Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition

Pasciuto, Emanuela, Burton, Oliver T., Roca, Carlos P., Lagou, Vasiliki, Rajan, Wenson D., Theys, Tom, Mancuso, Renzo, Tito, Raul Y., Kouser, Lubna, Callaerts-Vegh, Zsuzsanna, de la Fuente, Alerie G., Prezzemolo, Teresa, Mascali, Loriana G., Brajic, Aleksandra, Whyte, Carly E., Yshii, Lidia, Martinez-Muriana, Anna, Naughton, Michelle, Young, Andrew, Moudra, Alena, Lemaitre, Pierre, Poovathingal, Suresh, Raes, Jeroen, De Strooper, Bart, Fitzgerald, Denise C., Dooley, James, Liston, Adrian·2020·Cell
DOI 10.1016/j.cell.2020.06.026

Cited by (371)

Items 301–371 of 371

  1. Brain-Resident CD8 + T Cells Regulate Neuronal Activity and Behavior via Interferon-Gamma
    Kyungsoo Park, Juneil Jang, Shin Jeon, Sunsook Hwang, Kyuhyun Choi, timothy cox, Shin Foong Ngiow, julia flores, Camille F. Harrison, Shuaitong Liu et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  2. p38α-MAPK-deficient myeloid cells ameliorate symptoms and pathology of APP-transgenic AD mice
    Qinghua Luo, Laura Schnöder, Wenlin Hao, Kathrin Litzenburger, Yann Decker, Inge Tomic, Michael Dieter Menger, Klaus C Fassbender, Yang Liu · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  3. Des lymphocytes dans le cerveau sain
    Noëlle Guillon · 2020 · Pour la Science
  4. Faculty Opinions recommendation of AutoSpill is a principled framework that simplifies the analysis of multichromatic flow cytometry data.
    Howard A. Young · 2021 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  5. Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection
    Chase E Hawes, Sonny R. Elizaldi, Danielle Beckman, Giovanne Baroni Diniz, Yashavanth Shaan Lakshmanappa, Sean P. Ott, Blythe P Durbin-Johnson, Ashok Reddy Dinasarapu, Andrea L. Gompers, John H. Morrison et al. · 2022 · Research Square
  6. Lymphocyte deficiency alters the transcriptomes of oligodendrocytes, but not astrocytes or microglia
    Mitchell C. Krawczyk, Lin Pan, Alice J Zhang, Ye Zhang · 2023 · PLoS ONE
  7. Perkembangan Otak dan Fungsi Kognitif Anak: Peran Nutrisi dan Sistem Imun pada Awal Kehidupan
    Rahmi Novita Yusuf, Helmi Helmi · 2022 · Bioscientist Jurnal Ilmiah Biologi
  8. Immunotherapy
    Cai Zhang · 2023 · Research Publications (Maastricht University)
  9. Microbiota influence brain systems—Work in animal models
    Jane Allyson Foster, Gerard A. Clarke · 2024 · Elsevier eBooks
  10. Neonatal meningitis induces ADHD-like behaviors via modulation of dopaminergic inputs by macrophages
    Shogo Tanabe, Rieko Muramatsu · 2024 · Research Square
  11. Additional file 3 of Identification of mitochondrial related signature associated with immune microenvironment in Alzheimer’s disease
    Yaodan Zhang, Yuyang Miao, Jin Tan, Fanglian Chen, Ping Lei, Qiang Zhang · 2023 · Figshare
  12. Additional file 7 of Identification of mitochondrial related signature associated with immune microenvironment in Alzheimer’s disease
    Yaodan Zhang, Yuyang Miao, Jin Tan, Fanglian Chen, Ping Lei, Qiang Zhang · 2023 · Figshare
  13. Additional file 4 of Identification of mitochondrial related signature associated with immune microenvironment in Alzheimer’s disease
    Yaodan Zhang, Yuyang Miao, Jin Tan, Fanglian Chen, Ping Lei, Qiang Zhang · 2023 · Figshare
