Nemo-like kinase, a multifaceted cell signaling regulator
Abstract
Nemo-like kinase (NLK) is an evolutionarily conserved MAP kinase-related kinase. Although NLK was originally identified as a Drosophila gene affecting cell movement during eye development, recent studies show that NLK also contributes to cell proliferation, differentiation, and morphological changes during early embryogenesis and nervous system development in vertebrates. In addition, NLK has been reported to be involved in the development of several human cancers. NLK is able to play a role in multiple processes due to its capacity to regulate a diverse array of signaling pathways, including the Wnt/β-catenin, Activin, IL-6, and Notch signaling pathways. Although the molecular mechanisms that regulate NLK activity remain unclear, our recent research has presented a new model for NLK activation. Here, we summarize the current understanding of the function and regulation of NLK and discuss the aspects of NLK regulation that remain to be resolved.
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NLK is known as a negative regulator of Wnt signalling in most studies, but few studies show NLK positively promotes Wnt signalling.
“NLK is known as a negative regulator of Wnt signalling in most studies; however, there are few studies in which NLK has been shown to positively promote the Wnt signalling pathway [20].”
From Nemo-Like Kinase in Development and Diseases: Insights from Mouse Studies (2020) · cites this paper as [20]
Cites
Ishitani, T., Ninomiya-Tsuji, J., Nagai, S.-I., Nishita, M., Meneghini, M., Barker, N., Waterman, M., Bowerman, B., Clevers, H., Shibuya, H., et al. (1999) · Nature · doi:10.1038/21674 · Cited by 624 · see citing works
Self-citationRotation of photoreceptor clusters in the developing drosophila eye requires the nemo gene
Choi, K.-W., & Benzer, S. (1994) · Cell · doi:10.1016/0092-8674(94)90579-7 · Cited by 339 · see citing works
Ishitani, T., Ninomiya-Tsuji, J., & Matsumoto, K. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1379-1389.2003 · Cited by 212 · see citing works
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Nemo-Like Kinase in Development and Diseases: Insights from Mouse Studies
Daams, R., & Massoumi, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239203 · Cited by 21 · see citing works
“NLK is known as a negative regulator of Wnt signalling in most studies; however, there are few studies in which NLK has been shown to positively promote the Wnt signalling pathway [20].”
Background
- Authors
- Ishitani, T., & Ishitani, S.
- Affiliations
- Kyushu University (JP)
- Corresponding author
- Ishitani, Tohru
- Venue
- Cellular Signalling
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 25
- Issue
- 1
- Pages
- 190-197
- ISSN
- 0898-6568 (ISSN-L)
- OpenAlex
- W2085721550
- Cited by
- 71
- References
- 3
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 9 · 2019: 2 · 2018: 5 · 2017: 7 · 2016: 10 · 2015: 9 · 2014: 5 · 2013: 5
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cellular Signalling (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Health Labour Sciences Research
- Kaibara Morikazu Medical Science Promotion Foundation
- Kurata Memorial Hitachi Science and Technology Foundation
- Nakajima Foundation
- Kyushu University P&P
- Hayashi Memorial Foundation for Female Natural Scientists
- Grants-in-Aid for Scientific Research programs in Japan
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Nemo-like kinase, cell signaling regulation, Wnt/β-catenin signaling, activin signaling, IL-6 signaling, Notch signaling, kinase activation mechanism, embryonic development, brain development, cancer, cell proliferation, cell differentiation
- MeSH terms
- Animals, Humans, Nervous System, Signal Transduction, Mitogen-Activated Protein Kinases, MicroRNAs, Wnt Proteins, Catenins, Lymphoid Enhancer-Binding Factor 1
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