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Cited by 961

The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.

Endometriosis: Etiology, pathobiology, and therapeutic prospects

Open access
Saunders, Philippa T.K., Horne, Andrew W.·2021·Cell
DOI 10.1016/j.cell.2021.04.041
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Abstract

Endometriosis is a common condition associated with infertility that causes chronic pain in many, but not all, women. It is defined by the presence of endometrial-like tissue outside the uterus. Although the cause and natural history of the disorder remain uncertain, hormonal, neurological, and immunological factors are all implicated in the mechanisms contributing to development of symptoms. Because definitive diagnosis requires surgery, there is often a long diagnostic delay after onset of symptoms. Current interventions for endometriosis have limited efficacy and unacceptable side effects/risks and are associated with high rates of symptom recurrence. Here, we review recent advances in our understanding of the etiology of endometriosis, discuss current diagnostic and treatment strategies, highlight current clinical trials, and consider how recent results offer new avenues for the identification of endometriosis biomarkers and the development of effective non-surgical therapies that are fertility-sparing.

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Citations

Cites

Show all 170 references

Research works printed but not linked: 6

  1. Armstrong, 2017, Endometrial apoptosis and neutrophil infiltration during menstruation exhibits spatial and temporal dynamics that are recapitulated in a mouse model, Sci. Rep., 7, 17416, 10.1038/s41598-017-17565-x · doi:10.1038/s41598-017-17565-x
  2. Blumenfeld, 2020, Pharmacology and Pharmacokinetics of Ubrogepant: A Potent, Selective Calcitonin Gene-Related Peptide Receptor Antagonist for the Acute Treatment of Migraine, J. Fam. Pract., 69, S8
  3. Hickey, 2020, Reclassifying endometriosis as a syndrome would benefit patient care, The BMJ Opinion
  4. Israel, 2018, CGRP Monoclonal Antibodies for the Preventative Treatment of Migraine, Curr. Pain Headache Rep., 22, 38, 10.1007/s11916-018-0686-4 · doi:10.1007/s11916-018-0686-4
  5. Norman, 2004, The potential danger of COX-2 inhibitors, Fertil. Steril., 81, 493, 10.1016/j.fertnstert.2003.10.016 · doi:10.1016/j.fertnstert.2003.10.016
  6. Onuora, 2020, Gut microbiome linked with OA knee pain, Nat. Rev. Rheumatol., 16, 2

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Metadata

Authors
Saunders, P. T. K., & Horne, A. W.
Venue
Cell
Publisher
Elsevier BV
Published
2021-05
Volume
184
Issue
11
Pages
2807-2824
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2021.04.041
OpenAlex
W3165294846
Cited by
961
References
170
FWCI
99.66
Type
journal article
Language
en
Open access
bronze
Licence
Funders
AbbVie

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CoChat. (2026). Citation check: Endometriosis: Etiology, pathobiology, and therapeutic prospects. https://app.cochat.ai/papers/10.1016/j.cell.2021.04.041
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Saunders, P. T. K., & Horne, A. W. (2021). Endometriosis: Etiology, pathobiology, and therapeutic prospects. Cell. https://doi.org/10.1016/j.cell.2021.04.041

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.