Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli
Abstract
The p38 mitogen-activated protein kinase (MAPK) signaling pathway plays an important role in cellular responses to inflammatory stimuli and environmental stress. Activation of p38 is mediated through phosphorylation by upstream MAPKK, which in turn is activated by MAPKKK. However, the mechanism of how different upstream MAP2Ks and MAP3Ks specifically contribute to p38 activation in response to different stimuli is still not clearly understood. By using double-stranded RNA-mediated interference (RNAi) in Drosophila cells, we demonstrate that D-MKK3 is a major MAP2K responsible for D-p38 activation by UV, heat shock, NaCl or peptiodglycan (PGN). Stimulation of UV and PGN activates D-p38 through D-MEKK1, heat shock-induced activation of D-p38 signals through both D-MEKK1 and D-ASK1. On the other hand, maximal activation of D-p38 by NaCl requires the expression of four MAP3Ks.
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Mekk1 is a MAP3K that leads to the phosphorylation and activation of p38/MAPK, which is activated in response to cell stress.
“Mekk1 is a MAP3K that leads to the phosphorylation and activation of p38/MAPK (87), which is activated in response to cell stress (142–144).”
From Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation (2011) · cites this paper as [144]
Cites
Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers
Schaeffer, H. J., & Weber, M. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2435 · Cited by 1,600 · see citing works
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Ambegaokar, S. S., & Jackson, G. R. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr432 · Cited by 113 · see citing works
- Authors
- Zhuang, Z.-H., Zhou, Y., Yu, M.-C., Silverman, N., & Ge, B.-X.
- Affiliations
- Chinese Academy of Sciences (CN)
- University of Massachusetts Chan Medical School (US)
- Venue
- Cellular Signalling
- Publisher
- Elsevier BV
- Published
- 2006-04
- Volume
- 18
- Issue
- 4
- Pages
- 441-448
- ISSN
- 0898-6568 (ISSN-L)
- OpenAlex
- W1999696542
- Cited by
- 45
- References
- 1
- Citations by year
- 2026: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2014: 3 · 2013: 1 · 2012: 5
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cellular Signalling (publishedVersion)
- PubMed (publishedVersion)
- eScholarship@UMassChan (submittedVersion)
- Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (AI060025)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Keywords
- p38 MAPK activation, MEK, MAP3K, Drosophila, MEKK1, ASK1, MKK3, heat shock, UV stress, peptidoglycan, NaCl stress, MAPK signaling, stress response
- MeSH terms
- Animals, Cell Line, Drosophila, Hot Temperature, Peptidoglycan, RNA, Double-Stranded, Sodium Chloride, Ultraviolet Rays, Signal Transduction, MAP Kinase Signaling System, RNA Interference, p38 Mitogen-Activated Protein Kinases, MAP Kinase Kinase 1, MAP Kinase Kinase 2, MAP Kinase Kinase 3, MAP Kinase Kinase Kinase 5
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