, Naomi Hasegawa et al. · 2021 · eLife
  31. Targeting cellular senescence to combat cancer and ageing
    Chen Wang, Xue Hao, Rugang Zhang · 2022 · Molecular Oncology
  32. Adoptive Cell Therapy in Pediatric and Young Adult Solid Tumors: Current Status and Future Directions
    John A. Ligon, Kristin M. Wessel, Nirali N. Shah, John W. Glod · 2022 · Frontiers in Immunology
  33. EGFL7 drives the evolution of resistance to EGFR inhibitors in lung cancer by activating NOTCH signaling
    Yubo Wang, Pu Chen, Man Zhao, Hongxin Cao, Yuelei Zhao, Meiju Ji, Peng Hou, Mingwei Chen · 2022 · Cell Death and Disease
  34. ACAP1 Deficiency Predicts Inferior Immunotherapy Response in Solid Tumors
    Qiyi Yi, Youguang Pu, Fengmei Chao, Po Bian, Lei Lv · 2022 · Cancers
  35. CHRNA1 and its correlated-myogenesis/cell cycle genes are prognosis-related markers of metastatic melanoma
    Mohamed Nabil Bakr, Haruko Takahashi, Yutaka Kikuchi · 2023 · Biochemistry and Biophysics Reports
  36. Combination of multiple omics techniques for a personalized therapy or treatment selection
    Chiara Massa, Barbara Seliger · 2023 · Frontiers in Immunology
  37. Cathepsin V is correlated with the prognosis and tumor microenvironment in liver cancer
    Junyu Liu, Wen Zhang, Zhijie Wang, Yichuan Wang, Tianxing Li, Yaping Wang, Jin Ding, Beifang Ning · 2023 · Molecular Carcinogenesis
  38. Persisting cancer cells are different from bacterial persisters
    Morgane Decollogny, Sven Rottenberg · 2024 · Trends in cancer
  39. Myeloid-T cell interplay and cell state transitions associated with checkpoint inhibitor response in melanoma
    Ramona Schlenker, Petra Catalina Schwalie, Steffen Dettling, Tamara Huesser, Anja Irmisch, Marisa Mariani, Julia M. Martínez Gómez, Alison Ribeiro, Florian Limani, Sylvia Herter et al. · 2024 · Med
  40. Single-cell sequencing edges into clinical trials
    Amanda B. Keener · 2019 · Nature Medicine
  41. Co-regulation of the antagonistic RepoMan:Aurora-B pair in proliferating cells
    Maria Giulia Manzione, Jan Rombouts, Mikhail Yu. Steklov, Lorenzo Pasquali, Anna A. Sablina, Lendert Gelens, Junbin Qian, Mathieu Bollen · 2020 · Molecular Biology of the Cell
  42. 2DImpute: imputation in single-cell RNA-seq data from correlations in two dimensions
    Kaiyi Zhu, Dimitris Anastassiou · 2020 · Bioinformatics
  43. https://cdrjournal.com/article/view/3531
    Marco Moreira, Cédric Pobel, Nicolas Epaillard, Audrey Simonaggio, Stéphane Marie. Oudard, Yann Alexandre Vano · 2020 · Cancer Drug Resistance
  44. Testing for Phylogenetic Signal in Single-Cell RNA-Seq Data
    Jiří C. Moravec, Robert Lanfear, David L. Spector, Sarah D. Diermeier, Alex Gavryushkin · 2022 · Journal of Computational Biology
  45. Preclinical models of breast cancer: Two-way shuttles for immune checkpoint inhibitors from and to patient bedside
    Amal Kamal Abdel‐Aziz, Mona Kamal Saadeldin, Paolo D’Amico, Stefania Orecchioni, Francesco Bertolini, Giuseppe Curigliano, Saverio Minucci · 2019 · European Journal of Cancer
  46. Prediction of immunotherapy responsiveness in melanoma through single-cell sequencing-based characterization of the tumor immune microenvironment
    Yucheng Dong, Zhizhuo Chen, Fan Yang, Jiaxin Wei, Jiuzuo Huang, Xiao Long · 2024 · Translational Oncology
  47. inDrops-2: a flexible, versatile and cost-efficient droplet microfluidic approach for high-throughput scRNA-seq of fresh and preserved clinical samples