  14. The Impact of Juvenile Microglia Transcriptomics on the Adult Brain Regeneration after Cerebral Ischemia.
    Flavia Semida Ghinea, Marius Viorel Ionică, Ilona Mihaela Liliac, Simion Pătru, Denissa Greta Olaru, Aurel Popa‐Wagner · 2024 · PubMed Central
  15. Microglia aging in the hippocampus advances through intermediate states that drive inflammatory activation and cognitive decline
    Jeremy M. Shea, Saul Villeda · 2024 · eLife
  16. Cerebrospinal Fluid and Plasma Metabolites with Parkinson’s Disease: A Mendelian Randomization Study
    Jia-Li Wang, Ran Zheng, Yi Fang, Jin Cao, Baorong Zhang · 2024 · medRxiv
  17. Role of Regulatory Immune Cells in Psychiatric Disorders
    Simge Seren Kirlioglu Balcioglu, Yasin Hasan Balcıoğlu · 2024 · Integrated science
  18. Cognitive and anti-inflammatory effects of Palmaria palmata in a schizophrenia mouse model: insights into CREB signaling, Iba-1 expression, and CD4+ cell modulation
    Shimaa Mohammad Yousof, Badrah Saeed Ali Alghamdi, Thamer Mohammed Ahmed Alqurashi, Mohammad Zubair Alam, Reham Fathy Tash, Noha M. Abd El‐Fadeal, Samy A. Abusikkien, Lamis AbdelGadir Kaddam · 2025 · Frontiers in Neuroscience
  19. T cells fast-track gut signals to the brain
    Emanuela Pasciuto, Adrian Liston · 2025 · Nature Immunology
  20. Regulation
    Gerd Kempermann · 2025 · Oxford University Press eBooks
  21. Molecular determinants of brain-resident CD8 + T cell formation and function
    Tarek Elmzzahi, Chun-Hsi Su, Mehrnoush Hadaddzadeh Shakiba, Doaa Hamada, Darya Malko, Maren Köhne, Aleksej Frolov, Teisha Mason, Rebekka Scholz, Yuanfang Li et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  22. Helminth infection induces neuroimmune remodeling and clinical remission in a mouse model of multiple sclerosis 2260051
    Naomi M. Fettig, Sarah Popple, Madilyn Portas, Andrew J Sharon, Arman Sawhney, Thomas Worthington, Blair K Hardman, Morgan Coburn, Ukpong B. Eyo, Mark C. Siracusa et al. · 2026 · The Journal of Immunology
  23. Childhood brain tumours instruct cranial haematopoiesis and immunotolerance
    Elizabeth Alexandra Cooper, David A Posner, Colin Y.C. Lee, Linda Hu, Sigourney Bonner, Jessica Taylor, Oscar Baldwin, Rocío Jiménez‐Guerrero, Katherine Elizabeth Masih, Katherine Wickham-Rahrmann et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  24. A single-cell transcriptomic atlas reveals resident dendritic-like cells in the zebrafish brain parenchyma
    Mireia Rovira, Giuliano Ferrero, Magali Miserocchi, Alice Montanari, Ruben Lattuca, Valérie Wittamer · 2025 · eLife
  25. Cytometric features of cellular immune compartment in participants of current military conflicts
    Sergey L. Pashnin, Давыдова Евгения Валерьевна, Daniel Altman, Зурочка Владимир Александрович, Igor Yu. Zhuravlev, Ya. T. Zhakupova · 2025 · Medical Immunology (Russia)
