Cited by 628Yeasts and Rust Fungi StudiesFungal and yeast genetics researchGenomics and Phylogenetic Studies

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Tempo and Mode of Genome Evolution in the Budding Yeast Subphylum

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Shen, Xing-Xing, Opulente, Dana A., Kominek, Jacek, Zhou, Xiaofan, Steenwyk, Jacob L., Buh, Kelly V., Haase, Max A.B., Wisecaver, Jennifer H., Wang, Mingshuang, Doering, Drew T., Boudouris, James T., Schneider, Rachel M., Langdon, Quinn K., Ohkuma, Moriya, Endoh, Rikiya, Takashima, Masako, Manabe, Ri-ichiroh, Čadež, Neža, Libkind, Diego, Rosa, Carlos A., DeVirgilio, Jeremy, Hulfachor, Amanda Beth, Groenewald, Marizeth, Kurtzman, Cletus P., Hittinger, Chris Todd, Rokas, Antonis·2018·Cell

DOI 10.1016/j.cell.2018.10.023PMC PMC6291210

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Abstract

Budding yeasts (subphylum Saccharomycotina) are found in every biome and are as genetically diverse as plants or animals. To understand budding yeast evolution, we analyzed the genomes of 332 yeast species, including 220 newly sequenced ones, which represent nearly one-third of all known budding yeast diversity. Here, we establish a robust genus-level phylogeny comprising 12 major clades, infer the timescale of diversification from the Devonian period to the present, quantify horizontal gene transfer (HGT), and reconstruct the evolution of 45 metabolic traits and the metabolic toolkit of the budding yeast common ancestor (BYCA). We infer that BYCA was metabolically complex and chronicle the tempo and mode of genomic and phenotypic evolution across the subphylum, which is characterized by very low HGT levels and widespread losses of traits and the genes that control them. More generally, our results argue that reductive evolution is a major mode of evolutionary diversification.

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Additional file 11 of Sex without crossing over in the yeast Saccharomycodes ludwigii
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Additional file 1 of Divergent patterns of selection on metabolite levels and gene expression
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Additional file 5 of Divergent patterns of selection on metabolite levels and gene expression
Kern, A., Yang, G. X., Khosla, N. M., Ang, R. M. L., Snyder, M. P., & Fraser, H. B. (2021) · Figshare · doi:10.6084/m9.figshare.16702996
Additional file 1 of CAZyme prediction in ascomycetous yeast genomes guides discovery of novel xylanolytic species with diverse capacities for hemicellulose hydrolysis
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Additional file 1 of Proteogenomics analysis of CUG codon translation in the human pathogen Candida albicans
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Additional file 6 of Sex without crossing over in the yeast Saccharomycodes ludwigii
Papaioannou, I. A., Dutreux, F., Peltier, F. A., Maekawa, H., Delhomme, N., Bardhan, A., Friedrich, A., Schacherer, J., & Knop, M. (2021) · Figshare · doi:10.6084/m9.figshare.16928306
Additional file 1 of Sex without crossing over in the yeast Saccharomycodes ludwigii
Papaioannou, I. A., Dutreux, F., Peltier, F. A., Maekawa, H., Delhomme, N., Bardhan, A., Friedrich, A., Schacherer, J., & Knop, M. (2021) · Figshare · doi:10.6084/m9.figshare.16928288
Additional file 3 of CAZyme prediction in ascomycetous yeast genomes guides discovery of novel xylanolytic species with diverse capacities for hemicellulose hydrolysis
Ravn, J. L., Engqvist, M. K. M., Larsbrink, J., & Geijer, C. (2021) · Figshare · doi:10.6084/m9.figshare.14903954