    Simonas Juzėnas, Karolis Goda, Vaidotas Kiseliovas, Justina Žvirblytė, Àlvaro Quintanal-Villalonga, Juozas Siurkus, Juozas Nainys, Linas Mažutis · 2024 · Nucleic Acids Research
  48. Decoding melanoma’s cellular mosaic to unlock immunotherapy potential
    Joanna Poźniak, Jean‐Christophe Marine · 2025 · Trends in Cell Biology
  49. The regulatory role of CDK4/6 inhibitors in tumor immunity and the potential value of tumor immunotherapy (Review)
    Feifan He, Qiuchen Zhang, Yunjie Chen, Suli Ge, Yu Xie, Ruihong Sun, Yuqing Wu, Jian Xu · 2025 · International Journal of Molecular Medicine
  50. Redirecting the Neo-Substrate Specificity of Cereblon-Targeting PROTACs to Helios
    Alyssa L. Verano, Inchul You, Katherine A. Donovan, Nada Mageed, Hong Yue, Radosław P. Nowak, Eric S. Fischer, Eric S. Wang, Nathanael S. Gray · 2022 · ACS Chemical Biology
  51. Exploration of Tumor Biopsy Gene Signatures to Understand the Role of the Tumor Microenvironment in Outcomes to Lisocabtagene Maraleucel
    N. Eric Olson, Seamus P. Ragan, David J. Reiss, Jerill Thorpe, Yeonhee Kim, Jeremy S. Abramson, Candice McCoy, Kathryn J. Newhall, Brian A. Fox · 2023 · Molecular Cancer Therapeutics
  52. Melanoma-intrinsic NR2F6 activity regulates antitumor immunity
    Hyungsoo Kim, Yong-Mei Feng, Rabi Murad, J. Pozniak, C. Pelz, Yeqing Chen, B. Dalal, R. Sears, E. Sergienko, Michael Jackson et al. · 2022 · bioRxiv
  53. Exploring the Complex and Multifaceted Interplay between Melanoma Cells and the Tumor Microenvironment
    Magdalena Kuras · 2023 · International Journal of Molecular Sciences
  54. Multimodal analysis unveils tumor microenvironment heterogeneity linked to immune activity and evasion
    Óscar Lapuente-Santana, Gregor Sturm, J A Kant, Markus Außerhofer, Constantin Zackl, Maria Zopoglou, Nicholas McGranahan, Dietmar Rieder, Zlatko Trajanoski, Noel F.C.C. de Miranda et al. · 2024 · iScience
  55. An In Vitro Model of Mast Cell Recruitment and Activation by Breast Cancer Cells Supports Anti-Tumoral Responses
    Angélica Aponte-López, Jennifer Enciso, Samira Muñoz-Cruz, Ezequiel M. Fuentes‐Pananá · 2020 · International Journal of Molecular Sciences
  56. UniPath: a uniform approach for pathway and gene-set based analysis of heterogeneity in single-cell epigenome and transcriptome profiles
    Smriti Chawla, Sudhagar Samydurai, Say Li Kong, Zhengwei Wu, Zhenxun Wang, Wai Leong Tam, Debarka Sengupta, Vibhor Kumar · 2020 · Nucleic Acids Research
  57. Nano-STING agonist-decorated microrobots boost innate and adaptive anti-tumor immunity
    Yixin Wang, Zhaoting Li, Yu Chen, Allie Barrett, Fanyi Mo, Quanyin Hu · 2023 · Nano Research
  58. Cellular Senescence and Immunosenescence in Melanoma: Insights From the Tumor Microenvironment
    Lihua Xiong, Jian Cheng · 2025 · Cancer Medicine
  59. In vivo generation of CAR myeloid cells through erythrocyte-mediated mRNA delivery for cancer immunotherapy
    Xiaoqian Nie, Yuehua Liu, Yuting Song, Xingyun Yao, Yulin Chen, Hsiang‐Ying Lee, Xiaofei Gao · 2026 · Science Translational Medicine
  60. Refining the Molecular Framework for Pancreatic Cancer with Single-cell and Spatial Technologies
    Jimmy A. Guo, Hannah I. Hoffman, Colin D. Weekes, Lei Zheng, David Tsai Ting, William L. Hwang · 2021 · Clinical Cancer Research
  61. IRF8 Regulates Intrinsic Ferroptosis through Repressing p53 Expression to Maintain Tumor Cell Sensitivity to Cytotoxic T Lymphocytes
