Medial entorhinal cortex lesions only partially disrupt hippocampal place cells and hippocampus-dependent place memory
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The entorhinal cortex provides the primary cortical projections to the hippocampus, a brain structure critical for memory. However, it remains unclear how the precise firing patterns of medial entorhinal cortex (MEC) cells influence hippocampal physiology and hippocampus-dependent behavior. We found that complete bilateral lesions of the MEC resulted in a lower proportion of active hippocampal cells. The remaining active cells had place fields, but with decreased spatial precision and decreased long-term spatial stability. In addition, MEC rats were as impaired in the water maze as hippocampus rats, while rats with combined MEC and hippocampal lesions had an even greater deficit. However, MEC rats were not impaired on other hippocampus-dependent tasks, including those in which an object location or context was remembered. Thus, the MEC is not necessary for all types of spatial coding or for all types of hippocampus-dependent memory, but it is necessary for the normal acquisition of place memory.
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Lesions of the MEC did not disrupt memory in the OPP test, but impaired spatial memory tested by the water maze escape task, and combined lesions of the MEC and hippocampus led to a stronger impairment.
“However, another study showed that lesions of the MEC did not disrupt memory in the OPP test, but impaired spatial memory tested by the water maze escape task and that combined lesions of the MEC and hippocampus led to a stronger impairment (Hales et al., 2014).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Hales et al., 2014
The MEC is engaged in the processing of "general" information about space and its interaction with the hippocampus, particularly in situations with increased complexity of objects.
“These data illustrate the engagement of the MEC in the processing of “general” information about space and its interaction with the hippocampus (Hales et al., 2014; Hales et al., 2018), particularly in situation with increased complexity of objects.”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Hales et al., 2014
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References 40 · Cited by 204
- Authors
- Hales, J. B., Schlesiger, M. I., Leutgeb, J. K., Squire, L. R., Leutgeb, S., & Clark, R. E.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Leutgeb, Stefan
- Clark, Robert E.
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 9
- Issue
- 3
- Pages
- 893-901
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W1995540943
- Cited by
- 204
- References
- 40
- Citations by year
- 2026: 15 · 2025: 15 · 2024: 15 · 2023: 16 · 2022: 11 · 2021: 22 · 2020: 16 · 2019: 21 · 2018: 16 · 2017: 24 · 2016: 12 · 2015: 20 · 2014: 1
- FWCI
- 10.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute on Aging (P50AG005131)
- National Institute of Mental Health (MH020002-13, R37MH024600, T32MH020002, R01MH024600, MH24600)
- National Institute of Neurological Disorders and Stroke (R01NS086947)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- medial entorhinal cortex, place cells, place memory, entorhinal cortex lesion, hippocampal lesions, spatial coding, place fields, spatial precision, water maze, hippocampal-dependent memory, object location memory, contextual memory
- MeSH terms
- Animals, Hippocampus, Male, Neurons, Entorhinal Cortex, Maze Learning, Rats, Long-Evans, Spatial Memory
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