The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Targeted Disruption of Hotair Leads to Homeotic Transformation and Gene Derepression
Open accessAbstract
Long noncoding RNAs (lncRNAs) are thought to be prevalent regulators of gene expression, but the consequences of lncRNA inactivation in vivo are mostly unknown. Here, we show that targeted deletion of mouse Hotair lncRNA leads to derepression of hundreds of genes, resulting in homeotic transformation of the spine and malformation of metacarpal-carpal bones. RNA sequencing and conditional inactivation reveal an ongoing requirement of Hotair to repress HoxD genes and several imprinted loci such as Dlk1-Meg3 and Igf2-H19 without affecting imprinting choice. Hotair binds to both Polycomb repressive complex 2, which methylates histone H3 at lysine 27 (H3K27), and Lsd1 complex, which demethylates histone H3 at lysine 4 (H3K4) in vivo. Hotair inactivation causes H3K4me3 gain and, to a lesser extent, H3K27me3 loss at target genes. These results reveal the function and mechanisms of Hotair lncRNA in enforcing a silent chromatin state at Hox and additional genes.
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Cites
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Tsai, M.-C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., Lan, F., Shi, Y., Segal, E., & Chang, H. Y. (2010) · Science · doi:10.1126/science.1192002 · Cited by 3,290 · cited 18×
“Other lncRNAs, such as HOTAIR and lincp21, act in trans to guide silencing complexes to sites throughout the genome (Huarte et al., 2010; Rinn et al., 2007).”
BackgroundMethodInfluentialSelf-citationKhalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904715106 · Cited by 2,872
Cited by
Long non-coding RNAs: new players in cell differentiation and development
Fatica, A., & Bozzoni, I. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3606 · Cited by 2,980
The emerging role of lncRNAs in cancer
Huarte, M. (2015) · Nature Medicine · doi:10.1038/nm.3981 · Cited by 2,702
Morris, K. V., & Mattick, J. S. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3722 · Cited by 1,371
Transcriptional and Post-Transcriptional Gene Regulation by Long Non-Coding RNA
Dykes, I. M., & Emanueli, C. (2017) · Genomics, Proteomics & Bioinformatics · doi:10.1016/j.gpb.2016.12.005 · Cited by 914
The bright side of dark matter: lncRNAs in cancer
Evans, J. R., Feng, F. Y., & Chinnaiyan, A. M. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84421 · Cited by 451
Metadata
- Authors
- Li, L., Liu, B., Wapinski, O. L., Tsai, M.-C., Qu, K., Zhang, J., Carlson, J. C., Lin, M., Fang, F., Gupta, R. A., Helms, J. A., & Chang, H. Y.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 5
- Issue
- 1
- Pages
- 3-12
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2111309204
- Cited by
- 317
- References
- 3
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- gold
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- Li, L., Liu, B., Wapinski, O. L., Tsai, M.-C., Qu, K., Zhang, J., Carlson, J. C., Lin, M., Fang, F., Gupta, R. A., Helms, J. A., & Chang, H. Y. (2013). Targeted Disruption of Hotair Leads to Homeotic Transformation and Gene Derepression. Cell Reports. https://doi.org/10.1016/j.celrep.2013.09.003
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