Additional file 5 of Proteogenomics analysis of CUG codon translation in the human pathogen Candida albicans
Mühlhausen, S., Schmitt, H. D., Plessmann, U., Mienkus, P., Sternisek, P., Perl, T., Weig, M., Urlaub, H., Bader, O., & Kollmar, M. (2021) · Figshare · doi:10.6084/m9.figshare.17125700
Additional file 6 of Oxygenation influences xylose fermentation and gene expression in the yeast genera Spathaspora and Scheffersomyces
Barros, K. O., Mader, M., Krause, D. J., Pangilinan, J. L., Andreopoulos, B., Lipzen, A., Mondo, S. J., Grigoriev, I. V., Rosa, C. A., Sato, T. K., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26677883
Self-citation
Additional file 5 of Oxygenation influences xylose fermentation and gene expression in the yeast genera Spathaspora and Scheffersomyces
Barros, K. O., Mader, M., Krause, D. J., Pangilinan, J. L., Andreopoulos, B., Lipzen, A., Mondo, S. J., Grigoriev, I. V., Rosa, C. A., Sato, T. K., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26677880
Self-citation
Additional file 2 of A novel aminotransferase gene and its regulator acquired in Saccharomyces by a horizontal gene transfer event
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Additional file 11 of A novel aminotransferase gene and its regulator acquired in Saccharomyces by a horizontal gene transfer event
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Additional file 7 of Extensive remodeling of sugar metabolism through gene loss and horizontal gene transfer in a eukaryotic lineage
Pontes, A., Paraíso, F., Silva, M., Lagoas, C., Aires, A., Brito, P. H., Rosa, C. A., Lachance, M.-A., Sampaio, J. P., Gonçalves, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26727853
Self-citation
Additional file 4 of Divergent patterns of selection on metabolite levels and gene expression
Kern, A., Yang, G. X., Khosla, N. M., Ang, R. M. L., Snyder, M. P., & Fraser, H. B. (2021) · Figshare · doi:10.6084/m9.figshare.16702993
Additional file 2 of CAZyme prediction in ascomycetous yeast genomes guides discovery of novel xylanolytic species with diverse capacities for hemicellulose hydrolysis
Ravn, J. L., Engqvist, M. K. M., Larsbrink, J., & Geijer, C. (2021) · Figshare · doi:10.6084/m9.figshare.14903951
Additional file 3 of Extensive remodeling of sugar metabolism through gene loss and horizontal gene transfer in a eukaryotic lineage
Pontes, A., Paraíso, F., Silva, M., Lagoas, C., Aires, A., Brito, P. H., Rosa, C. A., Lachance, M.-A., Sampaio, J. P., Gonçalves, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26727841
Self-citation
Additional file 4 of A novel aminotransferase gene and its regulator acquired in Saccharomyces by a horizontal gene transfer event
Tapia, S. M., Macías, L. G., Pérez‐Torrado, R., Daroqui, N., Manzanares, P., Querol, A., & Barrio, E. (2024) · Figshare · doi:10.6084/m9.figshare.26587962
Additional file 1 of A systematic screen for co-option of transposable elements across the fungal kingdom
Oggenfuss, U., Badet, T., & Croll, D. (2024) · Figshare · doi:10.6084/m9.figshare.26670309
Additional file 3 of Oxygenation influences xylose fermentation and gene expression in the yeast genera Spathaspora and Scheffersomyces
Barros, K. O., Mader, M., Krause, D. J., Pangilinan, J. L., Andreopoulos, B., Lipzen, A., Mondo, S. J., Grigoriev, I. V., Rosa, C. A., Sato, T. K., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26677874
Self-citation
Additional file 13 of A novel aminotransferase gene and its regulator acquired in Saccharomyces by a horizontal gene transfer event
