Immune Cell Toll-like Receptor 4 Mediates the Development of Obesity- and Endotoxemia-Associated Adipose Tissue Fibrosis
Vila, Isabelle K., Badin, Pierre-Marie, Marques, Marie-Adeline, Monbrun, Laurent, Lefort, Corinne, Mir, Lucile, Louche, Katie, Bourlier, Virginie +11 more·2014·Cell Reports
Cited by (165)
Items 101–165 of 165
- Adipocyte size, adipose tissue fibrosis, macrophage infiltration and disease risk are different in younger and older individuals with childhood versus adulthood onset obesityLaurent Turner, Marie‐Frédérique Gauthier, Annie Lafortune, André Tchernof, Sylvia Santosa · 2022 · International Journal of Obesity
- Role of long non-coding RNAs in adipose tissue metabolism and associated pathologiesAna Corral, Martín Alcalá, Ma Carmen Durán-Ruiz, Ana I. Arroba, Jesús Gustavo Ponce‐González, Marijana Todorčević, Dolors Serra, María Calderón‐Domínguez, Laura Herrero · 2022 · Biochemical Pharmacology
- La fibrose du tissu adipeuxGeneviève Marcelin, Karine Clément · 2018 · médecine/sciences
- Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosisFrederike J. Graelmann, Fabian Gondorf, Yasmin Majlesain, Birte Niemann, Katarina Klepac, Dominic Gosejacob, Marlene Gottschalk, Michelle Mayer, Irina Iriady, Philip Hatzfeld et al. · 2024 · Molecular Metabolism
- Low-intensity pulsed ultrasound improves metabolic dysregulation in obese mice by suppressing inflammation and extracellular matrix remodelingMin He, Hong Zhu, Jingsong Dong, Wen-Zhen Lin, Boyi Li, Ying Li, Dean Ta · 2024 · Ultrasonics
- New perspectives on obesity-induced adipose tissue fibrosis and related clinical manifestationsYutaka Hasegawa · 2022 · Endocrine Journal
- Meta-fibrosis links positive energy balance and mitochondrial metabolism to insulin resistanceDaniel Stephen Lark, David H. Wasserman · 2017 · F1000Research
- Toll‑like receptor 2 mediates deposition of collagen I in adipose tissue of high fat diet‑induced obese miceBing Song, Haoqiang Zhang, Suping Zhang · 2018 · Molecular Medicine Reports
- Aberrant Mesenteric Adipose Extracellular Matrix Remodelling is Involved in Adipocyte Dysfunction in Crohn’s Disease: The Role of TLR-4-mediated MacrophagesLugen Zuo, Jing Li, Xiaofeng Zhang, Zhijun Geng, Xue Song, Yueyue Wang, Sitang Ge, Ruohan Shi, Yueqing Zhou, Yuanyuan Ge et al. · 2022 · Journal of Crohn s and Colitis
- Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signallingKlara Piletič, Amir Hossein Kayvanjoo, Felix Clemens Richter, Mariana Borsa, Ana Victoria Lechuga‐Vieco, Oliver Popp, Sacha Grenet, Jacky K. L. Ko, Lin Luo, Kristina Zec et al. · 2025 · Nature Communications
- Unraveling the complex roles of macrophages in obese adipose tissue: an overviewChang Si Peng, Jun Chen, Rui Wu, Haowen Jiang, Jia Xuan Li · 2024 · Frontiers of Medicine
- Muscle Arnt/Hif1β Is Dispensable in Myofiber Type Determination, Vascularization and Insulin SensitivityPierre-Marie Badin, Danesh H. Sopariwala, Sabina Lorca, Vihang A. Narkar · 2016 · PLoS ONE
- Toll-like receptors in B cells and obesityPai Wang, Can Hou, Florence Susan Wong, Wen Li · 2025 · Trends in Molecular Medicine
- The cyclin dependent kinase inhibitor Roscovitine prevents diet-induced metabolic disruption in obese miceNabil Rabhi, Kathleen Desevin, Briana Noel Cortez, Ryan Matthew Hekman, Jean Z. Lin, Andrew Emili, Stephen R. Farmer · 2021 · Scientific Reports
- Increased Fibrosis in White Adipose Tissue of Male and Female bGH Transgenic Mice Appears Independent of TGF-β ActionStephen Robert Clyde Bell, Jonathan A Young, Edward Owen List, Reetobrata Basu, Delaney K. Geitgey, Grace Lach, Kevin Y. Lee, Deborah Swegan, Lydia J. Caggiano, Shigeru Okada et al. · 2023 · Endocrinology