    Dakota B. Poschel, Mercy Kehinde‐Ige, John David Klement, Dafeng Yang, Alyssa D. Merting, Natasha M. Savage, Huidong Shi, Kebin Liu · 2023 · Cells
  62. Proteomic and single-cell landscape reveals novel pathogenic mechanisms of HBV-infected intrahepatic cholangiocarcinoma
    Yifei Shen, Shuaishuai Xu, Chanqi Ye, Qiong Li, Ruyin Chen, Wei Wu, Qi Jiang, Yunlu Jia, Xiaochen Zhang, Longjiang Fan et al. · 2023 · iScience
  63. Targeting Upregulated cIAP2 in SOX10-Deficient Drug Tolerant Melanoma
    McKenna Q. Glasheen, Signe Caksa, Amelia G. Young, Nicole A. Wilski, Connor A. Ott, Inna Chervoneva, Keith T. Flaherty, Meenhard Herlyn, Xiaowei Xu, Andrew E. Aplin et al. · 2023 · Molecular Cancer Therapeutics
  64. Skin in the game: a review of single-cell and spatial transcriptomics in dermatological research
    Samuel Schepps, Jonathan Xu, Henry Y. Yang, Jenna L. Mandel, Jaanvi Mehta, Julianna Tolotta, Nicole Baker, Volkan Tekmen, Neda Nikbakht, Paolo M. Fortina et al. · 2024 · Clinical Chemistry and Laboratory Medicine (CCLM)
  65. Unveiling major histocompatibility complex-mediated pan-cancer immune features by integrated single-cell and bulk RNA sequencing
    Hao-Ran Feng, Xiaonan Shen, Xiaoming Zhu, Wen-Tao Zhong, De-Xiang Zhu, Ji Zhao, Yan-Jie Chen, Feng Shen, Kun Liu, Li Liang · 2024 · Cancer Letters
  66. Perspectives in melanoma: meeting report from the Melanoma Bridge (November 29th–1 December 1st, 2018, Naples, Italy)
    Paolo A. Ascierto, Sanjiv S. Agarwala, Gerardo Botti, Alfredo Budillon, Michael A. Davies, Reinhard Dummer, Marc S. Ernstoff, Soldano Ferrone, Silvia Chiara Formenti, Thomas Frank Gajewski et al. · 2019 · Journal of Translational Medicine
  67. Single-Cell Epigenomics in Cancer: Charting a Course to Clinical Impact
    Danielle R. Bond, Kumar Uddipto, Anoop Kumar Enjeti, Heather J Lee · 2020 · Epigenomics
  68. Single-cell technologies and analyses in hematopoiesis and hematological malignancies
    Ignacio Campillo‐Marcos, Damiana Álvarez‐Errico, Regina Antoni Alandes, Elisabetta Mereu, Manel Esteller · 2021 · Experimental Hematology
  69. High-Dimensional Single-Cell Transcriptomics in Melanoma and Cancer Immunotherapy
    Camelia Y. J. Quek, Xinyu Bai, Georgina Venetia Long, Richard A. Scolyer, James S. Wilmott · 2021 · Genes
  70. PTEN Loss and BRCA1 Promoter Hypermethylation Negatively Predict for Immunogenicity in BRCA-Deficient Ovarian Cancer
    Adam Kraya, Kara N. Maxwell, Monika A. Eiva, Bradley Stephen Wubbenhorst, John B. Pluta, Michael D. Feldman, Anupma Nayak, Daniel J. Powell, Susan M. Domchek, Robert H. Vonderheide et al. · 2022 · JCO Precision Oncology
  71. The SRPK inhibitor N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl) isonicotinamide (SRPIN340) increases the immune response against metastatic melanoma in mice
    Gabriela Alves Moreira, Mônica Maria Magalhães Caetano, Juliana Alves do Vale, Janine Cerqueira de Paiva, Victor Hugo Sousa Gonçalves, Alisson Andrade Almeida, Lucas Viana Gomes Silva, Fernanda Rebellato Giordano Martim, Marcus Vinícius de Andrade Barros, Gabriela Rapozo Guimarães et al. · 2022 · Biochemical Pharmacology
  72. Identification of fatty acid metabolism–related molecular subtype biomarkers and their correlation with immune checkpoints in cutaneous melanoma
    Yujian Xu, Youbai Chen, Weiqian Jiang, Xiangye Yin, Dongsheng Chen, Yuan Chi, Yuting Wang, Julei Zhang, Qixu Zhang, Yan Han · 2022 · Frontiers in Immunology
