The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Paclitaxel enhances early dendritic cell maturation and function through TLR4 signaling in mice
Open accessAbstract
Subclinical doses of Paclitaxel (PTX) given 1 day prior to a HER-2/neu (neu)-targeted, granulocyte-macrophage colony stimulating factor (GM-CSF)-secreting whole-cell vaccine enhances neu-specific T cell responses and slows neu+ tumor growth in tolerized HER-2/neu (neu-N) mice. We demonstrate that co-administration of PTX and Cyclophosphamide (CY) synergizes to slow tumor growth, and that in vitro, DC precursors exposed to PTX before LPS maturation results in greater co-stimulatory molecule expression, IL-12 production, and the ability to induce CD8+ T cells with enhanced lytic activity against neu+ tumors. PTX treatment also enhances maturation marker expression on CD11c+ DCs isolated from vaccine-draining lymph nodes. Ex vivo, these DCs activate CD8+ T cells with greater lytic capability than DC’s from vaccine alone-treated neu-N mice. Finally, PTX treatment results in enhanced antigen-specific, IFN-γ-secreting CD8+ T cells in vivo. Thus, administration of PTX with a tumor vaccine improves T cell priming through enhanced maturation of DC.
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Immunogenic and tolerogenic cell death
Green, D. R., Ferguson, T., Zitvogel, L., & Kroemer, G. (2009) · Nature Reviews Immunology · doi:10.1038/nri2545 · Cited by 1,176
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Self-citationWanderley, C. W., Colón, D. F., Luiz, J. P. M., Oliveira, F. F., Viacava, P. R., Leite, C. A., Pereira, J. A., Silva, C. M., Silva, C. R., Silva, R. L., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3480 · Cited by 420
Metadata
- Authors
- Pfannenstiel, L. W., Lam, S. S. K., Emens, L. A., Jaffee, E. M., & Armstrong, T. D.
- Venue
- Cellular Immunology
- Publisher
- Elsevier BV
- Published
- 2010
- Volume
- 263
- Issue
- 1
- Pages
- 79-87
- ISSN
- 0008-8749 (ISSN-L)
- OpenAlex
- W1970712517
- Cited by
- 159
- References
- 2
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Pfannenstiel, L. W., Lam, S. S. K., Emens, L. A., Jaffee, E. M., & Armstrong, T. D. (2010). Paclitaxel enhances early dendritic cell maturation and function through TLR4 signaling in mice. Cellular Immunology. https://doi.org/10.1016/j.cellimm.2010.03.001
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