Metagenome-informed metaproteomics of the human gut microbiome, host, and dietary exposome uncovers signatures of health and inflammatory bowel disease

Valdés-Mas, Rafael; Leshem, Avner; Zheng, Danping; Cohen, Yotam; Kern, Lara; Zmora, Niv; He, Yiming; Katina, Corine; Eliyahu-Miller, Shimrit; Yosef-Hevroni, Tal; Richman, Liron; Raykhel, Barbara; Allswang, Shira; Better, Reut; Shmueli, Merav; Saftien, Aurelia; Cullin, Nyssa; Slamovitz, Fernando; Ciocan, Dragos; Ouyang, Kyanna S.; Mor, Uria; Dori-Bachash, Mally; Molina, Shahar; Levin, Yishai; Atarashi, Koji; Jona, Ghil; Puschhof, Jens; Harmelin, Alon; Stettner, Noa; Chen, Minhu; Suez, Jotham; Honda, Kenya; Lieb, Wolfgang; Bang, Corinna; Kori, Michal; Maharshak, Nitsan; Merbl, Yifat; Shibolet, Oren; Halpern, Zamir; Shouval, Dror S.; Shamir, Raanan; Franke, Andre; Abdeen, Suhaib K.; Shapiro, Hagit; Savidor, Alon; Elinav, Eran

doi:10.1016/j.cell.2024.12.016

Metagenome-informed metaproteomics of the human gut microbiome, host, and dietary exposome uncovers signatures of health and inflammatory bowel disease

Host-microbiome-dietary interactions play crucial roles in regulating human health, yet their direct functional assessment remains challenging. We adopted metagenome-informed metaproteomics (MIM), in mice and humans, to non-invasively explore species-level microbiome-host interactions during comm…