  73. Tumor-infiltrating immune cell status predicts successful response to immune checkpoint inhibitors in renal cell carcinoma
    Akira Kazama, Vladimir N. Bilim, Masayuki Tasaki, Tsutomu Anraku, Hiroo Kuroki, Yuko Shirono, Masaki Murata, Kaede Hiruma, Yoshihiko Tomita · 2022 · Scientific Reports
  74. Evaluation of single-cell RNAseq labelling algorithms using cancer datasets
    Erik Christensen, Ping Luo, Andrei L. Turinsky, Mia Husić, Alaina Mahalanabis, Alaine Naidas, J. Javier Díaz-Mejía, Michael Brudno, Trevor J. Pugh, Arun K Ramani et al. · 2022 · Briefings in Bioinformatics
  75. Characterization and Optimization of Multiomic Single-Cell Epigenomic Profiling
    Letícia Sandoval, Wazim Mohammed Ismail, Amelia Mazzone, Mihai Gabriel Dumbrava, Jenna A. Fernandez, Amik Munankarmy, Terra L. Lasho, Moritz Binder, Vernadette A. Simon, Kwan‐Hyun Kim et al. · 2023 · Genes
  76. The Ins and Outs of Chemokine-Mediated Immune Cell Trafficking in Skin Cancer
    Andrew On Wah Yam, Tatyana Chtanova · 2019 · Frontiers in Immunology
  77. Breaking barriers for T cells by targeting the EPHA2/TGF-β/COX-2 axis in pancreatic cancer
    Jose Ramon Conejo-Garcia · 2019 · Journal of Clinical Investigation
  78. Understanding genetic determinants of resistance to immune checkpoint blockers
    Sandrine Aspeslagh, Roman M. Chabanon, Stéphane Champiat, Sophie C. Postel-Vinay · 2019 · Seminars in Cancer Biology
  79. Lymphoma Heterogeneity Unraveled by Single-Cell Transcriptomics
    Loïc Ysebaert, Anne Quillet‐Mary, Marie Tosolini, Frédéric Pont, Camille Laurent, Jean‐Jacques Fournié · 2021 · Frontiers in Immunology
  80. Cholinergic T cells revitalize the tumor immune microenvironment: TIME to ChAT
    Chunxing Zheng, Shaofeng Liu, Nastaran Fazel Modares, Michael St. Paul, Tak W. Mak · 2025 · Nature Immunology
  81. Metabolic networks in the tumor microenvironment: roles of amino acid and lipid metabolism pathways in cancer progression and therapy
    Yulseung Sung, Dae Kyoung Kim, Jun Se Kim, Seong-Jang Kim, Jae Ho Kim, Jung Min Han · 2026 · Experimental & Molecular Medicine
  82. CD161, a promising Immune Checkpoint, correlates with Patient Prognosis: A Pan-cancer Analysis
    Wenrui Ye, Cong Luo, Chenglong Li, Zhixiong Liu, Fangkun Liu · 2021 · Journal of Cancer
  83. Upregulation of MTA1 in Colon Cancer Drives A CD8+ T Cell-Rich But Classical Macrophage-Lacking Immunosuppressive Tumor Microenvironment
    Yantong Zhou, Peng Nan, Chunxiao Li, Hongnan Mo, Ying Zhang, Haijuan Wang, Dongkui Xu, Fei Ma, Haili Qian · 2022 · Frontiers in Oncology
  84. STUB1 is an intracellular checkpoint for interferon gamma sensing
    Simon Ng, Shuhui Lim, Adrian Chong Nyi Sim, Ruban Mangadu, Ally Lau, Chunsheng Zhang, Sarah Bollinger Martinez, Arun Chandramohan, U-Ming Lim, Samantha Shu Wen Ho et al. · 2022 · Scientific Reports
  85. The Potent and Paradoxical Biology of Cellular Senescence in Cancer
    Paul Bernard Romesser, Scott W. Lowe · 2023 · Annual Review of Cancer Biology
  86. CD83 expression characterizes precursor exhausted T cell population
    Zhiwen Wu, Toshiaki Yoshikawa, Satoshi Inoue, Yusuke Ito, Hitomi Kasuya, Takahiro Nakashima, Haosong Zhang, Saki Kotaka, Waki Hosoda, Shiro Suzuki et al. · 2023 · Communications Biology
  87. Enhanced systemic tumor suppression by in situ vaccine combining radiation and OX40 agonist with CpG therapy