  26. Local B cell maturation and mast cell regulation of choroid plexus function in early life.
    Samir Ali-Moussa, Ana Blas-Medina, Joseph M. Josephides, Olivier Mirabeau, Inès Bouteau, Tamara Matijevic, Mariángeles Kovacs, Victoria Pakulska, Andrei Reyes Pangan, Christian Thomas et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  27. Additional file 1 of Predictors of neutralizing antibody response to BNT162b2 vaccination in allogeneic hematopoietic stem cell transplant recipients
    Lorenzo Canti, Stéphanie Humblet‐Baron, Isabelle Desombere, Julika Neumann, Pieter Pannus, Heyndrickx, Leo, Aurélie Henry, Sophie Servais, Évelyne Willems, Grégory Ehx et al. · 2021 · Figshare
  28. Additional file 1 of Identification of mitochondrial related signature associated with immune microenvironment in Alzheimer’s disease
    Zhang, Yaodan, Miao, Yuyang, Jin Tan, Chen, Fanglian, Lei, Ping, Zhang, Qiang · 2023 · Figshare
  29. Additional file 1 of Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection
    Chase E Hawes, Sonny R. Elizaldi, Danielle Beckman, Giovanne Baroni Diniz, Shaan Lakshmanappa, Yashavanth, Sean P. Ott, Durbin-Johnson, Blythe P., Ashok Reddy Dinasarapu, Andrea Gompers, Morrison, John H. et al. · 2022 · Figshare
  30. Additional file 6 of Identification of mitochondrial related signature associated with immune microenvironment in Alzheimer’s disease
    Zhang, Yaodan, Miao, Yuyang, Jin Tan, Chen, Fanglian, Lei, Ping, Zhang, Qiang · 2023 · Figshare
  31. Additional file 2 of Regulatory T cells limit age-associated retinal inflammation and neurodegeneration
    María Llorián‐Salvador, Alerie Guzman de la Fuente, Christopher E McMurran, Amy Dashwood, James Dooley, Liston, Adrian, Rosana G. Peñalva, Yvonne Dombrowski, Alan W. Stitt, Denise C. Fitzgerald · 2024 · Figshare
  32. Additional file 2 of Identification of mitochondrial related signature associated with immune microenvironment in Alzheimer’s disease
    Zhang, Yaodan, Miao, Yuyang, Jin Tan, Chen, Fanglian, Lei, Ping, Qiang Zhang · 2023 · Figshare
  33. Additional file 5 of Key role of the CCR2-CCL2 axis in disease modification in a mouse model of tauopathy
    Hila Ben-Yehuda, Michal Arad, Javier María Peralta Ramos, Sharon, Efrat, Giulia Castellani, Shir Ferrera, Liora Cahalon, Sarah Phoebeluc Colaiuta, Salame, Tomer-Meir, Schwartz, Michal · 2021 · Figshare
  34. Additional file 3 of Key role of the CCR2-CCL2 axis in disease modification in a mouse model of tauopathy
    Hila Ben-Yehuda, Michal Arad, Javier María Peralta Ramos, Sharon, Efrat, Giulia Castellani, Shir Ferrera, Liora Cahalon, Sarah Phoebeluc Colaiuta, Salame, Tomer-Meir, Schwartz, Michal · 2021 · Figshare
  35. Additional file 1 of Regulatory T cells limit age-associated retinal inflammation and neurodegeneration
    María Llorián‐Salvador, Alerie Guzman de la Fuente, Christopher E McMurran, Amy Dashwood, James Dooley, Liston, Adrian, Rosana G. Peñalva, Yvonne Dombrowski, Alan W. Stitt, Denise C. Fitzgerald · 2024 · Figshare
  36. Additional file 4 of Key role of the CCR2-CCL2 axis in disease modification in a mouse model of tauopathy
    Hila Ben-Yehuda, Michal Arad, Javier María Peralta Ramos, Sharon, Efrat, Giulia Castellani, Shir Ferrera, Liora Cahalon, Sarah Phoebeluc Colaiuta, Salame, Tomer-Meir, Schwartz, Michal · 2021 · Figshare
  37. Additional file 5 of Identification of mitochondrial related signature associated with immune microenvironment in Alzheimer’s disease
    Zhang, Yaodan, Miao, Yuyang, Jin Tan, Chen, Fanglian, Lei, Ping, Zhang, Qiang · 2023 · Figshare
  38. Additional file 2 of Key role of the CCR2-CCL2 axis in disease modification in a mouse model of tauopathy
    Hila Ben-Yehuda, Michal Arad, Javier María Peralta Ramos, Sharon, Efrat, Giulia Castellani, Shir Ferrera, Liora Cahalon, Sarah Phoebeluc Colaiuta, Salame, Tomer-Meir, Schwartz, Michal · 2021 · Figshare
