The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Neutrophil profiling illuminates anti-tumor antigen-presenting potency
Open accessAbstract
Neutrophils, the most abundant and efficient defenders against pathogens, exert opposing functions across cancer types. However, given their short half-life, it remains challenging to explore how neutrophils adopt specific fates in cancer. Here, we generated and integrated single-cell neutrophil transcriptomes from 17 cancer types (225 samples from 143 patients). Neutrophils exhibited extraordinary complexity, with 10 distinct states including inflammation, angiogenesis, and antigen presentation. Notably, the antigen-presenting program was associated with favorable survival in most cancers and could be evoked by leucine metabolism and subsequent histone H3K27ac modification. These neutrophils could further invoke both (neo)antigen-specific and antigen-independent T cell responses. Neutrophil delivery or a leucine diet fine-tuned the immune balance to enhance anti-PD-1 therapy in various murine cancer models. In summary, these data not only indicate the neutrophil divergence across cancers but also suggest therapeutic opportunities such as antigen-presenting neutrophil delivery.
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Cited by
Yu, X., Tian, W., Bao, X., Li, Z., Tu, H., Xu, X., Chen, J., Zhang, Q., Chen, J., Liu, C., et al. (2026) · Hepatology · doi:10.1097/hep.0000000000001427 · Cited by 14
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Metadata
- Authors
- Wu, Y., Ma, J., Yang, X., Nan, F., Zhang, T., Ji, S., Rao, D., Feng, H., Gao, K., Gu, X., Jiang, S., Song, G., Pan, J., Zhang, M., Xu, Y., Zhang, S., Fan, Y., Wang, X., Zhou, J., Yang, L., Fan, J., Zhang, X., & Gao, Q.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2024-03
- Volume
- 187
- Issue
- 6
- Pages
- 1422-1439.e24
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W4392456271
- Cited by
- 435
- References
- 98
- FWCI
- 60.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wu, Y., Ma, J., Yang, X., Nan, F., Zhang, T., Ji, S., Rao, D., Feng, H., Gao, K., Gu, X., Jiang, S., Song, G., Pan, J., Zhang, M., Xu, Y., Zhang, S., Fan, Y., Wang, X., Zhou, J., . . . Gao, Q. (2024). Neutrophil profiling illuminates anti-tumor antigen-presenting potency. Cell. https://doi.org/10.1016/j.cell.2024.02.005
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