BDNF in the dentate gyrus is required for consolidation of “pattern-separated” memories.
Open accessAbstract
Successful memory involves not only remembering information over time, but also keeping memories distinct and less confusable. The computational process for making representations for similar input patterns more distinct from each other has been referred to as "pattern separation." In this work, we developed a set of behavioral conditions that allowed us to manipulate the load for pattern separation at different stages of memory. Thus, we provide experimental evidence that a brain-derived neurotrophic factor (BDNF)-dependent pattern separation process occurs during the encoding/storage/consolidation, but not the retrieval stage of memory processing. We also found that a spontaneous increase in BDNF in the dentate gyrus of the hippocampus is associated with exposure to landmarks delineating similar, but not dissimilar, spatial locations, suggesting that BDNF is expressed on an "as-needed" basis for pattern separation.
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Brain-derived neurotrophic factor acts on adult-born granule cells within the dentate gyrus to facilitate pattern separation.
“Recent studies have shown that BDNF is required for the pattern separation to occur in memory encoding and consolidation, and specifically that BDNF acts on adult-born granule cells within the DG to facilitate pattern separation (Bekinschtein et al., 2013, 2014).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Bekinschtein et al., 2013
Brain-derived neurotrophic factor is required for pattern separation to occur in memory encoding and consolidation.
“Recent studies have shown that BDNF is required for the pattern separation to occur in memory encoding and consolidation, and specifically that BDNF acts on adult-born granule cells within the DG to facilitate pattern separation (Bekinschtein et al., 2013, 2014).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Bekinschtein et al., 2013
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References 32 · Cited by 124
- Authors
- Bekinschtein, P., Kent, B. A., Oomen, C. A., Clemenson, G. D., Gage, F. H., Saksida, L. M., & Bussey, T. J.
- Affiliations
- University of Cambridge (GB)
- Salk Institute for Biological Studies (US)
- Corresponding author
- Bekinschtein, Pedro
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 5
- Issue
- 3
- Pages
- 759-768
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC3898274
- OpenAlex
- W2005198162
- Cited by
- 124
- References
- 32
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 7 · 2023: 10 · 2022: 14 · 2021: 10 · 2020: 8 · 2019: 12 · 2018: 17 · 2017: 4 · 2016: 10 · 2015: 13 · 2014: 10
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Scholarship@Western (Western University) (submittedVersion, cc-by)
- Radboud Repository (Radboud University) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
- Funders
- James S. McDonnell Foundation
- Wellcome Trust (089703)
- European Federation of Pharmaceutical Industries and Associations
- European Commission (115008)
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council (BB/G019002/1)
- National Institute on Aging
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- brain-derived neurotrophic factor, dentate gyrus, pattern separation, memory consolidation, hippocampus, spatial memory, memory encoding, memory retrieval, BDNF expression, landmarks
- MeSH terms
- Animals, Brain Mapping, Humans, Memory, Recombinant Proteins, Dentate Gyrus, Brain-Derived Neurotrophic Factor, Pattern Recognition, Physiological, Rats
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