  39. Additional file 1 of Key role of the CCR2-CCL2 axis in disease modification in a mouse model of tauopathy
    Hila Ben-Yehuda, Michal Arad, Javier María Peralta Ramos, Sharon, Efrat, Giulia Castellani, Shir Ferrera, Liora Cahalon, Sarah Phoebeluc Colaiuta, Salame, Tomer-Meir, Schwartz, Michal · 2021 · Figshare
  40. Additional file 3 of Regulatory T cells limit age-associated retinal inflammation and neurodegeneration
    María Llorián‐Salvador, Alerie Guzman de la Fuente, Christopher E McMurran, Amy Dashwood, James Dooley, Liston, Adrian, Rosana G. Peñalva, Yvonne Dombrowski, Alan W. Stitt, Denise C. Fitzgerald · 2024 · Figshare
  41. Additional file 6 of Key role of the CCR2-CCL2 axis in disease modification in a mouse model of tauopathy
    Hila Ben-Yehuda, Michal Arad, Javier María Peralta Ramos, Sharon, Efrat, Giulia Castellani, Shir Ferrera, Liora Cahalon, Sarah Phoebeluc Colaiuta, Salame, Tomer-Meir, Schwartz, Michal · 2021 · Figshare
  42. The role of complement and CD4 T cells in preeclampsia and offspring neurodevelopment
    Jean F. Regal, Courtney A. O’Kane, Sabrina Marie Scroggins · 2026 · Current Opinion in Physiology
  43. Integrated proteomic and single-cell transcriptomic profiling elucidates immunomodulatory effects of L-serine in autism spectrum disorder
    Jaemyung Jang, Seungeun Yeo, Jong Pil Kim, Soonbong Baek, Hyun Jin Jung, Su‐Kyeong Hwang, Youngshik Choe · 2026 · Scientific Reports
  44. Immune dysfunction in psychiatric disorders: emerging genomic insights
    Isabelle M. McGrath, Mary-Ellen Lynall · 2026 · Current Opinion in Genetics & Development
  45. Mechanisms controlling microglial colonization of the forebrain
    Cécile Bridlance · 2023 · theses.fr (ABES)
  46. Regulatory T cells dysregulation in neurodevelopment: An underlying mechanism in the pathophysiology of autism
    Rachel J Moreno, Paul Ashwood · 2026 · Brain Behavior and Immunity
  47. Treg–Based Therapies for Neurological Disorders: Insights Inspired by the 2025 Nobel Prize in Physiology or Medicine
    Mengdi Gao, Cheng Peng, Bin Li, Xueyu Dai, Yan Zhou · 2026 · Neuropharmacology and Therapy
  48. From barrier invasion to niche formation: mechanisms and therapies in breast cancer brain metastases
    Huan Yang, Xiao Li, Shiliang Xu, Yuexin Zhao, S J Cai, Dingqi Feng, Yizheng Yao · 2026 · Journal of Advanced Research
  49. The Epidermal Growth Factor Receptor (EGFR) as a means of neuro-immune cross-conversation
    Katharina Gryksa, Maria Chiara Sibilia, Veit Rothhammer, Adrian Liston, Dietmar M. W. Zaiss · 2026 · Journal of Neuroinflammation
  50. Recent advances in neuroimmune dialog: from homeostasis to inflammation
    Wenqian Huang, Xiangyang Wang, Yingjiao Cao · 2026 · Trends Open
  51. Elucidating the role of Toxoplasma gondii EF-hand containing protein 1 in parasite biology and its potential as a subunit vaccine antigen
    Xiaowei Tian, Hangbin Ma, Shuoxiang Gao, Yajing Li, Boya Zhu, Jing Zhang, Jinghui Wang, Yina Hu, Yun Li, Qiangqiang Wang et al. · 2026 · Acta Tropica
  52. Zika virus infection in the brains of lymphocyte-deficient mice does not lead to neurological symptoms despite sustained high viral load
    Amelia Montemarano, Elizabeth Balint, Ali A. Ashkar · 2026 · Journal of NeuroVirology
  53. Hunting for an Antigen: Humoral Immunity in Alzheimer’s Disease
    Angel M. Delgado, Braxton D. Greer, Robert W. Maul, Patricia J. Gearhart · 2026 · Cells
  54. Short‐Chain Fatty Acid–Dependent Neuroimmune Regulation in Autism Spectrum Disorder Pathogenesis
    Arpan Dhungel, Rinchi Bora · 2026 · European Journal of Neuroscience
  55. Potential preventive role of low-dose methotrexate against incident recorded psychosis: a retrospective cohort study based on electronic health records