Tapia, S. M., Macías, L. G., Pérez‐Torrado, R., Daroqui, N., Manzanares, P., Querol, A., & Barrio, E. (2024) · Figshare · doi:10.6084/m9.figshare.26587989
Additional file 8 of Extensive remodeling of sugar metabolism through gene loss and horizontal gene transfer in a eukaryotic lineage
Pontes, A., Paraíso, F., Silva, M., Lagoas, C., Aires, A., Brito, P. H., Rosa, C. A., Lachance, M.-A., Sampaio, J. P., Gonçalves, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26727856
Self-citation
Additional file 9 of Sex without crossing over in the yeast Saccharomycodes ludwigii
Papaioannou, I. A., Dutreux, F., Peltier, F. A., Maekawa, H., Delhomme, N., Bardhan, A., Friedrich, A., Schacherer, J., & Knop, M. (2021) · Figshare · doi:10.6084/m9.figshare.16928318
Additional file 10 of Extensive remodeling of sugar metabolism through gene loss and horizontal gene transfer in a eukaryotic lineage
Pontes, A., Paraíso, F., Silva, M., Lagoas, C., Aires, A., Brito, P. H., Rosa, C. A., Lachance, M.-A., Sampaio, J. P., Gonçalves, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26727862
Self-citation
Additional file 3 of Proteogenomics analysis of CUG codon translation in the human pathogen Candida albicans
Mühlhausen, S., Schmitt, H. D., Plessmann, U., Mienkus, P., Sternisek, P., Perl, T., Weig, M., Urlaub, H., Bader, O., & Kollmar, M. (2021) · Figshare · doi:10.6084/m9.figshare.17125691
Additional file 8 of A novel aminotransferase gene and its regulator acquired in Saccharomyces by a horizontal gene transfer event
Tapia, S. M., Macías, L. G., Pérez‐Torrado, R., Daroqui, N., Manzanares, P., Querol, A., & Barrio, E. (2024) · Figshare · doi:10.6084/m9.figshare.26587974
Additional file 2 of Extensive remodeling of sugar metabolism through gene loss and horizontal gene transfer in a eukaryotic lineage
Pontes, A., Paraíso, F., Silva, M., Lagoas, C., Aires, A., Brito, P. H., Rosa, C. A., Lachance, M.-A., Sampaio, J. P., Gonçalves, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25940247
Self-citation
Additional file 7 of Translational landscape and protein biogenesis demands of the early secretory pathway in Komagataella phaffii
Alva, T. R., Riera, M., & Chartron, J. W. (2021) · Figshare · doi:10.6084/m9.figshare.13620095
Additional file 2 of Sex without crossing over in the yeast Saccharomycodes ludwigii
Papaioannou, I. A., Dutreux, F., Peltier, F. A., Maekawa, H., Delhomme, N., Bardhan, A., Friedrich, A., Schacherer, J., & Knop, M. (2021) · Figshare · doi:10.6084/m9.figshare.16928291
Additional file 12 of A novel aminotransferase gene and its regulator acquired in Saccharomyces by a horizontal gene transfer event
Tapia, S. M., Macías, L. G., Pérez‐Torrado, R., Daroqui, N., Manzanares, P., Querol, A., & Barrio, E. (2024) · Figshare · doi:10.6084/m9.figshare.26587986
Additional file 9 of Extensive remodeling of sugar metabolism through gene loss and horizontal gene transfer in a eukaryotic lineage
Pontes, A., Paraíso, F., Silva, M., Lagoas, C., Aires, A., Brito, P. H., Rosa, C. A., Lachance, M.-A., Sampaio, J. P., Gonçalves, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26727859
Self-citation
Additional file 3 of A systematic screen for co-option of transposable elements across the fungal kingdom
Oggenfuss, U., Badet, T., & Croll, D. (2024) · Figshare · doi:10.6084/m9.figshare.26670315
Additional file 1 of A novel aminotransferase gene and its regulator acquired in Saccharomyces by a horizontal gene transfer event
Tapia, S. M., Macías, L. G., Pérez‐Torrado, R., Daroqui, N., Manzanares, P., Querol, A., & Barrio, E. (2024) · Figshare · doi:10.6084/m9.figshare.26587953
