X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women

Yan, Yan, Wang, Xinming, Chaput, Dale, Shin, Min-Kyoo, Koh, Yeojung, Gan, Li, Pieper, Andrew A., Woo, Jung-A.A. +1 more·2022·Cell

Cited by (147)

Items 101–147 of 147

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  2. The E3 ubiquitin ligase SPRYD3-MYCBP2(PAM) regulates mitotic cell fate and ubiquitination of USP11 to control spindle assembly
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  3. Non-catalytic UBL2 domain directs deubiquitinase USP11 toward K48-linked polyubiquitin chains
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  4. Targeting innovative therapeutic approaches to the hallmarks of aging to combat Alzheimer’s disease
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  8. Microglial OTUD6A promotes neuroinflammation and Alzheimer’s disease pathogenesis by deubiquitinating C/EBPβ
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  9. Frontotemporal dementia associated CHCHD10V57E mutation aggravates tau pathology via disrupting the CHCHD10-Rab7A-TBC1D15 complex
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  10. Sex Differences in Alzheimer’s Disease Pathogenesis
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  11. Alzheimer’s X-chromosome risk
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  12. Common pathogenetic factors in metabolic syndrome and dementia
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  13. USP11 deubiquitinates E-cadherin and maintains luminal fate of mammary cells to suppress breast cancer
    Qian Tao, Feng Bai, Shiwen Zhang, Yuping Xu, Yuchan Wang, Shuping Yuan, Xiong Liu, Yaru Du, Bin Peng, Wei‐Guo Zhu et al. · 2023 · Research Square
  14. X-Chromosome Dependent Differences in the Neuronal Molecular Signatures and Their Implications in Sleep Patterns
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  15. Heteroscedastic Personalized Regression Unveils Genetic Basis of Alzheimer’s Disease Stratified by Cognitive Level
    Zhirong Chen, Haohan Wang · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  16. Increased Maternal Compared to Paternal Transmission of Alzheimer’s Disease May Be Due to Increased Incidence of Depression in Women
    Steven P. Lehrer, Peter H. Rheinstein · 2023 · In Vivo
  17. The ubiquitin-proteasome system in neurodegenerative diseases
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  18. X-Chromosome-wide association study for Alzheimer’s disease
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  19. Disease-specific tau polymorphs define unique protein interaction networks across proteinopathies
    Nicha Puangmalai, Nemil N. Bhatt, Nopparat Suthprasertporn, Ernesto G. Miranda-Morales, Nikita Shchankin, Madison Samples, Ahmet E. Balci, Jia Yi Liew, Mauro Montalbano, Yingxin Zhao et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  20. Sex specific differences of protein expression profiles in Alzheimer’s disease
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  21. LOU/c/jall rat as a model of resilience in the context of streptozotocin-induced cognitive impairment
    Lucas Gephine, Sophie Corvaisier, Benoı̂t Bernay, Thomas Fréret, Marianne Léger · 2025 · Frontiers in Aging Neuroscience
  22. Early, sex-dependent and progressive proteomic imbalance in the amygdala during Alzheimers disease progression
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  23. Molecular chaperone and chaperone-based therapeutic approaches for Alzheimer’s disease
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  24. Additional file 3 of Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury
    Parra Bravo, Celeste, Karen Krukowski, Barker, Sarah, Chao Wang, Li, Yaqiao, Fan, Li, Edwin Vázquez‐Rosa, Shin, Min-Kyoo, Man Ying Wong, McCullough, Louise D. et al. · 2024 · Figshare
  25. Additional file 2 of Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury
    Parra Bravo, Celeste, Karen Krukowski, Barker, Sarah, Chao Wang, Li, Yaqiao, Fan, Li, Edwin Vázquez‐Rosa, Shin, Min-Kyoo, Man Ying Wong, McCullough, Louise D. et al. · 2024 · Figshare
  26. Additional file 1 of Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury
