Differences in Tumor Microenvironment Dictate T Helper Lineage Polarization and Response to Immune Checkpoint Therapy

Jiao, Shiping; Subudhi, Sumit K.; Aparicio, Ana; Ge, Zhongqi; Guan, Baoxiang; Miura, Yuji; Sharma, Padmanee

doi:10.1016/j.cell.2019.10.029

Differences in Tumor Microenvironment Dictate T Helper Lineage Polarization and Response to Immune Checkpoint Therapy

Immune checkpoint therapy (ICT) shows encouraging results in a subset of patients with metastatic castration-resistant prostate cancer (mCRPC) but still elicits a sub-optimal response among those with bone metastases. Analysis of patients' bone marrow samples revealed increased Th17 instead of Th…