Additional file 1 of Translational landscape and protein biogenesis demands of the early secretory pathway in Komagataella phaffii
Alva, T. R., Riera, M., & Chartron, J. W. (2021) · Figshare · doi:10.6084/m9.figshare.13620077
Additional file 1 of Extensive remodeling of sugar metabolism through gene loss and horizontal gene transfer in a eukaryotic lineage
Pontes, A., Paraíso, F., Silva, M., Lagoas, C., Aires, A., Brito, P. H., Rosa, C. A., Lachance, M.-A., Sampaio, J. P., Gonçalves, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25939962
Self-citation
Additional file 5 of A novel aminotransferase gene and its regulator acquired in Saccharomyces by a horizontal gene transfer event
Tapia, S. M., Macías, L. G., Pérez‐Torrado, R., Daroqui, N., Manzanares, P., Querol, A., & Barrio, E. (2024) · Figshare · doi:10.6084/m9.figshare.26587965
Additional file 8 of Sex without crossing over in the yeast Saccharomycodes ludwigii
Papaioannou, I. A., Dutreux, F., Peltier, F. A., Maekawa, H., Delhomme, N., Bardhan, A., Friedrich, A., Schacherer, J., & Knop, M. (2021) · Figshare · doi:10.6084/m9.figshare.16928315
Additional file 9 of A novel aminotransferase gene and its regulator acquired in Saccharomyces by a horizontal gene transfer event
Tapia, S. M., Macías, L. G., Pérez‐Torrado, R., Daroqui, N., Manzanares, P., Querol, A., & Barrio, E. (2024) · Figshare · doi:10.6084/m9.figshare.26587977
Additional file 3 of Divergent patterns of selection on metabolite levels and gene expression
Kern, A., Yang, G. X., Khosla, N. M., Ang, R. M. L., Snyder, M. P., & Fraser, H. B. (2021) · Figshare · doi:10.6084/m9.figshare.16702987
Additional file 10 of Sex without crossing over in the yeast Saccharomycodes ludwigii
Papaioannou, I. A., Dutreux, F., Peltier, F. A., Maekawa, H., Delhomme, N., Bardhan, A., Friedrich, A., Schacherer, J., & Knop, M. (2021) · Figshare · doi:10.6084/m9.figshare.16928282
Additional file 4 of Oxygenation influences xylose fermentation and gene expression in the yeast genera Spathaspora and Scheffersomyces
Barros, K. O., Mader, M., Krause, D. J., Pangilinan, J. L., Andreopoulos, B., Lipzen, A., Mondo, S. J., Grigoriev, I. V., Rosa, C. A., Sato, T. K., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26677877
Self-citation
Additional file 6 of A novel aminotransferase gene and its regulator acquired in Saccharomyces by a horizontal gene transfer event
Tapia, S. M., Macías, L. G., Pérez‐Torrado, R., Daroqui, N., Manzanares, P., Querol, A., & Barrio, E. (2024) · Figshare · doi:10.6084/m9.figshare.26587968
Additional file 2 of A systematic screen for co-option of transposable elements across the fungal kingdom
Oggenfuss, U., Badet, T., & Croll, D. (2024) · Figshare · doi:10.6084/m9.figshare.26670312
Additional file 1 of Utilization of lignocellulosic biofuel conversion residue by diverse microorganisms
Wadler, C. S., Wolters, J. F., Fortney, N. W., Throckmorton, K., Zhang, Y., Miller, C. R., Schneider, R. M., Wendt-Pienkowski, E., Currie, C. R., Donohue, T. J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20156792
Self-citation
Additional file 10 of A novel aminotransferase gene and its regulator acquired in Saccharomyces by a horizontal gene transfer event
Tapia, S. M., Macías, L. G., Pérez‐Torrado, R., Daroqui, N., Manzanares, P., Querol, A., & Barrio, E. (2024) · Figshare · doi:10.6084/m9.figshare.26587980
Additional file 2 of Divergent patterns of selection on metabolite levels and gene expression
Kern, A., Yang, G. X., Khosla, N. M., Ang, R. M. L., Snyder, M. P., & Fraser, H. B. (2021) · Figshare · doi:10.6084/m9.figshare.16702984
Additional file 4 of Extensive remodeling of sugar metabolism through gene loss and horizontal gene transfer in a eukaryotic lineage
