The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Infection trains the host for microbiota-enhanced resistance to pathogens
Open accessAbstract
The microbiota shields the host against infections in a process known as colonization resistance. How infections themselves shape this fundamental process remains largely unknown. Here, we show that gut microbiota from previously infected hosts display enhanced resistance to infection. This long-term functional remodeling is associated with altered bile acid metabolism leading to the expansion of taxa that utilize the sulfonic acid taurine. Notably, supplying exogenous taurine alone is sufficient to induce this alteration in microbiota function and enhance resistance. Mechanistically, taurine potentiates the microbiota's production of sulfide, an inhibitor of cellular respiration, which is key to host invasion by numerous pathogens. As such, pharmaceutical sequestration of sulfide perturbs the microbiota's composition and promotes pathogen invasion. Together, this work reveals a process by which the host, triggered by infection, can deploy taurine as a nutrient to nourish and train the microbiota, promoting its resistance to subsequent infection.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“For example, deconjugation of taurine-conjugated BAs has been shown to impact the establishment of colonization resistance against Klebsiella pneumoniae, the development of colorectal cancer and more recently metabolic disease43–45.”
From Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut (2023) · cites this paper as [44]
In the citing paper
“Reanalysis of the shotgun datasets using the same bioinformatics pipeline11,34,35 mostly reproduced reported taxonomic differences between Rs and NRs with minimal overlap between datasets (Supplementary Fig. 7a–d).”
From Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1 (2022) · cites this paper as [34]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
Fiji: an open-source platform for biological-image analysis
Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548
Fast gapped-read alignment with Bowtie 2
Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206
Cutadapt removes adapter sequences from high-throughput sequencing reads
Martin, M. (2011) · EMBnet.journal · doi:10.14806/ej.17.1.200 · Cited by 33,889
SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell Sequencing
Bankevich, A., Nurk, S., Antipov, D., Gurevich, A. A., Dvorkin, M. V., Kulikov, A. S., Lesin, V. M., Nikolenko, S., Pham, S., Prjibelski, A. D., et al. (2012) · Journal of Computational Biology · doi:10.1089/cmb.2012.0021 · Cited by 26,312
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
Bolyen, E., Rideout, J. R., Dillon, M. R., Bokulich, N. A., Abnet, C. C., Al-Ghalith, G. A., Alexander, H., Alm, E. J., Arumugam, M., Asnicar, F., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0209-9 · Cited by 23,742
Prokka: rapid prokaryotic genome annotation
Seemann, T. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu153 · Cited by 18,937
Flagged first, then by citations
Cited by
Sorted by citations
McCulloch, J. A., Davar, D., Rodrigues, R. R., Badger, J. H., Fang, J. R., Cole, A. M., Balaji, A. K., Vetizou, M., Prescott, S. M., Fernandes, M. R., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01698-2 · Cited by 472
Self-citationImmunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: A review
Zhao, M., Chu, J., Feng, S., Guo, C., Xue, B., He, K., & Li, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114985 · Cited by 510
