The Calcineurin-NFAT-Angiopoietin-2 Signaling Axis in Lung Endothelium Is Critical for the Establishment of Lung Metastases

Minami, Takashi; Jiang, Shuying; Schadler, Keri; Suehiro, Jun-ichi; Osawa, Tsuyoshi; Oike, Yuichi; Miura, Mai; Naito, Makoto; Kodama, Tatsuhiko; Ryeom, Sandra

doi:10.1016/j.celrep.2013.07.021

The Calcineurin-NFAT-Angiopoietin-2 Signaling Axis in Lung Endothelium Is Critical for the Establishment of Lung Metastases

SUMMARY The pre-metastatic niche is a pre-determined site of metastases, awaiting the influx of tumor cells. However, regulation of the angiogenic switch at these sites has not been examined. Here we demonstrate that the calcineurin-NFAT pathway is activated specifically in lung endothelium prior…