    Parra Bravo, Celeste, Karen Krukowski, Barker, Sarah, Chao Wang, Li, Yaqiao, Fan, Li, Edwin Vázquez‐Rosa, Shin, Min-Kyoo, Man Ying Wong, McCullough, Louise D. et al. · 2024 · Figshare
  27. Additional file 4 of Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury
    Parra Bravo, Celeste, Karen Krukowski, Barker, Sarah, Wang, Chao, Li, Yaqiao, Fan, Li, Edwin Vázquez‐Rosa, Shin, Min-Kyoo, Man Ying Wong, McCullough, Louise D. et al. · 2024 · Figshare
  28. USP11 drives stress-induced synaptic structural deficits and depression-like behaviors through GSK3β/mTOR signaling
    Ningyuan Li, Yuqi Feng, Qian Gong, Hao Duan, Hanchun Yan, Honghan Zhang, Chao Wang, Zhongchun Liu · 2026 · Neurobiology of Stress
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  30. Early, sex-dependent and progressive proteomic imbalance in the amygdala during Alzheimer´s disease continuum
    Silvia Romero-Murillo, Mercedes Lachén‐Montes, Paz Cartas‐Cejudo, Elena Anaya‐Cubero, Marina De Miguel, Leire Extramiana, Isidró Ferrer, Joaquín Fernández‐Irigoyen, Enrique Santamaría · 2026 · Biology of Sex Differences
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    Chengde Wang, Dongping Huang, Jian Wang, Xuebao Wang, Guorong Tao, Hanbin Shan, Weitang Liu, Yuqiang Ding, Saidan Ding · 2026 · Brain Behavior and Immunity
  32. X‐Linked USP11 Drives Depression‐Like Behaviors by Stabilizing CK2α and Disrupting Mitochondrial Function
    Yuqi Feng, Ningyuan Li, Lingfeng Zhang, Wei Wang, Hao Duan, Siqi Sun, Ruiling Li, Yuhui Zhang, Xinhua Song, Yingyue Zhang et al. · 2026 · CNS Neuroscience & Therapeutics
  33. Synergetic inhibition of deubiquitinases and acetyltransferases to regulate tau acetylation and aggregation in SH-SY5Y cell line model of Alzheimer’s disease
    Basavaraju K C, Harshitha D K, Poornima Priyadarshini C. G. · 2026 · Methods in enzymology on CD-ROM/Methods in enzymology
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    Shannon Thomson, Xinran C Li, Sophie Walker, Tiffany C. Y. Tang, Mark Evan Graham, Sam W.Z. Olechnowicz, Rory J. Bowden, Katherine A. Waugh, Chad M Slawson, Jeffrey Murray Burns et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  35. Structure-activity relationship analysis of a Pyrrolo-Phenylamidine scaffold as a chemotype for ubiquitin-specific protease 11 (USP11) inhibition
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    Joel Tong, Isuru M. Jayalath, James V. Parsons, Ju-An Kim, Matthew D. Mann, Michal Tokmina‐Roszyk, Thomas J. Kodadek · 2026 · RSC Chemical Biology
  38. Vorinostat ameliorates cognitive impairment and Tau pathology in an AAV-P301L-Tau-induced tauopathy mouse model: insights into neuroinflammation and PI3K/AKT/GSK3β signaling
    Zhidan Shi, Xinyi Cheng, Chu Zhang, Jiayi Hu, Xinqi He, Shuting Chen, Hao Wu, Meng Tian, Chuang Yan, Ling He · 2026 · International Immunopharmacology
  39. Disease-specific tau polymorphs are associated with unique protein networks across proteinopathies
    Nicha Puangmalai, Nemil N. Bhatt, Nopparat Suthprasertporn, Ernesto G. Miranda-Morales, Nikita Shchankin, Madison Samples, Ahmet E. Balci, Jia Yi Liew, Mauro Montalbano, Yingxin Zhao et al. · 2026 · The EMBO Journal
  40. STINGing the brain: S-nitrosylation drives neuroinflammation in Alzheimer’s disease
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  41. UPS-mediated P-glycoprotein regulation in Alzheimer’s disease: pharmacological implications for the amyloid pathology
    Aditi Joshi, Jotiram Salunkhe, Vinod G. Ugale · 2026 · Molecular Biology Reports
  42. A miR-10a-5p-γCaMKII axis links periphery-to-brain signaling to cognitive vulnerability during female midlife
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  43. USP11 exacerbates intestinal I/R injury by driving NCOA4-mediated ferritinophagy and ferroptosis via Beclin-1 deubiquitination
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  46. Sex‐specific brain reserve and progression from mild cognitive impairment to Alzheimer's disease dementia
    Xulin Liu, Sterre C. M. de Boer, M Tartaglia, for the Alzheimer's Disease Neuroimaging Initiative · 2026 · Alzheimer s & Dementia
  47. Deubiquitinating Enzymes in Alzheimer’s Disease: From Protein Homeostasis to Diverse Pathological Processes
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