The microbiome and gut homeostasis
Lee, J., Tsolis, R. M., & Bäumler, A. J. (2022) · Science · doi:10.1126/science.abp9960 · Cited by 452
Bile acids as modulators of gut microbiota composition and function
Larabi, A. B., Masson, H. L. P., & Bäumler, A. J. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2172671 · Cited by 443
Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring
Lim, A. I., McFadden, T. E., Link, V. M., Han, S., Karlsson, R., Stacy, A., Farley, T. K., Lima-Junior, D. S., Harrison, O. J., Desai, J. V., et al. (2021) · Science · doi:10.1126/science.abf3002 · Cited by 231
Self-citationThe spread of antibiotic resistance to humans and potential protection strategies
Ding, D., Wang, B., Zhang, X., Zhang, J., Zhang, H., Liu, X., Gao, Z., & Yu, Z. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114734 · Cited by 239
Guan, B., Tong, J., Hao, H., Yang, Z., Chen, K., Xu, H., & Wang, A. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.12.011 · Cited by 215
Foley, M. H., Walker, M. E., Stewart, A. K., O’Flaherty, S., Gentry, E. C., Patel, S., Beaty, V. V., Allen, G., Pan, M., Simpson, J. B., et al. (2023) · Nature Microbiology · doi:10.1038/s41564-023-01337-7 · Cited by 181
Vatanen, T., Jabbar, K. S., Ruohtula, T., Honkanen, J. K., Ávila-Pacheco, J., Siljander, H., Stražar, M., Oikarinen, S., Hyöty, H., Ilonen, J., et al. (2022) · Cell · doi:10.1016/j.cell.2022.11.023 · Cited by 182
Host control of the microbiome: Mechanisms, evolution, and disease
Wilde, J., Slack, E. M. C., & Foster, K. R. (2024) · Science · doi:10.1126/science.adi3338 · Cited by 172
Exploring rhizo-microbiome transplants as a tool for protective plant-microbiome manipulation
Jiang, G., Zhang, Y., Gan, G., Li, W., Wan, W., Jiang, Y., Yang, T., Zhang, Y., Xu, Y., Wang, Y., et al. (2022) · ISME Communications · doi:10.1038/s43705-022-00094-8 · Cited by 162
Immunity to the microbiota promotes sensory neuron regeneration
Enamorado, M., Kulalert, W., Han, S., Rao, I., Delaleu, J., Link, V. M., Yong, D., Smelkinson, M. G., Gil, L., Nakajima, S., et al. (2023) · Cell · doi:10.1016/j.cell.2022.12.037 · Cited by 144
Self-citationZhao, C., Wu, K., Hao, H., Zhao, Y., Bao, L., Qiu, M., He, Y., He, Z., Zhang, N., Hu, X., et al. (2023) · npj Biofilms and Microbiomes · doi:10.1038/s41522-023-00374-8 · Cited by 141
Sessitsch, A., Wakelin, S. A., Schloter, M., Maguin, E., Cernava, T., Champomier‐Vergès, M., Charles, T. C., Cotter, P. D., Ferrocino, I., Kriaa, A., et al. (2023) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00212-22 · Cited by 122
Qi, Q., Zhang, H., Jin, Z., Wang, C., Xia, M., Chen, B., Lv, B., Diaz, L. P., Li, X., Feng, R., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01068-x · Cited by 129
Foley, S. E., Tuohy, C. A., Dunford, M., Grey, M. J., Luca, H. E. D., Cawley, C., Szabady, R. L., Maldonado‐Contreras, A., Houghton, J. M., Ward, D. V., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01137-3 · Cited by 121
Johansen, J., Atarashi, K., Arai, Y., Hirose, N., Sørensen, S. J., Vatanen, T., Knip, M., Honda, K., Xavier, R. J., Rasmussen, S., et al. (2023) · Nature Microbiology · doi:10.1038/s41564-023-01370-6 · Cited by 110
Enteric pathogens induce tissue tolerance and prevent neuronal loss from subsequent infections
Ahrends, T., Aydın, B., Matheis, F., Classon, C., Marchildon, F., Furtado, G. C., Lira, S. A., & Mucida, D. (2021) · Cell · doi:10.1016/j.cell.2021.10.004 · Cited by 102
Versatile Triad Alliance: Bile Acid, Taurine and Microbiota
