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Thermosensory and Nonthermosensory Isoforms of Drosophila melanogaster TRPA1 Reveal Heat-Sensor Domains of a ThermoTRP Channel
Open accessAbstract
Specialized somatosensory neurons detect temperatures ranging from pleasantly cool or warm to burning hot and painful (nociceptive). The precise temperature ranges sensed by thermally sensitive neurons is determined by tissue-specific expression of ion channels of the transient receptor potential(TRP) family.We show here that in Drosophila, TRPA1 is required for the sensing of nociceptive heat. We identify two previously unidentified protein isoforms of dTRPA1, named dTRPA1-C and dTRPA1-D, that explain this requirement. A dTRPA1-C/D reporter was exclusively expressed in nociceptors, and dTRPA1-C rescued thermal nociception phenotypes when restored to mutant nociceptors. However,surprisingly, we find that dTRPA1-C is not a direct heat sensor. Alternative splicing generates at least four isoforms of dTRPA1. Our analysis of these isoforms reveals a 37-amino-acid-long intracellular region (encoded by a single exon) that is critical for dTRPA1 temperature responses. The identification of these amino acids opens the door to a biophysical understanding of a molecular thermosensor.
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Cited by
A multilevel multimodal circuit enhances action selection in drosophila
Ohyama, T., Schneider-Mizell, C. M., Fetter, R. D., Aleman, J. V., Franconville, R., Rivera-Alba, M., Mensh, B. D., Branson, K. M., Simpson, J. H., Truman, J. W., et al. (2015) · Nature · doi:10.1038/nature14297 · Cited by 502
Liman, E. R., Zhang, Y. V., & Montell, C. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.022 · Cited by 473
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
Talavera, K., Startek, J. B., Alvarez-Collazo, J., Boonen, B., Alpizar, Y. A., Sanchez, A., Naert, R., & Nilius, B. (2020) · Physiological Reviews · doi:10.1152/physrev.00005.2019 · Cited by 403
A gustatory receptor paralogue controls rapid warmth avoidance in Drosophila
Ni, L., Bronk, P., Chang, E. C., Lowell, A. M., Flam, J. O., Panzano, V. C., Theobald, D. L., Griffith, L. C., & Garrity, P. A. (2013) · Nature · doi:10.1038/nature12390 · Cited by 254
TRPA1 channels: molecular sentinels of cellular stress and tissue damage
Viana, F. (2016) · The Journal of Physiology · doi:10.1113/jp270935 · Cited by 210
Metadata
- Authors
- Zhong, L., Bellemer, A., Yan, H., Honjo, K., Robertson, J., Hwang, R. Y., Pitt, G. S., & Tracey, W. D.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 1
- Issue
- 1
- Pages
- 43-55
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2162328888
- Cited by
- 242
- References
- 0
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhong, L., Bellemer, A., Yan, H., Honjo, K., Robertson, J., Hwang, R. Y., Pitt, G. S., & Tracey, W. D. (2012). Thermosensory and Nonthermosensory Isoforms of Drosophila melanogaster TRPA1 Reveal Heat-Sensor Domains of a ThermoTRP Channel. Cell Reports. https://doi.org/10.1016/j.celrep.2011.11.002
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