Butyrate interferes with the differentiation and function of human monocyte-derived dendritic cells
Abstract
Dendritic cells (DCs) are specialized antigen-presenting cells that are uniquely capable of either inducing immune responses or maintaining a state of self-tolerance, depending on their stage of maturation. In the present study, we describe a way to interfere with DCs maturation. The compound butyrate can affect the differentiation of DCs generated from human monocytes and can inhibit T cell proliferation. We demonstrate that butyrate substantially down-regulates the expression of CD80, CD83, and MHC class II molecules; increases endocytic capability; reduces allostimulatory abilities; promote interleukin-10 (IL-10) production; and inhibits interleukin-12 (IL-12) and interferon-γ (IFN-γ) production. These results demonstrate a specific immune suppression property of butyrate and supports further investigation for butyrate as a new immunotherapeutic agent.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Butyrate and propionate inhibit dendritic cell maturation.
“Several studies have demonstrated that butyrate and propionate inhibit the maturation of dendritic cells (DCs), which form a central bridge between the innate and adaptive immune systems (Lu Liu et al., 2012; Millard et al., 2002; Singh et al., 2010; B. Wang et al., 2008).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Lu Liu et al., 2012
The citation lists haven’t been fetched yet
References 40 · Cited by 172
- Authors
- Liu, L., Li, L., Min, J., Wang, J., Wu, H., Zeng, Y., Chen, S., & Chu, Z.
- Affiliations
- Sun Yat-sen University (CN)
- Corresponding author
- Chu, Zhonghua
- Venue
- Cellular Immunology
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 277
- Issue
- 1-2
- Pages
- 66-73
- ISSN
- 0008-8749 (ISSN-L)
- OpenAlex
- W1975488300
- Cited by
- 172
- References
- 40
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 21 · 2023: 24 · 2022: 12 · 2021: 21 · 2020: 16 · 2019: 16 · 2018: 5 · 2017: 7 · 2016: 7 · 2015: 4 · 2014: 1 · 2013: 3
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Cellular Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- butyrate, dendritic cells, monocyte-derived dendritic cells, dendritic cell maturation, immunosuppression, T cell proliferation, CD80, CD83, MHC class II, endocytosis, allostimulation, IL-10, IL-12, interferon-gamma, antigen presentation, immunotherapy
- MeSH terms
- CD83 Antigen, Butyrates, Cell Differentiation, Cells, Cultured, Dendritic Cells, Endocytosis, HLA-DR Antigens, Humans, Immunoglobulins, Immunosuppression Therapy, Membrane Glycoproteins, Monocytes, Down-Regulation, Antigens, CD, Cytokines, B7-1 Antigen
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