    Zhichen Sun, Yanhong Chu, Jie Xiao, Yueling Yang, Fanyan Meng, Xinyue Wang, Yanbing Dong, Junmeng Zhu, Yirong Wu, Lanqun Qin et al. · 2023 · Journal of Translational Medicine
  88. Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
    Alexa Christine Cannon, Konstantin Budagyan, Cristina Uribe‐Alvarez, Alison Kurimchak, Daniela Araiza‐Olivera, Kathy Qi Cai, Suraj Peri, Yan Zhou, James S. Duncan, Jonathan Chernoff · 2024 · Oncogene
  89. B7-H3 is associated with the armored-cold phenotype and predicts poor immune checkpoint blockade response in melanoma
    Bozhi Shen, Jie Mei, Rui Xu, Yun Cai, Mengyun Wan, Ji Zhou, Junli Ding, Yichao Zhu · 2024 · Pathology - Research and Practice
  90. IFN-α/β/IFN-γ/IL-15 pathways identify GBP1-expressing tumors with an immune-responsive phenotype
    Lei Wang, Yuxuan Wei, Zheng Jin, Fangfang Liu, Xuchang Li, Xiao Zhang, Xiumei Bai, Qingzhu Jia, Bo Zhu, Qian Chu · 2024 · Clinical and Experimental Medicine
  91. Crosslinking of Ly6a metabolically reprograms CD8 T cells for cancer immunotherapy
    Avishai Maliah, Nadine Santana-Magal, Shivang Parikh, Sagi Gordon, Keren Reshef, Yuval Sade, Aseel Khateeb, Alon Richter, Amit Gutwillig, Roma Parikh et al. · 2024 · Nature Communications
  92. Arsenic trioxide (ATO) induced degradation of Cyclin D1 sensitized PD-1/PD-L1 checkpoint inhibitor in oral and esophageal squamous cell carcinoma
    Guanxia Zhu, Xia Li, Jiong Li, Wei Zhou, Zhongjian Chen, Yun Fan, Youhua Jiang, Yue Zhao, Guogui Sun, Weimin Mao · 2020 · Journal of Cancer
  93. Anti-cancer therapy with cyclin-dependent kinase inhibitors: impact and challenges
    Marika Reinius, Elizabeth Catherine Smyth · 2021 · Expert Reviews in Molecular Medicine
  94. Modulation of Type I Interferon Responses to Influence Tumor-Immune Cross Talk in PDAC
    Carlotta Cattolico, Peter Bailey, Simon T. Barry · 2022 · Frontiers in Cell and Developmental Biology
  95. Pharmacological intervention of cholesterol sulfate-mediated T cell exclusion promotes antitumor immunity
    Takaaki Tatsuguchi, Takehito Uruno, Yuki Sugiura, Kounosuke Oisaki, Daisuke Takaya, Daiji Sakata, Yoshihiro Izumi, Takaya Togo, Yuko Hattori, Kazufumi Kunimura et al. · 2022 · Biochemical and Biophysical Research Communications
  96. Solving the puzzle of what makes immunotherapies work
    Xiaoxiao Ma, Timothy An-thy Chan · 2022 · Trends in cancer
  97. JAML immunotherapy targets recently activated tumor-infiltrating CD8+ T cells
    S. Eschweiler, A. Wang, C. Ramírez-Suástegui, A. von Witzleben, Yingcong Li, Serena J. Chee, Hayley Simon, M. Mondal, M. Ellis, G. Thomas et al. · 2023 · Cell Reports
  98. spongEffects: ceRNA modules offer patient-specific insights into the miRNA regulatory landscape
    Fabio Boniolo, Markus Hoffmann, Norman Roggendorf, Bahar Tercan, Jan Baumbach, Mauro A. A. Castro, A Gordon Robertson, Dieter Saur, Markus List · 2023 · Bioinformatics
  99. HLA Class II Loss and JAK1/2 Deficiency Coevolve in Melanoma Leading to CD4 T-cell and IFNγ Cross-Resistance
    Simone Stupia, Christina Heeke, Alicia Brüggemann, Anne Zaremba, Beatrice Thier, Julia Kretz, Antje Sucker, Manuel Philip, Gennadiy Zelinskyy, Soldano Ferrone et al. · 2023 · Clinical Cancer Research
  100. The Sophisticated Transcriptional Response Governed by Transposable Elements in Human Health and Disease
    Federica Marasca, Erica Gasparotto, Benedetto Polimeni, Rebecca Vadalà, Valeria Ranzani, Beatrice Bodega · 2020 · International Journal of Molecular Sciences