Pontes, A., Paraíso, F., Silva, M., Lagoas, C., Aires, A., Brito, P. H., Rosa, C. A., Lachance, M.-A., Sampaio, J. P., Gonçalves, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26727844
Self-citation
Additional file 7 of Sex without crossing over in the yeast Saccharomycodes ludwigii
Papaioannou, I. A., Dutreux, F., Peltier, F. A., Maekawa, H., Delhomme, N., Bardhan, A., Friedrich, A., Schacherer, J., & Knop, M. (2021) · Figshare · doi:10.6084/m9.figshare.16928309
Additional file 6 of Translational landscape and protein biogenesis demands of the early secretory pathway in Komagataella phaffii
Alva, T. R., Riera, M., & Chartron, J. W. (2021) · Figshare · doi:10.6084/m9.figshare.13620092
Additional file 1 of Oxygenation influences xylose fermentation and gene expression in the yeast genera Spathaspora and Scheffersomyces
Barros, K. O., Mader, M., Krause, D. J., Pangilinan, J. L., Andreopoulos, B., Lipzen, A., Mondo, S. J., Grigoriev, I. V., Rosa, C. A., Sato, T. K., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25157430
Self-citation
Additional file 3 of Sex without crossing over in the yeast Saccharomycodes ludwigii
Papaioannou, I. A., Dutreux, F., Peltier, F. A., Maekawa, H., Delhomme, N., Bardhan, A., Friedrich, A., Schacherer, J., & Knop, M. (2021) · Figshare · doi:10.6084/m9.figshare.16928297
Additional file 7 of A novel aminotransferase gene and its regulator acquired in Saccharomyces by a horizontal gene transfer event
Tapia, S. M., Macías, L. G., Pérez‐Torrado, R., Daroqui, N., Manzanares, P., Querol, A., & Barrio, E. (2024) · Figshare · doi:10.6084/m9.figshare.26587971
Additional file 3 of A novel aminotransferase gene and its regulator acquired in Saccharomyces by a horizontal gene transfer event
Tapia, S. M., Macías, L. G., Pérez‐Torrado, R., Daroqui, N., Manzanares, P., Querol, A., & Barrio, E. (2024) · Figshare · doi:10.6084/m9.figshare.26587959
Additional file 5 of Sex without crossing over in the yeast Saccharomycodes ludwigii
Papaioannou, I. A., Dutreux, F., Peltier, F. A., Maekawa, H., Delhomme, N., Bardhan, A., Friedrich, A., Schacherer, J., & Knop, M. (2021) · Figshare · doi:10.6084/m9.figshare.16928303
Additional file 4 of Sex without crossing over in the yeast Saccharomycodes ludwigii
Papaioannou, I. A., Dutreux, F., Peltier, F. A., Maekawa, H., Delhomme, N., Bardhan, A., Friedrich, A., Schacherer, J., & Knop, M. (2021) · Figshare · doi:10.6084/m9.figshare.16928300
Additional file 5 of Extensive remodeling of sugar metabolism through gene loss and horizontal gene transfer in a eukaryotic lineage
Pontes, A., Paraíso, F., Silva, M., Lagoas, C., Aires, A., Brito, P. H., Rosa, C. A., Lachance, M.-A., Sampaio, J. P., Gonçalves, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26727847
Self-citation
Additional file 11 of Extensive remodeling of sugar metabolism through gene loss and horizontal gene transfer in a eukaryotic lineage
Pontes, A., Paraíso, F., Silva, M., Lagoas, C., Aires, A., Brito, P. H., Rosa, C. A., Lachance, M.-A., Sampaio, J. P., Gonçalves, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26727865
Self-citation
Additional file 1 of Genotypic and phenotypic diversity among Komagataella species reveals a hidden pathway for xylose utilization
Heistinger, L., Dohm, J. C., Paes, B. G., Koizar, D., Troyer, C., Ata, Ö., Mairinger, T., & Mattanovich, D. (2022) · Figshare · doi:10.6084/m9.figshare.19654453
Additional file 2 of Oxygenation influences xylose fermentation and gene expression in the yeast genera Spathaspora and Scheffersomyces