- Hypothermia Promotes Interleukin-22 Expression and Fine-Tunes Its Biological ActivityEvgeny Chichelnitskiy, Britta Himmelseher, Malte Bachmann, Josef M. Pfeilschifter, Heiko Mühl · 2017 · Frontiers in Immunology
- Berberine ameliorates mesenteric vascular dysfunction by modulating perivascular adipose tissue in diet-induced obese in ratsMan Wang, Xufang Geng, Kaipeng Li, Yawen Wang, Xiaofeng Duan, Congcong Hou, Lili Zhao, Huimin Zhou, Ding Zhao · 2022 · BMC Complementary Medicine and Therapies
- Nutritional Regulation of Mammary Tumor MicroenvironmentNikita Thakkar, Ye Bin Shin, Hoon‐Ki Sung · 2022 · Frontiers in Cell and Developmental Biology
- Diet-Induced Early Inflammatory Response of Visceral Adipose Tissue in Healthy Male Wistar RatsIliyan Valeriev Dimitrov, Teodora R. Stankova, Penka Angelova, Nikolay Boyadjiev, Katerina Nikolova Georgieva, Ivica Dimov, Anelia Veselinova Bivolarska, Milena Draganova-Filipova, Fanka Gerginska, Elena Daskalova et al. · 2024 · Nutrients
- Time-Restricted Feeding Attenuates Adipose Tissue Inflammation and Fibrosis in Mice Under Chronic Light ExposureJiyeon Nah, Narae Yun, Hyunjin Yoo, Surin Park, Munkyong Pae · 2024 · International Journal of Molecular Sciences
- Microglia/macrophage-specific deletion of TLR-4 protects against neural effects of diet-induced obesity in a sexually dimorphic mannerJiahui Liu, Ali Hussainy Zaidi, Christian J. Pike · 2025 · Journal of Neuroinflammation
- RETRACTED: PFKFB3, a key glucose metabolic enzyme regulated by pathogen recognition receptor TLR4 in liver cellsYan Lu, Lei Zhang, Ran Zhu, Huijuan Zhou, Huaying Fan, Qiang Wang · 2020 · Therapeutic Advances in Endocrinology and Metabolism · Retracted
- Fibrocytes enhance mammary gland fibrosis in obesityGenevra M. Kuziel, Brittney N. Moore, Grace P. Haugstad, Lisa M. Arendt · 2023 · The FASEB Journal
- Effects of Porphyromonas gingivalis Bacteria on Inflammation, Oxidative Stress and Lipid Metabolism in Models of Obese db/db Mice and 3T3-L1 Adipose CellsKaty Thouvenot, Fanny Le Sage, Angélique Arcambal, David Couret, Wildriss Viranaïcken, Philippe Rondeau, Olivier Meilhac, Marie‐Paule Gonthier · 2025 · Microorganisms
- Nuclear hormone-sensitive lipase regulates adipose tissue mass and adipocyte metabolismJérémy Dufau, Emeline Recazens, Laura Bottin, Camille Bergoglio, Aline Mairal, Karima Chaoui, Marie-Adeline Marqués, Verónica Jiménez, Miquel García, Tongtong Wang et al. · 2025 · Cell Metabolism
- Salvia hispanica L. (chia) seed have beneficial effects upon visceral adipose tissues extracellular matrix disorders and inflammation developed in a sucrose-rich diet-induced adiposity rodent modelVictoria Aiassa, María del Rosario Ferreira, Paola I. Ingaramo, Marı́a Eugenia D’Alessandro · 2024 · Molecular and Cellular Endocrinology
- The adipocyte apolipoprotein M is negatively associated with inflammationLaurie Frances, Mikaël Croyal, Soline Pittet, Léa Da Costa Fernandes, Milan Boulaire, Laurent Monbrun, Ellen E. Blaak, Christina Christoffersen, Cédric Moro, Geneviève Tavernier et al. · 2024 · Journal of Lipid Research
- Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s diseasePhillip Gu, Shishir Dube, Norman H Gellada, So Yung Choi, Susan Win, Yoo Jin Lee, Shaohong Yang, Talin Haritunians, GIL Y. MELMED, Eric A. Vasiliauskas et al. · 2024 · World Journal of Gastrointestinal Surgery
- Lysozyme Gene Expression in 3T3-L1 Cells Sustains Expression of Adipogenic Genes and Adipocyte DifferentiationAina Lluch, Jèssica Latorre, José Manuel Fernández‐Real, José María Moreno‐Navarrete · 2022 · Frontiers in Cell and Developmental Biology