Duszka, K. (2022) · Cells · doi:10.3390/cells11152337 · Cited by 101
Li, G., Liu, L., Lu, T., Sui, Y., Zhang, C., Wang, Y., Zhang, T., Xie, Y., Xiao, P., Zhao, Z., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41950-y · Cited by 101
Gut microbial metabolome in inflammatory bowel disease: From association to therapeutic perspectives
Li, M., Yang, L., Mu, C., Sun, Y., Gu, Y., Chen, D., Liu, T., & Cao, H. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.03.038 · Cited by 89
Commensal inter-bacterial interactions shaping the microbiota
Kern, L., Abdeen, S. K., Kolodziejczyk, A. A., & Elinav, E. (2021) · Current Opinion in Microbiology · doi:10.1016/j.mib.2021.07.011 · Cited by 82
Diao, M., Dyksma, S., Koeksoy, E., Ngugi, D. K., Anantharaman, K., Loy, A., & Pester, M. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad058 · Cited by 88
Metabolic ecology of microbiomes: Nutrient competition, host benefits, and community engineering
Bakkeren, E., Piskovsky, V., & Foster, K. R. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.05.013 · Cited by 95
Sleep Deprivation and Gut Microbiota Dysbiosis: Current Understandings and Implications
Sun, J., Fang, D., Wang, Z., & Liu, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119603 · Cited by 82
Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges
Ailioaie, L. M., & Litscher, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094942 · Cited by 70
Zhou, A., Yuan, Y., Yang, M., Huang, Y., Li, X., Li, S., Yang, S., & Tang, B. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.832672 · Cited by 71
Omics in gut microbiome analysis
Whon, T. W., Shin, N., Kim, J. Y., & Roh, S. W. (2021) · The Journal of Microbiology · doi:10.1007/s12275-021-1004-0 · Cited by 69
Effects of Taurine on Gut Microbiota Homeostasis: An Evaluation Based on Two Models of Gut Dysbiosis
Qian, W., Li, M., Yu, L., Tian, F., Zhao, J., & Zhai, Q. (2023) · Biomedicines · doi:10.3390/biomedicines11041048 · Cited by 63
Modelling host–microbiome interactions in organ-on-a-chip platforms
Shin, Y. C., Than, N., Min, S., Shin, W., & Kim, H. J. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00130-9 · Cited by 58
T helper 17 (Th17) cell responses to the gut microbiota in human diseases
Sun, C., Yang, N. Y., Zheng, Z., Liu, D., & Xu, Q. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114483 · Cited by 60
Colonization resistance: metabolic warfare as a strategy against pathogenic Enterobacteriaceae
Shealy, N. G., Yoo, W., & Byndloss, M. X. (2021) · Current Opinion in Microbiology · doi:10.1016/j.mib.2021.09.014 · Cited by 53
Sun, M., Li, D., Mei, H., Miao, X., Su, Y., Chi, Y., Li, Y., Sun, R., Niu, H., & Wang, J. (2022) · Food & Function · doi:10.1039/d2fo01165d · Cited by 52
Toward prevention of childhood ALL by early-life immune training
Hauer, J., Fischer, U., & Borkhardt, A. (2021) · Blood · doi:10.1182/blood.2020009895 · Cited by 54
Fang, D., Xu, T., Sun, J., Shi, J., Li, F., Yin, Y., Wang, Z., & Liu, Y. (2023) · Advanced Science · doi:10.1002/advs.202207170 · Cited by 49
Host-acting antibacterial compounds combat cytosolic bacteria
Liu, X., Wu, Y., Mao, C., Shen, J., & Zhu, K. (2022) · Trends in Microbiology · doi:10.1016/j.tim.2022.01.006 · Cited by 45
Ecological memory of prior nutrient exposure in the human gut microbiome
Letourneau, J., Holmes, Z. C., Dallow, E. P., Durand, H. K., Jiang, S., Carrion, V. M., Gupta, S. K., Mincey, A., Muehlbauer, M. J., Bain, J. R., et al. (2022) · The ISME Journal · doi:10.1038/s41396-022-01292-x · Cited by 41
Sensing and regulation of reactive sulfur species (RSS) in bacteria
