TGF-β signaling in health and disease
Open accessAbstract
The TGF-β regulatory system plays crucial roles in the preservation of organismal integrity. TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury repair through coordinated effects on cell proliferation, phenotypic plasticity, migration, metabolic adaptation, and immune surveillance of multiple cell types in shared ecosystems. Defects of TGF-β signaling, particularly in epithelial cells, tissue fibroblasts, and immune cells, disrupt immune tolerance, promote inflammation, underlie the pathogenesis of fibrosis and cancer, and contribute to the resistance of these diseases to treatment. Here, we review how TGF-β coordinates multicellular response programs in health and disease and how this knowledge can be leveraged to develop treatments for diseases of the TGF-β system.
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The induction of some TGFβ target genes does not require SMAD4.
“it is now apparent that the induction of some TGFβ target genes does not require SMAD4 (37).”
From Clinical Challenges of Consensus Molecular Subtype CMS4 Colon Cancer in the Era of Precision Medicine (2024) · cites this paper as [37]
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References 303 · Cited by 890
Research works printed but not linked: 1
- [69]Loeys BL, and Dietz HC (1993). Loeys-Dietz Syndrome. In GeneReviews((R)), Adam MP, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, and Amemiya A, eds. 20301312
- Authors
- Massagué, J., & Sheppard, D.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- University of California, San Francisco (US)
- Corresponding author
- Massagué, Joan
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2023-09
- Volume
- 186
- Issue
- 19
- Pages
- 4007-4037
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC10772989
- OpenAlex
- W4386788919
- Cited by
- 890
- References
- 303
- Citations by year
- 2026: 308 · 2025: 352 · 2024: 221 · 2023: 9
- FWCI
- 23.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- Memorial Sloan-Kettering Cancer Center (CA008748, P30 CA008748)
- National Institutes of Health (CA008748, CA129243)
- National Heart, Lung, and Blood Institute (R01HL145037, R01HL142568)
- National Cancer Institute (P01CA129243, P30CA008748, R35CA252978)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- TGF-beta signaling, fibrosis, cancer, inflammation, immune tolerance, epithelial cells, fibroblasts, immune cells, tissue homeostasis, injury repair, cell proliferation, phenotypic plasticity, cell migration, metabolic adaptation, immune surveillance, treatment resistance
- MeSH terms
- Adaptation, Physiological, Animals, Signal Transduction, Transforming Growth Factor beta, Embryonic Development, Cell Proliferation
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