- Microglia/macrophage-specific deletion of TLR-4 protects against neural effects of diet-induced obesityJiahui Liu, Ali Hussainy Zaidi, Christian J. Pike · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Innate immune signalling in the adipocytePhillip A. Dumesic · 2026 · The Journal of Biochemistry
- Combined pharmacological targeting of CD9+ progenitors alleviates obesity-induced adipose tissue fibrosis and metabolic impairmentClémentine Rebière, Ana Letícia Malheiros Silveira, A. C. Oliveira, Christine Rouault, Solia Adriouch, Sébastien Dussaud, Jimon Boniface Abatan, Cindy Rose, Simon Lecoutre, Alexandre Boissonnas et al. · 2025 · Cell Reports Medicine
- Fructooligosaccharide Upregulates Colonic Vitamin D Receptors and Modulates Inflammatory Status in High-Fat Diet-Induced Obese Male C57BL/6 MiceKelly Brunelle, Emily Butler, Zack Nobles, Lauren S. Lewis, Sophia Hernandez, Gar Yee Koh · 2026 · International Journal for Vitamin and Nutrition Research
- Hepatocyte-specific RIG-I loss attenuates metabolic dysfunction-associated steatotic liver disease in mice via changes in mitochondrial respiration and metabolite profilesJin Kyung Seok, Gabsik Yang, Jung in Jee, Han Chang Kang, Yong‐Yeon Cho, Hye Suk Lee, Joo Young Lee · 2024 · Toxicological Research
- Notch activation shifts the fate decision of senescent progenitors toward myofibrogenesis in human adipose tissueNathalie Boulet, Anaïs Briot, Valentin Jargaud, David Estève, Anne Rémaury, Chloé Belles, Pénélope Viana, Jessica Fontaine, Lucie Murphy, Catherine Déon et al. · 2023 · Aging Cell
- Molecular Mechanisms Underlying Obesity-Induced Chronic InflammationTakayoshi Suganami, Miyako Tanaka, Yoshihiro Ogawa · 2016 · Springer eBooks
- Fibulin-7 in progenitor cells promotes adipose tissue fibrosis and disrupts metabolic homeostasis in obesityHairong Yu, Fan Yang, Dandan Yan, Wei Chen, Lijun Yao, Hongli Chen, Siyu Lai, Jinyin Zha, Yi Xin Sun, Yicen Zong et al. · 2025 · Protein & Cell
- A Hydrogel Culture System Regulates Human Adipocyte FunctionJason Junhyoung Kwon, Jie Li, Joshua Yu-Chung Liu, Christopher Patsalis, Peizi Wu, Yoshiki H. Kawase, Alexander Ky, Carter Pasternak, Damian D. Mason, Nadejda Bozadjieva-Kramer et al. · 2025 · International Journal of Molecular Sciences
- Growth hormone causes reversible fibrosis in muscle and fat: a study in patients with acromegalyAmanda Bæk, Mai Christiansen Arlien-Søborg, Anne Kathrine Nissen Pedersen, Jakob Dal, Michael Alle Madsen, Morten Lyng Høgild, Darlene E. Berryman, John Joseph Kopchick, Steen B. Pedersen, Mette Bjerre et al. · 2026 · European Journal of Endocrinology
- Toll-like receptor 4 signaling links cytoskeletal remodeling to lipid accumulation in macrophagesEn Wang, Hamizah Shahirah Hamezah, Rongchun Han, Xiaohui Tong · 2026 · Inflammation and Regeneration
- Impact of Inflammation and Innate Immunity Response in Obesity Mediated DiabetesMichael J. Pugia · 2015 · Springer eBooks
- Tissu adipeux blancCindy Rose, Geneviève Marcelin · 2021 · Elsevier eBooks
- Obesity-elicited macrophages shape CD9 hi progenitor fate to promote adipose tissue fibrosis and dysfunctionHaoussa Askia, Sébastien Dussaud, Marina C. Oliveira, A. C. Oliveira, Lucie Poupel, Clémentine Rebière, Melissa Ouhachi, Raoul Manuel, Fatiha Merabtene, Laurent Genser et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Isoliquiritigenin: A Unique Component That Attenuates Adipose Tissue Inflammation and Fibrosis by Targeting the Innate Immune SensorsYoshinori Nagai, Yasuharu Watanabe, Hiroe Honda, Kiyoshi Takatsu · 2017 · InTech eBooks
- THE ROLE OF THE INTESTINAL MICROBIOTA IN THE MODULATION OF FOOD INTAKE AND BODY WEIGHTMatthew John Dalby · 2017
- Obesity: A Complex Disease with Immune ComponentsYuejun Liu, Karine Clément · 2017 · Wiley-VCH eBooks