Giedroc, D. P., Antelo, G. T., Fakhoury, J. N., & Capdevila, D. A. (2023) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2023.102358 · Cited by 42
Gut microbiome signatures and host colonization with multidrug-resistant bacteria
Isles, N. S., Mu, A., Kwong, J. C., Howden, B. P., & Stinear, T. P. (2022) · Trends in Microbiology · doi:10.1016/j.tim.2022.01.013 · Cited by 39
Wang, Z., Aweya, J. J., Yao, D., Zheng, Z., Wang, C., Zhao, Y., Li, S., & Zhang, Y. (2022) · Microbiome · doi:10.1186/s40168-022-01414-9 · Cited by 38
Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut
Ye, H., Borusak, S., Eberl, C., Krasenbrink, J., Weiß, A. S., Chen, S., Hanson, B. T., Hausmann, B., Herbold, C. W., Pristner, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41008-z · Cited by 44
Distinct developmental pathways generate functionally distinct populations of natural killer cells
Ding, Y., Lavaert, M., Grassmann, S. A., Band, V. I., Chi, L., Das, A., Das, S., Harly, C., Shissler, S. C., Malin, J., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01865-2 · Cited by 38
Self-citationWang, Z., Lan, R., Xu, Y., Zuo, J., Han, X., Phouthapane, V., Luo, Z., & Miao, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.631113 · Cited by 37
Ni, Z., Ding, J., Zhao, Q., Cheng, W., Yu, J., Zhou, L., Sun, S., & Yu, C. (2021) · American Journal of Reproductive Immunology · doi:10.1111/aji.13471 · Cited by 43
The longitudinal and cross-sectional heterogeneity of the intestinal microbiota
Miller, B. M., Liou, M. J., Lee, J., & Bäumler, A. J. (2021) · Current Opinion in Microbiology · doi:10.1016/j.mib.2021.08.004 · Cited by 44
Blachier, F. (2023) · Microorganisms · doi:10.3390/microorganisms11051317 · Cited by 38
Respiratory Viral and Bacterial Factors That Influence Early Childhood Asthma
Mthembu, N., Ikwegbue, P. C., Brombacher, F., & Hadebe, S. (2021) · Frontiers in Allergy · doi:10.3389/falgy.2021.692841 · Cited by 45
Calling for a systems approach in microbiome research and innovation
Meisner, A., Wepner, B., Kostić, T., van Overbeek, L. S., Bunthof, C. J., de Souza, R. S. C., Olivares, M., Sanz, Y., Lange, L., Fischer, D., et al. (2021) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2021.08.003 · Cited by 37
Role of the Microbiome in the Pathogenesis of COVID-19
De, R., & Dutta, S. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.736397 · Cited by 35
Kang, J. T. L., Teo, J. J. Y., Bertrand, D., Ng, A. H. Q., Ravikrishnan, A., Yong, M., Ng, O. T., Marimuthu, K., Chen, S. L., Chng, K. R., et al. (2022) · Nature Microbiology · doi:10.1038/s41564-022-01221-w · Cited by 35
Taurine: A Maternally Derived Nutrient Linking Mother and Offspring
Tochitani, S. (2022) · Metabolites · doi:10.3390/metabo12030228 · Cited by 36
Human Microbiome and Its Medical Applications
Zhang, Y., Zhou, L., Xia, J., Dong, C., & Luo, X. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.703585 · Cited by 32
Bacterial microcompartments and energy metabolism drive gut colonization by Bilophila wadsworthia
Sayavedra, L., Yasir, M., Goldson, A. J., Brion, A., Gall, G. L., Moreno‐Gonzalez, M., Altera, A., Paxhia, M. D., Warren, M. J., Savva, G. M., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60180-y · Cited by 33
Bacteroides thetaiotaomicron enhances H 2 S production in Bilophila wadsworthia
Davies, J., Mayer, M. J., Juge, N., Narbad, A., & Sayavedra, L. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2431644 · Cited by 30
The diet-microbiota axis: a key regulator of intestinal permeability in human health and disease