Barros, K. O., Mader, M., Krause, D. J., Pangilinan, J. L., Andreopoulos, B., Lipzen, A., Mondo, S. J., Grigoriev, I. V., Rosa, C. A., Sato, T. K., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25157829
Self-citation
Additional file 6 of Extensive remodeling of sugar metabolism through gene loss and horizontal gene transfer in a eukaryotic lineage
Pontes, A., Paraíso, F., Silva, M., Lagoas, C., Aires, A., Brito, P. H., Rosa, C. A., Lachance, M.-A., Sampaio, J. P., Gonçalves, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26727850
Self-citation
An outlaw yeast thrives with genetic chaos – and could provide clues for understanding cancer growth
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Wang, G., Yan, P., Zheng, B., Zeng, Q., Xing, Q., Hu, J., & Wang, M. (2026) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2026.105575
Self-citation

Authors: Shen, X.-X., Opulente, D. A., Kominek, J., Zhou, X., Steenwyk, J. L., Buh, K. V., Haase, M. A. B., Wisecaver, J. H., Wang, M., Doering, D. T., Boudouris, J. T., Schneider, R. M., Langdon, Q. K., Ohkuma, M., Endoh, R., Takashima, M., Manabe, R.-I., Čadež, N., Libkind, D., Rosa, C. A., DeVirgilio, J., Hulfachor, A. B., Groenewald, M., Kurtzman, C. P., Hittinger, C. T., & Rokas, A.
Affiliations: Vanderbilt University (US)
University of Wisconsin–Madison (US)
South China Agricultural University (CN)
RIKEN BioResource Research Center (JP)
RIKEN Center for Integrative Medical Sciences (JP)
University of Ljubljana (SI)
Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
Universidade Federal de Minas Gerais (BR)
Agricultural Research Service (US)
Westerdijk Fungal Biodiversity Institute (NL)
Corresponding author: Hittinger, Chris Todd
Rokas, Antonis
ORCID: Shen, Xing-Xing
Opulente, Dana A.
Kominek, Jacek
Zhou, Xiaofan
Steenwyk, Jacob L.
Haase, Max A.B.
Wisecaver, Jennifer H.
Wang, Mingshuang
Doering, Drew T.
Langdon, Quinn K.
Ohkuma, Moriya
Takashima, Masako
Manabe, Ri-ichiroh
Čadež, Neža
Libkind, Diego
Rosa, Carlos A.
DeVirgilio, Jeremy
Hulfachor, Amanda Beth
Groenewald, Marizeth
Kurtzman, Cletus P.
Hittinger, Chris Todd
Rokas, Antonis
Venue: Cell
Publisher: Elsevier BV
Published: 2018-11
Volume: 175
Issue: 6
Pages: 1533-1545.e20
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2018.10.023
PMC: PMC6291210
OpenAlex: W2899763402
Cited by: 619
References: 112
Citations by year: 2026: 56 · 2025: 72 · 2024: 109 · 2023: 83 · 2022: 70 · 2021: 116 · 2020: 68 · 2019: 43 · 2018: 1
FWCI: 20.28
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 393 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion, other-oa)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
PubMed Central (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
Funders: National Science Foundation (DEB-1442113, DEB-1442148, IOS-1401682, DGE-1256259)
DOE Great Lakes Bioenergy Research Center (DE-FC02-07ER64494, DE-SC0018409)
Pew Charitable Trusts
Vilas Trust Estate
Guggenheim
Vanderbilt
National Key Project for Basic Research of China (2015CB150600)
NHGRI (5T32HG002760)
NIH (5T32GM007133)
CONICET (PIP 392)
FONCyT (PICT 2542)
Universidad Nacional del Comahue (B199)
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Fundação de Amparo a Pesquisa do Estado de Minas Gerais
Topics: Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords: Saccharomyces cerevisiae, Saccharomycotina, genome evolution, phylogeny, horizontal gene transfer, metabolic phenotypes, common ancestor, reductive evolution, gene loss
MeSH terms: Saccharomycetales, Phylogeny, Genome, Fungal, Evolution, Molecular, Gene Transfer, Horizontal

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