The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
A Mitochondrial Switch Promotes Tumor Metastasis
Open accessAbstract
Metastatic progression of cancer is associated with poor outcome, and here we examine metabolic changes underlying this process. Although aerobic glycolysis is known to promote metastasis, we have now identified a different switch primarily affecting mitochondria. The switch involves overload of the electron transport chain (ETC) with preserved mitochondrial functions but increased mitochondrial superoxide production. It provides a metastatic advantage phenocopied by partial ETC inhibition, another situation associated with enhanced superoxide production. Both cases involved protein tyrosine kinases Src and Pyk2 as downstream effectors. Thus, two different events, ETC overload and partial ETC inhibition, promote superoxide-dependent tumor cell migration, invasion, clonogenicity, and metastasis. Consequently, specific scavenging of mitochondrial superoxide with mitoTEMPO blocked tumor cell migration and prevented spontaneous tumor metastasis in murine and human tumor models.
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Cites
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A role for mitochondria in nlrp3 inflammasome activation
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Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
Weinberg, F., Hamanaka, R., Wheaton, W. W., Weinberg, S., Joseph, J., Lopez, M., Kalyanaraman, B., Mutlu, G. M., Budinger, G. R. S., & Chandel, N. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003428107 · Cited by 1,742
ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis
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Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells
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Complex iii releases superoxide to both sides of the inner mitochondrial membrane
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Antioxidants Accelerate Lung Cancer Progression in Mice
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HIF-Dependent Antitumorigenic Effect of Antioxidants In Vivo
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Cited by
Fundamentals of Cancer Metabolism
DeBerardinis, R. J., & Chandel, N. S. (2016) · Science Advances · doi:10.1126/sciadv.1600200 · Cited by 3,013
Metabolic reprogramming and cancer progression
Faubert, B., Solmonson, A., & DeBerardinis, R. J. (2020) · Science · doi:10.1126/science.aaw5473 · Cited by 2,740
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Cancer metabolism: a therapeutic perspective
Martinez-Outschoorn, U. E., Peiris-Pagés, M., Pestell, R. G., Sotgia, F., & Lisanti, M. P. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.60 · Cited by 1,505
Metadata
- Authors
- Porporato, P. E., Payen, V. L., Pérez-Escuredo, J., De Saedeleer, C. J., Danhier, P., Copetti, T., Dhup, S., Tardy, M., Vazeille, T., Bouzin, C., Feron, O., Michiels, C., Gallez, B., & Sonveaux, P.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 8
- Issue
- 3
- Pages
- 754-766
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2148332345
- Cited by
- 571
- References
- 10
- FWCI
- 11.95
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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