Tamang, R. L., Juritsch, A. F., Ahmad, R., Salomon, J., Dhawan, P., Ramer‐Tait, A. E., & Singh, A. B. (2022) · Tissue Barriers · doi:10.1080/21688370.2022.2077069 · Cited by 29
Rise of the guardians: Gut microbial maneuvers in bacterial infections
Gupta, U., & Dey, P. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121993 · Cited by 31
Zhang, T., Hasegawa, Y., & Waldor, M. K. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01862-z · Cited by 31
Laboratory mice engrafted with natural gut microbiota possess a wildling-like phenotype
Runge, S., von Zedtwitz, S., Maucher, A., Bruno, P., Osbelt, L., Zhao, B., Gernand, A. M., Lesker, T. R., Gräwe, K., Rogg, M., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60554-2 · Cited by 33
Self-citationThe infant gut microbiota: in pursuit of non-protein nitrogen
Schimmel, P., Stahl, B., Knol, J., & Belzer, C. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2211917 · Cited by 28
Koike, K., Yoo, S., Bleymehl, K., Omura, M., Zapiec, B., Pyrski, M. M., Blum, T. S., Khan, M., Bai, Z., Leinders‐Zufall, T., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.05.032 · Cited by 29
Infection leaves a genetic and functional mark on the gut population of a commensal bacterium
Tawk, C., Lim, B., Bencivenga-Barry, N. A., Lees, H., Ramos, R. J. F., Cross, J. R., & Goodman, A. L. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.04.005 · Cited by 26
Convergence of Nanotechnology and Bacteriotherapy for Biomedical Applications
Liu, J., Yuan, S., Bremmer, A., & Hu, Q. (2024) · Advanced Science · doi:10.1002/advs.202309295 · Cited by 27
Effects of Bismuth Exposure on the Human Kidney—A Systematic Review
Pelepenko, L. E., Janini, A. C. P., Gomes, B. P. F. D. A., Soares, A. D. J., & Marciano, M. A. (2022) · Antibiotics · doi:10.3390/antibiotics11121741 · Cited by 27
Caballero-Flores, G. G., Pickard, J. M., & Núñez, G. (2021) · Current Opinion in Microbiology · doi:10.1016/j.mib.2021.07.003 · Cited by 26
Chen, B., Tang, G., Guo, W., Lei, J., Yao, J., & Xu, X. (2021) · Animals · doi:10.3390/ani11123363 · Cited by 25
Taurine as a key intermediate for host-symbiont interaction in the tropical sponge Ianthella basta
Moeller, F. U., Herbold, C. W., Schintlmeister, A., Mooshammer, M., Motti, C. A., Glasl, B., Kitzinger, K., Behnam, F., Watzka, M., Schweder, T., et al. (2023) · The ISME Journal · doi:10.1038/s41396-023-01420-1 · Cited by 25
Linking microbiome temporal dynamics to host ecology in the wild
Marsh, K. J., Bearhop, S., & Harrison, X. A. (2024) · Trends in Microbiology · doi:10.1016/j.tim.2024.05.001 · Cited by 25
Integrating natural commensals and pathogens into preclinical mouse models
Rehermann, B., Graham, A. L., Masopust, D., & Hamilton, S. E. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01108-3 · Cited by 25
Self-citationLuo, J., Wu, G. G., Alonso, S., Zhao, C., Lemenze, A. D., Lam, Y. Y., Zhao, L., & Edelblum, K. L. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00522-x · Cited by 22
Gut microbiota involved in leptospiral infections
Xie, X., Liu, J., Chen, X., Zhang, S., Tang, R., Wu, X., Zhang, W., & Cao, Y. (2021) · The ISME Journal · doi:10.1038/s41396-021-01122-6 · Cited by 21
Harnessing the human gut microbiota: an emerging frontier in combatting multidrug-resistant bacteria
Ding, W., Cheng, Y., Liu, X., Zhu, Z., Wu, L., Gao, J., Lei, W., Li, Y., Zhou, X., Wu, J., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1563450 · Cited by 26