    Fabiana Maria das Graças Corsi Zuelli, Maxime Taquet, J.F.W. Deakin, Rachel Upthegrove · 2026 · EClinicalMedicine
  56. CD4 T lymphocytes shape the development and maturation of the central nervous system
    Poliana Fialho de Carvalho, Felipe Henrique da Cunha Xavier, Eriane Cerqueira, Letícia Barros de Souza, Pedro Henrique Oliveira Vianna, Áquila Rodrigues Costa Santos, Rômulo Gonçalves Agostinho Galvani, Wilson Savino, Rudimar Luiz Frozza, Adriana Cesar Bonomo · 2026 · Brain Research Bulletin
  57. Correction of neuroimmune disorders in a post-viral chronic fatigue syndrome model using recombinant interleukin-2
    Tatiana A. Filatenkova, Шанин Сергей Николаевич, Elena E. Fomicheva, Natalia B. Serebryanaya · 2026 · Medical academic journal
  58. Peripheral blood mononuclear cell proteomic profiling reveals cytoskeletal- and chromatin-associated protein signatures in autism spectrum disorder
    Marlieke Lisanne van Erp, Wasana Yuwattana, Chayanit Poolcharoen, Thanit Saeliw, Sittiruk Roytrakul, Natchaya Vanwong, Valerie Wailin Hu, Pon Trairatvorakul, Weerasak Chonchaiya, Tewarit Sarachana · 2026 · Brain Behavior & Immunity - Health
  59. Regulatory T cells in intracerebral hemorrhage: mechanisms of immunomodulation and therapeutic potential
    Jiajie Xia, Xinjie Gao, Shanshan Huang · 2026 · Frontiers in Immunology
  60. Effect of redox status on the metabolic characteristics and microbiota composition of high-amylose maize starch during in vitro fermentation
    Zehao Huang, Yi Zhang, Lingjin Li, Yahui Gao, Zhengbiao Gu, Li Cheng, Yan Hong · 2026 · Food Chemistry
  61. Neurodegeneration as a dysregulation of neuroimmune crosstalk
    F. Chris Bennett, Soyon Youngae Hong, Ning Jenny Jiang, Ivan Marazzi · 2026 · Cell
  62. Nutritional regulation of gut-brain immune crosstalk across the lifespan
    Yulin Zhou, Sebastian Del Toro, Melody Yue Zeng · 2026 · Gut Microbes
  63. Proceedings and outlooks of microglia in immune-related ocular diseases
    Fan Cao, Shuhao Ceng, Fengyang Lei, Shengping Hou · 2026 · Scientia Sinica Vitae
  64. Kazachstania pintolopesii accelerates splenic senescence in aged mice via immune cell reprogramming, immunosenescence and amelioration by Astragaloside IV
    Yanqing Zhang, Yinrui Guo, Lei Li, Xiao Zhang, Haiting Zhang, 陈地灵 · 2026 · Frontiers in Immunology
  65. The effects of IFNγ on tissue physiology through structural cells
    Irah L. King, Bana Jabrì, Amanda W. Lund, Andrew Wang · 2026 · Nature reviews. Immunology
  66. A Hypothesis Linking Early-Life Adversity to Altered Synaptic Connectivity Through Disrupted Gut Microbiome–Microglia Communication
    Tulasi Pasam, Christian Bowers, Sahabuddin Ahmed, Arie Kaffman · 2026 · Nutrients
  67. Neuro-immune interactions in tumors, immune-related disorders, and infections
    Qing-Yuan Zhuang, Si-Wei Zhang, Zhi‐Ming Shao, Yi Xiao, Yi‐Zhou Jiang · 2026 · Signal Transduction and Targeted Therapy
  68. Microglia and immune signaling as architects of the brain
    Anna Kim, Cynthia M. Solek, Edward S. Ruthazer · 2026 · Frontiers in Cellular Neuroscience
  69. Central nervous system reservoirs and neuroHIV: lessons from rapid research autopsy studies
    Yuyang Tang, Guochun Jiang · 2026 · Current Opinion in HIV and AIDS
  70. Conserved Brain-Associated CD8 + T Cell Programs and Their Regulation by the Brain Microenvironment
    kyungsoo Park, Tavian Sanchez, Shin Jeon, Peter F. Schade, David G. C. Hildebrand, Yeong Shin Yim · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  71. Astrocyte–Regulatory T Cell Communication in Neuroinflammation: From Glial Reactivity to Immune Modulation
    Hipólito Juárez-Solano, Ivan Nicolás Pérez‐Osorio, Laura Virginia Adalid-Peralta, Adrián Guevara‐Salinas, Mónica Torres-Ramos · 2026 · Journal of Neuroimmune Pharmacology