The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Structures of the entire human opioid receptor family
Open accessAbstract
Opioids are effective analgesics, but their use is beset by serious side effects, including addiction and respiratory depression, which contribute to the ongoing opioid crisis. The human opioid system contains four opioid receptors (μOR, δOR, κOR, and NOPR) and a set of related endogenous opioid peptides (EOPs), which show distinct selectivity toward their respective opioid receptors (ORs). Despite being key to the development of safer analgesics, the mechanisms of molecular recognition and selectivity of EOPs to ORs remain unclear. Here, we systematically characterize the binding of EOPs to ORs and present five structures of EOP-OR-Gi complexes, including β-endorphin- and endomorphin-bound μOR, deltorphin-bound δOR, dynorphin-bound κOR, and nociceptin-bound NOPR. These structures, supported by biochemical results, uncover the specific recognition and selectivity of opioid peptides and the conserved mechanism of opioid receptor activation. These results provide a structural framework to facilitate rational design of safer opioid drugs for pain relief.
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PHENIX : a comprehensive Python-based system for macromolecular structure solution
Adams, P. D., Afonine, P. V., Bunkóczi, G., Chen, V. B., Davis, I. W., Echols, N., Headd, J. J., Hung, L.-W., Kapral, G. J., Grosse-Kunstleve, R. W., et al. (2010) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444909052925 · Cited by 23,716
MolProbity : all-atom structure validation for macromolecular crystallography
Chen, V. B., Arendall, W. B., Headd, J. J., Keedy, D. A., Immormino, R. M., Kapral, G. J., Murray, L. W., Richardson, J. S., & Richardson, D. C. (2010) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444909042073 · Cited by 14,115
Role of endogenous opioid system in the regulation of the stress response
Drolet, G., Dumont, É. C., Gosselin, I., Kinkead, R., Laforest, S., & Trottier, J.-F. (2001) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00161-0 · Cited by 421
The role of opioid receptors in immune system function
Eisenstein, T. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02904 · Cited by 286
Metadata
- Authors
- Wang, Y., Zhuang, Y., DiBerto, J. F., Zhou, X. E., Schmitz, G. P., Yuan, Q., Jain, M. K., Liu, W., Melcher, K., Jiang, Y., Roth, B. L., & Xu, H. E.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2023-01
- Volume
- 186
- Issue
- 2
- Pages
- 413-427.e17
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W4315705302
- Cited by
- 203
- References
- 4
- FWCI
- 15.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wang, Y., Zhuang, Y., DiBerto, J. F., Zhou, X. E., Schmitz, G. P., Yuan, Q., Jain, M. K., Liu, W., Melcher, K., Jiang, Y., Roth, B. L., & Xu, H. E. (2023). Structures of the entire human opioid receptor family. Cell. https://doi.org/10.1016/j.cell.2022.12.026
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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