Chen, K., Nakasone, Y., Yi, S., Ibrahim, H. R., Sakao, K., Hossain, M. A., & Hou, D. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c00555 · Cited by 21
Gut microbiome pattern impacts treatment response in primary biliary cholangitis
Liu, Q., Huang, B., Zhou, Y., Wei, Y., Li, Y., Li, B., Li, Y., Zhang, J., Qian, Q., Chen, R., et al. (2024) · Med · doi:10.1016/j.medj.2024.08.003 · Cited by 20
Aging‐induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense
Gu, P., Wei, R., Liu, R., Yang, Q., He, Y., Guan, J., He, W., Li, J., Zhao, Y., Xie, L. X., et al. (2025) · Advanced Science · doi:10.1002/advs.202411008 · Cited by 22
A Modern-World View of Host–Microbiota–Pathogen Interactions
Tan, C. Y., Ramirez, Z. E., & Surana, N. K. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100215 · Cited by 24
Ruíz-González, A., Rico, D. E., & Rico, J. E. (2022) · Metabolites · doi:10.3390/metabo12020142 · Cited by 23
Taurine promotes Oreochromis niloticus survival against Edwardsiella tarda infection
Peng, L.-T., Li, D.-L., Yang, D.-X., & Peng, B. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.08.065 · Cited by 21
The role of the gut microbiome in modulating immunotherapy efficacy in colorectal cancer
Zuo, S., Huang, Y., & Zou, J. (2024) · IUBMB Life · doi:10.1002/iub.2908 · Cited by 19
Role of sulfidogenic members of the gut microbiota in human disease
Pimenta, A. I., Bernardino, R. M., & Pereira, I. A. C. (2024) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2024.04.003 · Cited by 18
Leigh, S., Lynch, C. M. K., Bird, B., Griffin, B. T., Cryan, J. F., & Clarke, G. A. (2022) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2022.2043849 · Cited by 19
Li, S., Luo, X., Liao, Z., Xu, H., Liang, M., Mai, K., & Zhang, Y. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.09.015 · Cited by 19
Evolving concepts of host–pathobiont interactions in autoimmunity
Pereira, M. S., & Kriegel, M. A. (2022) · Current Opinion in Immunology · doi:10.1016/j.coi.2022.102265 · Cited by 21
He, S., Deng, Q., Liang, B., Yu, F., Yu, X., Guo, D., Liu, X., & Dong, H. (2021) · Molecules · doi:10.3390/molecules26247577 · Cited by 17
Yang, B.-Y., Zhao, F., Li, X., Zhao, M., Lv, J.-C., Shi, M., Li, J., Zhou, Z., Wang, J., & Song, J. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1133782 · Cited by 17
Zhang, L., Wang, F., Jia, L., Yan, H., Gao, L., Tian, Y., Su, X., Zhang, X., Lv, C., Ma, Z., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1135588 · Cited by 18
Wang, L., Wu, R., Yao, Y.-F., Fu, W.-W., Wan, M., Sang, T., & Li, W. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105991 · Cited by 17
Nielsen, K. L., Olsen, M. H., Pallejá, A., Ebdrup, S. R., Sørensen, N., Lukjančenko, O., Marvig, R. L., Møller, K., Frimodt‐Møller, N., & Hertz, F. B. (2021) · Microorganisms · doi:10.3390/microorganisms9122542 · Cited by 19
Nutraceuticals and Physical Activity as Antidepressants: The Central Role of the Gut Microbiota
Zeppa, S. D., Ferrini, F., Agostini, D., Amatori, S., Barbieri, E., Piccoli, G., Sestili, P., & Stocchi, V. (2022) · Antioxidants · doi:10.3390/antiox11020236 · Cited by 20
Born to be wild: utilizing natural microbiota for reliable biomedical research
Bruno, P., Schüler, T., & Rosshart, S. P. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.11.013 · Cited by 19
Lifestyle and host determinants of antitumor immunity and cancer health disparities
Swaby, A. M., Atallah, A., Varol, O., Cristea, A., & Quail, D. F. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.08.007 · Cited by 16
Cabezas‐Cruz, A., & Bermúdez‐Humarán, L. G. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2023.11.027 · Cited by 17