- Diet, Microbioma, and Diabetes in AgingShirley Steffany Muñoz Fernández, Sandra María Lima Ribeiro · 2020 · Current Geriatrics Reports
- Myocardin-Related Transcription Factor A Promotes Recruitment of ITGA5+ Profibrotic Progenitors During Obesity-Induced Adipose Tissue FibrosisJean Z. Lin, Nabil Rabhi, Stephen R. Farmer · 2018 · SSRN Electronic Journal
- The cyclin dependent kinase inhibitor Roscovitine reverses diet- induced metabolic disruption in obese miceNabil Rabhi, Kathleen Desevin, Briana Noel Cortez, Ryan Matthew Hekman, Jean Z. Lin, Andrew Emili, Stephen R. Farmer · 2021 · Research Square
- Additional file 1 of Transcriptomic changes in peripheral blood mononuclear cells with weight loss: systematic literature review and primary data synthesisDay, Kaitlin, Aimee L. Dordevic, Helen Truby, Melissa C. Southey, Susan L. Coort, Chiara Murgia · 2021 · Figshare
- Additional file 5 of Transcriptomic changes in peripheral blood mononuclear cells with weight loss: systematic literature review and primary data synthesisDay, Kaitlin, Aimee L. Dordevic, Helen Truby, Melissa C. Southey, Susan L. Coort, Chiara Murgia · 2021 · Figshare
- Additional file 4 of Transcriptomic changes in peripheral blood mononuclear cells with weight loss: systematic literature review and primary data synthesisKaitlin Day, Aimee L. Dordevic, Helen Truby, Melissa C. Southey, Susan L. Coort, Chiara Murgia · 2021 · Figshare
- Additional file 2 of Transcriptomic changes in peripheral blood mononuclear cells with weight loss: systematic literature review and primary data synthesisDay, Kaitlin, Aimee L. Dordevic, Helen Truby, Melissa C. Southey, Susan L. Coort, Chiara Murgia · 2021 · Figshare
- Additional file 6 of Transcriptomic changes in peripheral blood mononuclear cells with weight loss: systematic literature review and primary data synthesisDay, Kaitlin, Aimee L. Dordevic, Helen Truby, Melissa C. Southey, Susan L. Coort, Chiara Murgia · 2021 · Figshare
- Inflammation du tissu adipeux au cours de l'obésité humaine : implication des lymphocytes Th17Charles Caër · 2016 · theses.fr (ABES)
- Régulations fonctionnelles des lymphocytes T par les cellules souches adipocytaires : implication dans l’inflammation chronique et l’insulinorésistance du tissu adipeux du sujet obèseMarwa Chehimi · 2018 · theses.fr (ABES)
- Rôle de la mPGES-1 dans le développement de l'inflammation chronique de bas seuil et de l'obésitéPierre Clément · 2018 · theses.fr (ABES)
- Improvement of insulin sensitivity through hormone-sensitive lipase inhibition : study of the mechanisms involvedPauline Morigny · 2017 · theses.fr (ABES)
- Rôle des macrophages dans le remodelage pathologique du tissu adipeux au cours de l'obésitéHaoussa Askia · 2022 · theses.fr (ABES)
- Rôle nucléaire de la lipase hormono-sensible et de ChREBPβ dans le contrôle transcriptionnel de l’adipocyteEmeline Recazens · 2021 · theses.fr (ABES)
- Caractérisation structurale et fonctionnelle du tissu adipeux périprostatique : implication dans le cancer de la prostateMathieu Roumiguié · 2022
- Lipodystrophie partielle familiale de type 2 – description phénotypique et étude des paramètres d'insulino-résistance et d'inflammation dans une population atteinte du variant pathogène p.(Thr655Asnfs*49).Guillaume Treiber · 2023
- Étude et modulation des mécanismes contrôlant la résolution de la fibrose du tissu adipeux au cours de l’obésité et de la perte de poidsClémentine Rebière · 2024 · theses.fr (ABES)
- Targeting the Adipose–Liver Axis in Fibrosis and Liver Cancer: Pathogenic Mechanisms and Therapeutic PerspectivesFenqin Chen, Yue Guan, N Liu, Wei Jing · 2026 · Comprehensive physiology
- The role of adipose tissue macrophages in adipose tissue fibrosisDanhuai Zhang, Na Wu · 2026 · Metabolism