What’s for dinner? How Citrobacter rodentium’s metabolism helps it thrive in the competitive gut
Liang, Q., & Vallance, B. A. (2021) · Current Opinion in Microbiology · doi:10.1016/j.mib.2021.06.004 · Cited by 17
Enrico, V. T., Vo, N. N., Methé, B. A., Morris, A., & Sowa, G. (2022) · European Spine Journal · doi:10.1007/s00586-022-07429-y · Cited by 17
Effect of diet on pathogen performance in the microbiome
Strain, R., Stanton, C., & Ross, R. P. (2022) · Microbiome Research Reports · doi:10.20517/mrr.2021.10 · Cited by 15
Zhao, B., Osbelt, L., Lesker, T. R., Wende, M., Gálvez, E. J. C., Hönicke, L., Bublitz, A., Greweling‐Pils, M. C., Graßl, G. A., Neumann‐Schaal, M., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2023.112549 · Cited by 18
Microbiota configuration determines nutritional immune optimization
Han, S., Stacy, A., Corral, D., Link, V. M., Siqueira, M. K. D., Chi, L., Teijeiro, A., Yong, D., Pérez‐Chaparro, P. J., Bouladoux, N. J., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2304905120 · Cited by 17
Self-citationWestern lifestyle as a driver of dysbiosis in colorectal cancer
Foegeding, N. J., Jones, Z., & Byndloss, M. X. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.049051 · Cited by 14
Mechanisms conferring multi-layered protection against intestinal Salmonella Typhimurium infection
Kroon, S., & Hardt, W. (2025) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaf038 · Cited by 14
Bacterial approaches to sensing and responding to respiration and respiration metabolites
Price, E. E., Román‐Rodríguez, F., & Boyd, J. M. (2021) · Molecular Microbiology · doi:10.1111/mmi.14795 · Cited by 14
Yasir, M., Alzahrani, I., Khan, R., Soliman, S. A., Turkistani, S. A., Alawi, M., & Azhar, E. I. (2024) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2024.103957 · Cited by 15
Metadata
- Authors
- Stacy, A., Andrade-Oliveira, V., McCulloch, J. A., Hild, B., Oh, J. H., Perez-Chaparro, P. J., Sim, C. K., Lim, A. I., Link, V. M., Enamorado, M., Trinchieri, G., Segre, J. A., Rehermann, B., & Belkaid, Y.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Stacy, Apollo
- Belkaid, Yasmine
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 184
- Issue
- 3
- Pages
- 615-627.e17
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC8786454
- OpenAlex
- W3118956265
- Cited by
- 239
- References
- 70
- Citations by year
- 2026: 27 · 2025: 37 · 2024: 38 · 2023: 56 · 2022: 46 · 2021: 35
- FWCI
- 13.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Servier
- National Institute of General Medical Sciences (1FI2GM128736-01)
- National Cancer Institute
- Human Frontier Science Program (LT000191/2018)
- Cancer Research Institute
- University of California, Los Angeles
- College of Engineering, University of Wisconsin-Madison
- Deutsche Forschungsgemeinschaft (HI 2088/1-1)
- National Institute of Allergy and Infectious Diseases (1ZIAAI001115-11)
- National Institutes of Health
- National Human Genome Research Institute (1ZIAHG000180-19)
- National Institute of Diabetes and Digestive and Kidney Diseases (1ZIADK054508-22)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- gut microbiota, colonization resistance, taurine, bile acid metabolism, sulfide, host-pathogen interaction, host defense against infection
- MeSH terms
- Gastrointestinal Microbiome, Animals, Bacterial Infections, Immunity, Mice, Inbred C57BL, Sulfides, Taurine, Colony Count, Microbial, Mice, Host-Pathogen Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review